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24 pages, 18326 KB  
Article
A Human Intention and Motion Prediction Framework for Applications in Human-Centric Digital Twins
by Usman Asad, Azfar Khalid, Waqas Akbar Lughmani, Shummaila Rasheed and Muhammad Mahabat Khan
Biomimetics 2025, 10(10), 656; https://doi.org/10.3390/biomimetics10100656 - 1 Oct 2025
Abstract
In manufacturing settings where humans and machines collaborate, understanding and predicting human intention is crucial for enabling the seamless execution of tasks. This knowledge is the basis for creating an intelligent, symbiotic, and collaborative environment. However, current foundation models often fall short in [...] Read more.
In manufacturing settings where humans and machines collaborate, understanding and predicting human intention is crucial for enabling the seamless execution of tasks. This knowledge is the basis for creating an intelligent, symbiotic, and collaborative environment. However, current foundation models often fall short in directly anticipating complex tasks and producing contextually appropriate motion. This paper proposes a modular framework that investigates strategies for structuring task knowledge and engineering context-rich prompts to guide Vision–Language Models in understanding and predicting human intention in semi-structured environments. Our evaluation, conducted across three use cases of varying complexity, reveals a critical tradeoff between prediction accuracy and latency. We demonstrate that a Rolling Context Window strategy, which uses a history of frames and the previously predicted state, achieves a strong balance of performance and efficiency. This approach significantly outperforms single-image inputs and computationally expensive in-context learning methods. Furthermore, incorporating egocentric video views yields a substantial 10.7% performance increase in complex tasks. For short-term motion forecasting, we show that the accuracy of joint position estimates is enhanced by using historical pose, gaze data, and in-context examples. Full article
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22 pages, 10283 KB  
Article
Outlier Correction in Remote Sensing Retrieval of Ocean Wave Wavelength and Application to Bathymetry
by Zhengwen Xu, Shouxian Zhu, Wenjing Zhang, Yanyan Kang and Xiangbai Wu
Remote Sens. 2025, 17(19), 3284; https://doi.org/10.3390/rs17193284 - 24 Sep 2025
Viewed by 50
Abstract
The extraction of ocean wave wavelengths from optical imagery via Fast Fourier Transform (FFT) exhibits significant potential for Wave-Derived Bathymetry (WDB). However, in practical applications, this method frequently produces anomalously large wavelength estimates. To date, there has been insufficient exploration into the mechanisms [...] Read more.
The extraction of ocean wave wavelengths from optical imagery via Fast Fourier Transform (FFT) exhibits significant potential for Wave-Derived Bathymetry (WDB). However, in practical applications, this method frequently produces anomalously large wavelength estimates. To date, there has been insufficient exploration into the mechanisms underlying image spectral leakage to low wavenumbers and its suppression strategies. This study investigates three plausible mechanisms contributing to spectral leakage in optical images and proposes a subimage-based preprocessing framework: prior to executing two-dimensional FFT, the remote sensing subimages employed for wavelength inversion undergo three sequential steps: (1) truncation of distorted pixel values using a Gaussian mixture model; (2) application of a polynomial detrending surface; (3) incorporation of a two-dimensional Hann window. Subsequently, the dominant wavenumber peak is localized in the power spectrum and converted to wavelength values. Water depth is then inverted using the linear dispersion equation, combined with wave periods derived from ERA5. Taking 2 m-resolution WorldView-2 imagery of Sanya Bay, China as a case study, 1024 m subimages are utilized, with validation conducted against chart-sounding data. Results demonstrate that the proportion of subimages with anomalous wavelengths is reduced from 18.9% to 3.3% (in contrast to 14.0%, 7.8%, and 16.6% when the three preprocessing steps are applied individually). Within the 0–20 m depth range, the water depth retrieval accuracy achieves a Mean Absolute Error (MAE) of 1.79 m; for the 20–40 m range, the MAE is 6.38 m. A sensitivity analysis of subimage sizes (512/1024/2048 m) reveals that the 1024 m subimage offers an optimal balance between accuracy and coverage. However, residual anomalous wavelengths persist in near-shore subimages, and errors still increase with increasing water depth. This method is both concise and effective, rendering it suitable for application in shallow-water WDB scenarios. Full article
(This article belongs to the Section Ocean Remote Sensing)
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11 pages, 245 KB  
Article
When Do We Use Alternative Methods? Examination of the Factors Affecting the Use of Alternative Methods in Cochlear Implantation Surgery
by Enver Can Öncül, Yüksel Olgun, Can Apaydın, Özden Savaş, Erdoğan Özgür, Enes Bilgin Türkmenoğlu and Enis Alpin Güneri
J. Clin. Med. 2025, 14(18), 6525; https://doi.org/10.3390/jcm14186525 - 17 Sep 2025
Viewed by 262
Abstract
Background/Objectives: This study aimed to evaluate factors necessitating alternative techniques during cochlear implant (CI) surgery and to compare outcomes with standard procedures. Methods: Patients of all ages who underwent CI at our center between January 2003 and January 2024 were included. Alternative methods [...] Read more.
Background/Objectives: This study aimed to evaluate factors necessitating alternative techniques during cochlear implant (CI) surgery and to compare outcomes with standard procedures. Methods: Patients of all ages who underwent CI at our center between January 2003 and January 2024 were included. Alternative methods were defined as removal of external auditory canal/posterior canal wall, removal of ossicles to enhance surgical view, use of an endoscope for round window visualization, or similar approaches. Results: A total of 404 patients (mean age 13 ± 19.7 years) were analyzed. Preoperative imaging revealed inner ear anomalies in 44 patients (10.9%). Alternative methods were used in 41 patients (10.1%), including incus removal (n = 16), endoscopic assistance (n = 14), posterior canal wall removal (n = 4), incus buttress removal (n = 3), combined ossicle removal (n = 3), and one canal wall down mastoidectomy with fat graft obliteration and blind pouch closure. Alternative methods were significantly more frequent in patients with inner ear anomalies or additional otologic disease (p = 0.01 and p < 0.01, respectively), but not across age groups (p = 0.65). Partial electrode insertion occurred in 17 cases. Electrode insertion and complication rates were comparable between groups (p = 0.08 and p = 0.99, respectively). Bony cochleostomy was significantly more common in the alternative methods group (p = 0.01). Conclusions: Inner ear anomalies and additional otologic diseases may necessitate alternative CI techniques. These methods achieve electrode insertion and complication rates comparable to standard approaches, supporting their effectiveness in selected cases. Full article
(This article belongs to the Special Issue The Challenges and Prospects in Cochlear Implantation)
18 pages, 2834 KB  
Article
LCA Views of Low-Carbon Strategy in Historic Shopping District Decoration—Case Study in Harbin
by Lin Geng, Jiayi Gao, Minghui Xue and Yuelin Yang
Buildings 2025, 15(16), 2944; https://doi.org/10.3390/buildings15162944 - 19 Aug 2025
Viewed by 491
Abstract
This study focuses on buildings in the Chinese–Baroque Historic Shopping District in Harbin. In view of global climate change and high carbon emissions from the construction industry, this study aims to quantify carbon emissions during the decoration process and explore low-carbon decoration strategies [...] Read more.
This study focuses on buildings in the Chinese–Baroque Historic Shopping District in Harbin. In view of global climate change and high carbon emissions from the construction industry, this study aims to quantify carbon emissions during the decoration process and explore low-carbon decoration strategies that suit the local characteristics. This research adopts a four-stage framework of “data collection–quantitative analysis–strategy design–verification and optimization” and integrates Life Cycle Assessment (LCA) and multi-objective optimization theory. Data are collected through questionnaires and field investigations, and simulations and analyses are carried out using Grasshopper and Honeybee. The results show that there are differences in carbon emissions between different decoration schemes. The chosen scheme of raw concrete and paint results in relatively low carbon emissions over the 10.12-year usage cycle. Based on this, design strategies such as extending the service life of decorations, rationally renovating windows, and preferentially selecting local low-carbon materials are proposed and applied to practical projects. This study not only fills a gap in the research on the low-carbon renovation of historical commercial blocks from the perspective of LCA but also provides practical solutions for the sustainable development of historical shopping blocks in Harbin and similar regions, promoting the low-carbon transformation of cities. Full article
(This article belongs to the Special Issue Architecture and Landscape Architecture)
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12 pages, 858 KB  
Article
Examining the Neurophysiology of Attentional Habituation to Repeated Presentations of Food and Non-Food Visual Stimuli
by Aruna Duraisingam, Daniele Soria and Ramaswamy Palaniappan
Algorithms 2025, 18(8), 525; https://doi.org/10.3390/a18080525 - 18 Aug 2025
Viewed by 560
Abstract
Existing research shows that the human salivary response habituates to repeated presentation of visual, olfactory, or gustatory food cues in adults and children. The aim of this research is to examine the neurophysiological effects of attentional habituation within sessions toward repetition of the [...] Read more.
Existing research shows that the human salivary response habituates to repeated presentation of visual, olfactory, or gustatory food cues in adults and children. The aim of this research is to examine the neurophysiological effects of attentional habituation within sessions toward repetition of the same high- and low-calorie food and non-food images. Participants’ event-related potential (ERP) responses were measured as they passively viewed the same food and non-food images repeatedly. The ERP analysis results from trial groups within a session over time indicated that repeated exposure to the same image has a distinct effect on the brain’s attentional responses to food and non-food images. The brain response modulated by motivation and attention decreases over time, and it is significant in the 170–300 ms onset time window for low-calorie images and 180–330 ms onset time window for non-food images in the parietal region of the brain. However, the modulation to high-calorie images remains sustained over time within the session. Furthermore, the ERP results show that high-calorie images have a slower rate of declination than low-calorie images, followed by non-food images. In conclusion, our ERP study showed that a habituation-like mechanism modulates attention to repeated low-calorie and non-food images, whereas high-calorie images have a negligible effect. High-energy foods have a larger reward value, which increases prolonged attention and reduces the process of habituation. This could be one of the reasons why a negligible neural attentional habituation and slow habituation rate to high-calorie diets could have negative health consequences. Full article
(This article belongs to the Special Issue Advancements in Signal Processing and Machine Learning for Healthcare)
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22 pages, 5007 KB  
Article
FTIR-Derived Feature Insights for Predicting Time-Dependent Antibiotic Resistance Progression
by Mitchell Bonner, Claudia P. Barrera Patiño, Andrew Ramos Borsatto, Jennifer M. Soares, Kate C. Blanco and Vanderlei S. Bagnato
Antibiotics 2025, 14(8), 831; https://doi.org/10.3390/antibiotics14080831 - 15 Aug 2025
Viewed by 646
Abstract
Background/Objectives: The progression of antibiotic resistance is increasingly recognized as a dynamic and time-dependent phenomenon, challenging conventional diagnostics that define resistance as a binary trait. Methods: Biomolecules have fingerprints in Fourier-transform infrared spectroscopy (FTIR). The targeting of specific molecular groups, combined with principal [...] Read more.
Background/Objectives: The progression of antibiotic resistance is increasingly recognized as a dynamic and time-dependent phenomenon, challenging conventional diagnostics that define resistance as a binary trait. Methods: Biomolecules have fingerprints in Fourier-transform infrared spectroscopy (FTIR). The targeting of specific molecular groups, combined with principal component analysis (PCA) and machine learning algorithms (ML), enables the identification of bacteria resistant to antibiotics. Results: In this work, we investigate how effective classification depends on the use of different numbers of principal components, spectral regions, and defined resistance thresholds. Additionally, we explore how the time-dependent behavior of certain spectral regions (different biomolecules) may demonstrate behaviors that, independently, do not capture a complete picture of resistance development. FTIR spectra were obtained from Staphylococcus aureus exposed to azithromycin, trimethoprim/sulfamethoxazole, and oxacillin at sequential time points during resistance induction. Combining spectral windows substantially improved model performance, with accuracy reaching up to 96%, depending on the antibiotic and number of components. Early resistance patterns were detected as soon as 24 h post-exposure, and the inclusion of all three biochemical windows outperformed single-window models. Each spectral region contributed distinctively, reflecting biochemical remodeling associated with specific resistance mechanisms. Conclusions: These results indicate that antibiotic resistance should be viewed as a temporally adaptive trajectory rather than a static state. FTIR-based biochemical profiling, when integrated with ML, enables projection of phenotypic transitions and supports real-time therapeutic decision-making. This strategy represents a shift toward adaptive antimicrobial management, with the potential to personalize interventions based on dynamic resistance monitoring through spectral biomarkers. Full article
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34 pages, 4433 KB  
Article
Estimation of Residential Vacancy Rate in Underdeveloped Areas of China Based on Baidu Street View Residential Exterior Images: A Case Study of Nanning, Guangxi
by Weijia Zeng, Binglin Liu, Yi Hu, Weijiang Liu, Yuhe Fu, Yiyue Zhang and Weiran Zhang
Algorithms 2025, 18(8), 500; https://doi.org/10.3390/a18080500 - 11 Aug 2025
Viewed by 1084
Abstract
Housing vacancy rate is a key indicator for evaluating urban sustainable development. Due to rapid urbanization, population outflow and insufficient industrial support, the housing vacancy problem is particularly prominent in China’s underdeveloped regions. However, the lack of official data and the limitations of [...] Read more.
Housing vacancy rate is a key indicator for evaluating urban sustainable development. Due to rapid urbanization, population outflow and insufficient industrial support, the housing vacancy problem is particularly prominent in China’s underdeveloped regions. However, the lack of official data and the limitations of traditional survey methods restrict in-depth research. This study proposes a vacancy rate estimation method based on Baidu Street View residential exterior images and deep learning technology. Taking Nanning, Guangxi as a case study, an automatic discrimination model for residential vacancy status is constructed by identifying visual clues such as window occlusion, balcony debris accumulation, and facade maintenance status. The study first uses Baidu Street View API to collect images of residential communities in Nanning. After manual annotation and field verification, a labeled dataset is constructed. A pre-trained deep learning model (ResNet50) is applied to estimate the vacancy rate of the community after fine-tuning with labeled street view images of Nanning’s residential communities. GIS spatial analysis is combined to reveal the spatial distribution pattern and influencing factors of the vacancy rate. The results show that street view images can effectively capture vacancy characteristics that are difficult to identify with traditional remote sensing and indirect indicators, providing a refined data source and method innovation for housing vacancy research in underdeveloped regions. The study further found that the residential vacancy rate in Nanning showed significant spatial differentiation, and the vacancy driving mechanism in the old urban area and the emerging area was significantly different. This study expands the application boundaries of computer vision in urban research and fills the research gap on vacancy issues in underdeveloped areas. Its results can provide a scientific basis for the government to optimize housing planning, developers to make rational investments, and residents to make housing purchase decisions, thus helping to improve urban sustainable development and governance capabilities. Full article
(This article belongs to the Special Issue Algorithms for Smart Cities (2nd Edition))
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20 pages, 6591 KB  
Article
UAV Imaging of the Riverbed in Small, Tree-Lined Streams: Importance of the Light Environment
by Richard Hedger and Marie-Pierre Gosselin
Remote Sens. 2025, 17(16), 2775; https://doi.org/10.3390/rs17162775 - 11 Aug 2025
Viewed by 479
Abstract
Unmanned aerial vehicles (UAVs) are an ideal platform for the remote sensing of riverbeds in small, tree-lined streams, allowing unobstructed viewing of the channel at high spatial resolution. However, effective UAV surveying of these riverbeds is hindered by a range of phenomena associated [...] Read more.
Unmanned aerial vehicles (UAVs) are an ideal platform for the remote sensing of riverbeds in small, tree-lined streams, allowing unobstructed viewing of the channel at high spatial resolution. However, effective UAV surveying of these riverbeds is hindered by a range of phenomena associated with the complex light environments of rivers, and small tree-lined streams in particular, including reflections of the overlying cloud layer from the water surface, sunglint on the water surface, and shadows from topography and riparian vegetation. We used UAV imagery acquired from small, tree-lined streams under different light conditions to identify the prevalence of the main phenomena—reflections of clouds, sunglint, and shadows—that hinder the ability to discern the riverbed. We characterized how large a constraint these phenomena are on the optimal imaging window. We then examined the degree to which sub-optimal light conditions may restrict this window, both within the year and within the day, across Europe. Our investigations suggest that different regions across Europe will have different priorities with regard to imaging, with surveys in northern rivers emphasizing avoiding low irradiant intensity in winter and those in southern rivers emphasizing avoiding sunglint around midday. We use our findings to suggest a protocol for improved riverbed imaging that is specific to the light environment of the stream under investigation. Full article
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18 pages, 461 KB  
Perspective
Why Every Asthma Patient Tells a Different Story
by Alessio Marinelli, Silvano Dragonieri, Andrea Portacci, Vitaliano Nicola Quaranta and Giovanna Elisiana Carpagnano
J. Clin. Med. 2025, 14(16), 5641; https://doi.org/10.3390/jcm14165641 - 9 Aug 2025
Viewed by 494
Abstract
Asthma has traditionally been viewed as a single disease, but recent research reveals its clinical and molecular complexity. This perspective highlights the need to shift from a traditional, uniform treatment paradigm to one that embraces the heterogeneity of asthma across individuals. Each patient [...] Read more.
Asthma has traditionally been viewed as a single disease, but recent research reveals its clinical and molecular complexity. This perspective highlights the need to shift from a traditional, uniform treatment paradigm to one that embraces the heterogeneity of asthma across individuals. Each patient presents a unique clinical story shaped by a complex interplay of genetic predispositions, developmental programming during critical early-life windows, the influence of sex and hormones, and lifelong environmental exposures. Asthma comprises multiple subtypes with distinct clinical and biological features. Furthermore, lifestyle factors such as obesity and smoking, along with highly prevalent comorbidities like allergic rhinitis and gastroesophageal reflux disease, significantly modify the disease’s course and response to treatment. This article explores how classifying the disease into clinical phenotypes (observable characteristics) and molecular endotypes (underlying mechanisms)—particularly the distinction between T2-high and T2-low inflammation—provides a crucial framework for managing this complexity. The application of this framework, guided by biomarkers, has enabled the development of targeted biologic therapies that can transform care for specific patient subgroups. Despite these advances, significant challenges remain. The pathophysiology of certain subgroups, particularly non-T2 asthma, remains poorly defined, and there is an urgent need for reliable predictive biomarkers to guide therapy and monitor outcomes. It is our opinion that future studies must adopt a systems-biology strategy, with a multi-omics approach that constructs a comprehensive molecular profile of each patient. This integrative methodology will require the use of advanced computational methods, including machine learning and artificial intelligence, to decipher the complex pathways linking genetic and environmental inputs to clinical disease. In conclusion, this article argues for a more personalized understanding of asthma, urging clinicians and researchers to consider each patient’s unique clinical presentation. Full article
(This article belongs to the Section Respiratory Medicine)
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24 pages, 4356 KB  
Article
A Study on the Effects of Distinct Visual Elements and Their Combinations in Window Views on Stress and Emotional States
by Ping Zhang, Tao Yang, Yunque Bo, Wenqi Song, Wenyu Liu, Wei Ni, Wenjie Gao and Xiaoyan Qi
Buildings 2025, 15(15), 2804; https://doi.org/10.3390/buildings15152804 - 7 Aug 2025
Viewed by 571
Abstract
As people spend extended periods of time indoors, stress and negative emotions caused by work have become increasingly difficult to ignore. Observing window views is widely considered an effective method to alleviate stress and promote mental health. However, the specific visual elements within [...] Read more.
As people spend extended periods of time indoors, stress and negative emotions caused by work have become increasingly difficult to ignore. Observing window views is widely considered an effective method to alleviate stress and promote mental health. However, the specific visual elements within these views that contribute to stress reduction and the differential restorative benefits across varying compositions remain insufficiently understood. This study focuses on four major visual elements commonly seen through windows: sky, buildings, greenery, and roads. Using a horizontal layering approach, nine window views were created based on different proportions of these elements. Participants were exposed to these views, and their responses were evaluated through the positive and negative affect scale (PANAS), as well as electroencephalographic (EEG) data acquisition. The findings indicate that greenery exhibits the most pronounced positive effect on stress mitigation and the enhancement of positive affect, while the presence of roads is more likely to elicit negative emotional responses. Additionally, the visual richness and structural completeness of the window scenes are found to significantly impact restorative outcomes. These findings provide empirical insights for landscape and architectural design aimed at improving psychological well-being. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
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17 pages, 384 KB  
Article
Reading Between the Lines: Toward a Methodology for Tracing Manichaean Echoes in the Epistulae of Augustine of Hippo
by Marc-Thilo Glowacki and Anthony Dupont
Religions 2025, 16(8), 981; https://doi.org/10.3390/rel16080981 - 29 Jul 2025
Viewed by 807
Abstract
Augustine of Hippo (354–430), one of the most influential theologians of Late Antiquity, spent nearly a decade in the Manichaean sect before becoming a central figure in the shaping of Western “orthodox” Christianity. While his major works such as the Confessiones and De [...] Read more.
Augustine of Hippo (354–430), one of the most influential theologians of Late Antiquity, spent nearly a decade in the Manichaean sect before becoming a central figure in the shaping of Western “orthodox” Christianity. While his major works such as the Confessiones and De civitate Dei have been extensively studied for their treatment of Manichaeism, the vast collection of his ca. 300 preserved letters (Epistulae) remains an understudied source for understanding this aspect of his intellectual and theological development. This article addresses that gap by proposing a methodology to identify both anti- and crypto-Manichaean themes in his letters. Drawing on phenomenological openness, hermeneutical perspective, and close reading, the study also incorporates genuine Manichaean sources and anti-Manichaean polemics to contextualise Augustine’s rhetorical strategies. The Epistulae, unpolished and situated in specific communicative contexts, offer a unique view of Augustine’s doctrinal positioning after his conversion. Traces of his Manichaean past re-emerge in vocabulary, argumentation, and theological emphasis. This is exemplified in Epistula 137 to Volusianus (411–412), which, without naming the sect, covertly critiques key Manichaean doctrines such as Docetism and materialism. These critiques align with extant Manichaean sources and may reflect Augustine’s awareness of latent Manichaean influence in Christian communities. By bringing the Epistulae into the broader discussion of Augustine’s anti-Manichaean engagement, this study highlights their value as a window into his theological evolution and pastoral strategy in a religiously contested environment. Full article
31 pages, 4576 KB  
Article
Detection, Isolation, and Identification of Multiplicative Faults in a DC Motor and Amplifier Using Parameter Estimation Techniques
by Sanja Antić, Marko Rosić, Branko Koprivica, Alenka Milovanović and Milentije Luković
Appl. Sci. 2025, 15(15), 8322; https://doi.org/10.3390/app15158322 - 26 Jul 2025
Viewed by 482
Abstract
The increasing complexity of modern control systems highlights the need for reliable and robust fault detection, isolation, and identification (FDII) methods, particularly in safety-critical and industrial applications. The study focuses on the FDII of multiplicative faults in a DC motor and its electronic [...] Read more.
The increasing complexity of modern control systems highlights the need for reliable and robust fault detection, isolation, and identification (FDII) methods, particularly in safety-critical and industrial applications. The study focuses on the FDII of multiplicative faults in a DC motor and its electronic amplifier. To simulate such scenarios, a complete laboratory platform was developed for real-time FDII, using relay-based switching and custom LabVIEW software 2009. This platform enables real-time experimentation and represents an important component of the study. Two estimation-based fault detection (FD) algorithms were implemented: the Sliding Window Algorithm (SWA) for discrete-time models and a modified Sliding Integral Algorithm (SIA) for continuous-time models. The modification introduced to the SIA limits the data length used in least squares estimation, thereby reducing the impact of transient effects on parameter accuracy. Both algorithms achieved high model output-to-measured signal agreement, up to 98.6% under nominal conditions and above 95% during almost all fault scenarios. Moreover, the proposed fault isolation and identification methods, including a decision algorithm and an indirect estimation approach, successfully isolated and identified faults in key components such as amplifier resistors (R1, R9, R12), capacitor (C8), and motor parameters, including armature resistance (Ra), inertia (J), and friction coefficient (B). The decision algorithm, based on continuous-time model coefficients, demonstrated reliable fault isolation and identification, while the reduced Jacobian-based approach in the discrete model enhanced fault magnitude estimation, with deviations typically below 10%. Additionally, the platform supports remote experimentation, offering a valuable resource for advancing model-based FDII research and engineering education. Full article
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35 pages, 638 KB  
Review
The Influence of Circadian Rhythms on Transcranial Direct Current Stimulation (tDCS) Effects: Theoretical and Practical Considerations
by James Chmiel and Agnieszka Malinowska
Cells 2025, 14(15), 1152; https://doi.org/10.3390/cells14151152 - 25 Jul 2025
Cited by 1 | Viewed by 1449
Abstract
Transcranial direct current stimulation (tDCS) can modulate cortical excitability in a polarity-specific manner, yet identical protocols often produce inconsistent outcomes across sessions or individuals. This narrative review proposes that much of this variability arises from the brain’s intrinsic temporal landscape. Integrating evidence from [...] Read more.
Transcranial direct current stimulation (tDCS) can modulate cortical excitability in a polarity-specific manner, yet identical protocols often produce inconsistent outcomes across sessions or individuals. This narrative review proposes that much of this variability arises from the brain’s intrinsic temporal landscape. Integrating evidence from chronobiology, sleep research, and non-invasive brain stimulation, we argue that tDCS produces reliable, polarity-specific after-effects only within a circadian–homeostatic “window of efficacy”. On the circadian (Process C) axis, intrinsic alertness, membrane depolarisation, and glutamatergic gain rise in the late biological morning and early evening, whereas pre-dawn phases are marked by reduced excitability and heightened inhibition. On the homeostatic (Process S) axis, consolidated sleep renormalises synaptic weights, widening the capacity for further potentiation, whereas prolonged wakefulness saturates plasticity and can even reverse the usual anodal/cathodal polarity rules. Human stimulation studies mirror this two-process fingerprint: sleep deprivation abolishes anodal long-term-potentiation-like effects and converts cathodal inhibition into facilitation, while stimulating at each participant’s chronotype-aligned (phase-aligned) peak time amplifies and prolongs after-effects even under equal sleep pressure. From these observations we derive practical recommendations: (i) schedule excitatory tDCS after restorative sleep and near the individual wake-maintenance zone; (ii) avoid sessions at high sleep pressure or circadian troughs; (iii) log melatonin phase, chronotype, recent sleep and, where feasible, core temperature; and (iv) consider mild pre-heating or time-restricted feeding as physiological primers. By viewing Borbély’s two-process model and allied metabolic clocks as adjustable knobs for plasticity engineering, this review provides a conceptual scaffold for personalised, time-sensitive tDCS protocols that could improve reproducibility in research and therapeutic gain in the clinic. Full article
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18 pages, 14112 KB  
Article
Visual Effects Created by Perforated Windows in Yangzhou Salt Merchant Gardens: A Case Study of the Ho Family Garden
by Tao Wu and Yuanhua Shao
Buildings 2025, 15(15), 2599; https://doi.org/10.3390/buildings15152599 - 23 Jul 2025
Viewed by 371
Abstract
Perforated windows are essential landscape elements in Chinese classical gardens that combine artistic design with multiple functions. This study examines the Ho family Garden, a representative Yangzhou salt merchant garden, to classify perforated windows by type, spatial distribution, and dimensions. This study analyzes [...] Read more.
Perforated windows are essential landscape elements in Chinese classical gardens that combine artistic design with multiple functions. This study examines the Ho family Garden, a representative Yangzhou salt merchant garden, to classify perforated windows by type, spatial distribution, and dimensions. This study analyzes representative examples from various spaces and types to assess their visual effects, from static perspectives, focusing on landscape interfaces at different viewing distances, and dynamic perspectives, exploring their impact along different tour routes. The research also explores the penetrable viewing effects of perforated windows in the West Garden of the Ho family Garden and the sight system they create. The survey reveals that the setting characteristics of the perforated windows are related to the mode of spatial enclosure. Variations in the interface data of perforated windows at different distances relate to window size, while passive viewing effects depend on the location and number of perforated windows. The changes from the dynamic perspective primarily result from the landscape elements along different routes. In the West Garden, the penetrable view between the perforated windows and the doors increases the depth of landscape elements and spatial layers. The quantitative analysis reveals Yangzhou gardens’ unique spatial aesthetics while offering insights for contemporary landscape design. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
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51 pages, 4910 KB  
Review
The Impact of Building Windows on Occupant Well-Being: A Review Integrating Visual and Non-Visual Pathways with Multi-Objective Optimization
by Siqi He, Wenli Zhang and Yang Guan
Buildings 2025, 15(14), 2577; https://doi.org/10.3390/buildings15142577 - 21 Jul 2025
Cited by 1 | Viewed by 1155
Abstract
This review investigates the role of building windows in supporting occupant well-being through access to natural views and daylight. This review synthesizes recent interdisciplinary research from environmental psychology, building science, and human physiology to examine how windows impact cognitive performance, psychological restoration, and [...] Read more.
This review investigates the role of building windows in supporting occupant well-being through access to natural views and daylight. This review synthesizes recent interdisciplinary research from environmental psychology, building science, and human physiology to examine how windows impact cognitive performance, psychological restoration, and circadian health. Drawing on 304 peer-reviewed studies from 2000 to 2024, the review identifies two core pathways: visual effects—related to daylight availability, glare control, and view quality—and non-visual effects—linked to circadian entrainment and neuroendocrine regulation via ipRGCs. These effects interact yet compete, necessitating a multi-objective optimization approach. This paper evaluates commonly used metrics for visual comfort, circadian-effective lighting, and view quality and discusses their integration in design frameworks. The review also highlights the potential of adaptive facade technologies and artificial window systems to balance human-centered lighting goals with energy efficiency. A research roadmap is proposed to support future integrative design strategies that optimize both visual and non-visual outcomes in diverse architectural contexts. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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