Search Results (85)

Background/Objectives: Ocular graft-versus-host disease (oGVHD) is a chronic, immune-mediated complication of allogeneic hematopoietic stem cell transplantation that can progress to corneal ulceration or perforation. These cases are often refractory to standard therapy and present a high risk of graft failure after keratoplasty. We report a case of oGVHD-related corneal perforation successfully managed with a novel amniotic membrane-assisted “envelope” technique during corneal transplantation. Case Report: A 42-year-old man with chronic oGVHD and a full-thickness corneal perforation underwent urgent repair with a lamellar patch graft completely wrapped in cryopreserved amniotic membrane, followed by penetrating keratoplasty (PKP) using an amniotic membrane envelope surrounding the donor lenticule. Results: The amniotic membrane provided a 360° biological barrier that isolated graft antigens from the inflammatory environment while supporting epithelial healing and stromal remodeling. Despite recurrent inflammatory episodes and multiple procedures—including cataract extraction, pars plana vitrectomy, and multilayer amniotic membrane transplantation—the graft remained clear and stable at 12-month follow-up, achieving a best-corrected visual acuity of 20/40. Conclusions: The amniotic membrane envelope technique may represent a valuable adjunct in managing high-risk corneal perforations secondary to oGVHD. By combining immune modulation and regenerative support, this approach can enhance tectonic stability, reduce rejection risk, and promote durable surface recovery, potentially delaying or avoiding keratoprosthesis in refractory cases. Full article

The comprehensive utilisation of solid waste is a primary approach to enhancing the utilisation efficiency of mineral resources. However, vanadium-titanium slag has long faced insufficient resource utilisation due to its low activity. To address this issue, this study integrated macro and micro analytical methods to systematically investigate the effect of mechanical grinding on the activity of vanadium-titanium slag, as well as its performance when partially replacing blast furnace slag in the system of slag—converter steel slag-desulfurization gypsum ternary gel system. Additionally, the hydration mechanism of this cementitious system was analysed. The research results indicate that mechanical grinding can significantly improve the activity index of vanadium-titanium slag and increase its specific surface area. Replacing an appropriate amount of slag with vanadium-titanium slag in the slag-steel slag-desulfurization gypsum ternary gel system can effectively enhance the mechanical properties of the cementitious system. The optimal mix proportion of vanadium-titanium slag:slag:steel slag:desulfurization gypsum as 10.5:31.5:42:16 with a water-to-binder ratio of 0.32, under which the 28-day compressive strength of the specimen reached 33.50 MPa. Through multiple microscopic analysis techniques, it was found that in the alkaline environment and sulfate excitation (provided by steel slag hydration and desulfurization gypsum), the cementitious system generates hydration products such as ettringite (AFt), C–S–H, and C–A–S–H gels. Some unreacted vanadium-titanium slag particles are wrapped and intertwined by hydrated calcium silicate (aluminium) gels, forming a stable dendritic structure that provides support for the system’s strength development. Full article

The strengthening performance of carbon-fiber-reinforced polymer (CFRP) in concrete structures primarily depends on the CFRP–concrete interfacial bond behavior. For CFRP-strengthened circular reinforced concrete (RC) pipe piles in marine environments, the interfacial bond behavior is susceptible to hygrothermal conditions. In this study, cylindrical concrete specimens were designed and subjected to pull-off tests to evaluate the CFRP–concrete interfacial performance under simulated marine environmental attacks (3 days in a 50 °C salt spray followed by 4 days of seawater immersion). The deterioration mechanism and failure modes of the CFRP–concrete bond behavior in such environments were analyzed, and relationship equations describing the interfacial bond degradation were proposed and validated. Test results indicated that the CFRP–concrete bond strength at circular interfaces is approximately 21% lower than that at planar interfaces. Under hygrothermal marine conditions, the average CFRP–concrete bond strength remained relatively stable in the early stages due to the competing effects of epoxy plasticization and post-curing, while variability increased significantly in later stages. For test specimens in Group A without concrete surface grinding before CFRP wrapping, an initial bond strength of 1.5 MPa was exhibited, while, for test specimens in Group B, with surface grinding, the initial bond strength started at 2.0 MPa. Both groups experienced a significant CFRP–concrete bond strength reduction of 0.4 MPa after the first wet–dry cycle, with the subsequent average strength stabilizing near initial values. Notably, Group B achieved a peak strength of 3.88 MPa at 84 days, attributed to surface grinding, which enhanced bond strength by 33% and delayed bond failure. The overall stable average strength resulted from averaging high-strength and degraded points. A bond degradation model based on averaged strength reduction was proposed: demonstrating a strength loss of 27%–36% after 98 days of accelerated marine environmental exposure. The proposed equations describing the interfacial bond degradation on a circular concrete surface predict well the flexural capacity of CFRP-wrapped RC beams under similar environmental conditions, where the calculated flexural capacity is 0.8 times the experimental value, confirming the model’s conservative and safe design applicability. Full article

Aerogels combine ultralow density with high surface area, yet their brittle, open networks preclude tensile deformation and hinder integration into wearable electronics. Here we introduce a prestrain-enabled coaxial architecture that converts a brittle conductive aerogel into a highly stretchable fiber. A porous thermoplastic elastomer (TPE) hollow sheath is wet-spun using a sacrificial lignin template to ensure solvent exchange and robust encapsulation. Conductive polymer-based precursor dispersions are infused into prestretched TPE tubes, frozen, and lyophilized; releasing the prestretch then programs a buckled aerogel core that unfolds during elongation without catastrophic fracture. The resulting TPE-wrapped aerogel fibers exhibit reversible elongation up to 250% while retaining electrical function. At low strains (<60%), resistance changes are small and stable (ΔR/R₀ < 0.04); at larger strains the response remains monotonic and fully recoverable, enabling broad-range sensing. The mechanism is captured by a strain-dependent percolation model in which elastic decompression, contact sliding, and controlled fragmentation/reconnection of the aerogel network govern the signal. This generalizable strategy decouples elasticity from conductivity, establishing a scalable route to ultralight, encapsulated, and skin-compatible aerogel fibers for smart textiles and deformable electronics. Full article

To address the problem of unstable seed filling and low seeding accuracy caused by poor seed flow in conventional peanut seed metering devices, a novel precision metering device based on a cam-swing link was developed. Using EDEM simulations, the capacity of different type hole installation positions to induce seed cluster disturbance was analyzed. A single-factor test and MBD–DEM coupled simulation were conducted to analyze the seeding performance. The simulation results indicate that when the type hole protrusion height was set to half the thickness of the seeding disc, seed cluster kinetic energy remained relatively stable, enhancing the capability to disturb seeds. As the seeding disc rotational speed increased from 10 to 40 rpm, the qualified index initially increased and then declined. Increasing the cluster wrap angle from 20° to 70° similarly led to a peak in the qualified index and a steady decrease in the missed index. Using the JPS-12 computer vision-based test platform, a second-order rotary orthogonal design was applied to evaluate the seeding performance. The experimental results show that when the seeding disc rotational speed was set at 26 rpm and the seed cluster wrap angle at 46°, the qualified index reached 89.95%, and the missed index was 4.04%. The average plant spacing of peanuts in field experiments was 137.82 mm. These results meet the operational requirements for precision peanut planting. Full article

This study examines the daily top 100 cryptocurrencies on Uniswap V3. It denoises the correlation coefficient matrix of cryptocurrencies by using sliding window techniques and random matrix theory. Further, this study constructs a time-varying correlation network of cryptocurrencies under different thresholds based on complex network methods and analyzes the Uniswap V3 network’s time-varying topological properties and risk contagion intensity of Uniswap V3. The study findings suggest the presence of random noise on the Uniswap V3 cryptocurrency market. The strength of connection relationships in cryptocurrency networks varies at different thresholds. With a low threshold, the cryptocurrency network shows high average degree and average clustering coefficient, indicating a small-world effect. Conversely, at a high threshold, the cryptocurrency network appears relatively sparse. Moreover, the Uniswap V3 cryptocurrency network demonstrates heterogeneity. Additionally, cryptocurrency networks exhibit diverse local time-varying characteristics depending on the thresholds. Notably, with a low threshold, the local time-varying characteristics of the network become more stable. Furthermore, risk contagion analysis reveals that WETH (Wrapped Ether) exhibits the highest contagion intensity, indicating its predominant role in propagating risks across the Uniswap V3 network. The novelty of this study lies in its capture of time-varying characteristics in decentralized exchange network topologies, unveiling dynamic evolution patterns in cryptocurrency correlation structures. Full article

Microfluidic devices rely on precise fluid control to enable complex operations in diagnostics, chemical synthesis, and biological research. Central to this control are microvalves, which regulate on-chip flow but require flexible membranes for active operation. While the laser cutting of thermoplastics offers a fast, automated method for fabricating rigid microfluidic components, integrating flexible elements like valves and pumps remains a key challenge. Thermoplastic polyurethane (TPU) membranes have been adopted to address this need but are costly and difficult to procure reliably. In this study, we present commercial food-wrap film (FWF) as a low-cost, widely available alternative membrane material. We demonstrate FWF’s compatibility with laser-cut thermoplastic microfluidic devices by successfully fabricating Quake-style valves and peristaltic pumps. FWF valves maintained reliable sealing at 40 psi, maintained stable flow rates of ~1.33 μL/min during peristaltic operation, and sustained over one million continuous actuation cycles without performance degradation. Burst pressure testing confirmed robustness up to 60 psi. Additionally, FWF’s thermal resistance up to 140 °C enabled effective thermal bonding with PMMA layers, simplifying device assembly. These results establish FWF as a viable substitute for TPU membranes, offering an accessible and scalable solution for microfluidic device fabrication, particularly in resource-limited settings where TPU availability is constrained. Full article

This paper presents a novel gait design for serpentine robots to smoothly wrap around and traverse vibration-damping hammers along overhead power lines. Cubic quasi-uniform B-spline curves are utilized to seamlessly transition between helical segments of varying diameters during obstacle crossing, effectively reducing motion-induced impacts. The design begins by determining the control points of the B-spline curves to ensure posture continuity and prevent collisions with surrounding hardware obstacles, resulting in the derivation of an obstacle-crossing curve equation. Using this equation, the node coordinates and postures of individual robot units are computed, followed by the calculation of joint angles via inverse kinematics. A dual-chain Hopf oscillator is then employed to generate the obstacle-crossing gait. The feasibility of the proposed gait is validated through simulations in CoppeliaSim and Simulink, which model the robot’s motion as it wraps around and crosses eccentric obstacles with varying diameters. Additionally, a simulation platform is developed to analyze variations in joint angles and angular velocities during obstacle traversal. Results demonstrate that the gait, generated by combining cubic quasi-uniform B-spline curves with a dual-chain Hopf oscillator, achieves smooth and stable wrapping and crossing of vibration-damping hammers. The robot exhibits no abrupt changes in joint angles, smooth angular velocity profiles without sharp peaks, and impact-free joint interactions, ensuring reliable performance in complex environments. Full article

Achieving high energy density while maintaining high power density and long cycle life in supercapacitors, particularly in supercapatteries (SCs), through a thermally stable, greener ionic liquid approach remains a significant challenge for an advanced energy storage application. In this work, we prepared high conductive and high charge storage capability bimetallic transition metal molybdate [Ag₂Mo₂O₇ (AgM)], synergistic with reduced graphene oxide (rGO) coated on nickel foam (AgM/rGO/NF). The physio-chemical characterization revealed a ball-like cluster morphology wrapped in rGO nanosheets and a spinel-type cubic structure using scanning electron microscopy (FE-SEM) displays and X-ray diffraction (XRD) analyses. Further, the electrochemical performance of AgM/rGO/NF electrode achieved a remarkable specific C_sp value of 573.63 F/g at a current density of 1.0 A/g in 3 M KOH electrolyte. An asymmetric SCs (ASCs) device was fabricated using AgM/rGO/NF as the positive and rGO as the negative electrodes, achieving a wide potential window of 1.3 V. The ASC demonstrated an energy density of 16.71 Wh/kg at a power density of 642.98 W/kg, highlighting AgM/rGO/NF’s potential as an advanced electrode material for energy storage applications. Full article

The purpose of this study was to evaluate the potential of alginate-based packaging materials with the incorporation of protein hydrolysates to improve the safety and quality of chicken meat during storage. Physicochemical parameters, microbiological indicators, and color characteristics of chicken meat packaged in bioactive films were determined. We observed a significant increase in moisture content for samples in polyethylene films (by 10.5%) and decrease for the samples in alginate-based films by 5.3%. The highest mass losses were found for the sample without packaging material (20.4%) and for the samples wrapped in alginate films (15.9–17.9%). When packing meat samples by immersion method, a gradual decrease in weight was found (up to 9.1%). On the 7th day of storage, the pH value of the control sample reached 6.55, while for the samples in bioactive alginate-based materials pH level was 6.0–6.15. The most pronounced oxidative processes were observed in the control meat sample (5.1 mmol (${\displaystyle \raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$2$}\right.}$O₂)/kg). The application of bioactive alginate-based films led to a significant reduction in fatty peroxide value by 56.2%. The total microbial count in the meat samples packaged in bioactive films was 3.5–5 times lower than in the control sample. Chicken meat wrapped in alginate-based films with protein hydrolysates maintains more stable color characteristics, the lightness index (L) decreased to 37.5, and the redness index (b) increased to 3.4 on the 7th day of storage. Full article

Background: Gene therapy can be viewed as a promising/valuable therapeutic approach directed to cancer treatment, including glioblastoma. Concretely, the combination of gene therapy with chemotherapy could increase its therapeutic index due to a synergistic effect. In this context, bovine serum albumin (BSA)-coated temozolomide (TMZ)-peptide (WRAP5)/p53 gene-based plasmid DNA complexes were developed to promote payload co-delivery. Methods: Design of experiments (DoE) was employed to unravel the BSA-coated TMZ-WRAP5/p53 nanocomplexes with the highest potential by considering the nitrogen to phosphate groups ratio (N/P), and the BSA concentration as inputs and the size, polydispersity index, surface charge and p53-based plasmid complexation capacity (CC) as DoE outputs. Results: The obtained quadratic models were statistically significant (p-value < 0.05) with an adequate coefficient of determination, and the correspondent optimal points were successfully validated. The optimal complex formulation had N/P of 1.03, a BSA concentration of 0.08%, a size of approximately 182 nm, a zeta potential of +9.8 mV, and a pDNA CC of 96.5%. The optimal nanocomplexes are approximately spherical. A cytotoxicity assay showed that these BSA-coated TMZ-WRAP5/p53 complexes did not elicit toxicity in normal brain cells, and a hemolysis study demonstrated the hemocompatibility of the complexes. The complexes were stable in cell culture medium and fetal bovine serum and assured pDNA protection and release. Moreover, the optimal BSA-coated complexes were able of gene transcription and promoted a significant inhibition of glioblastoma cell viability. Conclusions: The reported findings instigate the development of future research to evaluate their potential utility to TMZ/p53 co-delivery. The DoE tool proved to be a powerful approach to explore and tailor the composition of BSA-coated TMZ-WRAP5/p53 complexes, which are expected to contribute to the progress toward a more efficient therapy against cancer and, more specifically, against glioblastoma. Full article

In the process of mussel farming, the rope for attachment is indispensable, as it provides a stable attachment environment for mussel seedlings, directly affecting their survival rate and growth quality. The objective of this study is to examine the contamination of ropes, composed of polyethylene fibers, by heavy metals and polycyclic aromatic hydrocarbons (PAHs) after three years of deployment and to assess its influence on the attachment and locomotion behaviors of juvenile mussels. Utilizing a laboratory simulation of the seedling wrapping process, a comparative analysis was conducted to evaluate the number of juvenile mussels attached and their movement distances when exposed to contaminated old ropes versus uncontaminated new ropes. The findings indicated that the old ropes markedly diminished the attachment rate of juvenile mussels and heightened their movement distances. In particular, juvenile mussels utilizing old ropes exhibited a final attachment rate of 15.0% and an average movement distance of 0.86 cm, whereas those using new ropes achieved a final attachment rate of 96.7% with an average movement distance of 0.26 cm. Further inspection found that heavy metals and PAHs were present in the old rope, among which the concentrations of Zn (17.127 μg/g) and Pb (22.905 μg/g) in heavy metals were high, and the concentrations of Phe (5.53 μg/kg), Fla (6.35 μg/kg), and Pyr (5.17 μg/kg) in PAHs exceeded the detection limits, which were the main source of pollution. This research underscores the potential risk that heavy metal and PAHs contamination pose to the health of juvenile mussels and the profitability of aquaculture, emphasizing the critical need for the regular replacement of clean ropes. Full article

In this study, a single-outer-spiral electrode with inductance of 20 μH is employed to couple the energy input of a bipolar nanosecond pulse for the purpose of generating a large-scale atmospheric pressure plasma jet. When the spiral electrode is wrapped around a plasma jet tube with a length of 35 cm, the electrical field can be optimized, resulting in a stable laminar flow field, and a plasma jet with a length and diameter larger than 14 cm and 1.2 cm can be generated. A comparative study of the bipolar and unipolar pulse excitation voltages is also conducted, showing that the maximum lengths of the plasma jet excited by a bipolar pulse voltage, positive pulse voltage, and negative are 14 cm, 10 cm, and 7 cm, respectively. The temporal and spatially resolved spectra of the plasma jets excited by both bipolar and unipolar pulses are investigated, respectively, and the main physiochemical processes of the active species and the plasma dynamics’ evolution are discussed. Full article

To improve the resource utilization of dredged silt and industrial waste, this study explores the efficacy of using ground granulated blast furnace slag (GGBS), active calcium oxide (CaO), and sodium silicate (Na₂O·nSiO₂) as alkali activators for silt stabilization. Through a combination of addition tests, response surface method experiments, and microscopic analyses, we identified key factors influencing the unconfined compressive strength (UCS) of stabilized silt, optimized material ratios, and elucidated stabilization mechanisms. The results revealed the following: (1) CaO exhibited the most pronounced stabilization effect, succeeded by Na₂O·nSiO₂, whereas GGBS alone displayed marginal efficacy. CaO-stabilized silt demonstrated rapid strength augmentation within the initial 7 d, while Na₂O·nSiO₂-stabilized silt demonstrated a more gradual strength enhancement over time, attributable to the delayed hydration of GGBS in non-alkaline conditions, with strength increments noticeably during later curing phases. (2) Response surface analysis demonstrated substantial interactions among GGBS-CaO and GGBS-Na₂O·nSiO₂, with the optimal dosages identified as 11.5% for GGBS, 4.1% for CaO, and 5.9% for Na₂O·nSiO₂. (3) X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses clarified that the hydration reactions within the GGBS-Na₂O·nSiO₂ composite cementitious system synergistically enhanced one another, with hydration products wrapping, filling, and binding the silt particles, thereby rendering the microstructure denser and more stable. Based on these experimental outcomes, we propose a microstructural mechanism model for the stabilization of dredged silt employing GGBS-CaO-Na₂O·nSiO₂. Full article

Elastic yarns are the key component of high-performance compression garments. However, it remains a challenge to fabricate anti-fatigue yarns with high mechanical force and long elongation for generating compression garments with prolonged wear. In this paper, we report the development of anti-fatigue double-wrapped yarns with excellent mechanical properties by wrapping high-denier Spandex with nylon filaments in opposite twists. In particular, high-denier (560 D) Spandex as the core was untwisted, which can maximally reduce the interaction between the core and wrapping filaments, enabling high elongation of double-wrapped yarns. In addition, we chose 70 D nylon filaments with a tensile force of 3.87 ± 0.09 N as the wrapping materials to provide sufficient force for double-wrapped yarns. Notably, opposite twists were induced for the inner and outer wrapping filaments to achieve a balanced stable yarn structure. By systematically optimizing manufacturing parameters, including inner wrapping density, outer wrapping density, take-up ratio, and drafting ratio, we obtained double-wrapped yarn with excellent tensile stress (32.59 ± 0.82 MPa) and tensile strain (357.28% ± 9.10%). Notably, the stress decay rate of optimized yarns was only 12.0% ± 2.2%. In addition, the optimized yarn was used as the weft-lining yarn for generating weft-lined fabrics. The elastic recovery rate of the obtained fabric was decreased by only 2.6% after five cyclic stretches, much lower than the control fabric. Our design of anti-fatigue double-wrapped yarns could be widely used for fabricating high-performance compression garments. Full article