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Veterinary Sciences
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Advanced Therapy in Companion Animals—3rd Edition
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Advanced Therapy in Companion Animals—3rd Edition

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: 30 September 2026 | Viewed by 512

Special Issue Editors

Dr. Ziyao Zhou

E-Mail Website
Guest Editor
Department of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Interests: veterinary dentistry; computer-aided design; personalized medicine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Zhijun Zhong

E-Mail Website
Guest Editor
Department of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Interests: microbiology; antibiotic resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the enthusiastic response to the first two editions of the Special Issue “Advanced Therapy in Companion Animals”, and the successful publication of numerous high-quality papers in the second edition, we are pleased to launch the third edition of this collection. This new volume will continue to focus on cutting-edge therapeutic strategies that improve the health, welfare, and quality of life of companion animals, further consolidating this Special Issue as a key platform for innovation in veterinary medicine.

Building on the solid foundation established by the previous editions—where diverse studies have addressed regenerative medicine, gene therapy, immunotherapy, and precision medicine—we now aim to deepen and broaden the discussion around advanced interventions for both chronic and acute diseases. In this third edition, we particularly welcome work that integrates novel diagnostics, molecular and omics-based approaches, minimally invasive and image-guided procedures, biomaterials, and tissue engineering, as well as digital and technology-driven solutions (such as AI-assisted decision-making, advanced imaging, and smart drug-delivery systems) into clinical practice for companion animals.

We invite you to explore the papers published in the first and second editions, which showcase the progress already achieved in this field:

First Edition: https://www.mdpi.com/journal/vetsci/special_issues/537D79882B

Second Edition: https://www.mdpi.com/journal/vetsci/special_issues/5AEK176G58

We strongly encourage interdisciplinary contributions that bring together veterinarians, clinicians, researchers, and biotechnologists to bridge the gap between experimental findings and real-world applications. Original research articles, clinical trials, case reports, and case series, as well as comprehensive or focused review articles, are all welcome. We believe that this third edition will further advance the field of companion animal medicine and provide veterinary professionals with up-to-date insights into the latest therapeutic breakthroughs.

We look forward to receiving your contributions.

Dr. Ziyao Zhou
Prof. Dr. Zhijun Zhong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • companion animals
  • advanced therapy
  • regenerative medicine
  • gene therapy
  • immunotherapy
  • precision medicine
  • novel diagnostics
  • minimally invasive procedures
  • veterinary clinical trials
  • personalized treatment

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Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (2 papers)

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Research

10 pages, 870 KB  
Article
Postoperative Serum Quinolinic Acid and 3-Hydroxykynurenine in Dogs with Congenital Portosystemic Shunt: A Pilot Study of Their Association with Postattenuation Neurologic Signs
by Shoma Mikawa, Yuto Ishimaru and Yasuhiko Okamura
Vet. Sci. 2026, 13(4), 308; https://doi.org/10.3390/vetsci13040308 - 24 Mar 2026
Viewed by 81
Abstract
Postattenuation neurologic signs (PANS) are serious complications following surgical ligation of congenital portosystemic shunts (cPSS) in dogs, but their pathogenesis remains incompletely understood. We hypothesized that surgical ligation alters hepatic tryptophan metabolism through increased substrate delivery and inflammation, leading to changes in kynurenine [...] Read more.
Postattenuation neurologic signs (PANS) are serious complications following surgical ligation of congenital portosystemic shunts (cPSS) in dogs, but their pathogenesis remains incompletely understood. We hypothesized that surgical ligation alters hepatic tryptophan metabolism through increased substrate delivery and inflammation, leading to changes in kynurenine pathway metabolites that may contribute to PANS. Ten dogs diagnosed with cPSS between April 2019 and December 2023 underwent surgical ligation. Serum samples were collected preoperatively and on postoperative days 1, 2, and 3. Serum concentrations of quinolinic acid (QA) and 3-hydroxykynurenine (3OHKYN) were measured using ELISA in this retrospective observational study. Dogs exhibiting neurological signs within 3 days postoperatively were classified as having PANS. Serum QA concentrations showed no significant postoperative changes and did not differ between dogs with and without PANS. In contrast, serum 3OHKYN concentrations decreased significantly after surgery (p = 0.002). Dogs that developed PANS had significantly lower serum 3OHKYN concentrations on postoperative day 1 (p = 0.048) and exhibited greater reductions from baseline on postoperative days 1 and 3 (p = 0.024 and 0.017, respectively). These preliminary findings suggest that postoperative reductions in 3OHKYN, rather than increases in QA, are associated with PANS development, indicating that altered tryptophan metabolism may play a role in its pathogenesis and warrant further investigation in larger studies. Full article
(This article belongs to the Special Issue Advanced Therapy in Companion Animals—3rd Edition)
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18 pages, 5977 KB  
Article
First Evaluation of Roux-en-Y Gastric Bypass as a Novel Surgical Treatment for Diabetes and Glucose Metabolism Regulation in Cats
by Linfeng Li, Guoxiang Yuan, Qianbo Xiong, Wen Hao and Lingchen Yang
Vet. Sci. 2026, 13(3), 272; https://doi.org/10.3390/vetsci13030272 - 16 Mar 2026
Viewed by 152
Abstract
Objective: To evaluate the efficacy of Roux-en-Y gastric bypass (RYGB) in improving glucose regulation and metabolic parameters in feline diabetes mellitus (FDM). Methods: FDM was experimentally induced via partial pancreatectomy, splenectomy, and dexamethasone administration. Following insulin stabilization, the RYGB cohort underwent gastric bypass, [...] Read more.
Objective: To evaluate the efficacy of Roux-en-Y gastric bypass (RYGB) in improving glucose regulation and metabolic parameters in feline diabetes mellitus (FDM). Methods: FDM was experimentally induced via partial pancreatectomy, splenectomy, and dexamethasone administration. Following insulin stabilization, the RYGB cohort underwent gastric bypass, while the medical management group received glargine insulin. Untreated diabetic controls were monitored for 12 weeks. Blood glucose (GLU), fructosamine (FRU), biochemical profiles, and metabolic hormones were evaluated pre- and post-intervention. Hepatic and pancreatic tissues were collected for histopathological examination. Results: GLU and FRU concentrations in the RYGB group were significantly lower than in diabetic controls (p < 0.05), remaining comparable to the insulin-treated group (p > 0.05). Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were significantly reduced post-RYGB (p < 0.05), closely matching insulin therapy outcomes (p > 0.05). Hormonal assays demonstrated decreased gastric inhibitory polypeptide (GIP) and elevated glucagon-like peptide-1 (GLP-1) in RYGB cats. Histopathologically, the RYGB group exhibited attenuated hepatic steatosis and a higher density of pancreatic islet cells with abundant cytoplasm compared to the control groups. Conclusions: RYGB effectively restores glycemic control and metabolic hormone balance in FDM, promoting morphological improvements in pancreatic islets and offering a highly promising alternative therapy for diabetic felines. Full article
(This article belongs to the Special Issue Advanced Therapy in Companion Animals—3rd Edition)
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