A New Canthinone-Type Alkaloid Isolated from Ailanthus altissima Swingle
AbstractThe present investigation of the chemical constituents of the stem barks of Ailanthus altissima has resulted in the isolation of six canthinone-type alkaloids, including a new compound, (R)-5-(1-hydroxyethyl)-canthine-6-one (1), and five known compounds (2–6). Moreover, four phenyl propanoids (7–10), two lignans (11 and 12), two triterpenoids (13 and 14) and a fatty acid (15) having previously known chemical structures were isolated during the same course of this study. The structure of the new compound was elucidated by physical (m.p., [α]D) and spectroscopic data (1H-NMR, 13C-NMR, 2D NMR, and HR-DART-MS) interpretation and its absolute configuration was determined by electronic circular dichroism (ECD) data and quantum chemical calculations. The inflammatory activities of the isolates were screened on lipopolysaccharide (LPS)-induced nitric oxide (NO), a proinflammatory mediator, in RAW 264.7 cells. Among these isolated compounds, six compounds exhibited significant inhibition of NO production, with IC50 values in the range of 5.92 ± 0.9 to 15.09 ± 1.8 μM. View Full-Text
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Kim, H.M.; Lee, J.S.; Sezirahiga, J.; Kwon, J.; Jeong, M.; Lee, D.; Choi, J.-H.; Jang, D.S. A New Canthinone-Type Alkaloid Isolated from Ailanthus altissima Swingle. Molecules 2016, 21, 642.
Kim HM, Lee JS, Sezirahiga J, Kwon J, Jeong M, Lee D, Choi J-H, Jang DS. A New Canthinone-Type Alkaloid Isolated from Ailanthus altissima Swingle. Molecules. 2016; 21(5):642.Chicago/Turabian Style
Kim, Hye M.; Lee, Jin S.; Sezirahiga, Jurdas; Kwon, Jaeyoung; Jeong, Miran; Lee, Dongho; Choi, Jung-Hye; Jang, Dae S. 2016. "A New Canthinone-Type Alkaloid Isolated from Ailanthus altissima Swingle." Molecules 21, no. 5: 642.
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