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Brief Report

Immunogenicity of Foot-and-Mouth Disease Virus Dendrimer Peptides: Need for a T-Cell Epitope and Ability to Elicit Heterotypic Responses

by
Rodrigo Cañas-Arranz
1,
Patricia de León
1,
Sira Defaus
2,
Elisa Torres
3,
Mar Forner
2,
María J. Bustos
1,
David Andreu
2,
Esther Blanco
3 and
Francisco Sobrino
1,*
1
Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), 28049 Madrid, Spain
2
Departament de Ciències Experimentals i de la Salut (DCEXS-UPF), 08003 Barcelona, Spain
3
Centro de Investigación en Sanidad Animal (CISA-INIA), 28130 Valdeolmos, Spain
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(16), 4714; https://doi.org/10.3390/molecules26164714
Submission received: 12 July 2021 / Revised: 30 July 2021 / Accepted: 1 August 2021 / Published: 4 August 2021
(This article belongs to the Special Issue Dendrimers for Biomedical Applications)
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Abstract

An approach based on a dendrimer display of B- and T-cell epitopes relevant for antibody induction has been shown to be effective as a foot-and-mouth disease (FMD) vaccine. B2T dendrimers combining two copies of the major FMD virus (FMDV) type O B-cell epitope (capsid proteinVP1 (140–158)) covalently linked to a heterotypic T-cell epitope from non-structural protein 3A (21–35), henceforth B2T-3A, has previously been shown to elicit high neutralizing antibody (nAb) titers and IFN-γ-producing cells in both mice and pigs. Here, we provide evidence that the B- and T-cell epitopes need to be tethered to a single molecular platform for successful T-cell help, leading to efficient nAb induction in mice. In addition, mice immunized with a non-covalent mixture of B2T-3A dendrimers containing the B-cell epitopes of FMDV types O and C induced similarly high nAb levels against both serotypes, opening the way for a multivalent vaccine platform against a variety of serologically different FMDVs. These findings are relevant for the design of vaccine strategies based on B- and T-cell epitope combinations.
Keywords: FMDV; peptide vaccine; dendrimer FMDV; peptide vaccine; dendrimer

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MDPI and ACS Style

Cañas-Arranz, R.; de León, P.; Defaus, S.; Torres, E.; Forner, M.; Bustos, M.J.; Andreu, D.; Blanco, E.; Sobrino, F. Immunogenicity of Foot-and-Mouth Disease Virus Dendrimer Peptides: Need for a T-Cell Epitope and Ability to Elicit Heterotypic Responses. Molecules 2021, 26, 4714. https://doi.org/10.3390/molecules26164714

AMA Style

Cañas-Arranz R, de León P, Defaus S, Torres E, Forner M, Bustos MJ, Andreu D, Blanco E, Sobrino F. Immunogenicity of Foot-and-Mouth Disease Virus Dendrimer Peptides: Need for a T-Cell Epitope and Ability to Elicit Heterotypic Responses. Molecules. 2021; 26(16):4714. https://doi.org/10.3390/molecules26164714

Chicago/Turabian Style

Cañas-Arranz, Rodrigo, Patricia de León, Sira Defaus, Elisa Torres, Mar Forner, María J. Bustos, David Andreu, Esther Blanco, and Francisco Sobrino. 2021. "Immunogenicity of Foot-and-Mouth Disease Virus Dendrimer Peptides: Need for a T-Cell Epitope and Ability to Elicit Heterotypic Responses" Molecules 26, no. 16: 4714. https://doi.org/10.3390/molecules26164714

APA Style

Cañas-Arranz, R., de León, P., Defaus, S., Torres, E., Forner, M., Bustos, M. J., Andreu, D., Blanco, E., & Sobrino, F. (2021). Immunogenicity of Foot-and-Mouth Disease Virus Dendrimer Peptides: Need for a T-Cell Epitope and Ability to Elicit Heterotypic Responses. Molecules, 26(16), 4714. https://doi.org/10.3390/molecules26164714

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