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Beneficial Effects of Natural Bioactive Compounds from Hibiscus sabdariffa L. on Obesity

1
Department of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea
2
Institute of Agricultural Science & Technology, Kyungpook National University, Daegu 41566, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Min-Hsiung Pan
Molecules 2019, 24(1), 210; https://doi.org/10.3390/molecules24010210
Received: 29 November 2018 / Revised: 3 January 2019 / Accepted: 8 January 2019 / Published: 8 January 2019
(This article belongs to the Special Issue Natural Bioactives in Anti-Obesity Therapy)
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Abstract

Obesity is a condition associated with the accumulation of excess fat in the body, energy imbalance, lipogenesis, etc., which increases adipose tissue mass through adipogenesis and poses a health risk. Its prevalence has become an economic burden to the health care system and the world at large. One of the alternatives to tackling obesity involves the use of bioactive compounds. We critically examined the effects of Hibiscus sabdariffa extract (HSE) on various parameters associated with the development of obesity such as; the effect of HSE on body weight, the effect of HSE on lipid accumulation, cholesterol metabolism and plasma parameters, the inhibitory effect of HSE on pancreatic lipase, and the effect of HSE on adipocyte differentiation/adipogenesis. This review has gathered reports on the various anti-obesity effects of H. sabdariffa bioactive compounds in cell and animal models, as well as in humans. Available toxicology information on the consumption of H. sabdariffa revealed that its toxicity is dose-dependent and may cause an adverse effect when administered over a long period of time. Reports have shown that H. sabdariffa derived bioactive compounds are potent in the treatment of obesity with an evident reduction in body weight, inhibition of lipid accumulation and suppression of adipogenesis through the PPARγ pathway and other transcriptional factors. View Full-Text
Keywords: adipogenesis; bioactive compounds; fat accumulation; Hibiscus sabdariffa; lipase inhibition adipogenesis; bioactive compounds; fat accumulation; Hibiscus sabdariffa; lipase inhibition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ojulari, O.V.; Lee, S.G.; Nam, J.-O. Beneficial Effects of Natural Bioactive Compounds from Hibiscus sabdariffa L. on Obesity. Molecules 2019, 24, 210.

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