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Molecules 2016, 21(1), 31;

Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7

Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110122, China
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 29 November 2015 / Revised: 17 December 2015 / Accepted: 21 December 2015 / Published: 28 December 2015
(This article belongs to the Collection Bioactive Compounds)
Full-Text   |   PDF [739 KB, uploaded 28 December 2015]   |  


Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 35. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC50 value of 4.2 μM. View Full-Text
Keywords: marine-derived fungus; Aspergillus fumigatus; terpenoid; cell growth inhibition marine-derived fungus; Aspergillus fumigatus; terpenoid; cell growth inhibition

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Wang, Y.; Li, D.-H.; Li, Z.-L.; Sun, Y.-J.; Hua, H.-M.; Liu, T.; Bai, J. Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7. Molecules 2016, 21, 31.

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