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Open AccessArticle

Effects of Orally Consumed Rosa damascena Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats

1
Phytotherapy Research Center, Bezmialem Vakıf University, 34093 Fatih, İstanbul, Turkey
2
Department of Ophthalmology, Faculty of Medicine, Bezmialem Vakıf University, 34093 Fatih, İstanbul, Turkey
3
Department of Pathology, Faculty of Medicine, Bezmialem Vakıf University, 34093 Fatih, İstanbul, Turkey
*
Author to whom correspondence should be addressed.
Academic Editor: Lars P. Christensen
Molecules 2019, 24(22), 4069; https://doi.org/10.3390/molecules24224069 (registering DOI)
Received: 27 September 2019 / Revised: 5 November 2019 / Accepted: 8 November 2019 / Published: 10 November 2019
(This article belongs to the Special Issue Selected Papers from the Joint Symposia of MESMAP-5 & ISPBS-5)
Diabetes mellitus is a multisystemic metabolic disorder that may affect the eyes, kidneys, vessels, and heart. Chronic hyperglycemia causes non-enzymatic glycation of proteins and elevation of the polyol pathway resulting in oxidative stress that damages organs. The current study aimed to investigate the dose-dependent effects of orally consumed Rosa damascena Mill. hydrosol on hematology, clinical biochemistry, lens enzymatic activity, and lens pathology in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced into male Sprague–Dawley rats by intraperitoneal administration of STZ (40 mg/kg body weight). Rose hydrosols containing 1515 mg/L and 500 mg/L total volatiles (expressed as citronellol) were introduced to rats orally for 45 days. Consumption of 1515 mg/L volatile containing rose hydrosol successfully ameliorated hematologic, hepatic, and renal functions. Hydrosols also attenuated hyperglycemia and decreased the advanced glycation end-product formation in a dose-dependent manner. Rose hydrosol components significantly increased the lens enzymatic activities of glutathione peroxidase and decreased the activity of aldose reductase to prevent cataractogenesis. Histopathological examinations of rat lenses also indicated that increasing the dose of rose hydrosol had a protective effect on lenses in diabetic conditions. Additionally, in silico modeling of aldose reductase inhibition with rose hydrosol volatiles was carried out for extrapolating the current study to humans. The present results suggest that rose hydrosol exerts significant protective properties in diabetes mellitus and has no toxic effect on all studied systems in healthy test groups. View Full-Text
Keywords: Rosa damascena; rose hydrosol; diabetes; cataract; hematology; clinical chemistry; lens pathology; aldose reductase Rosa damascena; rose hydrosol; diabetes; cataract; hematology; clinical chemistry; lens pathology; aldose reductase
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MDPI and ACS Style

Demirbolat, İ.; Ekinci, C.; Nuhoğlu, F.; Kartal, M.; Yıldız, P.; Geçer, M.Ö. Effects of Orally Consumed Rosa damascena Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats. Molecules 2019, 24, 4069.

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