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Molecules, Volume 5, Issue 5 (May 2000) – 8 articles , Pages 701-755

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Open AccessBook Review
Agrochemicals: Composition, Production, Toxicology, Applications. Edited by Franz Müller
Molecules 2000, 5(5), 712-713; https://doi.org/10.3390/50500712 - 25 May 2000
Viewed by 3034
Abstract
This book is a valuable source of information for those involved in modern agricultural practices.[...] Full article
Open AccessArticle
Behaviour of Some Activated Nitriles Toward Barbituric Acid, Thiobarbituric Acid and 3-Methyl-1-Phenylpyrazol-5-one
Molecules 2000, 5(5), 746-755; https://doi.org/10.3390/50500746 - 20 May 2000
Cited by 9 | Viewed by 5298
Abstract
The effect of some active methylene containing heterocyclic compounds, namely barbituric acid, thiobarbituric acid and 3-methyl-1-phenylpyrazol-5-one on a-cyano-3,4,5-trimethoxycinnamonitrile and ethyl a-cyano-3,4,5-trimethoxycinnamate (1a,b) was investigated. The structure of the new products was substantiated by their IR,1H-NMR and mass spectra. Full article
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Open AccessArticle
Structural Elucidation of Z- and E- Isomers of 5-Alkyl-4-ethoxycarbonyl-5-(4`-chlorophenyl)-3-oxa-4-pentenoic Acids
Molecules 2000, 5(5), 737-745; https://doi.org/10.3390/50500737 - 20 May 2000
Cited by 2 | Viewed by 5562
Abstract
Z- and E-isomers of 5-alkyl-4-ethoxycarbonyl-5-(4`-chlorophenyl)-3-oxa-4-pentenoic acids were prepared via the condensation of p-chloroacetophenone and/or pchloropropiophenone with diethyl-2,2`-oxydiacetate in the presence of sodium hydride as a basic catalyst. The Z-isomers of 2a and 2b were found to be predominant. The behaviour of the corresponding [...] Read more.
Z- and E-isomers of 5-alkyl-4-ethoxycarbonyl-5-(4`-chlorophenyl)-3-oxa-4-pentenoic acids were prepared via the condensation of p-chloroacetophenone and/or pchloropropiophenone with diethyl-2,2`-oxydiacetate in the presence of sodium hydride as a basic catalyst. The Z-isomers of 2a and 2b were found to be predominant. The behaviour of the corresponding anhydrides towards the action of hydrazine, phenylhydrazine, primary aromatic amines, hydrocarbons and ethanolysis has also been investigated. The structures and configurations of the products have been elucidated by chemical and spectroscopic means. Full article
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Open AccessArticle
Synthesis of 2’-Modified Nucleotides
Molecules 2000, 5(5), 727-729; https://doi.org/10.3390/50500727 - 15 May 2000
Viewed by 4770
Abstract
We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense [...] Read more.
We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with potential application in gene therapy. Full article
Open AccessArticle
Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity
Molecules 2000, 5(5), 714-726; https://doi.org/10.3390/50500714 - 14 May 2000
Cited by 15 | Viewed by 6729
Abstract
A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacterially active substances were found only in the series of N,N'-diarylethanediamides and N,N'-diarylbutanediamides. Other [...] Read more.
A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacterially active substances were found only in the series of N,N'-diarylethanediamides and N,N'-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane- and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris. Their relatively low antialgal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes. Full article
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Open AccessArticle
Utility of Sulphones in Heterocyclic Synthesis: Synthesis of Some Pyridine, Chromene and Thiophene Derivatives
Molecules 2000, 5(5), 701-709; https://doi.org/10.3390/50500701 - 05 May 2000
Cited by 19 | Viewed by 5690
Abstract
Phenylsulfonylacetonitrile (1) when reacted with α,β-unsaturated nitriles (2a,b) and/or 2-hydroxynaphthaldehyde yields pyridine derivatives (3a,b) and / or the iminochromene derivative (4) respectively. The behavior of (1) towards some a-halogenated compounds has been investigated. Full article
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Open AccessBook Review
The Age of the Molecule. Edited by Nina Hall
Molecules 2000, 5(5), 710-711; https://doi.org/10.3390/50500710 - 23 Apr 2000
Viewed by 2694
Abstract
It is the age of the Internet, or the age of information.[...] Full article
Open AccessArticle
Synthesis and Characterization of New Surface Active Azo Initiators for Radical Reactions
Molecules 2000, 5(5), 730-736; https://doi.org/10.3390/50500730 - 18 Apr 2000
Cited by 10 | Viewed by 5607
Abstract
The synthesis of a water soluble azo initiators from 2,2’-azodiisobutyronitrile (AIBN) was performed in three steps: reaction of dinitrile with aromatic alcohols in the presence of HCl to form bisiminoesters hydrochlorides which are hydrolyzed to the esters and final regioselective sulfonation of the [...] Read more.
The synthesis of a water soluble azo initiators from 2,2’-azodiisobutyronitrile (AIBN) was performed in three steps: reaction of dinitrile with aromatic alcohols in the presence of HCl to form bisiminoesters hydrochlorides which are hydrolyzed to the esters and final regioselective sulfonation of the aromatic esters. The thermal decomposition of the azo initiators obtained leads to formation of two surface active radicals which can start the chain reaction. Full article
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