Dietary Habits in Liver Health and Disease: Preclinical and Clinical Studies

Abstract submission deadline

31 October 2026

Manuscript submission deadline

31 December 2026

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Topic Information

Dear Colleagues,

The liver is a very complex organ that performs numerous vital functions, many of which cannot yet be replaced by the most advanced therapeutic technologies. Liver health and nutrition are closely linked, and the relationship between dietary intake and liver disease has been extensively studied in recent years. Despite its importance in the development and severity of many medical problems, insufficient attention has been paid to nutrition. Nutrition plays an important role not only in the etiology but also in the pathogenesis of liver diseases. While an extreme nutritional state (malnutrition or obesity) can lead to liver dysfunction, a dysfunctional liver can lead to changes in the metabolism of macro- and micronutrients. Evidence from animal and human studies supports the harmful effects of consuming higher-fat, high-carbohydrate diets, which can lead to liver dysfunction that impacts overall health. Conversely, nutritional therapy plays an important role in the treatment of liver disease.

It is widely recognized that chronic liver diseases, particularly liver cirrhosis, can contribute to malnutrition. Additionally, malnutrition has been identified as a contributing factor to the progression of these liver diseases. Based on this evidence, the aim of this Topic is to explore several aspects of nutrition and liver health and disease in preclinical or clinical approaches.

We welcome original research articles (including basic science and human and animal studies) that address the impact of dietary habits on liver health and disease. We encourage submissions that highlight the interface between diet and microcirculation, a recognized significant mediator of chronic liver disease. We welcome submissions of original research articles, review articles, mini-reviews, narrative and systematic reviews, and meta-analyses and case reports related to, but not limited to, the following subtopics:

• Interdisciplinary and translational research and clinical application of nutritional interventions
• The contribution of nutrition to tissue/organ homeostasis
• The interrelationship between genetic factors and nutrition
• Dietary patterns and dysbiosis
• Changes in microcirculatory blood flow
• Endothelial function and damage
• Dietary interventions targeting the conditions described above
• Multi-omics-based methods for the diagnosis and management of nutritional status
• New techniques and advances in technology to shed light on the role of dietary habits in liver health and disease

Dr. Evelyn Nunes Goulart Da Silva Pereira
Prof. Dr. Rosane Härter Griep
Dr. Anissa Daliry
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Dietetics dietetics	-	-	2022	27.3 Days	CHF 1200	Submit
Nutrients nutrients	5.0	9.1	2009	15 Days	CHF 2900	Submit
Obesities obesities	1.3	1.8	2021	18.6 Days	CHF 1200	Submit
Diseases diseases	3.0	3.7	2013	21 Days	CHF 1800	Submit
International Journal of Molecular Sciences ijms	4.9	9.0	2000	17.8 Days	CHF 2900	Submit
Metabolites metabolites	3.7	6.9	2011	16.7 Days	CHF 2700	Submit

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Published Papers (2 papers)

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All Dietetics Nutrients Obesities Diseases IJMS Metabolites

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12 pages, 941 KB  

Open AccessArticle

Chronotype and Social Jetlag: Impacts on Nutritional Status and Dietary Intake of University Students

by Lyandra Deluchi Loch, Gabriela Iber Correa, Isabela Fernandes Araújo, Amanda Portugal, Gabriela Datsch Bennemann, Caryna Eurich Mazur, Guilherme Welter Wendt, Lirane Elize Defante Ferreto, Carolina Panis, Camila Elizandra Rossi, Kérley Braga Pereira Bento Casaril, Gisele Arruda, Léia Carolina Lucio, Cleide Viviane Buzanello, Geraldo Emílio Vicentini, Claudiceia Risso Pascotto, Aedra Carla Bufalo Kawassaki, Ana Paula Vieira, Dalila Moter Benvegnú, Franciele Ani Caovilla Follador and Mariana Abe Vicente Cavagnariadd Show full author list remove Hide full author list

Obesities 2026, 6(1), 3; https://doi.org/10.3390/obesities6010003 - 9 Jan 2026

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Abstract

The circadian cycle regulates metabolism in response to external stimuli, such as light exposure, sleep schedules, and eating patterns. However, misalignment between internal biological rhythms and social demands can compromise food choices, potentially leading to overweight and obesity. This research aimed to assess [...] Read more.

The circadian cycle regulates metabolism in response to external stimuli, such as light exposure, sleep schedules, and eating patterns. However, misalignment between internal biological rhythms and social demands can compromise food choices, potentially leading to overweight and obesity. This research aimed to assess how a person’s chronotype links to social jet lag (SJL), which in turn would relate to their nutritional status and food consumption patterns as a university student. 617 students from a State University located in the State of Paraná, Brazil, completed a cross-sectional research study that collected sociodemographic information/anthropometrics by means of an online survey. It included self-reported height/weight data and dietary habits. The Munich Chronotype Questionnaire (MCTQ) was utilized to determine each participant’s chronotype classification and SJL calculation. Researchers found that nearly half of the students (49.3%) displayed an Intermediate Chronotype, which is associated with a diet that contained elements of the “Mixed” Diet, meaning there are equal portions of healthy food (Fresh Fruits, Beans, etc.) and unhealthy foods (Sweetened Beverages). The multivariate logistic regression analyses identified age as a significant predictor of obesity risk (OR: 1.15, p < 0.001), while dietary habits such as fruit consumption played a protective role. Additionally, having a breakfast protected them from being classified as obese compared to those who did not eat breakfast (OR = 0.59). Contrary to expectations, late-night supper was not a statistically significant predictor in the adjusted model. Predictors of an Intermediate chronotype included being male and eating morning snacks regularly. The results of this study suggest that students with an intermediate chronotype will predictably have skewed eating patterns, such as skipping breakfast and eating late—both of which affect obesity risks. Nutritional strategies for university students should focus on promoting circadian regularity and optimizing meal timing. Full article

(This article belongs to the Topic Dietary Habits in Liver Health and Disease: Preclinical and Clinical Studies)

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Open AccessArticle

Global Epidemiology of Smoking and Liver Cancer from 1990 to 2021

by Jinguo Wang, Yang Ma, Aixu Duan and Xiaoming Fan

Diseases 2025, 13(11), 356; https://doi.org/10.3390/diseases13110356 - 3 Nov 2025

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Abstract

Liver cancer is a prevalent and highly malignant tumor worldwide, and smoking has been suggested as a potentially significant risk factor, but this association remains understudied and not widely recognized. This study utilized global epidemiological data (1990–2021) from open access databases, analyzing smoking-related [...] Read more.

Liver cancer is a prevalent and highly malignant tumor worldwide, and smoking has been suggested as a potentially significant risk factor, but this association remains understudied and not widely recognized. This study utilized global epidemiological data (1990–2021) from open access databases, analyzing smoking-related liver cancer burden and trends by age, sex, region, and country using mortality, disability-adjusted life years (DALYs), and age-standardized rates (ASRs), with projections for disease burden in 2040. The results show that from 1990 to 2021, the global number of smoking-attributable liver cancer deaths increased (cumulative growth: 67.10%; annual growth rate: 1.63%), while the age-standardized mortality rate (ASMR) declined. Similarly, global DALYs rose (cumulative growth: 49.5%; annual growth rate: 1.32%), yet age-standardized DALY rates (ASDRs) decreased. Significant disparities were observed across gender, age groups, regions, and countries, with higher burdens in males and in regions such as East Asia. Projections indicate that by 2040, both the ASMR and ASDR for smoking-associated liver cancer will decline significantly, particularly among the male population. In conclusion, although the burden of liver cancer related to smoking is on a downward trend, there are still significant demographic and regional differences. Future efforts should prioritize strengthened public health policies, targeted interventions, and further research into the smoking–liver cancer relationship to enhance prevention and control strategies. Full article

(This article belongs to the Topic Dietary Habits in Liver Health and Disease: Preclinical and Clinical Studies)

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