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Article

Antimicrobial Activity of Chamomile Essential Oil: Effect of Different Formulations

1
Department of Laboratory Medicine, Faculty of Medicine, University of Pécs, H-7624 Pécs, Hungary
2
Institute of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary
3
Faculty of Food Technology Osijek, University of Osijek, Franje Kuhaca 20, 31000 Osijek, Croatia
4
János Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Igor Jerković
Molecules 2019, 24(23), 4321; https://doi.org/10.3390/molecules24234321
Received: 31 October 2019 / Revised: 18 November 2019 / Accepted: 21 November 2019 / Published: 26 November 2019
(This article belongs to the Special Issue Progress in Volatile Organic Compounds Research)
Essential oils (EOs) are highly lipophilic, which makes the measurement of their biological action difficult in an aqueous environment. We formulated a Pickering nanoemulsion of chamomile EO (CPe). Surface-modified Stöber silica nanoparticles (20 nm) were prepared and used as a stabilizing agent of CPe. The antimicrobial activity of CPe was compared with that of emulsion stabilized with Tween 80 (CT80) and ethanolic solution (CEt). The antimicrobial effects were assessed by their minimum inhibitory concentration (MIC90) and minimum effective (MEC10) concentrations. Besides growth inhibition (CFU/mL), the metabolic activity and viability of Gram-positive and Gram-negative bacteria as well as Candida species, in addition to the generation of oxygen free radical species (ROS), were studied. We followed the killing activity of CPe and analyzed the efficiency of the EO delivery for examined formulations by using unilamellar liposomes as a cellular model. CPe showed significantly higher antibacterial and antifungal activities than CT80 and CEt. Chamomile EOs generated superoxide anion and peroxide related oxidative stress which might be the major mode of action of Ch essential oil. We could also demonstrate that CPe was the most effective in donation of the active EO components when compared with CT80 and CEt. Our data suggest that CPe formulation is useful in the fight against microbial infections. View Full-Text
Keywords: chamomile essential oil; Pickering emulsion; antimicrobial activity; free radical generation chamomile essential oil; Pickering emulsion; antimicrobial activity; free radical generation
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MDPI and ACS Style

Das, S.; Horváth, B.; Šafranko, S.; Jokić, S.; Széchenyi, A.; Kőszegi, T. Antimicrobial Activity of Chamomile Essential Oil: Effect of Different Formulations. Molecules 2019, 24, 4321. https://doi.org/10.3390/molecules24234321

AMA Style

Das S, Horváth B, Šafranko S, Jokić S, Széchenyi A, Kőszegi T. Antimicrobial Activity of Chamomile Essential Oil: Effect of Different Formulations. Molecules. 2019; 24(23):4321. https://doi.org/10.3390/molecules24234321

Chicago/Turabian Style

Das, Sourav, Barbara Horváth, Silvija Šafranko, Stela Jokić, Aleksandar Széchenyi, and Tamás Kőszegi. 2019. "Antimicrobial Activity of Chamomile Essential Oil: Effect of Different Formulations" Molecules 24, no. 23: 4321. https://doi.org/10.3390/molecules24234321

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