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  • Case Report
  • Open Access
1 Citations
2,247 Views
10 Pages

Case Report: Weakness and Recurrent Falls in an Older Patient

  • Mercedes Galloway,
  • Nannette Hoffman,
  • Christopher Lawrence Bray,
  • Ahmed Ebrahim,
  • Brittany Puebla and
  • David Ritchie

Background/Objectives: Lower-extremity weakness in older adults is often overlooked, yet it can have reversible or medical causes that contribute to increased falls. Common factors include vision disturbances, impaired balance due to otolith dysfunct...

  • Article
  • Open Access
6 Citations
4,110 Views
13 Pages

False Alarm Reduction Method for Weakness Static Analysis Using BERT Model

  • Dinh Huong Nguyen,
  • Aria Seo,
  • Nnubia Pascal Nnamdi and
  • Yunsik Son

9 March 2023

In the era of the fourth Industrial Revolution, software has recently been applied in many fields. As the size and complexity of software increase, security attack problems continue to arise owing to potential software defects, resulting in significa...

  • Review
  • Open Access
11 Citations
8,256 Views
16 Pages

Ultrasonographic Features of Muscular Weakness and Muscle Wasting in Critically Ill Patients

  • Michele Umbrello,
  • Etrusca Brogi,
  • Paolo Formenti,
  • Francesco Corradi and
  • Francesco Forfori

20 December 2023

Muscle wasting begins as soon as in the first week of one’s ICU stay and patients with multi-organ failure lose more muscle mass and suffer worse functional impairment as a consequence. Muscle wasting and weakness are mainly characterized by a...

  • Article
  • Open Access
40 Citations
5,653 Views
9 Pages

The Relationship between Sarcopenia and Respiratory Muscle Weakness in Community-Dwelling Older Adults

  • Tomoyuki Morisawa,
  • Yota Kunieda,
  • Shingo Koyama,
  • Mizue Suzuki,
  • Yuma Takahashi,
  • Tomokazu Takakura,
  • Yuta Kikuchi,
  • Tadamitsu Matsuda,
  • Yuji Fujino and
  • Toshiyuki Fujiwara
  • + 4 authors

An association between respiratory muscle weakness and sarcopenia may provide a clue to the mechanism of sarcopenia development. We aimed to clarify this relationship among community-dwelling older adults. In total, 117 community-dwelling older adult...

  • Article
  • Open Access
43 Citations
8,076 Views
14 Pages

Instruction2vec: Efficient Preprocessor of Assembly Code to Detect Software Weakness with CNN

  • Yongjun Lee,
  • Hyun Kwon,
  • Sang-Hoon Choi,
  • Seung-Ho Lim,
  • Sung Hoon Baek and
  • Ki-Woong Park

30 September 2019

Potential software weakness, which can lead to exploitable security vulnerabilities, continues to pose a risk to computer systems. According to Common Vulnerability and Exposures, 14,714 vulnerabilities were reported in 2017, more than twice the numb...

  • Review
  • Open Access
9 Citations
13,519 Views
14 Pages

ICU-Acquired Weakness: From Pathophysiology to Management in Critical Care

  • Martina Petrucci,
  • Stefania Gemma,
  • Luigi Carbone,
  • Andrea Piccioni,
  • Davide Antonio Della Polla,
  • Benedetta Simeoni,
  • Francesco Franceschi and
  • Marcello Covino

Intensive Care Unit-Acquired Weakness (ICU-AW) is a common and severe complication in critically ill patients, characterized by profound and often prolonged muscle weakness. The complexity of its diagnosis and management requires a multidimensional a...

  • Article
  • Open Access
10 Citations
6,973 Views
9 Pages

Soymilk Improves Muscle Weakness in Young Ovariectomized Female Mice

  • Yuriko Kitajima,
  • Shizuka Ogawa,
  • Shintaro Egusa and
  • Yusuke Ono

4 August 2017

Estrogens play a key role in an extensive range of physiological functions in various types of tissues throughout the body in females. We previously showed that estrogen insufficiency caused muscle weakness that could be rescued by estrogen administr...

  • Review
  • Open Access
3 Citations
5,961 Views
15 Pages

Anabolic Strategies for ICU-Acquired Weakness. What Can We Learn from Bodybuilders?

  • Jakub Tarnawski,
  • Maja Czub,
  • Marta Dymecki,
  • Medha Sunil and
  • Marcin Folwarski

25 June 2024

The study aimed to show the potential clinical application of supplements used among sportsmen for patients suffering from Intensive Care Unit-acquired Weakness (ICUAW) treatment. ICUAW is a common complication affecting approximately 40% of critical...

  • Review
  • Open Access
54 Citations
10,027 Views
17 Pages

Practical Recommendations for Diagnosis and Management of Respiratory Muscle Weakness in Late-Onset Pompe Disease

  • Matthias Boentert,
  • Hélène Prigent,
  • Katalin Várdi,
  • Harrison N. Jones,
  • Uwe Mellies,
  • Anita K. Simonds,
  • Stephan Wenninger,
  • Emilia Barrot Cortés and
  • Marco Confalonieri

17 October 2016

Pompe disease is an autosomal-recessive lysosomal storage disorder characterized by progressive myopathy with proximal muscle weakness, respiratory muscle dysfunction, and cardiomyopathy (in infants only). In patients with juvenile or adult disease o...

  • Review
  • Open Access
98 Citations
24,898 Views
30 Pages

Intensive Care Unit-Acquired Weakness: Not Just Another Muscle Atrophying Condition

  • Heta Lad,
  • Tyler M. Saumur,
  • Margaret S. Herridge,
  • Claudia C. dos Santos,
  • Sunita Mathur,
  • Jane Batt and
  • Penney M. Gilbert

22 October 2020

Intensive care unit-acquired weakness (ICUAW) occurs in critically ill patients stemming from the critical illness itself, and results in sustained disability long after the ICU stay. Weakness can be attributed to muscle wasting, impaired contractili...

  • Concept Paper
  • Open Access
21 Citations
11,142 Views
15 Pages

6 January 2023

Respiratory and airway-protective muscle weakness caused by the blockade of neuromuscular transmission is a major cause of early mortality from snakebite envenoming (SBE). Once weakness is manifest, antivenom appears to be of limited effectiveness in...

  • Review
  • Open Access
33 Citations
5,540 Views
20 Pages

Skeletal muscle is a highly adaptable organ, and its amount declines under catabolic conditions such as critical illness. Aging is accompanied by a gradual loss of muscle, especially when physical activity decreases. Intensive care unit-acquired weak...

  • Case Report
  • Open Access
6 Citations
5,376 Views
7 Pages

11 June 2022

Rhabdomyolysis is a well-known clinical syndrome of muscle injury. Rhabdomyolysis following coronavirus disease 2019 (COVID-19) vaccination has recently been reported. The patients’ weakness gradually subsided and did not recur. Rhabdomyolysis...

  • Article
  • Open Access
4 Citations
2,123 Views
14 Pages

Phase Angle as Surrogate Marker of Muscle Weakness in Kidney Transplant Candidates Referred to Prehabilitation

  • Ester Marco,
  • María José Pérez-Sáez,
  • Elena Muñoz-Redondo,
  • Yulibeth G. Curbelo,
  • Cindry Ramírez-Fuentes,
  • Delky Meza-Valderrama,
  • Carolina Acuña-Pardo,
  • Mª Dolors Muns,
  • Olga Vázquez-Ibar and
  • Julio Pascual
  • + 4 authors

12 July 2024

Phase angle (PhA), a marker of nutritional status obtained by bioelectrical impedance analysis (BIA), is associated with the integrity of cell membranes. Damage to muscle fiber membranes can impact muscle strength, which is related to adverse outcome...

  • Article
  • Open Access
6 Citations
3,880 Views
17 Pages

Characterization of Muscle Weakness Due to Myasthenia Gravis Using Shear Wave Elastography

  • Manuela Zimmer,
  • Benedict Kleiser,
  • Justus Marquetand and
  • Filiz Ates

Myasthenia gravis (MG) is often accompanied with muscle weakness; however, little is known about mechanical adaptions of the affected muscles. As the latter can be assessed using ultrasound shear wave elastography (SWE), this study characterizes the...

  • Article
  • Open Access
1 Citations
2,076 Views
11 Pages

Oral Health-Related Quality of Life in Rare Disorders of Congenital Facial Weakness

  • Denise K. Liberton,
  • Konstantinia Almpani,
  • Rashmi Mishra,
  • Carol Bassim,
  • Carol Van Ryzin,
  • on behalf of the Moebius Syndrome Research Consortium,
  • Bryn D. Webb,
  • Ethylin Wang Jabs,
  • Elizabeth C. Engle and
  • Janice S. Lee
  • + 2 authors

Congenital facial weakness (CFW) encompasses a heterogenous set of rare disorders presenting with decreased facial movement from birth, secondary to impaired function of the facial musculature. The aim of the present study is to provide an analysis o...

  • Article
  • Open Access
5 Citations
3,178 Views
12 Pages

Muscle Weakness and Walking Slowness for the Identification of Sarcopenia in the Older Adults from Northern Brazil: A Cross-Sectional Study

  • Alex Barreto de Lima,
  • Duarte Henrinques-Neto,
  • Gustavo dos Santos Ribeiro,
  • Elvio Rúbio Gouveia and
  • Fátima Baptista

Background: This study aimed to analyze the prevalence of sarcopenia in elderly people from Northern Brazil according to muscle weakness or walking slowness. Methods: The sample consisted of 312 elderly people (72.6 ± 7.8 years). For walking s...

  • Feature Paper
  • Article
  • Open Access
7 Citations
4,357 Views
15 Pages

Genetic Profile of Patients with Limb-Girdle Muscle Weakness in the Chilean Population

  • Mathieu Cerino,
  • Patricio González-Hormazábal,
  • Mario Abaji,
  • Sebastien Courrier,
  • Francesca Puppo,
  • Yves Mathieu,
  • Alejandra Trangulao,
  • Nicholas Earle,
  • Claudia Castiglioni and
  • Jorge A. Bevilacqua
  • + 14 authors

16 June 2022

Hereditary myopathies are a group of genetically determined muscle disorders comprising more than 300 entities. In Chile, there are no specific registries of the distinct forms of these myopathies. We now report the genetic findings of a series of Ch...

  • Review
  • Open Access
42 Citations
7,317 Views
12 Pages

The COVID-19 pandemic has recently been the cause of a global public health emergency. Frequently, elderly patients experience a marked loss of muscle mass and strength during hospitalization, resulting in a significant functional decline. This paper...

  • Article
  • Open Access
7 Citations
3,126 Views
16 Pages

Rbm20ΔRRM Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness

  • Marloes van den Berg,
  • Eva L. Peters,
  • Robbert J. van der Pijl,
  • Shengyi Shen,
  • Leo M. A. Heunks,
  • Henk L. Granzier and
  • Coen A. C. Ottenheijm

10 December 2022

Diaphragm weakness frequently develops in mechanically ventilated critically ill patients and is associated with increased morbidity, including ventilator weaning failure, mortality, and health care costs. The mechanisms underlying diaphragm weakness...

  • Article
  • Open Access
7 Citations
1,898 Views
10 Pages

21 October 2023

Weak contact metric structures on a smooth manifold, introduced by V. Rovenski and R. Wolak in 2022, have provided new insight into the theory of classical structures. In this paper, we define new structures of this kind (called weak nearly Sasakian...

  • Article
  • Open Access
17 Citations
4,657 Views
26 Pages

28 August 2018

Since the 1992 United Nations Conference on environment and development held in Rio de Janeiro (Brazil) and the adoption by China State Council in March 1994 of the “China Agenda 21”, sustainability has become a major issue in China urban...

  • Article
  • Open Access
9 Citations
4,821 Views
12 Pages

Dysphagia and Muscle Weakness Secondary to Botulinum Toxin Type A Treatment of Cervical Dystonia: A Drug Class Analysis of Prescribing Information

  • Khashayar Dashtipour,
  • Han S. Lee,
  • Aaron Ellenbogen,
  • Rashid Kazerooni,
  • Todd M. Gross,
  • David A. Hollander and
  • Conor J. Gallagher

15 October 2024

The first-line management of cervical dystonia (CD) symptoms is intramuscular injection of botulinum toxin type A (BoNTA). However, a comparison of safety among BoNTAs is difficult because, per regulatory authorities, units of BoNTA activity are not...

  • Review
  • Open Access
11 Citations
5,218 Views
13 Pages

Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions

  • Felix Klawitter,
  • Uwe Walter,
  • Hubertus Axer,
  • Robert Patejdl and
  • Johannes Ehler

27 April 2023

Intensive care unit-acquired weakness (ICUAW) is one of the most common causes of muscle atrophy and functional disability in critically ill intensive care patients. Clinical examination, manual muscle strength testing and monitoring are frequently h...

  • Article
  • Open Access
2 Citations
2,719 Views
9 Pages

Iliopsoas Muscle Weakness as a Key Diagnostic Marker in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

  • Eiji Matsuura,
  • Satoshi Nozuma,
  • Mika Dozono,
  • Daisuke Kodama,
  • Masakazu Tanaka,
  • Ryuji Kubota and
  • Hiroshi Takashima

Human T-cell leukemia virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a slowly progressive neurological disease that arises from HTLV-1 infection. Pathologically, the condition is characterized by diffuse myelitis, wh...

  • Article
  • Open Access
2,317 Views
11 Pages

Transcriptome Analyses Indicate Significant Association of Increased Non-Additive and Allele-Specific Gene Expression with Hybrid Weakness in Rice (Oryza sativa L.)

  • Yingheng Wang,
  • Jing Xia,
  • Likun Huang,
  • Qiang Lin,
  • Qiuhua Cai,
  • Hongguang Xie,
  • Wei He,
  • Yidong Wei,
  • Huaan Xie and
  • Jianfu Zhang
  • + 2 authors

21 August 2022

The heterosis in hybrid rice is highly affected by the environment and hybrid weakness occurs frequently depending on the genotypes of the hybrid and its parents. Hybrid weakness was also observed in our field experiments on nine rice hybrids produce...

  • Article
  • Open Access
15 Citations
4,530 Views
14 Pages

HWA1- and HWA2-Mediated Hybrid Weakness in Rice Involves Cell Death, Reactive Oxygen Species Accumulation, and Disease Resistance-Related Gene Upregulation

  • Kumpei Shiragaki,
  • Takahiro Iizuka,
  • Katsuyuki Ichitani,
  • Tsutomu Kuboyama,
  • Toshinobu Morikawa,
  • Masayuki Oda and
  • Takahiro Tezuka

25 October 2019

Hybrid weakness is a type of reproductive isolation in which F1 hybrids of normal parents exhibit weaker growth characteristics than their parents. F1 hybrid of the Oryza sativa Indian cultivars ‘P.T.B.7′ and ‘A.D.T.14′ exhibi...

  • Article
  • Open Access
2 Citations
4,620 Views
20 Pages

10 August 2024

Smart contracts on blockchain platforms are susceptible to security issues that can lead to significant financial losses. This study converts the Solidity code into abstract syntax trees and generates control flow graphs and data flow graphs. These g...

  • Article
  • Open Access
2 Citations
4,659 Views
14 Pages

6 March 2025

Background/Objectives: Many patients evaluated by shoulder specialists suffer from intractable pain, neuropathy, and weakness. The pectoralis minor (PM) remains the only scapula muscle to receive lower trunk (C8-T1) input. We propose a novel syndrome...

  • Article
  • Open Access
18 Citations
4,055 Views
14 Pages

Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness

  • Lilian Jo Engelhardt,
  • Julius J. Grunow,
  • Tobias Wollersheim,
  • Niklas M. Carbon,
  • Felix Balzer,
  • Joachim Spranger and
  • Steffen Weber-Carstens

5 February 2022

(1) Background: Female sex is considered a risk factor for Intensive Care Unit-Acquired Weakness (ICUAW). The aim is to investigate sex-specific aspects of skeletal muscle metabolism in the context of ICUAW. (2) Methods: This is a sex-specific sub-an...

  • Communication
  • Open Access
6 Citations
2,393 Views
11 Pages

Increased Otoferlin Expression in B Cells Is Associated with Muscle Weakness in Untreated Juvenile Dermatomyositis: A Pilot Study

  • Ameera Bukhari,
  • Amer Khojah,
  • Wilfredo Marin,
  • Andrey Khramtsov,
  • Galina Khramtsova,
  • Christopher Costin,
  • Gabrielle Morgan,
  • Prathyaya Ramesh,
  • Marisa S. Klein-Gitelman and
  • Lauren M. Pachman
  • + 1 author

Otoferlin mRNA expression is increased in JDM patients’ PBMCs and muscle compared to healthy controls. This study aims to evaluate the role of otoferlin in JDM disease pathophysiology and its association with disease activity in untreated child...

  • Protocol
  • Open Access
2 Citations
4,600 Views
10 Pages

20 February 2025

Background: Post Intensive Care Syndrome (PICS) is a set of physical, cognitive, and mental health symptoms that arise following intensive care (ICU) hospitalization. Regarding physical changes, muscle weakness is highlighted, potentially leading to...

  • Article
  • Open Access
10 Citations
4,201 Views
22 Pages

Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients: Gender Differences

  • Xuejie Wang,
  • Ana Balaña-Corberó,
  • Juana Martínez-Llorens,
  • Liyun Qin,
  • Yingchen Xia,
  • Jianhua Zha,
  • José María Maiques and
  • Esther Barreiro

As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly al...

  • Article
  • Open Access
1 Citations
1,672 Views
10 Pages

An Investigation on Weak Concepts in Ordered Hyperstructures

  • Yongsheng Rao,
  • Jietong Zhao,
  • Aysha Khan,
  • Maryam Akhoundi and
  • Saber Omidi

2 December 2021

The class of weak pseudoorders and left weak interior hyperideals in ordered hyperstructures is a generalization of pseudoorders and interior hyperideals. In this work, we study the concept of weak pseudoorders and left weak interior hyperideals in o...

  • Article
  • Open Access
5 Citations
3,006 Views
17 Pages

Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca2+ Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation

  • Yurii S. Borovikov,
  • Armen O. Simonyan,
  • Stanislava V. Avrova,
  • Vladimir V. Sirenko,
  • Charles S. Redwood and
  • Olga E. Karpicheva

Substitution of Ala for Glu residue in position 173 of γ-tropomyosin (Tpm3.12) is associated with muscle weakness. Here we observe that this mutation increases myofilament Ca2+-sensitivity and inhibits in vitro actin-activated ATPase activity o...

  • Article
  • Open Access
1 Citations
2,819 Views
20 Pages

29 March 2019

In this paper we continue to investigate weak pseudo-quasi-Wajsberg algebras which are called weak PQW-algebras for short. First, some definitions are recalled and the basic properties of weak PQW-algebras are presented. Next, we define the notions o...

  • Article
  • Open Access
4 Citations
2,971 Views
11 Pages

Adding High-Intensity Interval Training to Classical Resistance Training Does Not Impede the Recovery from Inactivity-Induced Leg Muscle Weakness

  • Tomas Venckunas,
  • Marius Brazaitis,
  • Audrius Snieckus,
  • Mantas Mickevicius,
  • Nerijus Eimantas,
  • Andrejus Subocius,
  • Dalia Mickeviciene,
  • Håkan Westerblad and
  • Sigitas Kamandulis

22 December 2022

Inactivity is known to induce muscle weakness, and chronically increased levels of reactive oxygen species (ROS) are proposed to have a central causative role in this process. Intriguingly, high-intensity interval training (HIIT), which involves burs...

  • Article
  • Open Access
9 Citations
4,085 Views
23 Pages

13 June 2018

The interlayer shear weakness zone (ISWZ) is a deformation zone in stratified rock masses, with different width and spacing, due to tectonic stresses. It represents the main flow path in rocks due to higher permeability compared with massive rocks. T...

  • Article
  • Open Access
21 Citations
4,027 Views
14 Pages

Qualitative assessment by the Heckmatt scale (HS) and quantitative greyscale analysis of muscle echogenicity were compared for their value in detecting intensive care unit-acquired weakness (ICU-AW). We performed muscle ultrasound (MUS) of eight skel...

  • Article
  • Open Access
1 Citations
1,495 Views
23 Pages

The Augmented Weak Sharpness of Solution Sets in Equilibrium Problems

  • Ruyu Wang,
  • Wenling Zhao,
  • Daojin Song and
  • Yaozhong Hu

22 January 2024

This study considers equilibrium problems, focusing on identifying finite solutions for feasible solution sequences. We introduce an innovative extension of the weak sharp minimum concept from convex programming to equilibrium problems, coining this...

  • Review
  • Open Access
21 Citations
1,223 Views
12 Pages

Assessment of nonspeech tongue function is common in speech-language pathology. This paper reviews techniques used to determine tongue strength and endurance, and describes a constant-effort task. These techniques are intended to reveal and quantify...

  • Article
  • Open Access
8 Citations
2,090 Views
34 Pages

30 November 2020

Let (A,Δ) be a weak multiplier Hopf algebra. It is a pair of a non-degenerate algebra A, with or without identity, and a coproduct Δ:AM(AA), satisfying certain properties. In this paper, we continue the study of these objects and...

  • Article
  • Open Access
644 Views
16 Pages

Formulas for the Number of Weak Homomorphisms from Paths to Rectangular Grid Graphs

  • Penying Rochanakul,
  • Hatairat Yingtaweesittikul and
  • Sayan Panma

26 March 2025

A weak homomorphism from graph G to graph H is a mapping f:V(G)V(H), where either f(x)=f(y) or {f(x),f(y)}E(H) hold for all {x,y}E(G). A rectangular grid graph is formed by taking the Cartesian product of two paths. Counting weak ho...

  • Article
  • Open Access
6 Citations
1,816 Views
16 Pages

Aggregation of Weak Fuzzy Norms

  • Tatiana Pedraza,
  • Jorge Ramos-Canós and
  • Jesús Rodríguez-López

11 October 2021

Aggregation is a mathematical process consisting in the fusion of a set of values into a unique one and representing them in some sense. Aggregation functions have demonstrated to be very important in many problems related to the fusion of informatio...

  • Article
  • Open Access
2 Citations
3,347 Views
21 Pages

Measure of Weak Noncompactness and Fixed Point Theorems in Banach Algebras with Applications

  • Mohamed Amine Farid,
  • Karim Chaira,
  • El Miloudi Marhrani and
  • Mohamed Aamri

14 November 2019

In this paper, we prove some fixed point theorems for the nonlinear operator A · B + C in Banach algebra. Our fixed point results are obtained under a weak topology and measure of weak noncompactness; and we give an example of the appl...

  • Article
  • Open Access
9 Citations
4,099 Views
10 Pages

Molecular Characteristics of the Serological Weak D Phenotype in Koreans

  • Dajeong Jeong,
  • Sujin Oh,
  • Eun Young Song,
  • Yun Ji Hong and
  • Kyoung Un Park

Serological weak D is a reaction of 2+ or less to anti-D reagent and includes weak D and partial D phenotypes. Although identifying the RhD subtype is important for transfusion safety, serological tests are insufficient for defining the RhD subtype,...

  • Article
  • Open Access
6 Citations
3,961 Views
16 Pages

The presence of weak layers in geotechnical systems, including soil or rock masses, both natural and man-made, is more frequent than is normally believed. Weak layers can affect both failure mechanisms, in drained and in undrained conditions, as well...

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