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Molecules 2019, 24(8), 1519; https://doi.org/10.3390/molecules24081519

Natural Products in Alzheimer’s Disease Therapy: Would Old Therapeutic Approaches Fix the Broken Promise of Modern Medicines?

Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Central Avenue, Chatham-Maritime, Kent ME4 4TB, UK
Received: 2 April 2019 / Revised: 15 April 2019 / Accepted: 16 April 2019 / Published: 17 April 2019
(This article belongs to the Special Issue Natural Products in Alzheimer’s Disease Drug Discovery)
PDF [924 KB, uploaded 17 April 2019]
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Abstract

Despite extensive progress in understanding the pathology of Alzheimer’s disease (AD) over the last 50 years, clinical trials based on the amyloid–beta (Aβ) hypothesis have kept failing in late stage human trials. As a result, just four old drugs of limited clinical outcomes and numerous side effects are currently used for AD therapy. This article assesses the common pharmacological targets and therapeutic principles for current and future drugs. It also underlines the merits of natural products acting through a polytherapeutic approach over a monotherapy option of AD therapy. Multi-targeting approaches through general antioxidant and anti-inflammatory mechanisms coupled with specific receptor and/or enzyme-mediated effects in neuroprotection, neuroregeneration, and other rational perspectives of novel drug discovery are emphasized.
Keywords: Alzheimer’s disease; cholinergic; acetylcholinesterase; amyloid beta; anti-inflammatory; antioxidant; tau protein Alzheimer’s disease; cholinergic; acetylcholinesterase; amyloid beta; anti-inflammatory; antioxidant; tau protein
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Habtemariam, S. Natural Products in Alzheimer’s Disease Therapy: Would Old Therapeutic Approaches Fix the Broken Promise of Modern Medicines? Molecules 2019, 24, 1519.

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