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Molecules, Volume 10, Issue 12 (December 2005) – 4 articles , Pages 1429-1461

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36 KiB  
Article
Chromate Oxidation of α-Nitro Alcohols to α-Nitro Ketones: Significant Improvements to a Classic Method
by Tarek Abou Elmaaty and Lyle W. Castle
Molecules 2005, 10(12), 1458-1461; https://doi.org/10.3390/10121458 - 31 Dec 2005
Cited by 8 | Viewed by 7276
Abstract
A series of eight alkyl and aryl α-nitro ketones were prepared by the potassium dichromate oxidation of the corresponding nitro alcohols. Short reaction times allowed for the easy isolation of pure nitro ketones that are devoid of starting materials and/or other oxidation side [...] Read more.
A series of eight alkyl and aryl α-nitro ketones were prepared by the potassium dichromate oxidation of the corresponding nitro alcohols. Short reaction times allowed for the easy isolation of pure nitro ketones that are devoid of starting materials and/or other oxidation side products. Full article
143 KiB  
Article
Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues
by Naim H. Al-Said, Khaled Q. Shawakfeh and Wasim N. Abdullah
Molecules 2005, 10(12), 1446-1457; https://doi.org/10.3390/10121446 - 31 Dec 2005
Cited by 11 | Viewed by 9674
Abstract
Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2- carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode. Full article
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131 KiB  
Article
An Efficient Protocol for the Solid-phase Synthesis of Malondiamides
by Markus M. Vögtle and Andreas L. Marzinzik
Molecules 2005, 10(12), 1438-1445; https://doi.org/10.3390/10121438 - 31 Dec 2005
Viewed by 7699
Abstract
A novel and straightforward solid-phase synthesis of malondiamides containing a free nitrogen has been developed. These intermediates, which can be directly obtained in good yield and purity, can be further derivatised. This approach can be used for the synthesis of large split-and-mix-libraries. Full article
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179 KiB  
Article
Synthesis of Novel, Potentially Biologically Active Dibenzosuberone Derivatives
by Sonja Merkas, Mladen Litvic, Ivica Cepanec and Vladimir Vinkovic
Molecules 2005, 10(12), 1429-1437; https://doi.org/10.3390/10121429 - 31 Dec 2005
Cited by 19 | Viewed by 10931
Abstract
Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2) and 1,7- dibromo-5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene (3). These compounds are potential tricyclic antidepressants (TCAs), which are still the most frequently prescribed antidepressants in many countries. Full article
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