Search Results (14)

Background: Colorectal cancer (CRC), particularly the microsatellite-stable (MSS) subtype, remains largely unresponsive to immune checkpoint inhibitors (ICIs) due to immune escape, tumor-associated macrophage (TAM) enrichment, and cytokine-driven suppression that sustain a TAM-dominant tumor microenvironment (TME). To overcome these barriers, a pH-responsive solid lipid nanoparticle (SLN) system was engineered to co-deliver CB-5083 (a VCP/p97 inhibitor), miR-142 (a PD-L1-targeting microRNA), and imiquimod (R, a TLR7 agonist) for spatially confined induction of endoplasmic reticulum stress (ERS) and immune reprogramming in MSS CRC. Methods: The SLNs were coated with PEG–PGA for pH-triggered de-shielding and functionalized with PD-L1- and EGFR-binding peptides plus an ER-homing peptide, enabling tumor-selective and subcellular targeting. Results: The nanoplatform displayed acid-triggered PEG–PGA detachment, selective CRC/TAM uptake, and ER localization. CB-mediated VCP inhibition activated IRE1α/XBP1s/LC3II, PERK/eIF2α/ATF4/CHOP, and JNK/Beclin signaling, driving apoptosis and autophagy, while miR-142 suppressed PD-L1 expression and epithelial–mesenchymal transition markers. R facilitated dendritic cell maturation and M1 polarization. Combined CB + miR + R/SLN-CSW suppressed IL-17, G-CSF, and CXCL1, increased infiltration of CD4⁺ and CD8⁺ T cells, reduced Tregs and M2-TAMs, and inhibited tumor growth in CT-26 bearing mice. The treatment induced immunogenic cell death, reprogramming the TME into a T cell-permissive state and conferring resistance to tumor rechallenge. Biodistribution analysis confirmed tumor-preferential accumulation with minimal off-target exposure, and biosafety profiling demonstrated low systemic toxicity. Conclusions: This TME-responsive nanoplatform therefore integrates ERS induction, checkpoint modulation, and cytokine suppression to overcome immune exclusion in MSS CRC, representing a clinically translatable strategy for chemo-immunotherapy in immune-refractory tumors. Full article

The evaluation of tourism climate comfort is a systematic assessment of the climate conditions of tourist destinations. It is of great significance for improving the tourism experience, promoting the sustainable development of the tourism industry, and protecting the natural environment. In this study, the CiteSpace software was used to conduct a bibliometrics analysis of the study on tourism climate comfort in China, and the conceptual framework of this study was established based on the bibliometrics results. In the conceptual framework, this study firstly summarized eight indicators widely used in the current evaluation of tourism climate comfort. Secondly, four key technical means in the evaluation process were summarized, including geographic information system, analytic hierarchy process, fuzzy comprehensive evaluation, and cluster analysis. And three calculation methods of tourism climate comfort period were summarized, namely number of days with comfortable climate, five-day moving average method, and probability of climate-suitable days. Subsequently, the main application areas of tourism climate comfort evaluation were introduced: (1) exploration of the relationship between climate comfort and tourism activities (i.e., heat/cold-escape tourism, ice-snow tourism, outdoor rafting, coastal tourism, and other types of tourism activities); (2) exploration of the relationship between climate comfort and tourist flow; (3) the response of climate comfort to climate change; and (4) tourism climate regionalization. Finally, the main problems of current research and future development directions were proposed. Full article

A wind erosion instrument is a core instrument for collecting sand particles in wind and sand flows and studying the laws of wind and sand movement. To study the influence of the internal structure of the wind erosion instrument on its sand collection efficiency, a built-in louver separation device was designed. Based on CFD and Fluent 2022 software, numerical analysis was conducted using an RNG k-ε model, and the discrete phase model (DPM) method was used to calculate the sand collection efficiency. The flow field analysis of the new wind–sand separator was carried out. The influence of blade inclination angle, blade thickness, and blade number on sand collection efficiency was studied using single-factor and response surface analysis methods. The optimal parameter combination was obtained as blade inclination angle of 30°, blade thickness of 1.25 mm, and blade number of 10. A simulation model was established based on the optimal combination parameters, and the performance of the wind erosion instrument before and after the addition of the louver separation device was compared. The simulation results show that adding a louver separation device can increase static pressure, alleviate short-circuit flow and back-mixing phenomena, and stabilize the flow field; increasing tangential velocity leads to an increase in particle centrifugal force; reduce axial velocity, prolong particle stagnation time, and minimize particle escape. The particle trajectory pattern is mostly a continuous spiral path, which is conducive to capturing particles and improving sand collection efficiency. Compared with the original structure, for particles with diameters ranging from 0.001–0.05 mm, 0.005–0.01 mm, 0.01–0.05 mm, 0.05–0.1 mm, and 0.1–0.5 mm, the addition of a louver separation device increased the sand collection efficiency by 32.74%, 22.55%, 33.17%, 11.45%, and 0.13%, respectively. When the wind speed is 13.8 m/s and the diameter range is 0.001–0.5 mm, the average sand collection efficiency obtained from simulation tests and wind tunnel tests is 86.18% and 84.32%, respectively, with an error of 2.2%. The simulation results are reliable. The research results show that adding a louver separation device can improve the sand collection efficiency of the wind erosion instrument, and has better overall performance compared to the original wind–sand separator. This study provides a basis for further research on the structure of wind erosion gauges and the environmental protection of farmland. Strengthening land management can effectively protect soil resources, reduce wind erosion, ensure the stability of the ecosystem, and lay the foundation for promoting the sustainable use of land. Full article

Farmers have a pivotal responsibility in soil conservation: they can either preserve or deplete it through their choices. The responsibility of agriculture increases when practised in delicate ecosystems, such as lagoonal ones. The Venetian Lagoon islands, which are increasingly subjected to natural and anthropic subsidence, occasional flooding events (acqua alta), and eustatic sea level rise, are constantly exposed to erosive processes that challenge farmers to play with their adaptive capability. This research was carried out on the islands of Sant’Erasmo and Vignole, the most representative of island agriculture in the Venetian Lagoon: they almost exclusively rely on agriculture, which is almost nil in the other islands. This empirical research aimed to explore farmers’ agricultural practices, perceptions of soil changes, and how they adapt to them. It was fundamental for this study that the field research involved direct human contact with farmers (through semi-structured interviews) for data collection and using qualitative methods for data analysis, integrating scientific and non-scientific forms of knowledge and actors. The final purpose was to demonstrate the sustainability (valued on the potential depletion or regeneration capability) of agricultural practices and adaptation strategies on a theoretical basis. Despite their polycultural landscape (maintained by low-input farming systems), escaped from the predominant landscape oversimplification, Sant’Erasmo and Vignole are also subjected to unsustainable agricultural practices, including heavy mechanisation and synthetic inputs. Coupled with natural soil salinity that is exacerbated by increasing drought periods, these practices can contribute to soil degradation and increased salinity. The reported adaptation strategies, such as zeroed, reduced, or more conscious use of machines, were guided by the need to reduce the negative impact of soil changes on productivity. Our research revealed some of them as sustainable and others as unsustainable (such as increasing irrigation to contrast soil salinity). Participatory action research is needed to support farmers in designing effective sustainable agricultural practices and adaptation strategies. Full article

Facilitating the sustained and stable growth of farmers’ income is crucial for achieving sustainable development in forest regions. As an emerging driving force, the digital economy has demonstrated substantial potential in enhancing farmers’ income and promoting regional economic prosperity in forest areas. Based on survey data from 1043 households across 10 counties in Guizhou Province, China, this study empirically examined the direct and indirect effects of digital economy participation on income growth among farmers in forest regions. The findings revealed that, first, participation in the digital economy significantly contributed to income growth for these households. This effect remained robust across various estimation methods, restricted sample tests, and when replacing dependent variables. Second, forestry management and its diversification played a mediating role in the relationship between digital economy participation and farmers’ income. Participation in the digital economy indirectly influenced income growth by fostering forestry management activities and their diversification. Third, the heterogeneity analysis indicated that digital economy participation had a significant positive impact on the income growth of pure farming households, part-time farming households, and households that had previously escaped poverty. This discovery underscored the unique role of the digital economy in alleviating poverty and preventing its recurrence. The conclusions of this study provide essential theoretical and practical guidance for empowering forestry development through the digital economy and advancing the digital transformation of the forestry industry. More critically, this research presents a novel pathway for the deep integration of the digital economy with forestry, jointly fostering income growth for farmers in forest regions, which holds significant implications for achieving rural sustainable development. Full article

Today’s adolescents represent an elective target in addressing environmental challenges. Education is a key factor in achieving a sustainable future for them. However, formal education can represent a challenge when youths are its target, as they are considered the “interactive generation”. Game-based learning, and, in particular, Digital Educational Escape Rooms (DERs), have emerged as innovative methods in education, with promising applications in environmental sustainability studies. In this study, we developed 14 Digital Escape Rooms using the Social Cognitive Theory of Bandura as a theoretical framework. These were focused on environmental education and we tested them on a sample of 411 students (aged 12–18 years; 158 female, 38.4%). A one-group quasi-experimental research design was adopted, carrying out a pre-test post-test analysis. Each participant completed assessments at two time points: before engaging in the escape rooms (T0) and after (T1). The assessment tools included the Goal Assessment Scale (GAS) and the Perceived Climate Self-Efficacy Scale. Our findings revealed no significant gender differences in goal achievement. However, at T0, females exhibited higher levels of perceived climate self-efficacy in both individual and collective dimensions. Instead, the Digital Escape Rooms appeared particularly effective in increasing self-efficacy among male participants. These results suggest that Digital Escape Rooms hold potential for enhancing environmental self-efficacy, although gender differences in baseline efficacy levels warrant further exploration. Full article

Lithium-ion batteries (LIBs) are a widely used energy storage technology as they possess high energy density and are characterized by the reversible intercalation/deintercalation of Li ions between electrodes. The rapid development of LIBs has led to increased production efficiency and lower costs for manufacturers, resulting in a growing demand for batteries and their application across various industries, particularly in different types of vehicles. In order to meet the demand for LIBs while minimizing climate-impacting emissions, the reuse, recycling, and repurposing of LIBs is a critical step toward achieving a sustainable battery economy. This paper provides a comprehensive review of lithium-ion battery recycling, covering topics such as current recycling technologies, technological advancements, policy gaps, design strategies, funding for pilot projects, and a comprehensive strategy for battery recycling. Additionally, this paper emphasizes the challenges associated with developing LIB recycling and the opportunities arising from these challenges, such as the potential for innovation and the creation of a more sustainable and circular economy. The environmental implications of LIB recycling are also evaluated with methodologies able to provide a sustainability analysis of the selected technology. This paper aims to enhance the comprehension of these trade-offs and encourage discussion on determining the “best” recycling route when targets are in conflict. Full article

This study aims to identify types of virtual/augmented reality–based brand experiences (VR/AR experiences) to understand their impacts on consumer–brand relationships. For this study, brand experiences were divided into four types: entertainment, aesthetic, educational, and real-escape experiences. Today, consumers can experience virtual/augmented reality–based brand experiences. In this study, a survey of consumers who participated in brand experiences was conducted. A total of 518 consumers participated in the survey. To verify the study hypotheses, structural equation modeling was conducting using the EQS 6 program. The results confirmed that entertainment, aesthetic, educational, and real-escape experiences were the main types of brand experiences that consumers accessed through AR/VR technologies. Additionally, brand experiences utilizing VR/AR technologies were found to affect consumer–brand relationship-building. Moreover, consumer–brand relationships were found to have a positive effect on consumer satisfaction, which, in turn, had a positive effect on purchase intentions. Furthermore, perceived brand authenticity played an important role in moderating the relationship between the brand experience types and consumer–brand relationship-building. It was found that there were interactions between study participants who perceived brand authenticity as high or low with all regulatory variables. These empirical studies of actual consumers’ AR and VR have the advantage of being able to present the most reliable analysis method for researchers to access their goals through various statistical data and analysis techniques. One of the most important factors in empirical research is sample size. This is because samples have a significant impact on generalizing the results. This means that the validity of the research results is high. The impact of VR and AR on sustainability examined in this study, the impact of VR and AR, and consumer-brand relationship building tried to deviate from the existing perspective in explaining sustainable behavior. It is judged that it contributed to grasping the causal relationship by establishing the relationship with the variables of brand experience with VR and AR and purchase intention. The fact that this study established the impact of VR and AR experience in predicting sustainable behavior of consumers contributed to the field of sustainable marketing. Full article

It is crucial to conduct a comprehensive evaluation of the effectiveness of targeted poverty alleviation (TPA) policies in promoting sustainable livelihoods among impoverished populations, particularly in light of the COVID-19 pandemic. The existing literature, however, predominantly focuses on assessing the policies’ effectiveness in terms of income, while neglecting other critical dimensions of sustainable livelihoods. In line with sustainable livelihood theory, we utilized data from the Chinese Household Financial Survey Database from 2017 and 2019 and employed a fuzzy regression discontinuity (FRD) method to systematically examine the implementation outcomes of TPA policies through the lens of “capability-strategy-results”. Our analysis revealed that the implementation of TPA policies had a positive impact on the ability of poor households to cope with unexpected shocks, as evidenced by an increase in the accumulation rates of material, social, and financial capital. Furthermore, we observed an optimization of livelihood strategies among poor households, with a significant increase in the proportion of wage income. These policies also had a positive impact on their livelihood outcomes, such as a reduced likelihood of falling back into poverty and an increased possibility of escaping from marginal poverty without relying on government subsidies; however, some limitations require attention. Notably, our analysis revealed that the policies did not effectively improve the human capital of poor households. To further explore the heterogeneity of policy effects, we categorized poor households into three groups based on their farmer’s market participation ability and willingness. Our findings indicate that TPA policies effectively reduced poverty among households lacking labor force through government subsidies and saw an increase in the proportion of medical insurance reimbursement; however, households lacking motivation or capability did not experience positive outcomes in the short term. Therefore, future support policies should prioritize these vulnerable groups and monitor their progress closely. Moreover, our analysis revealed that migrant work is the primary livelihood strategy among the poor, and stabilizing their employment faces significant challenges amid the COVID-19 pandemic. Consequently, additional policies and interventions are needed to address the adverse impact of the pandemic on the employment and livelihoods of low-income households. Full article

Accurately identifying the degree of poverty and poverty-causing factors of poverty-stricken farmer households is the first key step to alleviating absolute and relative poverty. This paper introduces a multiobjective spatio-temporal evolution analysis method to examine poverty reduction of poverty-stricken farmer households under different development goals. A G-TOPSIS model was constructed to evaluate poverty-stricken households under short-, medium-, and long-term development goals. Then, GIS analysis methods were employed to reveal the spatio-temporal distribution of poverty-stricken households, and poverty causing factors were detected using the obstacle degree model. Taking Fugong County in Yunnan Province, China, as an example, the empirical results show that: (1) Great progress has been made in poverty reduction during the study period; however, some farmer households which have escaped absolute poverty are still in relative poverty and are still highly vulnerable. (2) Farmers with higher achievement rates under three different development goals are mainly distributed in the central and northern regions of study area, with a pattern of high–high agglomeration under the medium and low development goals, while low–low agglomeration mostly appears in central-southern regions. (3) Under the short-term development goals, the main poverty-causing factors are per capita net income, safe housing, sanitary toilets, years of education of labor force and family health. Under the medium- and long-term goals, per capita net income, labor force education and safe housing are the development limitations. (4) Infrastructure and public service are crucial to ending absolute poverty, and the endogenous force of regional development should be applied to alleviate the relative poverty through sustainable development industries and high-quality national education. Full article

Free vibration and wave analysis of thick rectangular graphene are studied by employing the wave propagation method. To consider small-scale effects and thickness of a plate in nanoscales, equations of motions are represented by the Eringen nonlocal theory coupled with the Mindlin plate theory of thick plates. To solve the governing equations of motion with the wave propagation technique, propagation and reflection matrices are derived. These matrices are combined to obtain exact natural frequencies of graphene sheets for all six possible boundary conditions. To check the accuracy and reliability of the method, natural frequencies are compared with the results of the literature, and excellent agreement is observed. Additionally, wave analysis of the graphene sheet is performed and different types of waves in the graphene sheet are captured. Deriving the dispersion relation of the graphene sheet, bifurcation frequencies (cut-off and escape frequencies) are analytically found. Finally, the effects of graphene sheet thickness and nonlocal parameter on the natural frequencies and bifurcation frequencies are investigated. It is observed that natural frequencies are highly dependent on the graphene sheet’s thickness and nonlocal parameter. More importantly, the number and order of bifurcation frequencies depend on these two parameters as well. Our findings are valuable for the sustainable design and fabrication of graphene-based sensors, in which structural health monitoring of embedded graphene sheets is of great importance. Full article

This work reports and analyzes the mechanical properties of some composites obtained using stabilized waste with epoxy resins E-227. For comparison, correspondent composite samples were realized using calcite as a filler. The recovered stabilized waste was obtained by means of a new method to stabilize municipal solid waste incineration (MSWI) fly ash (FA), based on the use of bottom ash (BA). The aim of this paper is to show that the stabilization process, which can be considered a zero—waste treatment, produces inert materials, that can be reused as a filler. The production of new filler was made on a pilot plant, designed to verify the transferability of the proposed stabilization technology. Mechanical analysis revealed that flexural modulus raises by increasing the filler content around 30% wt, independently of filler type, stabilized sample or calcium carbonate. Mechanical properties are lower in the samples with the high amount of filler due to the crowding effect. The morphology of composite materials showed a non-homogeneous dispersion of particles in stabilized sample filler, characterized by large particle agglomerates. Finally, according to the ESCAPE simplified method, the obtained composites result more sustainable in comparison with the corresponding ones produced by using natural resources (like calcite). These findings open new possibilities for the reuse of the stabilized material, in frame of circular economy principles, with environmental and economic advantages. Full article

Subway infrastructure is a representative urban infrastructure for sustainable urban development as part of its policy to harmonize with economic growth. As the transportation infrastructure of large cities develops with high speed and intelligence, more attention will be paid to its safety. The main cause of death in subway fires is asphyxiation, due to the closed specificity of the underground space. Therefore, smoke exhaust facilities should be capable of minimizing the effects of smoke to ensure the safe evacuation of passengers in the event of fire. In this study, three kinds of fire locations are adopted to analyze the distribution of platform temperature, CO, and visibility in connection with the smoke exhaust system operation method. We evaluate the performance of the applicable smoke exhaust system from ASET-based untenable area analysis. Fatality evaluation by escape analysis according to the smoke exhaust system estimates the fatality based on the tenability performance evaluation. Moreover, the FED method was used to evaluate tenability performance. Therefore, the result of this study suggests a solution for sustainable subway Disaster response from the performance evaluation of the subway platform smoke exhaust system for safe evacuation of passengers, which is essential for subway construction or remodeling. Full article

The US National Research Council recently released a report promoting sustainability assessment as the future of environmental regulation. Thirty years earlier, this organization (under the same senior author) had issued a similar report promoting risk assessment as a new method for improving the science behind regulatory decisions. Tools for risk assessment were subsequently developed and adopted in state and federal agencies throughout the US. Since then, limitations of the traditional forms of risk assessment have prompted some dramatic modifications toward cumulative assessments that combine multiple chemical and non-chemical stressors in community settings. At present, however, there is little momentum within the risk assessment community for abandoning this evolved system in favor of a new sustainability-based one. The key question is, how best to proceed? Should sustainability principles be incorporated into current risk assessment procedures, or vice versa? Widespread recognition of the importance of sustainability offers no clear guidance for the risk assessment community, especially in light of institutional commitments to sustainability tools and definitions that appear to have little in common with cumulative risk notions. The purpose of this paper is to reframe the sustainability challenge for risk assessors by offering analytical guidance to chart a way out. We adopt a decision analysis framework to overcome some conceptual barriers separating these two forms of assessment, and thereby, both escape the either/or choice and accept the inevitability of sustainability as a central regulatory concern in the U.S. Full article