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Molecules 2018, 23(2), 472; https://doi.org/10.3390/molecules23020472

Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum

1
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China
2
Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Institute of Science and Technology, HaiKou 571126, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 2 January 2018 / Revised: 6 February 2018 / Accepted: 11 February 2018 / Published: 22 February 2018
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Two new phenolic glycosides (1 and 2) and two new isocoumarin glycosides (3 and 4), along with 14 known compounds (518), were isolated from the stems of Homalium paniculiflorum. Their structures were established on the basis of extensive spectroscopic analyses and chemical methods. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Compounds 1 and 4 exhibited inhibitory activities with IC50 values of 30.23 ± 1.23 μM and 19.36 ± 0.19 μM, respectively. View Full-Text
Keywords: Homalium paniculiflorum; phenolic glycosides; isocoumarin glycosides; NO production inhibition Homalium paniculiflorum; phenolic glycosides; isocoumarin glycosides; NO production inhibition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wu, S.-Y.; Fu, Y.-H.; Zhou, Q.; Bai, M.; Chen, G.-Y.; Zhao, S.-Y.; Han, C.-R.; Song, X.-P. Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum. Molecules 2018, 23, 472.

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