Prospects of Multi-Target Agonists in Metabolic and Epigenetic Medicine

Dear Colleagues,

Multi-target agonists are emerging as a promising therapeutic strategy in metabolic medicine, offering the potential to address the complex and interconnected pathways underlying metabolic disorders. This Special Issue aims to highlight recent progress in the discovery, optimization, and clinical translation of multi-target agonists in metabolic medicine, including their mechanistic basis, therapeutic potential, and safety considerations. Relevant topics include, but are not limited to, the following:

• Design and synthesis of multi-target metabolic agonists;
• Mechanistic insights into multi-receptor synergy;
• Preclinical and clinical evaluation in metabolic disease models;
• Artificial intelligence in multi-target drug discovery;
• Safety, tolerability, and long-term efficacy studies;
• Combination therapies and personalized medicine approaches;
• Metabolites;
• Epigenetic regulation to metabolic disease.

Dr. Riham Abouleisa
Dr. Yanling Li
Topic Editors