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Natural Products in Alzheimer’s Disease Therapy: Would Old Therapeutic Approaches Fix the Broken Promise of Modern Medicines?

Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Central Avenue, Chatham-Maritime, Kent ME4 4TB, UK
Molecules 2019, 24(8), 1519; https://doi.org/10.3390/molecules24081519
Received: 2 April 2019 / Revised: 15 April 2019 / Accepted: 16 April 2019 / Published: 17 April 2019
(This article belongs to the Special Issue Natural Products in Alzheimer’s Disease Drug Discovery)
Despite extensive progress in understanding the pathology of Alzheimer’s disease (AD) over the last 50 years, clinical trials based on the amyloid–beta (Aβ) hypothesis have kept failing in late stage human trials. As a result, just four old drugs of limited clinical outcomes and numerous side effects are currently used for AD therapy. This article assesses the common pharmacological targets and therapeutic principles for current and future drugs. It also underlines the merits of natural products acting through a polytherapeutic approach over a monotherapy option of AD therapy. Multi-targeting approaches through general antioxidant and anti-inflammatory mechanisms coupled with specific receptor and/or enzyme-mediated effects in neuroprotection, neuroregeneration, and other rational perspectives of novel drug discovery are emphasized. View Full-Text
Keywords: Alzheimer’s disease; cholinergic; acetylcholinesterase; amyloid beta; anti-inflammatory; antioxidant; tau protein Alzheimer’s disease; cholinergic; acetylcholinesterase; amyloid beta; anti-inflammatory; antioxidant; tau protein
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MDPI and ACS Style

Habtemariam, S. Natural Products in Alzheimer’s Disease Therapy: Would Old Therapeutic Approaches Fix the Broken Promise of Modern Medicines? Molecules 2019, 24, 1519.

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