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Open AccessArticle

Therapeutic Use of Scoparia dulcis Reduces the Progression of Experimental Osteoarthritis

Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, São Luís 65080-805, Brazil
Universidade Ceuma, São Luís 65075-120, Brazil
Universidade Federal do Maranhão, Coordenação de Ciências Naturais, Campus Bacabal, São Luís 65080-80, Brazil
Hospital Universitário Presidente Dutra, São Luís 65020-070, Brazil
Departamento de Química, Universidade Federal do Maranhão, São Luís 65080-805, Brazil
Faculdade Santa Terezinha, São Luís 65045-180, Brazil
Authors to whom correspondence should be addressed.
Academic Editor: Maria da Graça Costa G. Miguel
Molecules 2019, 24(19), 3474;
Received: 30 July 2019 / Revised: 7 September 2019 / Accepted: 10 September 2019 / Published: 25 September 2019
(This article belongs to the Special Issue Anti-Inflammatory Activity of Natural Products)
Pain is recognized as one of the main symptoms in knee osteoarthritis and is the main reason why patients seek medical attention. Scoparia dulcis has been popularly used to relieve discomfort caused by various painful conditions. The objective of the study is to evaluate the analgesic and anti-inflammatory effect of the crude extract of S. dulcis, in an experimental model of osteoarthritis. The experiment was performed with Wistar rats divided into 4 groups with 5 animals each: healthy, saline, crude extract, and meloxicam groups. Knee osteoarthritis was induced by intra-articular injection of sodium mono-iodoacetate. First, clinical parameters of pain were assessed at days 0, 5, 10, 15, and 20 after induction. Second, the potential cyclooxygenase inhibition was evaluated, and the cytokines of the synovial fluid were quantified. An in silico test and Molecular Docking tests were performed. A histopathological evaluation was made on articular cartilage with safranin O staining. The results showed that a 15-day treatment with crude extract reduced edema, spontaneous pain, peripheral nociceptive activity, and proinflammatory cytokines in the synovial fluid. The highest inhibition of cyclooxygenase 2 in the crude extract occurred at 50 µg/mL. The crude extract of S. dulcis presents therapeutic potential for the treatment of osteoarthritis due to its anti-inflammatory and anti-nociceptive action. View Full-Text
Keywords: Scoparia dulcis; Osteoarthritis; Pain; Inflammation; Treatment Scoparia dulcis; Osteoarthritis; Pain; Inflammation; Treatment
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MDPI and ACS Style

Lima, M.V.V.; Freire, A.O.; Sousa, E.L.F.; Vale, A.A.M.; Lopes, A.J.O.; Vasconcelos, C.C.; Lima-Aragão, M.V.V.; Serra, H.O.; Liberio, R.N.M.G.; Santos, A.P.S.A.; Silva, G.E.B.; Rocha, C.Q.; Moreira Lima, F.C.V.; Cartágenes, M.S.S.; Garcia, J.B.S. Therapeutic Use of Scoparia dulcis Reduces the Progression of Experimental Osteoarthritis. Molecules 2019, 24, 3474.

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