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Molecules
Volume 28
Issue 3
10.3390/molecules28031087
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Article
Peer-Review Record

Development of Polymersomes Co-Delivering Doxorubicin and Melittin to Overcome Multidrug Resistance

Molecules 2023, 28(3), 1087; https://doi.org/10.3390/molecules28031087
by Eunkyung Han 1,†, Doyeon Kim 1,†, Youngheun Cho 1, Seonock Lee 2, Jungho Kim 2 and Hyuncheol Kim 1,3,*
Reviewer 1: Anonymous
Reviewer 2:
Peter Herrlich
Reviewer 3:
Mohamed W. Attwa
Molecules 2023, 28(3), 1087; https://doi.org/10.3390/molecules28031087
Submission received: 26 December 2022 / Revised: 19 January 2023 / Accepted: 19 January 2023 / Published: 21 January 2023
(This article belongs to the Special Issue New Therapeutic Tools against MDR Tumors: Discovery, Synthesis and Evaluation of Bioactive Compounds)

Round 1

Reviewer 1 Report

The work submitted for review concerns a very important issue - the ability to overcome multidrug resistance, which is one of the main factors of chemotherapy failure. The authors developed a polymersome made of poly(lactic acid) (PLA-hyaluronic acid (HA) di-block copolymer charged with two substances - melittin and doxorubicin.

The experiment was well planned and executed. In P. 4.3 Characterizations of DOX-Mel PL, it is necessary to provide the parameters of the chromatographic separation - column, mobile phase, flow rate, etc. Whether the release test was performed once or whether the presented results are the average value of several determinations, which should be precisely stated. If it was performed once, the test should be repeated at least twice to make the results reliable, as in the case of data from the cultured calls and animals (means ± standard error).

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

I wondered whether the binding of the polymer to CD44 induces a CD44e dependent reaction. And: CD44 is an almost ubiquitously expressed protein. How do the authors think to reach specificity and to avoid uptake of the drugs into many non-tumor cells. Have they considered to expand the nano-polymers to interact wiith other surface proteins.

Author Response

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Author Response File: Author Response.pdf

Reviewer 3 Report

Dear editor,

The manuscript is very good and perfect for publication. I have only one minor comment

The author should examine the delivery system for each analyte alone and in combination to give a clear idea about the mechanism and the potency of combination and the importance of the delivery system

 

With my best regards:

 

Author Response

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Author Response File: Author Response.pdf

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