Next Article in Journal
Nanoliposomes as Vehicles for Astaxanthin: Characterization, In Vitro Release Evaluation and Structure
Next Article in Special Issue
Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2+
Previous Article in Journal
Synthesis of Novel Shikonin Derivatives and Pharmacological Effects of Cyclopropylacetylshikonin on Melanoma Cells
Previous Article in Special Issue
Phytochemical and Analytical Characterization of Novel Sulfated Coumarins in the Marine Green Macroalga Dasycladus vermicularis (Scopoli) Krasser
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview

Genuine and Sequestered Natural Products from the Genus Orobanche (Orobanchaceae, Lamiales)

Pharmazeutisches Institut, Abteilung Pharmazeutische Biologie, Christian-Albrechts-Universität zu Kiel, Gutenbergstraße 76, 24118 Kiel, Germany
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(11), 2821; https://doi.org/10.3390/molecules23112821
Received: 10 October 2018 / Revised: 26 October 2018 / Accepted: 28 October 2018 / Published: 30 October 2018
(This article belongs to the Special Issue Natural Products and Drug Discovery)
  |  
PDF [14762 KB, uploaded 15 November 2018]
  |  

Abstract

The present review gives an overview about natural products from the holoparasitic genus Orobanche (Orobanchaceae). We cover both genuine natural products as well as compounds sequestered by Orobanche taxa from their host plants. However, the distinction between these two categories is not always easy. In cases where the respective authors had not indicated the opposite, all compounds detected in Orobanche taxa were regarded as genuine Orobanche natural products. From the about 200 species of Orobanche s.l. (i.e., including Phelipanche) known worldwide, only 26 species have so far been investigated phytochemically (22 Orobanche and four Phelipanche species), from 17 Orobanche and three Phelipanche species defined natural products (and not only natural product classes) have been reported. For two species of Orobanche and one of Phelipanche dedicated studies have been performed to analyze the phenomenon of natural product sequestration by parasitic plants from their host plants. In total, 70 presumably genuine natural products and 19 sequestered natural products have been described from Orobanche s.l.; these form the basis of 140 chemosystematic records (natural product reports per taxon). Bioactivities described for Orobanche s.l. extracts and natural products isolated from Orobanche species include in addition to antioxidative and anti-inflammatory effects, e.g., analgesic, antifungal and antibacterial activities, inhibition of amyloid β aggregation, memory enhancing effects as well as anti-hypertensive effects, inhibition of blood platelet aggregation, and diuretic effects. Moreover, muscle relaxant and anti-spasmodic effects as well as anti-photoaging effects have been described. View Full-Text
Keywords: Orobanche s.l.; Orobanchaceae; Lamiales; natural products; secondary metabolites; phenylpropanoid glycosides; phenylethanoid glycosides; bioactivities of natural products; chemosystematics Orobanche s.l.; Orobanchaceae; Lamiales; natural products; secondary metabolites; phenylpropanoid glycosides; phenylethanoid glycosides; bioactivities of natural products; chemosystematics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Scharenberg, F.; Zidorn, C. Genuine and Sequestered Natural Products from the Genus Orobanche (Orobanchaceae, Lamiales). Molecules 2018, 23, 2821.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top