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Article

Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study

1
School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av do Café s/n, Ribeirão Preto 14040-903, SP, Brazil
2
Abyss Ingredients, 860 Route de Caudan, 56850 Caudan, France
*
Author to whom correspondence should be addressed.
Academic Editors: Irene Dini and Sonia Laneri
Molecules 2021, 26(16), 4880; https://doi.org/10.3390/molecules26164880
Received: 7 June 2021 / Revised: 14 July 2021 / Accepted: 15 July 2021 / Published: 12 August 2021
(This article belongs to the Special Issue Nutricosmetics: A New Area of Cosmetic Product)
Collagen and its peptides are natural ingredients used in food supplements and nutricosmetics with the claim of providing benefits for skin health and beauty. In this context, the aim of the present study was to evaluate the clinical efficacy of oral supplementation with hydrolyzed fish cartilage for the improvement of chronological and photoaging-induced skin changes. A total of 46 healthy females aged 45 to 59 years were enrolled and divided into two groups: G1—placebo and G2—oral treatment with hydrolyzed fish cartilage. Measurements of skin wrinkles, dermis echogenicity and thickness, and morphological and structural characteristics of the skin were performed in the nasolabial region of the face before and after a 90-day period of treatment using high-resolution imaging, ultrasound, and reflectance confocal microscopy image analyses. A significant reduction in wrinkles and an increase of dermis echogenicity were observed after a 90-day period of treatment with hydrolyzed fish cartilage compared to the placebo and baseline values. In addition, reflectance confocal microscopy (RCM) image analysis showed improved collagen morphology and reduced elastosis after treatment with hydrolyzed fish cartilage. The present study showed the clinical benefits for the skin obtained with oral supplementation with a low dose of collagen peptides from hydrolyzed fish cartilage. View Full-Text
Keywords: skin aging; hydrolyzed fish cartilage; nutricosmetics; imaging analysis; clinical efficacy skin aging; hydrolyzed fish cartilage; nutricosmetics; imaging analysis; clinical efficacy
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MDPI and ACS Style

Maia Campos, P.M.B.G.; Franco, R.S.B.; Kakuda, L.; Cadioli, G.F.; Costa, G.M.D.; Bouvret, E. Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study. Molecules 2021, 26, 4880. https://doi.org/10.3390/molecules26164880

AMA Style

Maia Campos PMBG, Franco RSB, Kakuda L, Cadioli GF, Costa GMD, Bouvret E. Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study. Molecules. 2021; 26(16):4880. https://doi.org/10.3390/molecules26164880

Chicago/Turabian Style

Maia Campos, Patrícia M.B.G., Rodolfo S.B. Franco, Letícia Kakuda, Gabriel F. Cadioli, Gabriela M.D. Costa, and Elodie Bouvret. 2021. "Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study" Molecules 26, no. 16: 4880. https://doi.org/10.3390/molecules26164880

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