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Keywords = surface fatigue index

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23 pages, 6098 KiB  
Article
Performance Optimization of Stacked Weld in Hydrogen Production Reactor Based on Response Surface Methodology–Genetic Algorithm
by Yu Liu, Hongtao Gu, Jincheng Zhang, Zhiyi Leng, Ziguang Wang and Shengfang Zhang
Coatings 2025, 15(8), 889; https://doi.org/10.3390/coatings15080889 (registering DOI) - 31 Jul 2025
Viewed by 181
Abstract
To address the issues of hydrogen embrittlement, creep, and fatigue that commonly occur in the welds of hydrogen production reactor operating under hydrogen exposure, high temperature and high pressure, this study proposes adding Si and Mo as reinforcing elements to the welding materials [...] Read more.
To address the issues of hydrogen embrittlement, creep, and fatigue that commonly occur in the welds of hydrogen production reactor operating under hydrogen exposure, high temperature and high pressure, this study proposes adding Si and Mo as reinforcing elements to the welding materials to enhance weld performance. Given the varying performance requirements of different weld layers in the stacked weld, a gradient performance optimization method for the stacked weld of hydrogen production reactors based on the response surface methodology (RSM)–genetic algorithm (GA) is proposed. Using tensile strength, the hydrogen embrittlement sensitivity index, fatigue strain strength, creep rate and weld performance evaluation indices, a high-precision regression model for Si and Mo contents and weld performance indices was established through RSM and analysis of variance (ANOVA). A multi-objective optimization mathematical model for gradient improvement of the stacked weld was also established. This model was solved using a GA to obtain the optimal element content combination added to the welding wire and the optimal weld thickness for each weld layer. Finally, submerged arc welding experiments of the stacked weld were conducted according to the optimization results. The results show that the tensile strength of the base layer, filling layer and cover layer of the stacked weld increased by 5.60%, 6.16% and 4.53%, respectively. Hydrogen embrittlement resistance increased by 70.56%, 52.40% and 45.16%, respectively. The fatigue and creep resistance were also improved. The experimental results validate the feasibility and accuracy of the proposed optimization method. Full article
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16 pages, 2185 KiB  
Article
Interplay Among Muscle Oxygen Saturation, Activation, and Power on a Swim-Bench
by Vittorio Coloretti, Claudio Quagliarotti, Giorgio Gatta, Maria Francesca Piacentini, Matteo Cortesi and Silvia Fantozzi
Sensors 2025, 25(13), 4148; https://doi.org/10.3390/s25134148 - 3 Jul 2025
Viewed by 400
Abstract
Muscle activity during exercise is typically assessed using oximeters, to evaluate local oxygen saturation (SmO2), or surface electromyography (sEMG), to analyze electrical activation. Despite the importance of combining these analyses, no study has evaluated both of them during specific swimming exercises [...] Read more.
Muscle activity during exercise is typically assessed using oximeters, to evaluate local oxygen saturation (SmO2), or surface electromyography (sEMG), to analyze electrical activation. Despite the importance of combining these analyses, no study has evaluated both of them during specific swimming exercises in combination with mechanical power output. This study aimed to assess muscle activity during an incremental test on a swim-bench utilizing oximeters and sEMG. Nine male swimmers performed a five-steps test: PRE (3 min at rest), STEP 1, 2, and 3 (swimming at a frequency of 25, 30, and 40 cycle/min for a duration of 2, 2, and 1 min, respectively), and POST (5 min at rest). Each swimmer wore two oximeters and sEMG, one for each triceps brachii. Stroke frequency and arm mechanical power (from ~13 to ~52 watts) estimated by the swim-bench were different among all steps, while no differences between arms were found. SmO2 (from ~70% to ~60%) and sEMG signals (from ~20 to ~65% in signal amplitude) showed a significant increase among all steps. In both arms, a large/very large correlation was found between mechanical power and SmO2 (r < −0.634), mechanical power and sEMG onset/amplitude (r > 0.581), and SmO2 and sEMG amplitude (r > 0.508). No correlations were found between the slope of the sEMG spectral indexes and the slope of SmO2; only sEMG detected electrical manifestation of muscle fatigue through the steps (p < 0.05). Increased muscle activity, assessed by both oximeters and sEMG, was found at mechanical power increases, revealing both devices can detect effort variation during exercise. However, only sEMG seems to detect peripheral manifestations of fatigue in dynamic conditions. Full article
(This article belongs to the Section Wearables)
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22 pages, 2102 KiB  
Article
Crumb Rubber (CR) and Low-Density Polyethylene (LDPE)-Modified Asphalt Pavement Assessment: A Mechanical, Environmental, and Life Cycle Cost Analysis Study
by Maram Saudy, Minas Guirguis, Ayman Saeed, Abdallah Elshenawy, Farida Elkaramany, Nadeen Dawoud, Mohamed Darwish and Mohamed AbouZeid
Sustainability 2025, 17(13), 5785; https://doi.org/10.3390/su17135785 - 24 Jun 2025
Viewed by 510
Abstract
Due to the growing consumption of plastic and rubber products, effective waste management solutions are crucial. This study evaluates the use of crumb rubber (CR), low-density polyethylene (LDPE), and their combination (CR+LDPE), as asphalt binder modifiers for improving pavement performance and sustainability. The [...] Read more.
Due to the growing consumption of plastic and rubber products, effective waste management solutions are crucial. This study evaluates the use of crumb rubber (CR), low-density polyethylene (LDPE), and their combination (CR+LDPE), as asphalt binder modifiers for improving pavement performance and sustainability. The analyses covered two critical pavement layers: the wearing surface (WS) and the treated base (TB). The methodology included (1) Binder Development and Testing; (2) Superpave Mix Design; (3) mechanical testing, including Indirect Tensile Strength Testing and Semi-Circular Bending Testing; (4) life cycle cost analysis; and (5) carbon footprint analysis. The results revealed that CR+LDPE significantly enhanced the fatigue resistance of the TB mixes, with a fracture energy increase of 47%, and increased the flexibility index by 53% in the WS. CR increased the flexibility index by about 146% in the TB layer, while LDPE increased the fracture energy by 21% in the WS layer. The life cycle cost analysis demonstrated that using LDPE, CR, and CR+LDPE reduced the life cycle costs by about 16% in the WS layer. Meanwhile, the life cycle carbon footprint analysis showed that using LDPE and CR+LDPE reduced the carbon footprint by about 87% and 81% for the TB and WS layers, respectively. The study findings highlight the mechanical, economic, and environmental benefits of incorporating wastes into asphalt pavements. Full article
(This article belongs to the Special Issue Sustainable Development of Asphalt Materials and Pavement Engineering)
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26 pages, 3728 KiB  
Article
Developing a Novel Muscle Fatigue Index for Wireless sEMG Sensors: Metrics and Regression Models for Real-Time Monitoring
by Dimitrios Miaoulis, Ioannis Stivaros and Stavros Koubias
Electronics 2025, 14(11), 2097; https://doi.org/10.3390/electronics14112097 - 22 May 2025
Viewed by 801
Abstract
Muscle fatigue impacts performance in sports, rehabilitation, and daily activities, with surface electromyography (sEMG) widely used for monitoring. In this study, we developed a wearable sEMG device and conducted experiments to create a dataset for fatigue analysis. The sEMG signals were analyzed through [...] Read more.
Muscle fatigue impacts performance in sports, rehabilitation, and daily activities, with surface electromyography (sEMG) widely used for monitoring. In this study, we developed a wearable sEMG device and conducted experiments to create a dataset for fatigue analysis. The sEMG signals were analyzed through a multi-domain feature extraction pipeline, incorporating time-domain (e.g., RMS, ARV), frequency-domain (e.g., MNF), and hybrid-domain metrics (e.g., MNF/ARV ratio, Instantaneous Mean Amplitude Difference), to identify physiologically meaningful indicators of fatigue. To ensure inter-subject comparability, we applied a dynamic standardization strategy that normalized each feature based on the RMS value of the first active segment, establishing a consistent baseline across participants. Using these standardized features, we explored several fatigue index construction methods—such as weighted sums, t-SNE, and Principal Component Analysis (PCA)—to capture fatigue progression effectively. We then trained and evaluated multiple machine learning models such as LR, SVR, RF, GBM, LSTM, CNN, and kNN to predict fatigue levels, selecting the most effective approach for real-time monitoring. Integrated into a wireless BLE-enabled sensor platform, the system offers seamless body placement, mobility, and efficient data transmission. An initial calibration phase ensures adaptation to individual muscle profiles, enhancing accuracy. By balancing on-device processing with efficient wireless communication, this platform delivers scalable, real-time fatigue monitoring across diverse applications. Full article
(This article belongs to the Special Issue Wireless Sensor Network: Latest Advances and Prospects)
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28 pages, 2405 KiB  
Systematic Review
Systematic Review and Meta-Analysis of Electromyography Potential to Discriminate Muscular or Articular Temporomandibular Disorders and Healthy Patients
by Maria Isabella Federici, Francesca Di Pasquale, Chiara Valenti, Alessandro Nanussi, Ornella Tulli, Maddalena Coniglio, Stefano Eramo, Lorella Marinucci and Stefano Pagano
Healthcare 2025, 13(5), 466; https://doi.org/10.3390/healthcare13050466 - 21 Feb 2025
Cited by 1 | Viewed by 1254
Abstract
Background/Objectives: New devices such as surface electromyography (sEMG) have been proposed to support traditional gnathological examination and diagnostic protocols. The aim of this study is to investigate whether sEMG can be considered a diagnostic instrument to discriminate between healthy subjects and patients [...] Read more.
Background/Objectives: New devices such as surface electromyography (sEMG) have been proposed to support traditional gnathological examination and diagnostic protocols. The aim of this study is to investigate whether sEMG can be considered a diagnostic instrument to discriminate between healthy subjects and patients with temporomandibular disorders (TMDs) of an articular or muscular nature. Methods: A systematic review was conducted according to PRISMA guidelines using literature searches of MEDLINE (via PubMed), Scopus, and Web of Science. Inclusion criteria: recent clinical studies (≤10 years) in English or Italian, involving electromyography in TMD diagnosis, with a control group of healthy patients. Data considered to be homogenous were subjected to meta-analysis (95% confidence interval [CI]; α = 0.05). Hedge g was calculated because all variables were continuous. Articles meeting the inclusion criteria were checked for further consideration, and relevant data were collected into two tables. In total, 18 studies were included after full-text reading. Meta-analyses were carried out for the static impact index (IMP), percentage overlapping coefficient (POC), and torque coefficient, and dynamic Symmetrical Mastication Index (SMI). Results: Patients with TMD had lower values in all parameters except IMP. sEMG registered a reduction in masseter activity, lower chewing efficiency, and an increase in fatigue during contractions in TMD patients. Conclusions: sEMG is not reliable to distinguish healthy from TMD patients, but despite the limitations related to the high variability in the studies (type of electromyography, static or dynamic tests, and population characteristics), the sEMG results are reliable considering the POC and SMI parameters, encouraging more in-depth studies for a predictable clinical practice. Patients with TMD had lower values in the dynamic index SMI and in static indexes POC and torque coefficient, except IMP. EMG might performs better if employed in muscle forms. Full article
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22 pages, 2552 KiB  
Article
The Relationship Between Manual Dexterity and Toothbrushing Efficiency in Preschool Children: A Crossover Study
by Lisbeth Macote-Orosco, Andrea Martín-Vacas, Marta M. Paz-Cortés, María Rosa Mourelle Martínez and M. Joaquín de Nova
Children 2024, 11(12), 1498; https://doi.org/10.3390/children11121498 - 8 Dec 2024
Cited by 1 | Viewed by 1564
Abstract
Aim: The aim of this study was to evaluate the relationship between oral hygiene (OH) efficiency and manual dexterity skills in Spanish five-year-old children using two fine motor tests. Methods: A cross-sectional study with a pre–post evaluation was designed. The children’s OH was [...] Read more.
Aim: The aim of this study was to evaluate the relationship between oral hygiene (OH) efficiency and manual dexterity skills in Spanish five-year-old children using two fine motor tests. Methods: A cross-sectional study with a pre–post evaluation was designed. The children’s OH was measured according to the Silness and Löe plaque index (PI) before toothbrushing upon arrival at school (pre) and after supervised toothbrushing (post). Motor skills (children’s dexterity) were determined with the Visual Motor Skills and Resistance to Fatigue test (VMSRF test) and the scale for the Behavioural Assessment of Preschool Skills (BAPS scale). Data were analysed with the SPSS® statistics software with a 95% confidence interval and bilateral significance. Results: One hundred and twenty-nine children were evaluated. The mean PI was 2.5, indicating generally poor OH in the sample. No difference in OH was observed between genders or in the brushing frequency categories. No significant differences in OH or the PI were found between right- and left-handed children either (p > 0.05). Significant differences were found between the OH category pre and post toothbrushing in the total sample, as well as in the various sextants and surfaces evaluated. The results of the VMSRF and BAPS tests indicate moderate visuomotor skills and fatigue resistance and a poor average skill level. A statistically significant improvement in the PI was found in children with higher scores in the VMSRF and BAPS tests. Conclusions: A significantly higher OH efficacy was found in children with better motor skills, although five-year-old children showed moderate visuomotor skills and fatigue resistance and a poor average preschool skill level. Full article
(This article belongs to the Section Pediatric Dentistry & Oral Medicine)
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17 pages, 3809 KiB  
Article
The Effect of Blood Flow Restriction during Low-Load Resistance Training Unit on Knee Flexor Muscle Fatigue in Recreational Athletes: A Randomized Double-Blinded Placebo-Controlled Pilot Study
by Aleksandra Królikowska, Maciej Daszkiewicz, Julia Kocel, George Mihai Avram, Łukasz Oleksy, Robert Prill, Jarosław Witkowski, Krzysztof Korolczuk, Anna Kołcz and Paweł Reichert
J. Clin. Med. 2024, 13(18), 5444; https://doi.org/10.3390/jcm13185444 - 13 Sep 2024
Viewed by 3385
Abstract
Background/Objectives: Despite the growing popularity of training with a controlled form of vascular occlusion, known as blood flow restriction (BFR) training, in the rehabilitation of orthopedic patients and sports medicine, there remains ample space for understanding the basis of its mechanism. The pilot [...] Read more.
Background/Objectives: Despite the growing popularity of training with a controlled form of vascular occlusion, known as blood flow restriction (BFR) training, in the rehabilitation of orthopedic patients and sports medicine, there remains ample space for understanding the basis of its mechanism. The pilot study assessed the effect of BFR during a low-load resistance training unit on knee flexor muscle fatigue, intending to decide whether a larger trial is needed and feasible. Methods: The study used a prospective, randomized, parallel, double-blind, placebo-controlled design. Fifteen male healthy recreational athletes were randomly assigned to three equal groups: BFR Group, Placebo Group, and Control Group. The primary outcome was the change in the surface electromyography-based (sEMG-based) muscle fatigue index, which was determined by comparing the results obtained before and after the intervention. The intervention was the application of BFR during low-load resistance training for knee flexors. The occurrence of any adverse events was documented. Results: In all groups, the sEMG-based fatigue index for semitendinosus and biceps femoris muscles decreased after low-load resistance training, with the largest decrease in the BFR group. Although not statistically significant, BFR showed moderate and large effect sizes for the fatigue index of semitendinosus and biceps femoris, respectively. No adverse events were noted. Conclusions: The pilot study suggested that BFR during a low-load resistance training unit might affect knee flexor muscle fatigue, supporting the development of a larger randomized clinical trial. Full article
(This article belongs to the Section Orthopedics)
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21 pages, 8896 KiB  
Article
Application of FBG Sensing Technology for Real-Time Monitoring in High-Stress Tunnel Environments
by Chao Ren, Xiaoming Sun, Manchao He and Zhigang Tao
Appl. Sci. 2024, 14(18), 8202; https://doi.org/10.3390/app14188202 - 12 Sep 2024
Cited by 3 | Viewed by 1268
Abstract
In the process of tunnel construction, problems such as high-stress rockburst, large deformation of soft rock, water inrush and mud gushing, secondary cracking of linings, blasting interference, man-made damage, and mechanical damage are often encountered. These pose a great challenge to the installation [...] Read more.
In the process of tunnel construction, problems such as high-stress rockburst, large deformation of soft rock, water inrush and mud gushing, secondary cracking of linings, blasting interference, man-made damage, and mechanical damage are often encountered. These pose a great challenge to the installation of monitoring equipment and line protection. In order to solve these problems, the 2# inclined shaft of Muzhailing Tunnel in the Gansu Province of China, which exists under high stress, water bearing, and bias conditions, was taken as the research object in this paper. By assembling a string, drilling grouting and sealing, and introducing multiple modes of protection, new fiber grating sensor group installation and line protection methods were proposed. The automatic continuous monitoring of the deep deformation of surrounding rock and the automatic continuous monitoring of steel arch stress were realized. The field monitoring results showed that: (1) the fiber grating displacement sensor group could be used to verify the authenticity of the surface displacement results monitored by the total station; (2) the NPR anchor cable coupling support effectively limited the large deformation of soft rock and the expansion of surrounding rock in a loose circle, and the range of the loose circle was stable at about 1 m; and (3) the main influence range of blasting was at a depth of 0~5 m in surrounding rock, and about 25 m away from the working face. In addition, to secure weak links in the steel arch due to the hardening phenomenon, a locking tube was set at the arch foot. In the support design, the fatigue life of the steel was found to be useful as the selection index for the steel arch frame to ensure the stability of the surrounding rock and the long-term safety of the tunnel. The present research adopted a robust method and integrates a variety of sensor technologies to provide a multifaceted view of the stresses and deformations encountered during the tunneling process, and the effective application of the above results could have certain research and reference value for the design and monitoring of high stress, water-bearing, and surrounding rock supports in tunnels. Full article
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14 pages, 6637 KiB  
Article
Monitoring Fatigue Damage of Orthotropic Steel Decks Using Nonlinear Ultrasonic Waves
by Jiahe Liu, Fangtong Zheng, Wei Shen and Dongsheng Li
Materials 2024, 17(12), 2792; https://doi.org/10.3390/ma17122792 - 7 Jun 2024
Cited by 1 | Viewed by 1324
Abstract
Orthotropic steel decks (OSDs) are commonly used in the construction of bridges due to their load-bearing capabilities. However, they are prone to fatigue damage over time due to the cyclic loads from vehicles. Therefore, the early structural health monitoring of fatigue damage in [...] Read more.
Orthotropic steel decks (OSDs) are commonly used in the construction of bridges due to their load-bearing capabilities. However, they are prone to fatigue damage over time due to the cyclic loads from vehicles. Therefore, the early structural health monitoring of fatigue damage in OSDs is crucial for ensuring bridge safety. Moreover, Lamb waves, as elastic waves propagating in OSD plate-like structures, are characterized by their long propagation distances and minimal attenuation. This paper introduces a method of emitting high-energy ultrasonic waves onto the OSD surface to capture the nonlinear Lamb waves formed, thereby calculating the nonlinear parameters. These parameters are then correlated with the fatigue damage endured, forming a damage index (DI) for monitoring the fatigue life of OSDs. Experimental results indicate that as fatigue damage increases, the nonlinear parameters exhibit a significant initial increase followed by a decrease. The behavior is distinct from the characteristic parameters of linear ultrasound (velocity and energy), which also exhibit changes but to a relatively smaller extent. The proposed DI and fatigue life based on nonlinear parameters can be fitted with a Gaussian curve, with the R-squared value of the fitting curve being close to 1. Additionally, this paper discusses the influence of rib welds within the OSDs on the DI, whereby as fatigue damage increases, it enlarges the value of the nonlinear parameters without altering their trend. The proposed method provides a more effective approach for monitoring early fatigue damage in OSDs. Full article
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18 pages, 6566 KiB  
Article
Multiaxial Fatigue Damage Analysis of Steel–Concrete Composite Beam Based on the Smith–Watson–Topper Parameter
by Da Wang, Nanchuan Li, Benkun Tan, Jialin Shi and Zhi Zhang
Buildings 2024, 14(6), 1601; https://doi.org/10.3390/buildings14061601 - 1 Jun 2024
Cited by 1 | Viewed by 980
Abstract
The fatigue performance of steel–concrete composite beams is crucial for ensuring structural safety. To account for the member’s multiaxial stress state, this study employed the critical surface method, using fatigue damage parameters as an evaluation index for assessing fatigue performance. Static and fatigue [...] Read more.
The fatigue performance of steel–concrete composite beams is crucial for ensuring structural safety. To account for the member’s multiaxial stress state, this study employed the critical surface method, using fatigue damage parameters as an evaluation index for assessing fatigue performance. Static and fatigue performance tests on steel–concrete beams were conducted to identify failure characteristics, which informed the development of a finite element model that incorporates concrete damage. Using the SWT model, the most unfavorable loading parameters were determined by analyzing critical paths on the test beams, providing a basis for predicting how initial defects impact fatigue performance. The impact of initial defects on the fatigue performance of the composite beam is assessed using this criterion. The results indicate that the discrepancy between the actual and predicted load capacities of the test beam is within 5%, and cyclic loading significantly affects the test beam’s mechanical properties, resulting in a 27% reduction in load capacity and a 48% increase in deflection after 2 million cycles. Finite element modeling reveals that components experience multiaxial stress, with test beam mechanical property changes aligning with predicted fatigue damage parameters, confirming the reliability of using these parameters as a criterion. As the strength of the composite beams diminished due to pore defects, the fatigue damage parameter escalated, increasing the likelihood of crack formation. However, once the concrete’s strength fell to a level where the pegs were insufficiently constrained, the structural damage pattern shifted, and the fatigue damage parameter subsequently decreased. Full article
(This article belongs to the Section Building Structures)
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15 pages, 28225 KiB  
Article
Effect of Force and Heat Coupling on Machined Surface Integrity and Fatigue Performance of Superalloy GH4169 Specimens
by Xun Li, Ruijie Gou and Ning Zhang
Metals 2024, 14(5), 540; https://doi.org/10.3390/met14050540 - 2 May 2024
Cited by 1 | Viewed by 1395
Abstract
GH4169 is one of the key materials used to manufacture high-temperature load-bearing parts for aero-engines, and the surface integrity of these parts in service conditions significantly affects their high-temperature fatigue performance. Under a coupling effect of high temperature and alternating load, the evolution [...] Read more.
GH4169 is one of the key materials used to manufacture high-temperature load-bearing parts for aero-engines, and the surface integrity of these parts in service conditions significantly affects their high-temperature fatigue performance. Under a coupling effect of high temperature and alternating load, the evolution process of the machined surface integrity index of superalloy GH4169 specimens was studied, and fatigue performance tests at 20 °C, 450 °C, and 650 °C were carried out to analyze the primary factors affecting the high-temperature fatigue performance of specimens. The results indicated that the surface roughness of specimens remained essentially unchanged. However, the value of surface residual stress decreased significantly, with a release of more than 60% at the highest temperature. At 650 °C, the surface microhardness increased, while the degree of surface plastic deformation decreased under alternating loads. Simultaneously, when the surface roughness was less than Ra 0.4 μm, surface microhardness was the main factor affecting the high-temperature fatigue performance of specimens. The influence of surface microhardness on low-cycle fatigue performance was not consistent with that on high-cycle fatigue performance. The latter increased monotonically, whereas the former initially increased and then decreased with increasing surface microhardness. Full article
(This article belongs to the Special Issue Advances in Lightweight Alloys)
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15 pages, 3089 KiB  
Article
Inhibition of Metalloproteinases Extends Longevity and Function of In Vitro Human iPSC-Derived Skeletal Muscle
by Natali Barakat, Himanshi Jangir, Leandro Gallo, Marcella Grillo, Xiufang Guo and James Hickman
Biomedicines 2024, 12(4), 856; https://doi.org/10.3390/biomedicines12040856 - 12 Apr 2024
Cited by 3 | Viewed by 2034
Abstract
In vitro culture longevity has long been a concern for disease modeling and drug testing when using contractable cells. The dynamic nature of certain cells, such as skeletal muscle, contributes to cell surface release, which limits the system’s ability to conduct long-term studies. [...] Read more.
In vitro culture longevity has long been a concern for disease modeling and drug testing when using contractable cells. The dynamic nature of certain cells, such as skeletal muscle, contributes to cell surface release, which limits the system’s ability to conduct long-term studies. This study hypothesized that regulating the extracellular matrix (ECM) dynamics should be able to prolong cell attachment on a culture surface. Human induced pluripotent stem cell (iPSC)-derived skeletal muscle (SKM) culture was utilized to test this hypothesis due to its forceful contractions in mature muscle culture, which can cause cell detachment. By specifically inhibiting matrix metalloproteinases (MMPs) that work to digest components of the ECM, it was shown that the SKM culture remained adhered for longer periods of time, up to 80 days. Functional testing of myofibers indicated that cells treated with the MMP inhibitors, tempol, and doxycycline, displayed a significantly reduced fatigue index, although the fidelity was not affected, while those treated with the MMP inducer, PMA, indicated a premature detachment and increased fatigue index. The MMP-modulating activity by the inhibitors and inducer was further validated by gel zymography analysis, where the MMP inhibitor showed minimally active MMPs, while the inducer-treated cells indicated high MMP activity. These data support the hypotheses that regulating the ECM dynamics can help maximize in vitro myotube longevity. This proof-of-principle strategy would benefit the modeling of diseases that require a long time to develop and the evaluation of chronic effects of potential therapeutics. Full article
(This article belongs to the Special Issue The Promise and Challenge of Induced Pluripotent Stem Cells (iPSCs))
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13 pages, 769 KiB  
Article
Mood Profile Clusters among Greek Exercise Participants and Inactive Adults
by Peter C. Terry, Renée L. Parsons-Smith, Symeon P. Vlachopoulos and Andrew M. Lane
Sci 2024, 6(2), 18; https://doi.org/10.3390/sci6020018 - 26 Mar 2024
Cited by 1 | Viewed by 2298
Abstract
Mood profile clusters have previously been identified in several cultural contexts. In the present study, six mood profile clusters referred to as the iceberg, inverse Everest, inverse iceberg, shark fin, submerged, and surface profiles, were investigated in a Greek population. The names of [...] Read more.
Mood profile clusters have previously been identified in several cultural contexts. In the present study, six mood profile clusters referred to as the iceberg, inverse Everest, inverse iceberg, shark fin, submerged, and surface profiles, were investigated in a Greek population. The names of the mood profiles reflect how they appear after raw scores for Tension, Depression, Anger, Vigor, Fatigue, and Confusion (in that order), are converted to T-scores and depicted graphically. A Greek translation of the Brunel Mood Scale (BRUMS-Greek) was completed by 1786 adults, comprising 1417 exercise participants and 369 physically inactive adults (male = 578, female = 1208) aged 18–64 years (M = 34.73 ± 11.81 years). Although the male–female ratio emphasized females, sample sizes of over 500 suggest some degree of representativeness. Seeded k-means cluster analysis clearly identified the six hypothesized mood profiles. Men were over-represented for the iceberg profile. For age, the 18–25 years group were under-represented for the iceberg profile, whereas the 46–55 and 56+ years groups were over-represented. The 56+ years group were under-represented for the inverse Everest, and the 18–25 years group were over-represented for the shark fin profile. For body mass index (BMI), participants in the obese weight category were over-represented for the inverse iceberg and shark fin profiles and under-represented for the submerged profile. Active participants were over-represented for the iceberg and submerged profiles, and under-represented for the inverse Everest, inverse iceberg, and surface profiles. Findings supported the cross-cultural equivalence of the mood profile clusters and confirmed the link between physical inactivity, obesity, and negative mood profiles. Full article
(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2023)
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17 pages, 9791 KiB  
Article
Fatigue Life Prediction Model of FRP–Concrete Interface Based on Gene Expression Programming
by Zhimei Zhang and Yinglong Huo
Materials 2024, 17(3), 690; https://doi.org/10.3390/ma17030690 - 31 Jan 2024
Cited by 2 | Viewed by 1189
Abstract
Under fatigue loading, the interfacial fatigue life of fiber-reinforced polymer(FRP)–concrete is an important index for the analysis of the fatigue performance of reinforced concrete beams strengthened with FRP materials and the evaluation of the reinforcement effect. To solve the problems of the inconsistent [...] Read more.
Under fatigue loading, the interfacial fatigue life of fiber-reinforced polymer(FRP)–concrete is an important index for the analysis of the fatigue performance of reinforced concrete beams strengthened with FRP materials and the evaluation of the reinforcement effect. To solve the problems of the inconsistent and limited accuracy of existing fatigue life prediction models, gene expression programming (GEP) was used to study the interfacial fatigue life of FRP–concrete. Firstly, 219 sets of interfacial fatigue test data were collected, which included two kinds of reinforcement methods, namely, externally bonded (EB) reinforcement and near-surface-mounted (NSM) reinforcement; secondly, Pearson correlation analysis was used to determine the key factors affecting the fatigue life, and then GEP was used to explore the influence of different input forms on the prediction accuracy of the model. Fatigue life calculation formulas applicable to the two kinds of reinforcement methods, i.e., EB and NSM, were established, and a specific calculation formula was established. The model was subjected to parameter sensitivity analysis and variable importance analysis and was found to reflect the intrinsic relationship between the fatigue life and various factors. Finally, the GEP model was compared with the models proposed by other researchers. Five statistical indices, such as the coefficient of determination and the average absolute error, were selected to assess the model, and the results show that the GEP model has higher prediction accuracy than other models, with a coefficient of determination of 0.819, and indicators such as the average absolute error are also lower than those of the rest of the models. Full article
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17 pages, 5731 KiB  
Article
Research on Laboratory Testing Method of Fatigue Performance of Semi-Rigid Base Considering Spatial Stress State
by Longfei Wang, Zhizhong Zhao, Hao Liang, Yilong He, Xianzhang Kang and Meng Xu
Buildings 2024, 14(2), 365; https://doi.org/10.3390/buildings14020365 - 29 Jan 2024
Cited by 1 | Viewed by 1276
Abstract
In order to accurately assess the fatigue performance of semi-rigid base layers, this paper proposes a novel fatigue testing method for semi-rigid base layers that takes into account the spatial stress state. Based on this method, the fatigue performance of three types of [...] Read more.
In order to accurately assess the fatigue performance of semi-rigid base layers, this paper proposes a novel fatigue testing method for semi-rigid base layers that takes into account the spatial stress state. Based on this method, the fatigue performance of three types of reinforced semi-rigid base-layer materials (steel wire mesh, plastic geogrid, and fiberglass) was tested and compared with unreinforced materials. The fatigue strain evolution patterns of these materials were analyzed, and a fatigue strain characteristic value at the limit state was proposed as an evaluation index for the fatigue failure of base layer materials. The results showed that in terms of fatigue performance, plastic geogrid > steel wire mesh > fiberglass > unreinforced specimens. The development of tensile strain can be approximately classified into a three-stage growth pattern, consisting of “curve + straight line + curve”. For the unreinforced specimens, the three stages of bending strain accounted for 10%, 70%, and 20% of the total fatigue life, respectively. The fatigue failure stages of the three types of reinforced materials had similar proportional ranges, representing 5%, 75%, and 20% of the total fatigue life, respectively. The fatigue strain characteristic values for plastic geogrid, steel wire mesh, fiberglass, and unreinforced specimens were 371 με, 280 με, 280 με, and 195 με, respectively. In summary, the use of reinforced materials within semi-rigid base layers enhances their fatigue performance, providing new insights and methods for extending the service life of road surfaces and offering scientific guidance for the practical application of reinforced materials in semi-rigid base layer road surfaces’ fatigue performance. Full article
(This article belongs to the Special Issue Carbon-Neutral Infrastructure)
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