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Article

Analysis of Flavonoid Metabolites in Citrus Peels (Citrus reticulata “Dahongpao”) Using UPLC-ESI-MS/MS

by 1,2,†, 1,†, 1, 2,* and 1,*
1
Department of Pharmacy, Chengdu University of TCM, Standardization education ministry key laboratory of traditional Chinese medicine, Chengdu 611137, China
2
Food & Drugs Authority of Nanchong, Nanchong 637000, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Celestino Santos-Buelga
Molecules 2019, 24(15), 2680; https://doi.org/10.3390/molecules24152680
Received: 20 June 2019 / Revised: 14 July 2019 / Accepted: 22 July 2019 / Published: 24 July 2019
(This article belongs to the Special Issue Flavonoids: From Structure to Health Issues II)
Flavonoids are a kind of essential substance for the human body because of their antioxidant properties and extremely high medicinal value. Citrus reticulata “Dahongpao” (DHP) is a special citrus variety that is rich in flavonoids, however little is known about its systematic flavonoids profile. In the present study, the presence of flavonoids in five important citrus varieties, including DHP, Citrus grandis Tomentosa (HZY), Citrus ichangensis Swingle (YCC), Citrus sinensis (L.) Osbeck (TC), and Citrus reticulata ‘Buzhihuo’ (BZH), was determined using a UPLC-ESI-MS/MS-based, widely targeted metabolome. Results showed that a total of 254 flavonoid metabolites (including 147 flavone, 39 flavonol, 21 flavanone, 24 anthocyanins, 8 isoflavone, and 15 polyphenol) were identified. The total flavonoid content of peels from DHP was the highest. DHP could be clearly separated from other samples through clustering analysis and principal component analysis (PCA). Further, 169 different flavonoid metabolites were observed between DHP peels and the other four citrus peels, and 26 down-regulated differential metabolites displayed important biological activities in DHP. At the same time, a unique flavonoid component, tricin 4′-O-syringyl alcohol, was only found in DHP, which could be used as a marker to distinguish between other varieties. This work might facilitate a better understanding of flavonoid metabolites between DHP peels and the other four citrus peels and provide a reference for its sufficient utilization in the future. View Full-Text
Keywords: flavonoid metabolites; UPLC-ESI-MS/MS; Citrus reticulata “Dahongpao”; citrus peels; PCA; OPLS-DA flavonoid metabolites; UPLC-ESI-MS/MS; Citrus reticulata “Dahongpao”; citrus peels; PCA; OPLS-DA
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MDPI and ACS Style

Wang, F.; Chen, L.; Chen, H.; Chen, S.; Liu, Y. Analysis of Flavonoid Metabolites in Citrus Peels (Citrus reticulata “Dahongpao”) Using UPLC-ESI-MS/MS. Molecules 2019, 24, 2680. https://doi.org/10.3390/molecules24152680

AMA Style

Wang F, Chen L, Chen H, Chen S, Liu Y. Analysis of Flavonoid Metabolites in Citrus Peels (Citrus reticulata “Dahongpao”) Using UPLC-ESI-MS/MS. Molecules. 2019; 24(15):2680. https://doi.org/10.3390/molecules24152680

Chicago/Turabian Style

Wang, Fu, Lin Chen, Hongping Chen, Shiwei Chen, and Youping Liu. 2019. "Analysis of Flavonoid Metabolites in Citrus Peels (Citrus reticulata “Dahongpao”) Using UPLC-ESI-MS/MS" Molecules 24, no. 15: 2680. https://doi.org/10.3390/molecules24152680

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