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Article

Coupled Impact of Anthocyanin and Mineral Concentrations in Cranberry Juice on Gut Microbiota and Function Modulation: A First Demonstration

by
Eva Revellat
1,2,
Joanie Dupont-Morissette
3,
Thibault V. Varin
3,
Geneviève Pilon
3,
André Marette
1,3 and
Laurent Bazinet
1,2,*
1
Institute of Nutrition and Functional Foods (INAF) and Department of Food Sciences, Université Laval, Québec, QC G1V OA6, Canada
2
Laboratoire de Transformation Alimentaire et Procédés ElectroMembranaires (LTAPEM, Laboratory of Food Processing and ElectroMembrane Processes), Université Laval, Québec, QC G1V OA6, Canada
3
Heart and Lung Institute, Department of Medicine, Université Laval, Québec, QC G1V 4G5, Canada
*
Author to whom correspondence should be addressed.
Molecules 2025, 30(19), 3986; https://doi.org/10.3390/molecules30193986
Submission received: 27 June 2025 / Revised: 23 September 2025 / Accepted: 25 September 2025 / Published: 4 October 2025
(This article belongs to the Special Issue Analyses and Applications of Phenolic Compounds in Food—2nd Edition)
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Abstract

Cranberry juice (CJ), a natural source of anthocyanins, may provide additional health benefits when enriched, as anthocyanins have been shown to influence gut microbiota composition. This study investigated the effects of varying anthocyanin and mineral concentrations in CJ on gut microbiota in mice. Using electrodialysis with filtration membranes (EDFM), five CJ samples with different anthocyanin/mineral enrichment levels (0/0, −31/−85%, −19/−70%, 26/−32%, and 44/−60%) were produced and administered to C57BL/6J mice for four weeks. Gut microbiota composition was analyzed via 16S rRNA sequencing, and inflammation was determined in macroscopic observations of intestinal tissues. While α and β diversity remained unchanged, differential abundance analysis revealed that gut microbiota changes were influenced by anthocyanin and mineral concentrations. Synergistic trends were observed for Colidextribacter and Oscillibacter (increasing with both compounds) and for Turicibacter, Romboutsia, Enterorhabdus, and Bifidobacterium (decreasing with both compounds). Antagonistic trends emerged for Dubosiella, Acetatifactor, A2, Ruminococcus, and Intestinimonas (decreasing with anthocyanins and increasing with minerals), and the reverse was found for Ligilactobacillus. The most significant microbiota shifts occurred with the −31/−85% CJ, suggesting a strong effect of its low anthocyanin and mineral content. But further analysis is needed to assess their metabolic effects and impact on intestinal health.
Keywords: cranberry juice; anthocyanin; minerals; microbiota; modulation cranberry juice; anthocyanin; minerals; microbiota; modulation

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MDPI and ACS Style

Revellat, E.; Dupont-Morissette, J.; V. Varin, T.; Pilon, G.; Marette, A.; Bazinet, L. Coupled Impact of Anthocyanin and Mineral Concentrations in Cranberry Juice on Gut Microbiota and Function Modulation: A First Demonstration. Molecules 2025, 30, 3986. https://doi.org/10.3390/molecules30193986

AMA Style

Revellat E, Dupont-Morissette J, V. Varin T, Pilon G, Marette A, Bazinet L. Coupled Impact of Anthocyanin and Mineral Concentrations in Cranberry Juice on Gut Microbiota and Function Modulation: A First Demonstration. Molecules. 2025; 30(19):3986. https://doi.org/10.3390/molecules30193986

Chicago/Turabian Style

Revellat, Eva, Joanie Dupont-Morissette, Thibault V. Varin, Geneviève Pilon, André Marette, and Laurent Bazinet. 2025. "Coupled Impact of Anthocyanin and Mineral Concentrations in Cranberry Juice on Gut Microbiota and Function Modulation: A First Demonstration" Molecules 30, no. 19: 3986. https://doi.org/10.3390/molecules30193986

APA Style

Revellat, E., Dupont-Morissette, J., V. Varin, T., Pilon, G., Marette, A., & Bazinet, L. (2025). Coupled Impact of Anthocyanin and Mineral Concentrations in Cranberry Juice on Gut Microbiota and Function Modulation: A First Demonstration. Molecules, 30(19), 3986. https://doi.org/10.3390/molecules30193986

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