Topic Editors

Surgery Department, Baylor College of Medicine, Houston, TX 77030, USA
Dr. Yanling Li
Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA

Prospects of Multi-Target Agonists in Metabolic and Epigenetic Medicine

Abstract submission deadline
30 September 2026
Manuscript submission deadline
30 November 2026

Topic Information

Dear Colleagues,

Multi-target agonists are emerging as a promising therapeutic strategy in metabolic medicine, offering the potential to address the complex and interconnected pathways underlying metabolic disorders. This Special Issue aims to highlight recent progress in the discovery, optimization, and clinical translation of multi-target agonists in metabolic medicine, including their mechanistic basis, therapeutic potential, and safety considerations. Relevant topics include, but are not limited to, the following:

  • Design and synthesis of multi-target metabolic agonists;
  • Mechanistic insights into multi-receptor synergy;
  • Preclinical and clinical evaluation in metabolic disease models;
  • Artificial intelligence in multi-target drug discovery;
  • Safety, tolerability, and long-term efficacy studies;
  • Combination therapies and personalized medicine approaches;
  • Metabolites;
  • Epigenetic regulation to metabolic disease.

Dr. Riham Abouleisa
Dr. Yanling Li
Topic Editors

Keywords

  • metabolism
  • epigenetics
  • drug discovery
  • multi-target agonists
  • metabolic syndrome (MetS)
  • polypharmacology
  • type 2 diabetes (T2DM)
  • GLP-1/GIP receptor agonists
  • obesity therapeutics

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomedicines
biomedicines
3.9 6.8 2013 17 Days CHF 2600 Submit
Future Pharmacology
futurepharmacol
2.7 - 2021 21.8 Days CHF 1200 Submit
Pharmacy
pharmacy
1.8 - 2013 23.9 Days CHF 1800 Submit
International Journal of Molecular Sciences
ijms
4.9 9.0 2000 20.5 Days CHF 2900 Submit
Biomolecules
biomolecules
4.8 9.2 2011 19.4 Days CHF 2700 Submit
Genes
genes
2.8 5.5 2010 14.6 Days CHF 2600 Submit

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