Antimicrobial Resistance in Aquaculture: Balancing Health and Sustainability

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics in Animal Health".

Deadline for manuscript submissions: closed (15 November 2025) | Viewed by 881

Special Issue Editor


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Guest Editor
China-Norway Joint Lab on Fish Gut Microbiota, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Interests: aquatic microbiology; fish gut microbiota; aquaculture nutrition; interactions of commensal microbiota and viral infection; probiotics in aquaculture

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) in aquaculture has emerged as a critical global challenge, threatening both aquatic animal health and human food security. Intensive aquaculture practices, driven by the rising demand for seafood, have led to the overuse of antimicrobial agents, accelerating the evolution of resistant pathogens such as Vibrio parahaemolyticus, Escherichia coli, and multidrug-resistant Aeromonas species. These resistant bacteria and their associated genes can transfer to terrestrial ecosystems via water systems, posing significant risks under the "One Health" framework. Furthermore, climate change and pollution exacerbate AMR dissemination, highlighting the urgent need for sustainable interventions. This Special Issue of Antibiotics seeks to address these challenges by bridging gaps in understanding AMR dynamics, mitigation strategies, and policy frameworks. We invite original research, reviews, and case studies focusing on the following:

  • Mechanisms of AMR in aquatic pathogens, including genetic and environmental drivers of resistance gene transfer.
  • Surveillance and risk assessment of AMR in aquaculture environments, emphasizing zoonotic and foodborne pathogens.
  • Alternative therapies, such as probiotics and immunostimulants, to reduce antibiotic reliance.
  • Environmental impacts of antimicrobial residues and resistance genes in aquatic ecosystems.
  • Policy and stewardship innovations for antibiotic use regulation and AMR containment.

Prof. Dr. Zhigang Zhou
Guest Editor

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Keywords

  • antimicrobial resistance
  • aquaculture
  • one health approach
  • antibiotic stewardship
  • probiotics
  • zoonotic pathogens
  • resistance genes
  • sustainable practices
  • environmental impact

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Published Papers (1 paper)

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9 pages, 216 KB  
Systematic Review
Mangrove Ecosystems as Reservoirs of Antibiotic Resistance Genes: A Narrative Review
by Monthon Lertcanawanichakul, Phuangthip Bhoopong and Phusit Horpet
Antibiotics 2025, 14(10), 1022; https://doi.org/10.3390/antibiotics14101022 - 14 Oct 2025
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Abstract
Background: Mangrove ecosystems are critical coastal environments providing ecological services and acting as buffers between terrestrial and marine systems. Rising antibiotic use in aquaculture and coastal agriculture has led to the dissemination of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in [...] Read more.
Background: Mangrove ecosystems are critical coastal environments providing ecological services and acting as buffers between terrestrial and marine systems. Rising antibiotic use in aquaculture and coastal agriculture has led to the dissemination of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in these habitats. Aim: This narrative review aims to synthesize current knowledge on the prevalence, diversity, and environmental drivers of ARGs in mangrove ecosystems, highlighting their role as reservoirs and the potential for horizontal gene transfer. Methods: Studies published up to September 2024 were identified through PubMed, Scopus, Web of Science, and Google Scholar. Inclusion criteria focused on ARGs and ARB in mangrove sediments, water, and associated biota. Data on ARG prevalence, microbial community composition, detection methods, and environmental factors were extracted and narratively synthesized. Results: Seventeen studies from Asia, South America, and Africa were included. ARGs conferring resistance to tetracyclines, sulfonamides, β-lactams, and multidrug resistance were found to be widespread, particularly near aquaculture and urban-influenced areas. Metagenomic analyses revealed diverse resistomes with frequent mobile genetic elements, indicating high potential for horizontal gene transfer. Environmental factors, including sediment type, organic matter, and salinity, influenced ARG abundance and distribution. Conclusions: Mangrove ecosystems act as both reservoirs and natural buffers for ARGs. Sustainable aquaculture practices, continuous environmental monitoring, and integrated One Health approaches are essential to mitigate ARG dissemination in these sensitive coastal habitats. Full article
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