Search Results (279)

Understanding how learners process data visualizations with seductive details is essential for improving comprehension and engagement. This study examined the influence of task-relevant and task-irrelevant seductive details on attentional distribution and comprehension in the context of data story learning, using COVID-19 data visualizations as experimental materials. A gaze-based methodology was applied, using eye-movement data and saliency maps to visualize learners’ attentional patterns while processing bar graphs with varying embellishments. Results showed that task-relevant seductive details supported comprehension for learners with higher visuospatial abilities by guiding attention toward textual information, while task-irrelevant details hindered comprehension, particularly for those with lower visuospatial abilities who focused disproportionately on visual elements. Working memory capacity emerged as a significant predictor of attentional distribution. Additionally, repeated exposure to data visualizations enhanced participants’ ability to recognize visualization types, improving efficiency and reducing reliance on legends and supplementary text. Overall, this study highlights the cognitive mechanisms underlying visualization processing in data story learning and provides practical implications for education, human–computer interaction, and adaptive technology design, emphasizing the importance of tailoring visualization strategies to individual learner differences. Full article

The global aging population has led to a rising prevalence of cognitive impairment, posing a significant public health challenge. Resistance training (RT) is a non-pharmacological intervention that has been increasingly investigated for its potential to support cognitive function in older adults. Clinical evidence suggests that RT may be associated with benefits in certain cognitive domains, including memory, executive function, processing speed, and visuospatial ability. However, findings across studies remain heterogeneous, with several trials reporting neutral outcomes. Most intervention studies involve structured RT programs conducted at moderate to high intensity and performed multiple times per week. However, optimal training parameters have not yet been clearly established due to variability in study design and the absence of formal dose–response analyses. Emerging evidence suggests that the cognitive effects of RT may be mediated, at least in part, through muscle–brain axis signaling involving exercise-induced myokines. Factors such as irisin, brain-derived neurotrophic factor, interleukin-6, interleukin-15, and insulin-like growth factor-1 have been implicated in processes related to neuroplasticity, neuroinflammatory regulation, and neurovascular function, primarily based on preclinical and translational research. This review synthesizes current evidence on RT-related molecular mechanisms and clinical findings to provide an integrative perspective on the potential role of resistance training in mitigating age-related cognitive decline. Full article

Background/Objectives: Post-traumatic epileptogenesis is a frequent and clinically relevant consequence of traumatic brain injury (TBI), often contributing to worsened neurological and functional outcomes. In patients experiencing early post-injury seizures, rehabilitative strategies that support recovery while considering increased epileptogenic risk are needed. This case study explores the potential benefits of combining neurofeedback (NFB) with motor therapy on cognitive and motor recovery. Methods: A patient hospitalized for severe TBI who experienced an acute symptomatic seizure in the early post-injury phase underwent baseline quantitative EEG (qEEG), neuromotor, functional, and neuropsychological assessments. The patient then completed a three-week rehabilitation program (five days/week) including 30 sensorimotor rhythm (SMR) NFB sessions (35 min each) combined with daily one-hour motor therapy. qEEG and clinical assessments were repeated post-intervention and at 6-month follow-up. Results: Post-intervention qEEG showed significant reductions in Delta and Theta power, reflecting decreased cortical slowing and enhanced neural activation. Relative power analysis indicated reduced Theta activity and Alpha normalization, suggesting improved cortical stability. Increases were observed in Beta and High-beta activity, alongside significant reductions in the Theta/Beta ratio, consistent with improved attentional regulation. Neuropsychological outcomes revealed reliable improvements in global cognition, memory, and visuospatial abilities, mostly maintained or enhanced at follow-up. Depressive and anxiety symptoms decreased markedly. Motor and functional assessments demonstrated meaningful improvements in motor performance, coordination, and functional independence. Conclusions: Findings suggest that integrating NFB with motor therapy may support recovery processes and be associated with sustained neuroplastic changes in the early post-injury phase after TBI, a condition associated with elevated risk for post-traumatic epilepsy. Full article

This study aimed to investigate the effect of inaudible-frequency binaural beats (BB), excluding the influence of audible sound, on visuospatial working memory performance (VSWMP). In particular, the effects were examined in relation to the stimulation timing of the stimulus and the task performance level of participants. Thirty adults in their 20 s (20 males, 25.7 ± 1.8 years; 10 females, 24.3 ± 1.6 years) participated in the experiment. A 10 Hz BB stimulus was generated by simultaneously presenting 18,000 Hz and 18,010 Hz tones to the left and right ears, respectively. The experiment employed a within-participant design consisting of a rest phase (5 min) and a task phase (5 min), with four BB stimulation conditions: Control (no BB), Exp1 (BB during both rest and task phases), Exp2 (BB during rest only), and Exp3 (BB during task only). VSWMP was assessed using corrected hit rate and reaction time in a 3-back task. Results indicated that all BB conditions (Exp1, Exp2, Exp3) significantly improved VSWMP compared to the Control condition, regardless of the stimulation timing. When participants were grouped based on task performance level into high- and low-performing groups (HPG, LPG), significant improvements in VSWMP were particularly evident in the LPG across all BB conditions compared to the Control. Notably, in Exp3, LPG participants demonstrated VSWMP comparable to that of the HPG. In conclusion, while BB stimulation enhances VSWMP regardless of its stimulation timing, its effectiveness may vary depending on the task performance level. Full article

Background/Objectives: This cross-sectional study examined how training age, chronological age, and biological maturity influence motor and perceptual–cognitive performance in youth soccer players, with relevance for health and well-being through sport participation. Methods: Forty-one male athletes (age = 14.86 ± 0.81 years) completed a two-day field-based assessment following a holistic framework integrating motor (sprinting, jumping, and agility) and perceptual–cognitive components (psychomotor speed, visuospatial working memory, and spatial visualization). Biological maturity was estimated using the maturity offset method. Results: Regression analyses showed that biological maturity and training age significantly predicted motor performance, particularly sprinting, jumping, and pre-planned agility, whereas chronological age was not a predictor. In contrast, neither maturity nor training experience influenced perceptual–cognitive skills. Among cognitive measures, only psychomotor speed significantly predicted reactive agility, emphasizing the role of rapid information processing in dynamic, game-specific contexts. Conclusions: Youth soccer training should address both physical and cognitive development through complementary strategies. Physical preparation should be tailored to maturity status to ensure safe and progressive loading, while systematic training of psychomotor speed and decision-making should enhance reactive agility and game intelligence. Integrating maturity and perceptual–cognitive assessments may support individualized development, improved performance, and long-term well-being. Full article

Background/Objectives: Mild Cognitive Impairment (MCI) represents a critical transition stage between normal aging and dementia, with executive dysfunction playing a key prognostic role. Traditional neuropsychological tests show limited ecological validity and may fail to detect early executive deficits. Virtual Reality (VR) offers an innovative alternative by reproducing everyday situations in realistic environments. This study investigated whether the Picture Interpretation Test 360° (PIT 360°), a VR-based assessment, can (1) discriminate between MCI patients and healthy controls (HCs); (2) identify executive dysfunction within the MCI group; and (3) correlate with standard neuropsychological measures. Methods: One hundred and one participants aged ≥65 years (53 MCI, 48 HCs) underwent a comprehensive neuropsychological assessment and PIT 360° evaluation. The PIT 360° requires interpreting a complex scene in a 360-degree virtual environment. Hierarchical linear regression, Receiver operating characteristic (ROC) curve analysis, and binary logistic regression were performed to examine group differences and diagnostic accuracy. MCI patients were stratified based on their performance on the Modified Five Point Test to identify visuospatial dysexecutive deficits. Results: MCI patients showed significantly longer PIT 360° completion times than HCs (92.6 vs. 65.3 s, p = 0.006), independent of age. MCI patients with visuospatial dysexecutive deficits exhibited the most severe deficits (median = 105 s, p = 0.017 vs. HCs). ROC analysis revealed adequate discriminative ability (AUC = 0.64, 95% CI [0.53, 0.75]) with a preliminary, sample-derived cut-off at ≥22 s, yielding high sensitivity (86.5%) but low specificity (42.6%). This threshold requires validation in independent samples. PIT 360° completion time correlated significantly with visuospatial executive functions, visual memory, and verbal fluency. Conclusions: The PIT 360° effectively screens for visuospatial executive dysfunction in MCI with high sensitivity, making it suitable for ruling out clinically significant impairment. Its ecological validity, brief administration, and correlations with traditional measures support integration into routine clinical practice for early detection and rehabilitation planning. Full article

Background/Objective: Neuroimmune and metabolic dysregulation have been increasingly implicated in the cognitive heterogeneity of autism spectrum disorder (ASD). However, it remains unclear whether anti-inflammatory diets engage distinct biological and cognitive pathways in autistic and neurotypical children. This study examined whether a 12-week anti-inflammatory dietary protocol produces group-specific neuroimmune–metabolic signatures and cognitive responses in autistic children, neurotypical children receiving the same diet, and untreated neurotypical controls. Methods: Twenty-two children (11 with ASD, six a on neurotypical diet [NT-diet], and five neurotypical controls [NT-control]) completed pre–post assessments of plasma IFN-γ, CXCL1, RANTES (CCL5), trimethylamine-N-oxide (TMAO), and an extensive ENI-2/WISC-IV neuropsychological battery. Linear mixed-effects models were used to test the Time × Group effects on biomarkers and cognitive domains, adjusting for age, sex, and baseline TMAO. Bayesian estimation quantified individual changes (posterior means, 95% credible intervals, and posterior probabilities). Immune–cognitive coupling was explored using Δ–Δ correlation matrices, network metrics (node strength, degree centrality), exploratory mediation models, and responder (≥0.5 SD domain improvement) versus non-responder analyses. Results: In ASD, the diet induced robust reductions in IFN-γ, RANTES, CXCL1, and TMAO, with decisive Bayesian evidence for IFN-γ and RANTES suppression (posterior P(δ < 0) > 0.99). These shifts were selectively associated with gains in verbal learning, semantic fluency, verbal reasoning, attention, and visuoconstructive abilities, whereas working memory and executive flexibility changes were heterogeneous, revealing executive vulnerability in individuals with smaller TMAO reductions. NT-diet children showed modest but consistent improvements in visuospatial processing, attention, and processing speed, with minimal biomarker changes; NT controls remained biologically and cognitively stable. Network analyses in ASD revealed a dense chemokine-anchored architecture with CXCL1 and RANTES as central hubs linking biomarker reductions to improvements in fluency, memory, attention, and executive flexibility. ΔTMAO predicted changes in executive flexibility only in ASD (explaining >50% of the variance), functioning as a metabolic node of executive susceptibility. Responders displayed larger coordinated decreases in all biomarkers and broader cognitive gains compared to non-responders. Conclusions: A structured anti-inflammatory diet elicits an ASD-specific, coordinated neuroimmune–metabolic response in which suppression of CXCL1 and RANTES and modulation of TMAO are tightly coupled with selective improvements in verbal, attentional, and executive domains. Neurotypical children exhibit modest metabolism-linked cognitive benefits and minimal immune modulation. These findings support a precision-nutrition framework in ASD, emphasizing baseline immunometabolic profiling and network-level biomarkers (CXCL1, RANTES, TMAO) to stratify responders and design combinatorial interventions targeting neuroimmune–metabolic pathways. Full article

Classroom acoustics and noise exposure significantly impact students’ emotional, cognitive, and academic well-being. This study investigates how classroom noise and acoustics affect auditory and cognitive performance among 131 children in three primary schools in northeast Italy. Student performance was assessed using standardised tests evaluating working memory, verbal short and long-term memory, and visuospatial memory. Children were tested under two distinct acoustic conditions: ambient classroom noise and artificially induced noise (comprising a sequence of typical internal and external classroom sounds, intelligible speech, and unintelligible conversations). Prior to testing, hearing threshold was assessed, in order to reveal any existing impairments. Following each experimental session, children rated their perceived effort and fatigue in completing the tests. Acoustic characterisation of empty classrooms was performed using Reverberation Time (T₂₀), Clarity (C₅₀), and Speech Transmission Index (STI), while noise level was measured during all testing phases. Regression analysis was employed to correlate noise levels and reverberation times with class-average performance and perception scores. Results indicate that noise significantly impaired both verbal working memory and visual attention, increasing perceived effort and fatigue. Notably, both ambient and induced noise conditions exhibited comparable adverse effects on attentional and memory task performance. These findings underscore the critical importance of acoustic design in educational environments and provide empirical support for developing classroom acoustic standards. Full article

Objective: Gliomas disrupt functional brain networks and impair neurological functions. While left-hemispheric tumors are well-studied because of their impact on language domains, the influence of right-sided gliomas on higher cognitive functions remains less understood. This study aimed to assess pre- and postoperative neurocognitive performance and to link cognitive outcomes with structural findings derived from function-based tractography in patients with right-hemispheric gliomas. Methods: Patients with gliomas were enrolled in this prospective observational study. A structured neurocognitive test battery was administered preoperatively, postoperatively, and at 3-month follow-up. Preoperative cortical mapping using navigated transcranial magnetic stimulation (nTMS) and function-based fiber tracking, based on diffusion tensor imaging (DTI), was performed. Results: Eighteen patients aged 52.7 ± 18.3 years were included. Preoperatively, 88.8% of patients showed impairments in at least one cognitive test, most frequently in the Nine-Hole Peg Test (66.7%), Bells Test task completion time (61.1%), Trail Making Test A and B (TMT-A: 50.0%; TMT-B: 44.4%), and digit symbol substitution test (27.8%). At follow-up, task performance improved on most cognitive tests. Function-based tractography showed that involvement of the superior longitudinal fasciculi I–III (44.4% of cases) was associated with impairments in attention, executive function, visuospatial processing, and processing speed. The involvement of the inferior frontooccipital fasciculus (55.5% of cases) was related to deficits in processing speed, attention, executive function, and episodic memory. Conclusions: Neurocognitive deficits are common in patients with right-hemispheric gliomas even before surgery. Maximal safe resection and sparing of these tracts is associated with cognitive recovery at follow-up. Function-based tractography emphasizes the structural involvement of key association fibers related to these cognitive deficits. Full article

The most prevalent chromosomal condition, Down syndrome (DS), is often linked to deficiencies in working memory, executive function, and visuospatial skills. Innovative approaches to promote cortical plasticity and improve cognitive development have been suggested, including play- and technology-based therapies like LEGO^®-based neurohabilitation. In this pre-experimental study, a 16-year-old adolescent with DS undertook 30 sessions of increasingly sophisticated LEGO^®-based therapy, covering everything from robotic assembly and programming to block creation. Before and after the session, a neuropsychological evaluation was carried out using the Rey complex figure, motor control, and five-digit tests. The reliable change index (RCI) was used to analyze changes in performance. Constructive praxis, processing speed, and overall efficiency all showed notable clinical improvements, especially in the copy score, total complexity, and total processing. These findings imply that LEGO^®-based neurohabilitation can provide significant gains in executive efficiency, visual–spatial abilities, and cognitive processing while offering a stimulating, developmentally appropriate therapy setting. Full article

Post-Traumatic Stress Disorder (PTSD) is consistently linked to multidimensional working memory (WM) impairments, encompassing deficits in sustained attention, verbal and visuospatial processing, and executive control, with inhibitory dysfunction emerging as a key feature. This scoping review synthesizes evidence from 39 studies examining neurobiological mechanisms, trauma-related factors, genetic and hormonal influences, gender differences, and task-specific variability. Findings indicated that PTSD is associated with altered activation and connectivity in the prefrontal cortex, hippocampus, and related neural networks, often resulting in compensatory but inefficient recruitment patterns. Emotional distraction and comorbidities such as depression, alcohol use, and traumatic brain injury can exacerbate cognitive deficits. Performance impairments are evident across both emotional and neutral WM tasks, with visuospatial and updating processes being particularly vulnerable. Risk factors include chronic trauma exposure, older age, APOE ε4 allele, and the BDNF Val66Met (rs6265) polymorphism, while modulators such as oxytocin, cortisol, and physical activity show potential cognitive benefits under specific conditions. Methodological heterogeneity and limited longitudinal data restrict generalizability. These findings underscore the importance of early screening, targeted cognitive interventions, and inclusion of underrepresented populations to refine prevention and treatment strategies for PTSD-related WM deficits. Full article

Background: Cognitive Reserve (CR) is a theoretical construct developed to explain individual differences in resilience to age-related cognitive decline. Empirical evidence supports its positive role across multiple cognitive domains. However, behavioral research has primarily focused on areas either vulnerable to aging, such as memory, or relatively preserved, such as language. In contrast, the relationship between CR and task-specific performance in domains like visuospatial processing—a domain critical for everyday functioning—remains underexplored. This study investigates whether CR, as measured by the Cognitive Reserve Index Questionnaire (CRIq), predicts performance in mental rotation tasks in healthy older adults. Methods: Participants (age 55–85) completed two tasks: (1) a hand laterality task, requiring judgments about whether a rotated hand image (palm or back view) was left or right; and (2) a letter-congruency task, in which participants determined whether simultaneously presented rotated letters were identical or mirror-reversed. Results: Generalized and linear mixed-effects models revealed a protective effect of cognitive reserve, with higher CRIq scores significantly predicting greater accuracy in both tasks. Efficiency benefits (i.e., shorter reaction times) were evident mainly in the easiest conditions, suggesting that CR supports processing resources more effectively under moderate rather than maximal task demands. This pattern indicates that cognitive reserve does not uniformly enhance performance but instead modulates the allocation of cognitive resources in a context-dependent manner. Conclusions: To our knowledge, this is the first study to demonstrate a modulatory role of CR on visuospatial abilities in healthy older adults. These findings open new avenues for investigating how CR may differentially affect performance across a broader spectrum of cognitive functions, including attention, executive control, and spatial processing. A better understanding of these mechanisms could inform targeted cognitive interventions to strengthen resilience and promote successful aging. Full article

Background: The implementation of effective, non-pharmacological interventions for enhancing cognitive function is a critical area of research. This pilot study evaluates the usability, feasibility, and acceptance of two novel immersive virtual reality (IVR) memory tasks designed for cognitive training. Materials and Methods: Thirty-three healthy young volunteers (mean age 20 ± 1.5 years) participated in a single session that included two IVR tasks: a “Virtual Face Name Memory Task” for long-term associative memory and a “Virtual Object Location Memory Task” for visuo-spatial working memory. The session, lasting approximately 30 min, was conducted using a Meta Quest 2 headset. To evaluate usability and feasibility, several standardized questionnaires were administered, including the User Satisfaction Evaluation Questionnaire, NASA Task Load Index, User Experience Questionnaire, Simulator Sickness Questionnaire, and System Usability Scale. Cognitive performance was measured through accuracy rates and the number of tasks completed. Results: Questionnaire results revealed an overwhelmingly positive user experience and high usability. Participants reported low frustration and a minimal incidence of cybersickness, confirming the procedure’s feasibility. Performance-wise, participants demonstrated high accuracy in immediate associative memory tasks (names: 80%, occupations: 95%) and visuospatial working memory tasks (change detection: 88–92%, localization: 90–95%). Associative memory performance declined after a 10 min delay (names: 49%, occupations: 59%) but improved significantly in the delayed recognition task (names: 76%, occupations: 88%). Conclusions: This pilot study provides compelling preliminary evidence for the usability and feasibility of two novel IVR memory tasks for cognitive training. The positive user experience, minimal cybersickness, and low frustration ratings indicate that the procedure is a feasible and engaging tool for cognitive intervention. Full article

Background/Objectives: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment for motor symptoms in Parkinson’s disease (PD), but concerns remain regarding its impact on cognitive function. Identifying neuroanatomical predictors of postoperative cognitive decline could improve patient selection and outcomes. This study aims to investigate the relationship between preoperative brain morphology and postoperative neuropsychological outcomes in PD patients undergoing bilateral STN-DBS. Methods: Thirty-eight PD patients underwent standardized neuropsychological testing and preoperative MRI before and 3–24 months after STN-DBS. Manual MRI morphometric measurements were obtained for 42 cortical, subcortical, and ventricular parameters. Changes in cognitive domains—including executive function, memory, language, visuospatial abilities, attention, and global cognition—were analyzed, and correlations between structural metrics and cognitive changes were assessed using Spearman’s coefficients. Results: Significant postoperative declines occurred selectively in language functions: verbal fluency (phonemic and semantic, d = −0.49 to −0.84) and confrontation naming (d = −0.47). Memory, executive functions, attention, and global cognition remained preserved. Enlarged lateral ventricles were consistently associated with poorer outcomes across multiple domains, while increased left precentral gyrus width correlated with executive and memory decline. Additionally, smaller midbrain and cingulate gyrus width were associated with greater executive impairment. Conclusions: STN-DBS in PD is associated with selective postoperative cognitive changes, most prominently in verbal fluency. Simple preoperative MRI morphometric measures, including ventricular size, limbic structure volumes, and specific cortical parameters, may serve as clinically feasible predictors of cognitive risk. Incorporating such measures into preoperative assessments could enhance patient selection, counseling, and individualized surgical planning. Full article

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a major impact on respiratory function, but also with possible underestimated effects on cognitive function. Although interest in cognitive impairment in chronic respiratory diseases, such as COPD, has increased, data on IPF remain limited and heterogeneous. Objective: This systematic review aimed to synthesize current evidence on cognitive impairment in IPF, identify the most affected domains, and evaluate the certainty of evidence using standardized methodological tools. Methods: A systematic review was conducted according to PRISMA 2020, with a registered PROSPERO protocol (CRD420251041866). Four databases (PubMed, Scopus, Web of Science, Cochrane Library) were searched for studies from 2014 to 2025. Methodological quality and certainty of evidence were appraised with the Joanna Briggs Institute (JBI) and GRADE frameworks. Results: Four studies met the inclusion criteria (two cross-sectional, one descriptive, one case–control). Across investigations, working and verbal memory emerged as the most consistently impaired domains, followed by processing speed and executive function, whereas visuospatial and language abilities were less frequently affected. Cognitive impairment was present even in mild IPF and became more pronounced with lower DLCO, shorter 6 min walk distance, greater desaturation, and obstructive sleep apnea. Certainty of evidence ranged from low to moderate due to small samples and heterogeneous testing. Conclusions: Cognitive dysfunction, particularly in memory, attention, and executive domains, is a frequent but under-recognized feature of IPF. Routine screening with brief, validated tools such as the MoCA may facilitate early detection and guide individualized rehabilitation. Full article