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Article

Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil

1
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
2
Department of Product Development Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50200, Thailand
3
Department of Herb and Extract Business Development, Tipco Biotech Company, Prachuapkhirikhan 77000, Thailand
4
Protein-Ligand Engineering and Molecular Biology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Thailand Science Park, Pathum Thani 12120, Thailand
5
Department of Haematology, O’Gormond Building, Institute of Cancer Research, Huntley Street, University College London, London WC1E 6BT, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Panagiotis Zoumpoulakis
Molecules 2020, 25(11), 2474; https://doi.org/10.3390/molecules25112474
Received: 30 April 2020 / Revised: 20 May 2020 / Accepted: 20 May 2020 / Published: 27 May 2020
(This article belongs to the Special Issue Bioactive Compounds with Applications in Health and Food)
Plant seeds have been found to contain bioactive compounds that have potential nutraceutical benefits. Guava seeds (Psidium guajava) are by-products in the beverage and juice industry; however, they can be utilized for a variety of commercial purposes. This study was designed to analyze the phytochemicals of the n-hexane extract of guava seed oil (GSO), to study its free-radical scavenging activity, and to monitor the changes in serum lipids and fatty acid profiles in rats that were fed GSO. The GSO was analyzed for phytochemicals using chromatographic methods. It was also tested for free-radical scavenging activity in hepatoma and neuroblastoma cells, and analyzed in terms of serum lipids and fatty acids. GSO was found to contain phenolic compounds (e.g., chlorogenic acid and its derivatives) and phytosterols (e.g., stimasterol, β-sitosterol and campesterol), and exerted radical-scavenging activity in cell cultures in a concentration-dependent manner. Long-term consumption of GSO did not increase cholesterol and triglyceride levels in rat serum, but it tended to decrease serum fatty acid levels in a concentration-dependent manner. This is the first study to report on the lipid, phytosterol and phenolic compositions, antioxidant activity, and the hepato- and neuro-protection of hydrogen peroxide-induced oxidative stress levels in the GSO extract. View Full-Text
Keywords: Psidium guajava; seed; hexane extract; lipid; phenolic compounds; phytosterols; antioxidant Psidium guajava; seed; hexane extract; lipid; phenolic compounds; phytosterols; antioxidant
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MDPI and ACS Style

Prommaban, A.; Utama-ang, N.; Chaikitwattana, A.; Uthaipibull, C.; Porter, J.B.; Srichairatanakool, S. Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil. Molecules 2020, 25, 2474. https://doi.org/10.3390/molecules25112474

AMA Style

Prommaban A, Utama-ang N, Chaikitwattana A, Uthaipibull C, Porter JB, Srichairatanakool S. Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil. Molecules. 2020; 25(11):2474. https://doi.org/10.3390/molecules25112474

Chicago/Turabian Style

Prommaban, Adchara, Niramon Utama-ang, Anan Chaikitwattana, Chairat Uthaipibull, John B. Porter, and Somdet Srichairatanakool. 2020. "Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil" Molecules 25, no. 11: 2474. https://doi.org/10.3390/molecules25112474

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