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Molecules 2017, 22(6), 858;

Insights into Penicillium brasilianum Secondary Metabolism and Its Biotechnological Potential

Instituto de Química, Universidade Estadual de Campinas, CP 6154, 13083-970 Campinas, Brazil
Departamento de Química, Universidade Federal de São Carlos, CP 676, 13.565-905 São Carlos, SP, Brazil
Authors to whom correspondence should be addressed.
Academic Editor: Mohamed A. Farag
Received: 29 March 2017 / Revised: 12 May 2017 / Accepted: 12 May 2017 / Published: 20 June 2017
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Over the past few years Penicillium brasilianum has been isolated from many different environmental sources as soil isolates, plant endophytes and onion pathogen. All investigated strains share a great ability to produce bioactive secondary metabolites. Different authors have investigated this great capability and here we summarize the metabolic potential and the biological activities related to P. brasilianums metabolites with diverse structures. They include secondary metabolites of an alkaloid nature, i.e., 2,5-diketopiperazines, cyclodepsipeptides, meroterpenoids and polyketides. Penicillium brasilianum is also described as a great source of enzymes with biotechnological application potential, which is also highlighted in this review. Additionally, this review will focus on several aspects of Penicillium brasilianum and interesting genomic insights. View Full-Text
Keywords: Penicillium brasilianum; secondary metabolism; biotransformation; biological activity Penicillium brasilianum; secondary metabolism; biotransformation; biological activity

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Bazioli, J.M.; Amaral, L.D.S.; Fill, T.P.; Rodrigues-Filho, E. Insights into Penicillium brasilianum Secondary Metabolism and Its Biotechnological Potential. Molecules 2017, 22, 858.

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