Search Results (432)

The emergence of generative artificial intelligence (GenAI) in higher education offers new opportunities for academic support while also raising complex ethical concerns. This study explores how university students ethically evaluate the use of GenAI in three academic contexts: improving essay writing, preparing for exams, and generating complete essays without personal input. Drawing on the Multidimensional Ethics Scale (MES), the research assesses five philosophical frameworks—moral equity, relativism, egoism, utilitarianism, and deontology—based on a survey conducted among undergraduate social sciences students in Spain. The findings reveal that students generally view GenAI use as ethically acceptable when used to improve or prepare content, but express stronger ethical concerns when authorship is replaced by automation. Gender and full-time employment status also influence ethical evaluations: women respond differently than men in utilitarian dimensions, while working students tend to adopt a more relativist stance and are more tolerant of full automation. These results highlight the importance of context, individual characteristics, and philosophical orientation in shaping ethical judgments about GenAI use in academia. Full article

Obesity is a growing global health concern with widespread impacts on physical, psychological, and social well-being. Clinically, it is a major driver of type 2 diabetes (T2D), cardiovascular disease (CVD), non-alcoholic fatty liver disease (NAFLD), and cancer, reducing life expectancy by 5–20 years and imposing a staggering economic burden of USD 2 trillion annually (2.8% of global GDP). Despite its significant health and socioeconomic impact, earlier obesity medications, such as fenfluramine, sibutramine, and orlistat, fell short of expectations due to limited effectiveness, serious side effects including valvular heart disease and gastrointestinal issues, and high rates of treatment discontinuation. The advent of glucagon-like peptide-1 (GLP-1) receptor agonists (e.g., semaglutide, tirzepatide) has revolutionized obesity management. These agents demonstrate unprecedented efficacy, achieving 15–25% mean weight loss in clinical trials, alongside reducing major adverse cardiovascular events by 20% and T2D incidence by 72%. Emerging therapies, including oral GLP-1 agonists and triple-receptor agonists (e.g., retatrutide), promise enhanced tolerability and muscle preservation, potentially bridging the efficacy gap with bariatric surgery. However, challenges persist. High costs, supply shortages, and unequal access pose significant barriers to the widespread implementation of obesity treatment, particularly in low-resource settings. Gastrointestinal side effects and long-term safety concerns require close monitoring, while weight regain after medication discontinuation emphasizes the need for ongoing adherence and lifestyle support. This review highlights the transformative potential of incretin-based therapies while advocating for policy reforms to address cost barriers, equitable access, and preventive strategies. Future research must prioritize long-term cardiovascular outcome trials and mitigate emerging risks, such as sarcopenia and joint degeneration. A multidisciplinary approach combining pharmacotherapy, behavioral interventions, and systemic policy changes is critical to curbing the obesity epidemic and its downstream consequences. Full article

Background/Objectives: Opioid use disorder (OUD) remains a severe health problem globally, resulting in substantial social and economic challenges. While existing medications for managing OUD are proven to be effective, they also present certain challenges. A vaccine offers a promising therapeutic strategy to combat OUD and potentially reduce the risk of overdose death. The TT-6-AmHap heroin conjugate vaccine has effectively reduced heroin-induced pharmacological effects in behavioral assays as well as demonstrated the induction of high titer and high affinity antibody responses in mice and rats. In this GLP study conducted in rabbits, the potential local and systemic toxicity of the TT-6-AmHap heroin vaccine in combination with or without adjuvants ALF43 and Alhydrogel^® (ALFA) was investigated. Methods: Male and female New Zealand White rabbits were administered with vaccines or a saline control intramuscularly at two-week intervals over a 57-day study period. The presence, persistence or reversibility of any toxic effects of the vaccine was determined over a four-week recovery period. Results: Administration of TT-6-AmHap with or without the adjuvants induced high antibody-specific IgG in treatment groups compared to the controls. The study found no TT-6-AmHap-related effects on mortality, physical examinations, dermal Draize observations, body weights, body weight changes, food consumption, ophthalmology, clinical pathology (hematology, coagulation, clinical chemistry, and urinalysis), macroscopic pathology, or organ weights. Conclusions: Under the conditions of this study, these results demonstrate that the TT-6-AmHap vaccine with or without adjuvants was well tolerated, immunogenic, and the effects were not considered adverse in both male and female rabbits. Full article

The development of stock markets is pivotal for economic growth, particularly through the mobilization of idle resources into productive investments. Despite recent reforms to enhance Uzbekistan’s capital market, public engagement remains limited. This study examines the behavioral determinants of stock market investment intention and participation among university students, employing the Theory of Planned Behavior (TPB) and Partial Least Squares Structural Equation Modeling (PLS-SEM). The model investigates the influence of digital literacy, financial literacy, social interaction, herding behavior, overconfidence bias, risk tolerance, and financial well-being on investment intention and behavior. A survey of 369 university students was conducted to assess the proposed relationships. The results reveal that risk tolerance, overconfidence bias, and herding behavior significantly and positively affect investment intention, while digital literacy demonstrates a notable negative effect, suggesting caution in assuming technology readiness automatically translates to investment readiness. Investment intention, in turn, strongly predicts actual participation and mediates several of these effects. Conversely, financial literacy, financial well-being, and social interaction showed no significant direct or mediating influence. Additionally, differences according to gender and academic background were observed in how intention translates into behavior. The findings underscore the need for integrated financial and behavioral education to enhance market participation and contribute to policy discourse on youth financial engagement in emerging economies. Full article

Mycelium-bonded composites (MBCs), or myco-composites, represent a novel engineered material that combines natural lignocellulosic substrates with a fungal matrix. As a sustainable alternative to plastics, MBCs are gaining increasing interest; however, their large-scale industrial adoption remains limited, partly due to low social acceptance resulting from their unattractive appearance. Laser engraving provides a promising method for fabricating intricate patterns and functional surfaces on MBCs, minimizing tool wear, material loss, and environmental impact, while enhancing esthetic and engineering properties. This study investigates the influence of CO₂ laser parameters on the material removal rate during the engraving of myco-composites, focusing on the effects of variable laser power, beam defocus, and head feed rate on engraving outcomes. The results demonstrate that laser power and beam focus significantly impact material removal in mycelium-bonded composites. Specifically, increasing the laser power results in greater material removal, which is more pronounced when the beam is focused due to higher energy density. In contrast, a beam defocused by 1 mm produces less intense material removal. These findings highlight the critical role of beam focus—surpassing the influence of power alone—in determining engraving quality, particularly on irregular or uneven surfaces. Moreover, reducing the laser head feed rate at a constant power level increases the material removal rate linearly; however, it also results in excessive charring and localized overheating, revealing the low thermal tolerance of myco-composites. These insights are essential for optimizing laser processing techniques to fully realize the potential of mycelium-bonded composites as sustainable engineering materials, simultaneously maintaining their appearance and functional properties. Full article

The singular biodiversity of the Brazilian Caatinga inspires innovative solutions in food science. In this study, we evaluated the prebiotic potential of honeys produced by Apis mellifera in the Pajeú hinterland, Pernambuco, Brazil (Caatinga Biome), with different floral origins: Mastic (Aroeira), Mesquite (Algaroba), and mixed flowers. These were used to formulate synbiotic and alcoholic beverages fermented by Saccharomyces boulardii CNCM I-745. Static and dynamic simulations of the human gastrointestinal tract (GIT) were used, as well as physicochemical, rheological, and microbiological analyses. The results revealed that honey positively influences the viability and resilience of probiotic yeast, especially honey with a predominance of Algaroba, which promoted the highest survival rate (>89%) even after 28 days of refrigeration and in dynamic in vitro simulation of the GIT (more realistic to human physio-anatomical conditions). The phenolic composition of the honeys showed a correlation with this tolerance. The use of complementary methodologies, such as flow cytometry, validated the findings and highlighted the functional value of these natural matrices, revealing an even greater longevity potential compared to conventional microbiological methodology. The data reinforces the potential of the Caatinga as a source of bioactive and sustainable compounds, proposing honey as a promising non-dairy synbiotic vehicle. This work contributes to the appreciation of the biome and the development of functional food products with a positive social, economic, and ecological impact. Full article

Background/Objectives: Neurofibromatosis Type 1 (NF1) plexiform neurofibroma (PN) can cause morbidity, including disfigurement that can negatively impact social functioning. Historically, the mainstay treatment is surgical resection. However, complete resection is often prohibitive due to multiple nerve involvement. Moreover, post-operative recurrence is common. MEK inhibitors, including selumetinib and mirdametinib, have recently changed the treatment paradigm for these tumors. In 2020, selumetinib was FDA-approved for pediatric NF1 patients with inoperable symptomatic PNs, but selumetinib remains under investigation for their adult counterparts. In 2025, mirdametinib was FDA-approved for use in adults with symptomatic incompletely resectable NF1 PNs. Lower partial response rates have been reported with mirdametinib compared to selumetinib, but direct comparative analyses have not been conducted to establish the superiority of one agent over the other. Results: We present a case of a 38-year-old male with a right facial PN successfully treated with selumetinib, resulting in a 16.77% tumor volumetric reduction over 7 months. Selumetinib was well tolerated in our patient, with an asymptomatic Grade 3 CPK elevation that subsequently improved with a dose reduction. Conclusion: Our case adds to the growing body of evidence suggesting that selumetinib is effective and well tolerated in adult patients with NF1-associated PNs. Full article

In the face of economic, social, and environmental pressures, the issue of sustainable development has garnered widespread attention in the Logistics Service Supply Chain (LSSC) with risk attitudes under Technical Output Uncertainty. In this regard, this paper first constructs an optimal emission reduction investment game model for an LSSC composed of Logistics Service Integrators (LSIs) and Logistics Service Providers (LSPs) against the backdrop of Technical Output Uncertainty. To this end, it quantifies the participants’ risk attitudes using a mean-variance model to analyze optimal emission reduction investment decisions for centralized and decentralized LSSC under different levels of risk tolerance. Subsequently, it designs a joint contract with altruistic preferences for sharing emission reduction costs in the LSSC. This contract analyzes the parameter constraints for achieving Pareto optimization within the supply chain. Finally, the study employs a case simulation to analyze the changes in expected revenues for centralized LSSC and joint contracts under different risk tolerance levels. The study reveals that (1) in a centralized LSSC, under risk-neutral attitudes, there exists a unique optimal emission reduction investment, which yields the highest expected return from emission reduction. However, under risk-averse attitudes, the expected return is always lower than the optimal expected return under risk neutrality. (2) In a decentralized LSSC, the emission reduction investment decisions of the Logistics Service Providers are similar to those in a centralized LSSC. (3) Under risk-neutral attitudes, the cost-sharing and altruistic preference-based joint contract can also coordinate the risk-averse LSSC under certain constraints, and by adjusting the cost-sharing and altruistic preference parameters, the expected returns can be reasonably allocated. Full article

As digital connectivity transforms financial decision-making, this study offers one of the first empirical investigations into the relationship between social media use and socially responsible investing (SRI). Using data from the 2021 National Financial Capability Study, multinomial regression analysis was used to explore whether people who rely on social media for investment decisions were more likely to invest in ways that reflect their values. The results show that investors who use social media for investment information are more likely to value being socially responsible as an important reason for investing. Younger, less experienced, and more risk-tolerant investors were especially likely to follow SRI strategies, and certain platforms like Twitter were more associated with SRI interest than others. These findings suggest that social media is not just a platform for sharing information; it may also shape how people think about investing and the role their money can play in making a societal difference. As online platforms continue to influence financial behavior, understanding their impact on values-based investing becomes increasingly important. This research contributes novel insights to the emerging intersection of social media, behavioral finance, and values-driven investing. Full article

Sport can serve as a powerful tool for community building, fostering inclusion, challenging intolerance, and advancing social justice. It also supports positive youth development and active citizenship. When embedded in local life and accessible beyond athletics, sport creates unique conditions for community development and inclusive action. Sport and equity-focused community development are about relationships. The perspectives and behaviors stemming from youth participation in sport—what they learn about human relationships, relationship building, and life skills—carry forward through time in all phases and facets of their lives. The Gaelic Athletic Association (GAA), Ireland’s largest amateur sporting and cultural organization, exemplifies this potential. More than a sports organization, the GAA plays a central role in Irish society, offering opportunities for people of all ages to engage in sport, fitness, and well-being, while actively contributing to community life. GAA clubs often function as local social hubs, creating spaces for connection across generations. This article uses the GAA as a case study to explore how sport can be a unifying and inclusive structure for community building. Specifically, we will (1) examine the link between sport, youth, and active citizenship; (2) explore connections between sport, community, inclusion, and social justice; (3) offer a historical and cultural overview of the GAA; and (4) consider how organizations like the GAA can support efforts around inclusion, tolerance, and sustainability. The discussion will highlight implications for future community programming and policy. Full article

Housing informality in Morocco has taken root within Rabat’s formal neighborhoods, quietly reshaping façades, extending plot lines, and redrawing the texture of entire blocks. This ongoing transformation runs up against the rigidity of official planning frameworks, producing tension between state enforcement and tacit tolerance, as residents navigate persistent legal and economic ambiguities. Prior Moroccan studies are neighborhood-specific or socio-economic; the field lacks a city-wide, multi-class analysis linking everyday tactics to long-term governance dilemmas and policy design. The paper, therefore, asks how and why residents and architects across affordable, middle-class, and affluent districts craft unapproved modifications, and what urban order emerges from their cumulative effects. A mixed qualitative design triangulates (i) five resident focus groups and two architect focus groups, (ii) 50 short, structured interviews, and (iii) 500 geo-referenced façade photographs and observational field notes, thematically coded and compared across housing types. In addition to deciphering informality methods and impacts, the results reveal that informal modifications are shaped by both reactive needs—such as accommodating family growth and enhancing security—and proactive drivers, including esthetic expression and real estate value. Despite their legal ambiguity, these modifications are socially normalized and often viewed by residents as value-adding improvements rather than infractions. Full article

Political polarization in the United States has made conversations across ideological divides increasingly difficult to navigate. This study explores how students at a regional university in the southern U.S. experience and manage these challenges. Based on in-depth interviews with 30 students from diverse social and political backgrounds, we identify four key conversational strategies: disengagement, negotiation, context adaptation, and information processing. Rather than viewing these as surface-level techniques, we argue they represent deeper identity management processes aimed at reducing the social and cognitive risks of political disagreement. Drawing on Self-Categorization Theory and Identity Control Theory, we show how these strategies reflect efforts to maintain identity coherence and manage relational stakes when political identity becomes salient. Our findings suggest that while these strategies may help students avoid conflict in the moment, they may also limit deeper engagement across divides. We conclude by discussing the implications of these findings for dialog practice, highlighting the importance of fostering tolerance for identity discomfort and helping students rediscover the common bonds that unite them across political differences. Full article

This article examines the land-use politics of recreation development in rural China. Extending the lens of spatial informality, it analyzes how the appropriation and acquisition of space by small suburban leisure enterprises have constituted a de facto vehicle for rural spatial reconfiguration amidst land-use constraints. Drawing on ethnographic fieldwork and case studies, we illuminate emerging scenarios in which inbound businesses burgeoned through the production of informal spaces, which were subsequently formalized or tolerated by local governments geared towards social economic growth. More so, we reveal the potential and limitations of such an informal-to-formal approach for rural spatial reconfiguration by showing how its sustainability and survival depend upon the enterprises’ ability to enter into a tacit alliance of interests with local authorities. This article casts new light on emerging bottom-up processes of spatial reconfiguration, alongside its repercussions for local suburbs, in the development of rural tourism and suburban leisure. It further suggests that, as an analytical approach, a nuanced understanding of rural restructuring under the recent national rural revitalization strategy can benefit from moving beyond the sole emphasis on formal institutions to analyze the role played by ordinary market actors and their spatial practices that shape rural territories and spatial relationships. Full article

Motorbike taxis are widely used in Yaoundé and Douala, despite their association with heightened accident risks and relatively high fares. This research combines qualitative methods, including 38 semi-structured interviews and direct field observations, with a quantitative survey of 280 motorbike taxi passengers (customers). It employs a dynamic risk approach to analyse both the factors motivating individuals to choose motorbike taxis and the strategies adopted by drivers and passengers to mitigate and prevent accidents. The findings reveal that speed, cost-effectiveness, and the limited accessibility of certain neighbourhoods to other transport options are key factors driving regular motorbike taxi use. Moreover, strategies for managing accident risks include regulating passenger positions based on gender, perceived age, or physical stature; invoking deities for protection; and passengers’ verbal interactions with drivers to ensure safer behaviour. This research also explores how overloading, a collectively tolerated deviance, is managed to avoid or minimize the impact of accidents. By addressing both risk acceptance and prevention strategies, this study provides new insights into passengers’ social perceptions, which are often overlooked in motorbike taxi research. It expands the understanding of motorbike taxi use in urban Global South transport contexts, particularly in terms of users’ risk management behaviours. Full article

Background/Objectives: Rett Syndrome (RTT) is a rare neurodevelopmental disorder that affects girls and is characterized by severe motor and cognitive impairments, the loss of purposeful hand use, and communication difficulties. Children with RTT, especially those aged 5 to 9 years, often struggle to develop the foundational skills necessary for adaptive functioning, such as eye contact, object tracking, functional gestures, turn-taking, and basic communication. These abilities are essential for cognitive, social, and motor development and contribute to greater autonomy in daily life. This study aimed to explore the feasibility of a structured telerehabilitation program and to provide preliminary observations of its potential utility for young girls with RTT, addressing the presumed challenge of engaging this population in video-based interactive training. Methods: The intervention consisted of 30 remotely delivered sessions (each lasting 90 min), with assessments at baseline (A), after 5 weeks (B1), and after 10 weeks (B2). Quantitative outcome measures focused on changes in eye contact, object tracking, functional gestures, social engagement, and responsiveness to visual stimulus. Results: The findings indicate that the program was feasible and well-tolerated. Improvements were observed across all measured domains, and participants showed high levels of engagement and participation throughout the intervention. While these results are preliminary, they suggest that interactive digital formats may be promising for supporting foundational learning processes in children with RTT. Conclusions: This study provides initial evidence that telerehabilitation is a feasible approach for engaging young girls with RTT and supporting adaptive skill development. These findings may inform future research and the design of controlled studies to evaluate the efficacy of technology-assisted interventions in this population. Full article