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Molecules 1998, 3(3), 100-106;

A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones

Department of Organic Chemistry, State Academy of Fine Chemical Technology, Vernadsky Ave. 86, Moscow 117571, Russian Federation
Author to whom correspondence should be addressed.
Received: 28 January 1998 / Accepted: 18 February 1998 / Published: 9 March 1998
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An efficient one-pot synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones is described. The synthesis is based on the reaction of readily available α-tosyl substituted thioureas or ureas with enolates of β-oxoesters or 1,3-dicarbonyl compounds followed by acid-catalyzed dehydration of the obtained 5-acyl-4-hydroxyhexahydropyrimidine-2-thiones/ones. View Full-Text
Keywords: α-Tosyl substituted (thio)ureas; 5-acyl-1; 2; 3; 4-tetrahydropyrimidine-2-thiones/ones α-Tosyl substituted (thio)ureas; 5-acyl-1; 2; 3; 4-tetrahydropyrimidine-2-thiones/ones

Scheme 1

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Shutalev, A.D.; Kishko, E.A.; Sivova, N.V.; Kuznetsov, A.Y. A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones. Molecules 1998, 3, 100-106.

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