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Molecules, Volume 3, Issue 3 (March 1998), Pages 51-131, Articles M49-M73

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Open AccessArticle Evaluation of Effect of Microwave Irradiation on Syntheses and Reactions of Some New 3-Acyl-methylchromones
Molecules 1998, 3(3), 120-131; https://doi.org/10.3390/30300120
Received: 16 January 1998 / Accepted: 17 February 1998 / Published: 10 March 1998
Cited by 14 | Viewed by 5155 | PDF Full-text (68 KB) | HTML Full-text | XML Full-text
Abstract
The 3-Acyl-2-R-methylchromones (R = H, ArO, C6H4(CO)2N) were prepared in good yields by different methods from 2-hydroxyaroylacetone derivatives. Some subsequent reactions of these compounds with hydroxylamine and 3-formylchromones are described. The effect of microwave irradation on some condensation reactions was studied. Full article
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Open AccessArticle Enantiodivergent Synthesis of (R)- and (S)-Rolipram
Molecules 1998, 3(3), 107-119; https://doi.org/10.3390/30300107
Received: 2 November 1997 / Accepted: 23 February 1998 / Published: 10 March 1998
Cited by 36 | Viewed by 6898 | PDF Full-text (466 KB) | HTML Full-text | XML Full-text
Abstract
Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric amides obtained with (S)-(-)-phenylethylamine. Reduction of the nitro group and intramolecular transamidation
[...] Read more.
Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric amides obtained with (S)-(-)-phenylethylamine. Reduction of the nitro group and intramolecular transamidation gave (R)-(-)-1 and (S)-(+)-1, respectively. CD spectra of both enantiomers of rolipram are reported and discussed. Both enantiomers of rolipram presented the same potency of inhibitory activity against recombinant cyclic-AMP-selective phosphodiesterase (PDE4) subtypes. Full article
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Open AccessArticle A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones
Molecules 1998, 3(3), 100-106; https://doi.org/10.3390/30300100
Received: 28 January 1998 / Accepted: 18 February 1998 / Published: 9 March 1998
Cited by 110 | Viewed by 4798 | PDF Full-text (41 KB) | HTML Full-text | XML Full-text
Abstract
An efficient one-pot synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones is described. The synthesis is based on the reaction of readily available α-tosyl substituted thioureas or ureas with enolates of β-oxoesters or 1,3-dicarbonyl compounds followed by acid-catalyzed dehydration of the obtained 5-acyl-4-hydroxyhexahydropyrimidine-2-thiones/ones. Full article
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Open AccessReview Elemental and Molecular Heritage: An Internet-based Display
Molecules 1998, 3(3), 94-99; https://doi.org/10.3390/30300094
Received: 3 March 1998 / Accepted: 6 March 1998 / Published: 9 March 1998
Cited by 4 | Viewed by 6216 | PDF Full-text (414 KB) | HTML Full-text | XML Full-text
Abstract
The background to a Web page describing elemental and molecular heritage at Imperial College chemistry department is described. Photographs are shown of the original samples of elemental bromine and crystalline silicon, and molecular ferrocene and mauveine. 3D "Hyperactive" models of these systems are
[...] Read more.
The background to a Web page describing elemental and molecular heritage at Imperial College chemistry department is described. Photographs are shown of the original samples of elemental bromine and crystalline silicon, and molecular ferrocene and mauveine. 3D "Hyperactive" models of these systems are shown, together with a recently discovered heterocyclic systems scorpionine, which like mauveine is made by a deceptively simple chemical synthesis. Full article
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Open AccessShort Note (E)-3-(2-Methoxyphenyl)-2-butenoic Acid
Molecules 1998, 3(3), M73; https://doi.org/10.3390/M73
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2909 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (Z)-3-(2-Methoxyphenyl)-2-butenoate
Molecules 1998, 3(3), M72; https://doi.org/10.3390/M72
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2862 | Supplementary Files
Abstract
The synthetic procedure [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (E)-3-(2-Methoxyphenyl)-2-butenoate
Molecules 1998, 3(3), M71; https://doi.org/10.3390/M71
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2963 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note bis-[(Z)-5-Phenyl-2-penten-2-yl]mercury
Molecules 1998, 3(3), M70; https://doi.org/10.3390/M70
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2896 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note [(Z)-5-Phenyl-2-penten-2-yl]mercury Acetate
Molecules 1998, 3(3), M69; https://doi.org/10.3390/M69
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2945 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note [(Z)-5-Phenyl-2-penten-2-yl]mercury Bromide
Molecules 1998, 3(3), M68; https://doi.org/10.3390/M68
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2879 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Tributyl-[(Z)-5-phenyl-2-penten-2-yl]stannane
Molecules 1998, 3(3), M67; https://doi.org/10.3390/M67
Received: 27 February 1998 / Published: 6 March 1998
Cited by 2 | Viewed by 3075 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (Z)-2-Bromo-5-phenyl-2-pentene
Molecules 1998, 3(3), M66; https://doi.org/10.3390/M66
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 3091 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 2,3-Dibromo-2-methyl-5-phenylpentanoic Acid
Molecules 1998, 3(3), M65; https://doi.org/10.3390/M65
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2914 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (E)-2-Methyl-5-phenyl-2-pentenoic Acid
Molecules 1998, 3(3), M64; https://doi.org/10.3390/M64
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2902 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (Z)-2-Methyl-5-phenyl-2-pentenoate
Molecules 1998, 3(3), M63; https://doi.org/10.3390/M63
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2871 | Supplementary Files
Abstract
The synthetic procedure [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (E)-2-Methyl-5-phenyl-2-pentenoate
Molecules 1998, 3(3), M62; https://doi.org/10.3390/M62
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 3018 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 3-Hydroxy-3-methyl-5-phenylpentanoic Acid
Molecules 1998, 3(3), M61; https://doi.org/10.3390/M61
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2860 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl 3-Acetoxy-3-methyl-5-phenylpentanoate
Molecules 1998, 3(3), M60; https://doi.org/10.3390/M60
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2807 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl 3-Hydroxy-3-methyl-5-phenylpentanoate
Molecules 1998, 3(3), M59; https://doi.org/10.3390/M59
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2850 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (E)-1-Bromo-2-methyl-4-phenyl-1-butene
Molecules 1998, 3(3), M58; https://doi.org/10.3390/M58
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 3071 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (Z)-1-Bromo-2-methyl-4-phenyl-1-butene
Molecules 1998, 3(3), M57; https://doi.org/10.3390/M57
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2897 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 2(R,S),3(S,R)-2,3-Dibromo-3-methyl-5-phenyl-2-pentanoic Acid
Molecules 1998, 3(3), M56; https://doi.org/10.3390/M56
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 3040 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 2(S,R),3(R,S)-2,3-Dibromo-3-methyl-5-phenyl-2-pentanoic Acid
Molecules 1998, 3(3), M55; https://doi.org/10.3390/M55
Received: 27 February 1998 / Published: 6 March 1998
Cited by 1 | Viewed by 3166 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (Z)-3-Methyl-5-phenyl-2-pentenoic Acid
Molecules 1998, 3(3), M54; https://doi.org/10.3390/M54
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 3013 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (E)-3-Methyl-5-phenyl-2-pentenoic Acid
Molecules 1998, 3(3), M53; https://doi.org/10.3390/M53
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2949 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (Z)-3-Methyl-5-phenyl-2-pentenoate
Molecules 1998, 3(3), M52; https://doi.org/10.3390/M52
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2897 | Supplementary Files
Abstract
The synthetic procedure [1] has been presented elsewhere. Ethyl (Z)-3-methyl-5-phenyl-2-pentenoate was obtained (2.23 g, 23%) as a colourless oil.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (E)-3-methyl-5-phenyl-2-pentenoate
Molecules 1998, 3(3), M51; https://doi.org/10.3390/M51
Received: 27 February 1998 / Published: 6 March 1998
Viewed by 2987 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessArticle Application of Microwave in Organic Synthesis. Dry Synthesis of 2-Arylmethylene-3(2)-naphthofuranones
Molecules 1998, 3(3), 88-93; https://doi.org/10.3390/30300088
Received: 19 February 1998 / Accepted: 3 March 1998 / Published: 5 March 1998
Cited by 21 | Viewed by 5465 | PDF Full-text (55 KB) | HTML Full-text | XML Full-text
Abstract
3(2)-Naphthofuranone (1) was condensed in the presence of Al2O3-KF with aromatic aldehydes (4) to give arylidenenaphthofuranones (5a-f) without solvent under focused microwave irradiation. Full article
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Open AccessShort Note Methyl 2,3-O-Isopropylidene-a-D-mannofuranoside 5,6-Carbonate
Molecules 1998, 3(3), M50; https://doi.org/10.3390/M50
Received: 16 February 1998 / Published: 4 March 1998
Viewed by 2087 | Supplementary Files
Abstract
Sugar carbonates can be prepared by the condensation of the cis-glycol system of the carbohydrate with phosgene or with a chloroformic ester [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Cycloartan-2b-2-methyl ButanoateIsolated from Genus Espeletia (Asteraceae)
Molecules 1998, 3(3), M49; https://doi.org/10.3390/M49
Received: 12 February 1998 / Published: 4 March 1998
Cited by 1 | Viewed by 2107 | Supplementary Files
Abstract
We describe the isolation and characterization of a new cycloartane-type triterpenes, cycloartan- 2b-2-methyl butanoate.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
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