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Keywords = stress-permeability mode

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22 pages, 9502 KiB  
Article
Phase-Field Modeling of Thermal Fracturing Mechanisms in Reservoir Rock Under High-Temperature Conditions
by Guo Tang, Dianbin Guo, Wei Zhong, Li Du, Xiang Mao and Man Li
Appl. Sci. 2025, 15(15), 8693; https://doi.org/10.3390/app15158693 (registering DOI) - 6 Aug 2025
Abstract
Thermal stimulation represents an effective method for enhancing reservoir permeability, thereby improving geothermal energy recovery in Enhanced Geothermal Systems (EGS). The phase-field method (PFM) has been widely adopted for its proven capability in modeling the fracture behavior of brittle solids. Consequently, a coupled [...] Read more.
Thermal stimulation represents an effective method for enhancing reservoir permeability, thereby improving geothermal energy recovery in Enhanced Geothermal Systems (EGS). The phase-field method (PFM) has been widely adopted for its proven capability in modeling the fracture behavior of brittle solids. Consequently, a coupled thermo-mechanical phase-field model (TM-PFM) was developed in COMSOL 6.2 Multiphysics to probe thermal fracturing mechanisms in reservoir rocks. The TM-PFM was validated against the analytical solutions for the temperature and stress fields under steady-state heat conduction in a thin-walled cylinder, three-point bending tests, and thermal shock tests. Subsequently, two distinct thermal fracturing modes in reservoir rock under high-temperature conditions were investigated: (i) fracture initiation driven by sharp temperature gradients during instantaneous thermal shocks, and (ii) crack propagation resulting from heterogeneous thermal expansion of constituent minerals. The proposed TM-PFM has been validated through systematic comparison between the simulation results and the corresponding experimental data, thereby demonstrating its capability to accurately simulate thermal fracturing. These findings provide mechanistic insights for optimizing geothermal energy extraction in EGS. Full article
(This article belongs to the Special Issue Advances in Failure Mechanism and Numerical Methods for Geomaterials)
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35 pages, 7887 KiB  
Article
Triaxial Experimental Study of Natural Gas Hydrate Sediment Fracturing and Its Initiation Mechanisms: A Simulation Using Large-Scale Ice-Saturated Synthetic Cubic Models
by Kaixiang Shen, Yanjiang Yu, Hao Zhang, Wenwei Xie, Jingan Lu, Jiawei Zhou, Xiaokang Wang and Zizhen Wang
J. Mar. Sci. Eng. 2025, 13(6), 1065; https://doi.org/10.3390/jmse13061065 - 28 May 2025
Viewed by 317
Abstract
The efficient extraction of natural gas from marine natural gas hydrate (NGH) reservoirs is challenging, due to their low permeability, high hydrate saturation, and fine-grained sediments. Hydraulic fracturing has been proven to be a promising technique for improving the permeability of these unconventional [...] Read more.
The efficient extraction of natural gas from marine natural gas hydrate (NGH) reservoirs is challenging, due to their low permeability, high hydrate saturation, and fine-grained sediments. Hydraulic fracturing has been proven to be a promising technique for improving the permeability of these unconventional reservoirs. This study presents a comprehensive triaxial experimental investigation of the fracturing behavior and fracture initiation mechanisms of NGH-bearing sediments, using large-scale ice-saturated synthetic cubic models. The experiments systematically explore the effects of key parameters, including the injection rate, fluid viscosity, ice saturation, perforation patterns, and in situ stress, on fracture propagation and morphology. The results demonstrate that at low fluid viscosities and saturation levels, transverse and torsional fractures dominate, while longitudinal fractures are more prominent at higher viscosities. Increased injection rates enhance fracture propagation, generating more complex fracture patterns, including transverse, torsional, and secondary fractures. A detailed analysis reveals that the perforation design significantly influences the fracture direction, with 90° helical perforations inducing vertical fractures and fixed-plane perforations resulting in transverse fractures. Additionally, a plastic fracture model more accurately predicts fracture initiation pressures compared to traditional elastic models, highlighting a shift from shear to tensile failure modes as hydrate saturation increases. This research provides new insights into the fracture mechanisms of NGH-bearing sediments and offers valuable guidance for optimizing hydraulic fracturing strategies to enhance resource extraction in hydrate reservoirs. Full article
(This article belongs to the Special Issue Advances in Marine Gas Hydrates)
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28 pages, 6655 KiB  
Article
Investigation of Flowback Behavior for Multi-Fractured Horizontal Wells in Gulong Shale Oil Reservoir Based on Numerical Simulation
by Shuxin Yu, Yucheng Wu, Xiaogang Cheng, Binhui Li, Langyu Niu, Rui Wang, Pin Jia and Linsong Cheng
Energies 2025, 18(10), 2568; https://doi.org/10.3390/en18102568 - 15 May 2025
Viewed by 484
Abstract
After hydraulic fracturing, hydraulic fractures and opened beddings are intertwined, which results in a complex fracture network in shale oil reservoirs. In addition, the migration of multi-phase fluids during fracturing and shut-in processes leads to complex flowback performance and brings difficulty to flowback [...] Read more.
After hydraulic fracturing, hydraulic fractures and opened beddings are intertwined, which results in a complex fracture network in shale oil reservoirs. In addition, the migration of multi-phase fluids during fracturing and shut-in processes leads to complex flowback performance and brings difficulty to flowback strategies optimization. In this paper, taking the Daqing Gulong shale reservoir as an example, a numerical model, which considers oil–water–gas three-phase flow and the orthogonal fracture network, has been established for flowback period. The characteristics and influencing factors of flowback performance have been deeply studied, and the flowback modes of shale oil are reasonably optimized. Geological factors such as PTPG (pseudo-threshold pressure gradient), matrix permeability, and engineering factors such as opened bedding stress sensitivity, opened bedding permeability, and fracturing fluid distribution have obvious effects on the flowback performance, resulting in significant variations in production peaks, high production periods, and decline rates. Furthermore, three flowback modes distinguished by the BHP (bottom hole pressure) correspond to the three types of choke mode that have been optimized. This study reveals the main factors affecting the flowback performance. Meanwhile, the optimization method can be applied to optimize flowback strategies in Gulong and other similar shale reservoirs to obtain higher shale oil production. Full article
(This article belongs to the Topic Petroleum and Gas Engineering)
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19 pages, 6401 KiB  
Article
Rheological Properties and Permeation Grouting Reinforcement Effect of Cement-Bentonite Slurry
by Yuan Wang, Tian Qi, Chenxi Xu and Jiakun Gong
Buildings 2025, 15(5), 744; https://doi.org/10.3390/buildings15050744 - 25 Feb 2025
Cited by 1 | Viewed by 908
Abstract
Permeation grouting is one important method for preventing and controlling leakage in levees, with cement-bentonite slurry as a commonly used grouting material. In this study, the effect of water–cement ratio and bentonite content on the rheological properties of cement-bentonite slurry was investigated. The [...] Read more.
Permeation grouting is one important method for preventing and controlling leakage in levees, with cement-bentonite slurry as a commonly used grouting material. In this study, the effect of water–cement ratio and bentonite content on the rheological properties of cement-bentonite slurry was investigated. The reinforcement effect of cement-bentonite slurry under various conditions was explored by conducting a series of experiments via a self-designed apparatus. The grouting pressure, water–cement ratio, and bentonite content were taken as the grouting variables, and the compressive strength, deformation modulus, and permeability coefficient were adopted as indicators to evaluate the reinforcement effect. The experimental results indicate that the plastic viscosity and the yield stress of the cement-bentonite slurry rose as the water–cement ratio increased. The water–cement ratio served as the main controlling factor of the grouting reinforcement effect. The compressive strength, deformation modulus, and permeability of the grouted body decreased as the water–cement ratio increased. The bentonite content significantly impacted the grouting reinforcement effect. As the bentonite content of slurry increased, the permeability of the grouted body increased, while the compressive strength and deformation modulus first increased then decreased. An optimal bentonite content of cement-bentonite slurry can be decided. Moreover, the failure mode of the grouted body was also significantly impacted by the water–cement ratio. As the water–cement ratio increased, the heterogeneity of the grouted body became greater, and the failure mode changed from overall failure to local failure. The heterogeneity of the grouted body can be improved by enhancing the grouting pressure and the bentonite content of cement-bentonite slurry. Full article
(This article belongs to the Special Issue Advances in Soil-Structure Interaction for Building Structures)
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26 pages, 21259 KiB  
Article
Numerical Simulation of Microwave-Induced Cracking of Coal Containing Pyrite Powder Based on a Multi-Field Coupling Model
by Yidu Hong, Shengyi Long and Xiaowan Sun
Appl. Sci. 2024, 14(24), 11835; https://doi.org/10.3390/app142411835 - 18 Dec 2024
Viewed by 695
Abstract
Microwave irradiation has become a potential technical method for coalbed degassing, which can effectively improve its permeability. A coupled electromagnetic—thermomechanical damage (ETMD) model was established to study the damage characteristics of coal containing pyrites. Under microwave irradiation, the temperature increase rate of pyrite [...] Read more.
Microwave irradiation has become a potential technical method for coalbed degassing, which can effectively improve its permeability. A coupled electromagnetic—thermomechanical damage (ETMD) model was established to study the damage characteristics of coal containing pyrites. Under microwave irradiation, the temperature increase rate of pyrite was significantly higher compared to the coal matrix. The coal matrix was cracked by expansion stress in high-temperature spots. In the rotational heating mode, the coal matrix was easier to damage than under the static heating mode. The coal matrix damage efficiency was also related to the position of the sample under the static heating mode. Uniform centripetal pressure could inhibit coal matrix damage. Moreover, the pressure distribution affected the damage paths. Compared to no confining pressure, the percentage of areas damaged in coal was lower under low parallel pressure and higher under high parallel pressure. Full article
(This article belongs to the Section Energy Science and Technology)
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12 pages, 3406 KiB  
Article
Analysis of Changes in the Stress–Strain State and Permeability of a Terrigenous Reservoir Based on a Numerical Model of the Near-Well Zone with Casing and Perforation Channels
by Sergey Chernyshov, Sergey Popov, Xiaopu Wang, Vadim Derendyaev, Yongfei Yang and Huajie Liu
Appl. Sci. 2024, 14(21), 9993; https://doi.org/10.3390/app14219993 - 1 Nov 2024
Cited by 4 | Viewed by 1019
Abstract
A finite element model, which includes reservoir rock, cement stone, casing, and perforation channels, was developed. The purpose of the study is to create a geomechanical model of the zone around the well, which includes support elements and perforation channels. This model will [...] Read more.
A finite element model, which includes reservoir rock, cement stone, casing, and perforation channels, was developed. The purpose of the study is to create a geomechanical model of the zone around the well, which includes support elements and perforation channels. This model will help predict changes in the productivity coefficient of a terrigenous reservoir and determine the most efficient mode of operation of a producing well. In order to exclude the stress concentration within the casing–cement stone and cement stone–rock, the numerical model applies contact elements. As a result, structural elements slip, while the stresses are redistributed accurately. The numerical simulation of a stress state in the near-well zone was carried out by using the developed model with differential pressure drawdown on the terrigenous reservoir, one of the oil fields in the Perm region. It is shown that the safety factor of the casing reaches roughly 3–4 units. The only exceptions are the upper and lower parts of the perforations, where this parameter is close to one unit. The safety factor of cement stone accounts for 2–3 units. However, parts with its lowest value (1.35) are also concentrated near the perforation channels. In order to analyze the change in permeability, the dependence of the safety factor on effective stresses was taken into account. Therefore, it was found that, in the upper and lower parts of perforations, the stresses decreased, while permeability rose by up to 20% of the initial value. An increase in differential pressure drawdown, on the contrary, can lead to a permeability reduction of 25%, especially in the lateral parts of the perforations. Areas of rock destruction under tensile and compressive forces were identified by using the Mohr–Coulomb criterion. It is estimated that with an increase in pressure drawdown, the areas of rock destruction under tensile force disappear, while the areas of rock destruction under compression increase. After further analysis, it was found that, with the maximum pressure drawdown of 12 MPa, the well productivity index can decrease by 15% due to the reservoir rock compaction. Full article
(This article belongs to the Topic Petroleum and Gas Engineering)
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16 pages, 8448 KiB  
Article
Study on the Mechanical and Permeability Evolution of a Composite Rock Mass in an Aquifuge Under Hydraulic Coupling
by Changzheng Zhao, Shenggen Cao, Shuyu Du, Chiyuan Che, Yang Liu, Kaifei Wang and Ruiting Ma
Processes 2024, 12(11), 2391; https://doi.org/10.3390/pr12112391 - 30 Oct 2024
Viewed by 673
Abstract
The lithology and composition type of an aquifuge in overburden play a crucial role in influencing the crack evolution and permeability changes of the aquifuge. This study utilized the high-temperature and high-pressure rock triaxial seepage test system to conduct triaxial compression tests on [...] Read more.
The lithology and composition type of an aquifuge in overburden play a crucial role in influencing the crack evolution and permeability changes of the aquifuge. This study utilized the high-temperature and high-pressure rock triaxial seepage test system to conduct triaxial compression tests on mudstone, sandstone, and their combined rock samples. The mechanical characteristics and permeability evolution of each lithology law during the failure were investigated. Furthermore, computed tomography (CT) scanning technology was utilized for the three-dimensional (3D) reconstruction and theoretical permeability calculation of single and combined rock samples. The results indicated that the stress–strain curves for single and combined rock samples exhibited similar patterns, which were divided into four stages: pore compaction, linear elasticity, yield deformation, and post-peak residual deformation. The peak strength of rock samples positively correlated with confining pressure. Permeability trends for mudstone and sandstone exhibited an “N”-type pattern characterized by “slow decrease–gradual stabilization–sudden increase–rebound decrease”, while the permeability of mudstone–sandstone combined rock followed a “U”-type pattern of “initial decrease–stabilization–subsequent increase”. Notably, the permeability of the combined rock samples was significantly lower compared to the single rock samples. The failure mode indicated that fractures in a single rock sample transversed the entire sample, whereas failures in the combined rock samples were confined to the mudstone component. This observation accounted for the differences in the permeability changes between the rock sample types. Additionally, the theoretical permeability results from the 3D reconstruction correlated with the experimental results. Full article
(This article belongs to the Section Energy Systems)
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14 pages, 4648 KiB  
Article
Asynchronous Injection–Production Method in the High Water Cut Stage of Tight Oil Reservoirs
by Jianwen Chen, Dingning Cai, Tao Zhang, Linjun Yu, Dalin Zhou and Shiqing Cheng
Energies 2024, 17(19), 4838; https://doi.org/10.3390/en17194838 - 26 Sep 2024
Viewed by 1135
Abstract
Asynchronous injection–production cycle (AIPC) in a horizontal–vertical well pattern is an efficient strategy for enhancing water injection in tight reservoirs. However, current studies lack consideration of waterflood-induced fractures (WIFs) caused by long-term water injection. This paper takes block Z in the Ordos Basin, [...] Read more.
Asynchronous injection–production cycle (AIPC) in a horizontal–vertical well pattern is an efficient strategy for enhancing water injection in tight reservoirs. However, current studies lack consideration of waterflood-induced fractures (WIFs) caused by long-term water injection. This paper takes block Z in the Ordos Basin, China, as the research object and first clarifies the formation conditions of WIFs considering the horizontal principal stress and flow line. Then, the pressure-sensitive permeability equations for the induce-fracture region between wells are derived. Finally, the WIFs characteristics in a horizontal–vertical well network with different injection modes are discussed by numerical simulation. The results show that WIFs preferentially form where flow aligns with the maximum principal stress, influencing permeability distribution. Controlling the injection rate of vertical wells on the maximum principal stress and flow line and cyclically adjusting the production rate of horizontal wells can regulate the appropriate propagation of WIFs and expand the swept areas. The parallel injection mode (PIM) and the half-production injection mode are superior to the full-production injection mode. This study can provide theoretical support for the effective development of tight oil reservoirs. Full article
(This article belongs to the Special Issue Petroleum and Natural Gas Engineering)
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26 pages, 36425 KiB  
Article
Study on Bonding Characteristics of Polymer Grouted Concrete-Soil Interface
by Lina Wang, Xiaodong Yang, Yueliang Diao and Chengchao Guo
Polymers 2024, 16(15), 2207; https://doi.org/10.3390/polym16152207 - 2 Aug 2024
Cited by 2 | Viewed by 1691
Abstract
The issue of interfacial shear damage has been a significant challenge in the field of geotechnical engineering, particularly in the context of diaphragm walls and surrounding soils. Polymer grouting is a more commonly used repair and reinforcement method but its application to interface [...] Read more.
The issue of interfacial shear damage has been a significant challenge in the field of geotechnical engineering, particularly in the context of diaphragm walls and surrounding soils. Polymer grouting is a more commonly used repair and reinforcement method but its application to interface repair and reinforcement in the field of geotechnical engineering is still relatively rare. Consequently, this paper presents a new polymer grouting material for use in grouting reinforcement at the interface between concrete and soils. The bonding characteristics and shear damage mode of the interface after grouting were investigated by the direct shear test, and the whole process of interface shear damage was investigated by digital image correlation (DIC) technology. Finally, the reinforcement mechanism was analyzed by microscopic analysis. The results demonstrate that the permeable polymer is capable of effectively filling the pores of soil particles and penetrating into the concrete-soil interface. Through a chemical reaction with water in the soil, the polymer cements the soil particles together, forming chemical adhesion at the interface and thereby achieving the desired reinforcement and repair effect. In the shear process, as the normal stress increased, the horizontal displacement and horizontal compressive strain at the distal end of the loading end decreased, while the maximum vertical displacement and maximum vertical strain of the cured soil also decreased. The results of scanning electron microscopy (SEM) demonstrated that the four groups of test polymers exhibited a reduction in soil porosity of 53.47%, 58.79%, 52.71%, and 54.12%, respectively. Additionally, the form of concrete-soil interfacial bonding was observed in the concrete-cohesive layer-cured soil mode. The findings of this study provide a foundation for further research on diaphragm wall repair and reinforcement. Full article
(This article belongs to the Special Issue Application and Development of Polymers in Geotechnical Engineering)
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18 pages, 14858 KiB  
Article
Research on Mechanism of Non-Uniform In-Situ Stress Induced Casing Damage Based on Finite Element Analysis
by Tianjiang Wu, Mei Li, Nana Liu, Tao Zhang and Junwei Su
Appl. Sci. 2024, 14(14), 5987; https://doi.org/10.3390/app14145987 - 9 Jul 2024
Cited by 4 | Viewed by 1536
Abstract
Casing damage is a common problem encountered during oil and gas field development due to the complex stress state of the casing. Despite the large number of studies focusing on this problem, the mechanism of non-uniform in-situ stress-induced casing damage in a low-permeability [...] Read more.
Casing damage is a common problem encountered during oil and gas field development due to the complex stress state of the casing. Despite the large number of studies focusing on this problem, the mechanism of non-uniform in-situ stress-induced casing damage in a low-permeability reservoir is still unclear. In this study, casing damage due to non-uniform in-situ stress variations was investigated, and then the tectonic stress coefficients in the study area were determined by an in-situ stress inversion technique, which led to the derivation of formulas for calculating the maximum and minimum horizontal in-situ stresses. Subsequently, finite element numerical simulations were performed to assess the stress distribution during the formation of the casing cement sheath in a G155 block, a typical low-permeability reservoir. The results indicate that casing damage is caused not only by non-uniform in-situ stresses but also by various additional creep-induced loads. Subsequent finite element investigations into casing behavior under mudstone creep conditions indicated that immersion of mudstone in water instigated further shearing and deformation of the casing, culminating in premature well failure prior to water inundation. Notably, Von Mises stress levels exhibited a positive correlation with injection production ratios, with values exceeding critical thresholds leading to distinct modes of mechanical failure including shear-induced deformations, longitudinal tensile stress, and localized yielding near water wells. Maintenance of an optimal injection production ratio is identified as a key strategy for prolonging casing longevity in the region. To this end, recommendations include augmenting the casing wall thickness or enhancing the steel pressure specifications to mitigate casing damage progression, thereby extending the operational lifespan. This research serves as a pivotal theoretical framework for informing future development strategies aimed at mitigating and preempting casing failures in a low-permeability reservoir. Full article
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14 pages, 7078 KiB  
Article
Assessment of Refracturing Potential of Low Permeability Reservoirs Based on Different Development Approaches
by Jingchun Zhang, Ming Gao, Jingfeng Dong, Tianxi Yu, Kebao Ding and Yan Liu
Energies 2024, 17(11), 2526; https://doi.org/10.3390/en17112526 - 23 May 2024
Cited by 2 | Viewed by 1032
Abstract
The technique of refracturing is an effective method to solve the rapid decline in oil well production caused by factors such as severe reservoir energy loss and fracture failure after the initial hydraulic fracturing of low-permeability reservoirs. The key to designing refracturing lies [...] Read more.
The technique of refracturing is an effective method to solve the rapid decline in oil well production caused by factors such as severe reservoir energy loss and fracture failure after the initial hydraulic fracturing of low-permeability reservoirs. The key to designing refracturing lies in establishing a model for evaluating the potential fracturing layers. Based on the geological characteristics of the low-permeability conglomerate reservoir in the Lower Wuerhe area of the Eig District of the Xinjiang Oilfield, this paper studies the influence of different development approaches on the distribution pattern of remaining oil in the reservoir. A coupled model of remaining oil distribution and the in situ stress field is established and discusses the characteristics of the four-dimensional in situ stress field under different development modes. This paper analyzes the influence of geological factors and well network factors on the distribution of residual oil, and analyzes the influence of various factors, such as reservoir properties and injection and extraction parameters, on ground stress. Based on the residual oil distribution and ground stress changes, an evaluation method for screening potential fractured layers in reservoirs with different development modes (water injection development and depletion development) is developed. Full article
(This article belongs to the Special Issue Subsurface Energy and Environmental Protection)
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24 pages, 5520 KiB  
Review
Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways
by Ernesto López-Pascual, Ivan Rienda, Judith Perez-Rojas, Anna Rapisarda, Guillem Garcia-Llorens, Ramiro Jover and José V. Castell
Int. J. Mol. Sci. 2024, 25(10), 5203; https://doi.org/10.3390/ijms25105203 - 10 May 2024
Cited by 12 | Viewed by 6606
Abstract
Drug induced fatty liver disease (DIFLD) is a form of drug-induced liver injury (DILI), which can also be included in the more general metabolic dysfunction-associated steatotic liver disease (MASLD), which specifically refers to the accumulation of fat in the liver unrelated to alcohol [...] Read more.
Drug induced fatty liver disease (DIFLD) is a form of drug-induced liver injury (DILI), which can also be included in the more general metabolic dysfunction-associated steatotic liver disease (MASLD), which specifically refers to the accumulation of fat in the liver unrelated to alcohol intake. A bi-directional relationship between DILI and MASLD is likely to exist: while certain drugs can cause MASLD by acting as pro-steatogenic factors, MASLD may make hepatocytes more vulnerable to drugs. Having a pre-existing MASLD significantly heightens the likelihood of experiencing DILI from certain medications. Thus, the prevalence of steatosis within DILI may be biased by pre-existing MASLD, and it can be concluded that the genuine true incidence of DIFLD in the general population remains unknown. In certain individuals, drug-induced steatosis is often accompanied by concomitant injury mechanisms such as oxidative stress, cell death, and inflammation, which leads to the development of drug-induced steatohepatitis (DISH). DISH is much more severe from the clinical point of view, has worse prognosis and outcome, and resembles MASH (metabolic-associated steatohepatitis), as it is associated with inflammation and sometimes with fibrosis. A literature review of clinical case reports allowed us to examine and evaluate the clinical features of DIFLD and their association with specific drugs, enabling us to propose a classification of DIFLD drugs based on clinical outcomes and pathological severity: Group 1, drugs with low intrinsic toxicity (e.g., ibuprofen, naproxen, acetaminophen, irinotecan, methotrexate, and tamoxifen), but expected to promote/aggravate steatosis in patients with pre-existing MASLD; Group 2, drugs associated with steatosis and only occasionally with steatohepatitis (e.g., amiodarone, valproic acid, and tetracycline); and Group 3, drugs with a great tendency to transit to steatohepatitis and further to fibrosis. Different mechanisms may be in play when identifying drug mode of action: (1) inhibition of mitochondrial fatty acid β-oxidation; (2) inhibition of fatty acid transport across mitochondrial membranes; (3) increased de novo lipid synthesis; (4) reduction in lipid export by the inhibition of microsomal triglyceride transfer protein; (5) induction of mitochondrial permeability transition pore opening; (6) dissipation of the mitochondrial transmembrane potential; (7) impairment of the mitochondrial respiratory chain/oxidative phosphorylation; (8) mitochondrial DNA damage, degradation and depletion; and (9) nuclear receptors (NRs)/transcriptomic alterations. Currently, the majority of, if not all, adverse outcome pathways (AOPs) for steatosis in AOP-Wiki highlight the interaction with NRs or transcription factors as the key molecular initiating event (MIE). This perspective suggests that chemical-induced steatosis typically results from the interplay between a chemical and a NR or transcription factors, implying that this interaction represents the primary and pivotal MIE. However, upon conducting this exhaustive literature review, it became evident that the current AOPs tend to overly emphasize this interaction as the sole MIE. Some studies indeed support the involvement of NRs in steatosis, but others demonstrate that such NR interactions alone do not necessarily lead to steatosis. This view, ignoring other mitochondrial-related injury mechanisms, falls short in encapsulating the intricate biological mechanisms involved in chemically induced liver steatosis, necessitating their consideration as part of the AOP’s map road as well. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Hepatotoxicity—2nd Edition)
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13 pages, 11639 KiB  
Article
Experimental Investigation of the Effect of Fault Reactivation Induced by Water Injection
by Wenjing Liu and Hu Si
Appl. Sci. 2024, 14(8), 3322; https://doi.org/10.3390/app14083322 - 15 Apr 2024
Viewed by 1248
Abstract
An understanding of fault reactivation induced by water injection is of great significance for geothermal energy development and utilization. We conducted a series of water injection shear tests on low-permeability granite samples that each contained a single saw-cut fault under locally undrained conditions. [...] Read more.
An understanding of fault reactivation induced by water injection is of great significance for geothermal energy development and utilization. We conducted a series of water injection shear tests on low-permeability granite samples that each contained a single saw-cut fault under locally undrained conditions. Slip characteristics were analyzed by varying the fluid pressurization rate, confining pressure, and stress state of the fault to understand fault reactivation. The experimental results demonstrated that at a high pressurization rate, a higher local fluid pressure was needed to reactivate the fault than had been estimated theoretically, and the required fluid pressure increased with an increase in pressurization rate. The fluid pressurization rate and confining pressure both controlled the slip mode of the fault. The slip mode changed from dynamic slip to quasi-static slip at a high pressurization rate, and the peak slip rate of dynamic slip increased with an increasing pressurization rate. The fault showed significant stick-slip characteristics under a high confining pressure, as fault locking and reactivation phenomena occurred repeatedly. Faults with different initial stress states had little influence on the slip mode after the onset of slip. Full article
(This article belongs to the Section Earth Sciences)
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19 pages, 11810 KiB  
Article
Impact of Fracture–Seepage–Stress Coupling on the Sustainability and Durability of Concrete: A Triaxial Seepage and Mechanical Strength Analysis
by Zhuolin Shi, Chengle Wu, Furong Wang, Xuehua Li, Changhao Shan and Yingnan Xu
Sustainability 2024, 16(3), 1187; https://doi.org/10.3390/su16031187 - 31 Jan 2024
Cited by 2 | Viewed by 1279
Abstract
As an indispensable material in construction and engineering, concrete’s mechanical properties and permeability are crucial for structures’ stability and durability. In order to reasonably assess and improve the durability of fracture-containing concrete structures and to enhance the sustainable working life of concrete structures, [...] Read more.
As an indispensable material in construction and engineering, concrete’s mechanical properties and permeability are crucial for structures’ stability and durability. In order to reasonably assess and improve the durability of fracture-containing concrete structures and to enhance the sustainable working life of concrete structures, this research investigated the seepage characteristics of fracture-containing concrete and its mechanical property deterioration under fracture–seepage coupling by testing the permeability and strength of concrete samples before and after water penetration using triaxial seepage test and mechanical strength test. The results show that the fracture–seepage coupling action significantly affects the permeability characteristics and mechanical strength of fracture-containing concrete. In particular, the strength of concrete samples containing a single fracture decreased with increased fracture angle, with a maximum decrease of 32.8%. The fracture–seepage–stress coupling significantly reduced the strength of the fracture-containing concrete samples, which was about twice as much as the strength of the no-fracture concrete samples. Different fracture angles affect the mode of fracture expansion and damage (The fracture angle varies from small to large, and the damage form of concrete changes from tensile damage to tensile–shear composite damage). Moreover, the coupling effect of fracture–seepage–stress will further increase fracture-containing concrete’s fragmentation in the damage process. Therefore, improving the seepage and fracture resistance of concrete plays a vital role in improving the sustainable working life of concrete structures. Full article
(This article belongs to the Special Issue Advanced Concrete and Construction Materials)
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13 pages, 9107 KiB  
Article
A Study on the Production Simulation of Coal–Shale Interbedded Coal Measure Superimposed Gas Reservoirs under Different Drainage Methods
by Wenkai Wang, Shiqi Liu, Shuxun Sang, Ruibin Du and Yinghai Liu
Processes 2023, 11(12), 3424; https://doi.org/10.3390/pr11123424 - 13 Dec 2023
Cited by 3 | Viewed by 1112
Abstract
To study the influence of different drainage methods on the production performance of coal measure gas wells, the interbedded reservoir composed of coal and shale in the Longtan Formation of the Dahebian block was used as the research object. Considering the influence of [...] Read more.
To study the influence of different drainage methods on the production performance of coal measure gas wells, the interbedded reservoir composed of coal and shale in the Longtan Formation of the Dahebian block was used as the research object. Considering the influence of coal and shale matrix shrinkage, effective stress, and interlayer fluid flow on reservoir properties such as fluid migration behavior and permeability, a fluid–solid coupling mathematical model of coal measure superimposed gas reservoirs was established. Numerical simulations of coal measure gas production under different drainage and production modes were conducted to analyze the evolution of reservoir pressure, gas content in the matrix, permeability, and other characteristic parameters of the superimposed reservoir, as well as differences in interlayer flow. The results showed that, compared to single-layer drainage, cumulative gas production increased by 33% under multi-layer drainage. Both drainage methods involve interlayer energy and substance transfer. Due to the influence of permeability, porosity, and mechanical properties, significant differences exist in reservoir pressure distribution, preferential flow direction, gas content in the matrix, and permeability ratio between coal and shale reservoirs under different drainage and production modes. Multi-layer drainage effectively alleviates the influence of vertical reservoir pressure differences between reservoir layers, facilitates reservoir pressure transmission in shale reservoirs, enhances methane desorption in shale matrices, promotes matrix shrinkage, and induces the rebound of shale reservoir permeability, thus improving overall gas production. Full article
(This article belongs to the Special Issue Advances in Enhancing Unconventional Oil/Gas Recovery)
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