Search Results (4,524)

Systemic arterial hypertension (SAH) is a multifaceted condition marked by sustained elevations in arterial blood pressure. Its occurrence is closely related to alterations in target organs, such as the liver. Non-pharmacological treatments have been proposed for these effects. Thus, the aim of this study was to investigate the effects of açaí supplementation and resistance training, applied individually or in combination, on blood pressure and liver structural parameters. An experimental, quantitative, and longitudinal study was conducted using young Wistar rats (~60 days old) and spontaneously hypertensive rat (SHR) strains. Fifty rats were divided into five experimental groups: Wistar Control (C), Hypertensive Control (H), Hypertensive Trained (HT), Hypertensive Açaí-Supplemented (HA), and Hypertensive Trained plus Açaí Supplementation (HAT). Each group consisted of ten animals. Subsequently, analyses were performed for the antioxidant capacity and proximate composition of the açaí pulp, systolic blood pressure assessment, and histological evaluation of the liver. The açaí used exhibited high antioxidant capacity. At the end of the experimental period, the trained groups increased their maximal load carried, along with a reduction in systolic blood pressure in all treated groups. Açaí supplementation resulted in lower relative liver mass compared with the H group. The hypertensive condition promoted extracellular matrix expansion and a reduction in hepatocyte proportion. Both interventions attenuated these effects, and the combined treatment (HAT) produced the greatest improvement, indicating an additive response. Hypertension also elevated hepatic glycogen concentration, and the treatments reduced this alteration. It is concluded that açaí supplementation and resistance training could promote positive adaptations in the liver of hypertensive animals. Full article

Fractures are widely developed in deep coal-mine surrounding rocks. They weaken the load-bearing capacity and energy-storage capacity of rock specimens, which may induce surrounding-rock deformation, roof collapse, and other hazards. Current studies on fractured rock masses mainly focus on a single parameter, such as fracture number or fracture dip angle. However, their coupled effects remain unclear. Integrated analyses of mechanical behavior, crack propagation, and energy evolution are also limited. In this study, uniaxial compression simulations of intact sandstone, single-fracture sandstone, and double-fracture sandstone were conducted using PFC^2D. The effects of fracture number and fracture dip angle on mechanical properties and failure characteristics were investigated. The results show that fractures reduced the peak stress and modulus of elasticity. A stronger weakening effect was observed with increasing fracture number. With increasing fracture dip angle, both peak stress and modulus of elasticity showed a V-shaped trend. The minimum peak stress occurred at 15°, while the minimum modulus of elasticity occurred at 45°. Sandstone failure was mainly dominated by tensile cracks. At 15°, the total crack number was the lowest, with 932 and 818 cracks for single-fracture and double-fracture specimens, respectively. Energy analysis showed that increasing fracture number reduced elastic strain energy and promoted dissipated energy. The weakest energy-storage capacity was observed at 30°. Overall, fracture number and fracture dip angle jointly controlled strength degradation, crack propagation, and energy evolution. This study provides a reference for fracture–damage assessment and disaster prevention in deep coal-bearing sandstone. Full article

Candidozyma auris (formerly known as Candida auris) has emerged as a formidable clinical fungal pathogen as a result of its multidrug resistance and persistent colonization capabilities. In this study, three clinical C. auris strains (namely C. auris strain 01, C. auris strain 03, and C. auris strain 13) with distinct origins were characterized to investigate their phenotypic variations and mechanisms of azole resistance. Comprehensive profiling revealed significant inter-strain differences in biofilm formation, cell surface hydrophobicity, adhesion capacity, and phospholipase activity. Testing for antifungal susceptibility showed that the three clinical strains exhibited different minimum inhibitory concentrations for multiple azoles (fluconazole, voriconazole, and itraconazole) and echinocandins (anidulafungin and micafungin). Sequencing identified Y132F mutations in the ERG11 gene of the three clinical strains. Mechanistic investigations demonstrated that fluconazole exposure significantly upregulated the expression of efflux pump genes (CDR1 and CDR2) and the genes encoding their transcriptional regulators (MDR1 and TAC1b). In a murine skin colonization model, comparing data from the standard strain C. auris strain CBS12766 and clinical strains of C. auris strain 03 and C. auris strain 13 exhibited a significantly higher fungal burden of tissue, whereas strain C. auris strain 01 showed an intermediate level. Host immunity response analysis revealed that expression of the IL-1β gene was significantly elevated in C. auris strain CBS12766-infected mice, while expression of IL-6 and CXCL-1 genes was predominantly increased in the C. auris strain 01, with TNF-α gene expression levels being comparable across all strains. Histopathological examination confirmed local infiltration of inflammatory cells and mild epidermal edema, indicating active host immune engagement. Overall, our findings highlighted substantial phenotypic heterogeneity, different colonization capacities, and differences in expression of inflammatory cytokines among the C. auris strains. Further investigations into fluconazole-response mechanisms identified enhanced efflux pump activity, along with ERG11 gene Y132F mutations and transcription factor modulation among these clinical strains. Full article

Functional properties of caseins play a crucial role in the dairy industry, so it is important to develop methods to improve their functionality. The aim of this study is to investigate the combined effect of high-intensity ultrasound (HIUS) treatment and calcium chelation on functional properties of casein micelles. For this purpose, micellar casein concentrate (MCC) was prepared with a concentration of 3% (w/w) casein. Then, 0 and 10 mM of Disodium hydrogen phosphate was added. HIUS was performed at a frequency of 20 kHz, power intensity of 550 W/cm², and an amplitude of 100% for 0, 5, 10, 15, and 20 min at 25 °C. Factorial design was employed to investigate the effect of ultrasound time (UST) and disodium phosphate (DSP) on foam capacity (FC), emulsion activity index (EAI), gelation time (GT), G′ at 480 min of oscillation time (G′₄₈₀), slope of complex viscosity, and linear viscoelastic region (LVR). At 0 mM of DSP, increasing UST from 0 to 15 min decreased GT from 114.39 ± 3.20 to 83.52 ± 1.61 min, and it extended LVR from 40.36 ± 0.12 to 41.27 ± 0.27% of the applied strain. In addition, applying HIUS for 15 min increased the elasticity and firmness of MCC gel networks at 0 mM of DSP. G′₄₈₀ was not influenced by UST, but it was reduced by DSP from 108.40 ± 3.29 to 15.78 ± 1.58 Pa. Increasing both UST and DSP significantly increased FC from 110.00 ± 13.23 to 163.33 ± 11.55% and foam stability (FS) in all treatments. FS reached its maximum (doubled) after 10 min of UST at 0 mM of DSP. However, EAI and emulsion stability index (ESI) decreased with increasing both UST and DSP. HIUS treatment combined with calcium chelation might highlight a new approach to improve foaming properties. However, regardless of calcium chelation, HIUS treatment is a promising technology to improve the gelling properties of casein micelles. Full article

Flexible casing piles can form locally enlarged sections by expanding flexible casings during concrete casting, thereby filling karst cavities and improving the adaptability and bearing capacity of pile foundations in karst areas. However, the damage evolution and failure mechanism of the enlarged section under vertical loading remain insufficiently understood. In this study, a three-dimensional finite element model of a flexible casing pile was established using the Concrete Damaged Plasticity (CDP) model. The stress transfer, plastic strain development, and tensile–compressive damage evolution of the enlarged section under vertical static loading were investigated. The effects of karst cavity spacing, cavity number, and cavity diameter on the vertical bearing behavior were further analyzed. The results show that damage localization is governed by the transition zone between the pile shaft and the enlarged section, where plastic strain, tensile damage localization, and compressive damage accumulation develop in a coupled manner. Increasing the number and diameter of enlarged sections improves the ultimate bearing capacity, whereas cavity spacing mainly controls the interaction and synchronization of damage zones between adjacent enlarged sections. These findings establish a damage-based interpretation for identifying the failure-control region of flexible casing piles in karst cavities and provide a basis for bearing-capacity assessment and structural optimization. Full article

Self-healing biomaterials have attracted significant attention due to their ability to restore structural integrity, extend material lifetime, and reduce maintenance costs without external intervention. In this study, Polyvinyl Alcohol/Graphene Oxide/Eggshell Particle (PVA/GO/ESP) composite hydrogels were synthesized via a freeze–thawing method and characterized using XRD, SEM/EDS, and FTIR analyses. The effect of ESP incorporation on the self-healing and mechanical properties of the hydrogels was systematically investigated. Tensile test results demonstrated that incorporation of 1 wt% ESP improved the tensile strength up to 0.326 MPa while maintaining high strain capacity. Healing efficiency values calculated from recovered tensile strength showed approximately 69%, 47%, and 67% recovery for PVA/GO, PVA/GO/ESP (0.5%), and PVA/GO/ESP (1%) hydrogels, respectively. The developed hydrogels demonstrated rapid self-healing behavior at room temperature without external stimuli. These findings suggest that ESP-reinforced PVA/GO hydrogels may serve as promising candidates for future biomaterial and soft tissue engineering studies. The developed hydrogels demonstrated enhanced tensile strength, rapid self-healing behavior, and promising swelling properties, indicating their potential use in soft tissue engineering and biomaterial applications. Full article

Contemporary societies are characterized by increasing role multiplicity and accelerated social change, intensifying identity-related strain and inter-role conflict. Although role theory, narrative identity research, and psychological flexibility frameworks have independently advanced the understanding of psychological adaptation, an integrative structural model explaining how life domains are hierarchically organized and reorganized over time remains underdeveloped. This manuscript introduces Casa Vital (Vital House), a dynamic structural model that conceptualizes identity as a hierarchical architecture of interdependent life domains organized around a central integrative function. The model proposes three core constructs: structural coherence, structural modes (rigidity/flexibility) and self-directed agency, and argues that psychological adaptation depends not only on emotional regulation or narrative coherence but also on the capacity to reorganize domain hierarchies in alignment with personal values and contextual demands. By positioning identity at a meso-structural level of analysis, the framework integrates sociological, narrative, and contextual behavioral traditions while offering testable hypotheses and a falsifiable research agenda. Casa Vital expands the current models of adaptation by introducing hierarchical structural reorganization as a central component of identity functioning in complex contemporary contexts. Full article

A multiphase high-strength steel austempered at 260 °C for 24 h was investigated by quasi-in-situ tensile characterization and EBSD-based crystal plasticity finite element modeling. The experimental observations reveal that local plastic deformation is strongly heterogeneous: von Mises strain concentrates preferentially near bainitic-ferrite packets, phase boundaries, and retained-austenite/martensite–austenite regions, whereas blocky retained austenite contributes to strain accommodation at the early deformation stage. To quantify the underlying stress–strain partitioning, a quasi-two-dimensional representative volume element was reconstructed from EBSD data and implemented in ABAQUS through a user-defined material subroutine. The model contained the real grain morphology, phase distribution, and crystal orientation information of the 24 h austempered specimen. A rate-dependent crystal plasticity constitutive framework with BCC matrix, FCC retained austenite, and transformed martensite branches was calibrated against the macroscopic tensile curve. The simulated tensile response agrees well with the experimental curve before macroscopic instability, and the predicted local fields are consistent with the quasi-in-situ strain maps. The results show that local plastic strain first accumulates in M/A-related regions and phase-boundary-neighboring zones, while high Mises stress migrates dynamically with slip activity and stress-induced martensitic transformation. Retained-austenite transformation increases the local load-bearing capacity, modifies interphase load transfer, and delays the direct linkage of strain-localization bands. The present work clarifies the coupling among retained-austenite stability, TRIP-assisted load redistribution, and microstructural strain partitioning in multiphase high-strength steel, providing a mesoscale basis for microstructure-guided strength–ductility optimization. Full article

Polysaccharide-based hydrogels represent promising platforms for the development of bioactive wound dressings due to their biocompatibility, bioadhesive properties, and ability to maintain a moist environment at the wound interface. In this study, polymeric films were developed from natural polysaccharides incorporating olive mill wastewater (OMW) as a natural antibacterial agent. Chitosan (medium molecular weight), sodium alginate, sodium hyaluronate, and xanthan gum were selected to prepare hydrogel formulations either as single polymers or binary mixtures. Hydrogels were prepared by aqueous dispersion under magnetic stirring and subsequently converted into films using a solvent casting method. The resulting films were characterized in terms of rheological behavior, pH, morphology, thickness and water content. The obtained hydrogel films showed good casting ability, producing smooth and homogeneous matrices with adequate deformability and skin adhesion. Furthermore, they demonstrated a suitable capacity to absorb and retain water, mimicking the management of wound exudate. OMW was incorporated into the hydrogel formulations as a source of phenolic compounds with well-known antioxidant and antimicrobial properties. The presence of these bioactive compounds provides the films with potential antibacterial and antibiofilm activity against clinically relevant multidrug-resistant staphylococcal strains. These findings suggest that OMW-loaded polysaccharide hydrogels represent a promising and sustainable strategy for the development of antibacterial films for wound healing applications. Full article

Dietary fibers are valuable food components with documented health benefits, yet their native compact and highly crystalline structures often result in low water hydration, poor adsorption capacity, and limited bioactivity. Chemical modification offers a promising strategy to overcome these functional limitations by disrupting the dense structure and exposing active groups. This study aimed to investigate the effects of acid modification on the physicochemical properties of soybean and citrus dietary fibers and to evaluate the performance of the modified fibers in probiotic-fermented soy protein gels. Compared with native fibers, modified fibers exhibited reduced particle size, rougher and more porous microstructures, and increased exposure of hydroxyl groups. Consequently, they showed significantly (p < 0.05) enhanced hydration capacity (increased by 92–541%), antioxidant activity (increased by 15–65%), cholesterol adsorption (increased by 16–75%), and α-amylase inhibition (increased by 26–62%). When incorporated into soy protein-based gels, the modified fibers, particularly those from soybean, lowered gel pH, increased water holding capacity, gel strength, apparent viscosity, and storage modulus, while reducing strain, indicating improved gel network integrity. These findings indicate that acid modification effectively unlocks the functional potential of dietary fibers, positioning the modified fibers, especially from soybean, as promising prebiotic ingredients for plant-based fermented gel products. Full article

As a precious indigenous goose resource in China, the Zhedong white goose occupies an essential position in the domestic goose industry. However, this breed spontaneously enters a prolonged non-laying period of over two months per year, which greatly limits egg production capacity and restricts the economic development of the goose industry. Herein, this study systematically compared serum physiological indices and serum and fecal metabolome, as well as fecal microbial communities, between laying and non-laying Zhedong white geese, aiming to reveal the key regulatory mechanisms underlying reproductive stage transition. Physiological analyses indicated that non-laying geese had higher serum levels of GnRH, PRL, APOA, and T-AOC, whereas the concentrations of LH, E₂, TNF-α, IL-1, and calcium were significantly reduced; FSH, PROG, and BA levels showed no significant differences between the two groups. Metabolomic analysis identified 277 upregulated and 403 downregulated DAMs in feces, and 386 DAMs in serum. The shared enriched pathways across serum and fecal samples encompassed arginine biosynthesis, histidine metabolism, and pantothenate and CoA biosynthesis, as well as steroid hormone biosynthesis. A total of 120 DAMs overlapped in two specimens, and the non-laying geese presented pronounced depletion of tryptophan-derived metabolites and steroid hormone-related metabolites. Metagenomic results showed no significant difference in gut microbial alpha diversity between groups, while their microbial community structures were clearly differentiated. A total of 774 upregulated and 854 downregulated microbial species were screened in non-laying geese, and these differential microbes were primarily enriched in pathways associated with reproductive hormone signaling, steroid biosynthesis and energy metabolism. Multi-omics correlation analysis verified close associations between differential microbes and reproductive-related metabolites. Certain probiotic strains, including Pediococcus pentosaceus and Lactococcus raffinolactis, were positively correlated with steroid hormones and tryptophan metabolites, and their abundances declined obviously in the non-laying stage. Collectively, this study elaborates the holistic changes in serum biochemistry, gut metabolome and microbiome in geese at different reproductive stages. The dysregulation of amino acid and steroid hormone metabolism, combined with the loss of beneficial intestinal microbes, jointly induces the non-laying phenotype. This study provides new perspectives for understanding the gut–reproductive axis and supplies promising biomarkers to improve the laying performance of geese. Full article

Reinforced concrete (RC) infilled frames are widely used structural systems; however, seismic design provisions often idealize masonry infill as non-structural, leading to uncertainty in performance assessment. This study experimentally and numerically investigates the role of unreinforced masonry infill in RC frames, focusing on load-transfer mechanisms, strain evolution, and energy redistribution. Two 2/3-scale single-bay, single-storey RC frames (bare and fully infilled) were tested under constant axial load and quasi-static reversed cyclic lateral loading. Reinforcement strain gauges were used to capture local deformation demands, and a nonlinear macro-model was developed and validated against experimental results. Results show that the presence of masonry infill significantly increases ultimate strength, initial stiffness, and energy dissipation capacity, in comparatively more brittle post-peak cyclic behavior and accelerated stiffness degradation that leads to more abrupt post-peak degradation. Strain measurements provide clear evidence of a staged interaction mechanism: at low drift levels, the infill governs lateral resistance through diagonal compression strut action, limiting reinforcement demand in the frame; with increasing drift, progressive cracking and crushing of the infill promote a gradual transfer of forces to the RC frame, reflected by increasing reinforcement strains and stiffness degradation. At higher drift levels, the system transitions to frame-dominated behavior with localized strain concentration and shear failure at column bases or joints. These findings demonstrate that infill significantly modifies structural response and highlight the importance of incorporating strain-based mechanisms in the seismic assessment of infilled RC frames. Full article

Firms are increasingly expected to pursue multiple sustainability priorities, but the implementation consequences of expanding sustainability agendas remain insufficiently understood. This study investigates whether and how sustainability overload reduces sustainability execution consistency. Drawing on the attention-based view and the corporate sustainability tensions perspective, the study proposes that a broad and simultaneous sustainability agenda exceeds managers’ attentional and coordination capacity, thereby weakening implementation coherence across departments. Specifically, the study hypothesizes that sustainability overload increases managerial attention strain, which in turn increases interunit priority divergence, ultimately reducing sustainability execution consistency. To test this sequential mechanism, a randomized experimental vignette study was conducted with 300 middle- and senior-level managers working in Türkiye-based firms operating in sustainability-exposed sectors. Participants were assigned to either a focused sustainability strategy condition or an overloaded sustainability strategy condition. The results support all proposed hypotheses. The overloaded condition increased managerial attention strain and interunit priority divergence, while reducing perceived sustainability execution consistency. PROCESS Model 6 analysis confirmed the sequential mediation mechanism. The findings suggest that sustainability implementation depends not only on the breadth of sustainability goals, but also on whether these goals are organized through a manageable priority architecture. The study contributes to sustainability strategy implementation research by highlighting managerial attention and cross-functional divergence as mechanisms linking sustainability overload to execution inconsistency. Full article

This study presents an experimental characterization and numerical assessment of Cu–Al–Be (CAB) shape memory alloys (SMAs) for potential applications in U-shaped flexural plate (UFP) seismic dampers. Six alloy compositions were evaluated through monotonic tensile tests, ASTM F2516 superelastic protocols, and increasing-amplitude cyclic loading to identify the material exhibiting stable superelastic behavior at room temperature. Among the tested materials, alloy CAB4.76-A showed the most favorable response, with high transformation stress, stable pseudoelastic behavior, and strain recovery exceeding 95% for strains up to 2.5%. A phenomenological finite element model based on the Auricchio constitutive formulation was calibrated using experimental data within the validated strain range (ε ≤ 0.025), showing good agreement in stiffness and stress prediction. The calibrated model was subsequently applied to simulate the response of a UFP device under orthogonal cyclic loading. The results indicate a strong dependence on loading orientation due to coupled bending–torsion effects, with the 90° direction exhibiting significantly higher strength and energy dissipation capacity. Comparison with analytical formulations originally developed for steel UFPs showed that these expressions provide approximate estimates when applied to SMA-based devices. The results suggest that Cu–Al–Be alloys are a promising alternative for UFP applications, while highlighting the importance of loading orientation and the need for future experimental validation at a device scale. Full article

Rock pillars in deep underground mines are subjected to complex stress environments. The combined effects of in situ stress and cyclic disturbances from mining activities lead to a redistribution of the surrounding rock mass stress field, which readily triggers instability and failure, posing severe threats to mining engineering safety. To investigate the damage mechanism of cyclic loading on rock and its weakening effect on the bearing capacity of mine pillars, this study takes limestone as the research object. A series of uniaxial compression tests were conducted on limestone specimens subjected to triaxial cyclic pre-damage, complemented by numerical simulations to further characterize the energy and deformation evolution of the damaged limestone under cyclic loading conditions. The findings are as follows: (i) Triaxial cyclic tests on limestone show that both the input energy and dissipated energy follow similar trends, decreasing rapidly in the initial stage before stabilizing. The elastic strain energy remains largely constant, with most of the input energy being stored as elastic strain energy. Under constant stress levels and cycle numbers, increases in confining pressure and frequency reduce the rock’s input energy, elastic strain energy, and dissipated energy. (ii) The peak stress of damaged limestone exhibits a positive correlation with the pre-damage confining pressure and cyclic frequency, while it decreases with an increasing number of cycles. Higher confining pressure and frequency raise the input energy, elastic potential energy, and dissipated energy at the peak stress point. (iii) Deformation and failure in damaged limestone originate from the development and propagation of localized deformation zones. Increased lateral displacement within these zones promotes the formation of macroscopic fractures. Due to significant structural heterogeneity inside the localized areas, the evolution of deformation energy is influenced by regional characteristics. (iv) Simulation results indicate that the uniaxial compressive failure of limestone involves the accumulation and propagation of micro-scale tensile cracks, which ultimately coalesce into macro-scale shear fracture surfaces. During uniaxial loading of pre-damaged limestone, newly generated cracks predominantly initiate around pre-existing cracks, with only a limited number distributed randomly. Their peak intensity shows a positive correlation with the pre-damage confining pressure. Full article