Biomechanics and Biomaterial Engineering in Neurological Disorders

Dear Colleagues,

There are many complexities and vague points in the pathophysiology, diagnosis, prognosis, and treatment of neurological disorders. Clarifying these complexities can be difficult for physicians as common neuroimages and clinical symptoms can be confusing to diagnose and treat. The complexities in the management of these disorders may be due to our lack of knowledge about the bioengineering mechanisms of these disorders. Biomechanical analysis and evaluation of changes in biomaterial behavior of head substructures can have a prominent role in solving these problems.

Computer simulations and mathematical modeling can be helpful in finding numerical indicators to evaluate the condition of these patients. Biofluid analysis of intracranial fluid showed the critical impact of the pulsatile interaction of cerebral blood, cerebrospinal fluid, and brain in the management of various neurological disorders. Micro- and nanoparticles also play the main role in the treatment of neurological disorders, specifically brain tumors and cancers, as well as cerebral blood flow disorders. Recent advancements in brain tissue engineering shed light on the fundamental mechanism of central nervous system disorders. The delivery of drugs to the brain via various routes is also an emerging option in the treatment of various central nervous system disorders.

This Topic aims to present the application of biomechanics and biomaterial engineering to clarify the complexities and uncertainties in the mechanism of neurological disorders. This collection will provide neurosurgeons, neurophysicians, and neuroengineers with valuable data to help the diagnosis and treatment development of a broad spectrum of central nervous system disorders.

This Topic invites high-quality original research, hypothesis, technical notes, and review articles in all aspects of the rapidly expanding area of applications of biomechanics and biomaterial engineering in the pathophysiology, diagnosis, prognosis, and treatment of neurological disorders.

Dr. Seifollah Gholampour
Dr. Mohammad Reza Safaei
Topic Editors