Topic Editors
Metastatic Colorectal Cancer: From Laboratory to Clinical Studies, 2nd Edition
Topic Information
Dear Colleagues,
Colorectal cancer (CRC) remains a leading global health burden, ranking third in incidence and mortality. With the growing recognition of its molecular heterogeneity, CRC is increasingly seen not as a single disease, but as a constellation of distinct molecular subtypes with varied therapeutic responses. While next-generation sequencing, organoid models, and liquid biopsy technologies have deepened insights into the tumor microenvironment and mechanisms of resistance, translating these findings into durable clinical benefits remains a pressing challenge. Emerging areas such as immune evasion, tumor–stroma interactions, microbiome influences, and spatial transcriptomics are reshaping how we understand and treat metastatic CRC. Moreover, disparities in access to precision oncology and limited efficacy in microsatellite stable tumors highlight persistent gaps. This Special Issue invites original research and comprehensive reviews that explore novel biomarkers, therapeutic targets, resistance mechanisms, and integrated multimodal treatment strategies. We especially welcome multidisciplinary contributions that bridge molecular biology, immunology, surgical innovation, computational medicine, and translational oncology to advance personalized care in CRC. We look forward to receiving your submissions.
Dr. Ioannis Ntanasis-Stathopoulos
Dr. Diamantis I. Tsilimigras
Topic Editors
Keywords
- colorectal cancer (CRC)
- tumor microenvironment
- liquid biopsy
- immunotherapy resistance
- precision oncology
- cancer biomarkers
- next-generation sequencing (NGS)
- microsatellite instability (MSI)/stability (MSS)
- tumor heterogeneity
- multimodal cancer therapy
Participating Journals
| Journal Name | Impact Factor | CiteScore | Launched Year | First Decision (median) | APC | |
|---|---|---|---|---|---|---|
Cancers
|
4.4 | 8.8 | 2009 | 17.4 Days | CHF 2900 | Submit |
Diagnostics
|
3.3 | 5.9 | 2011 | 20.3 Days | CHF 2600 | Submit |
Gastrointestinal Disorders
|
0.8 | 1.2 | 2019 | 18 Days | CHF 1200 | Submit |
Journal of Clinical Medicine
|
2.9 | 5.2 | 2012 | 16 Days | CHF 2600 | Submit |
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