Search Results (288)

Driven by the high-end furniture industry’s demand for skin-tactile decorative boards, UV inkjet printing shows potential for wood-based surface finishing. Using primer-treated inkjet-printed melamine-faced panels, this study compared traditional UV varnish coatings with different thicknesses and UV curing intensities and 254 nm UV excimer-cured coatings with different radiant energies. Varnish thickness significantly affected surface roughness, 20° gloss, 85° gloss, and color difference, indicating a trade-off between matte tactile appearance and color fidelity. Thinner varnish coatings exhibited higher roughness and lower gloss but larger color differences, whereas thicker coatings better preserved color fidelity but resulted in higher gloss. For the UV excimer-cured system, one-way ANOVA showed significant treatment effects on acrylate conversion, water contact angle, 85° gloss, surface roughness, and abrasion mass loss. The coating prepared at an excimer radiant energy of 827.9 mJ/cm² showed the lowest 85° gloss of 5.28 GU and a pencil hardness of 3H, but also exhibited the highest abrasion mass loss in the short-cycle abrasion screening test. For both coating systems, three independently prepared specimens were tested for each processing condition. The UV varnish system was analyzed using two-way ANOVA, whereas the UV excimer-cured system was analyzed using one-way ANOVA. Friedman tests of sensory evaluation data showed significant differences among the eight selected samples for fineness, smoothness, and elasticity, with the excimer-cured coatings generally receiving higher fineness and smoothness scores than the UV varnish coatings. These results indicate that 254 nm UV excimer curing is a promising route for producing low-gloss, micro-wrinkle-induced skin-tactile surfaces on inkjet-printed melamine-faced panels, although optimization should balance tactile quality, gloss reduction, and abrasion resistance. Full article

Background: Conventional transdermal drug delivery systems are often limited by poor skin permeability and low drug loading efficiency, necessitating the development of advanced delivery platforms. Objectives: This study aimed to develop and optimize photopolymerizable bioinks (PBs) for liquid crystal display (LCD)-based 3D printing of crosslinked hydrogel microneedles (cHMNs) to enhance transdermal delivery of estradiol valerate (E2V). Methods: A Box–Behnken design (BBD) was used to optimize the effects of Gantrez™ S-97, Jurymer™, and polyvinyl alcohol (PVA) on viscosity, exposure time, hardness, and elasticity, with strong predictive performance (R² = 0.9702–0.9907). Results: Estradiol valerate-loaded nanoparticles (E2V-NPs) were prepared via ionotropic gelation, exhibiting a particle size of 698.33 (0.78) nm, PDI of 0.50 (0.06), zeta potential of −39.09 (7.32) mV, and high encapsulation efficiency (86.87 (0.78)%). The optimized PBs enabled fabrication of uniform cHMNs (~800 µm height) with adequate mechanical strength (hardness 20.45 (1.23) N; elasticity 2.97 (0.49) MPa) and effective insertion capability. The E2V-NPs-loaded cHMNs exhibited sustained drug release over 12 days (~56.92 (4.27)%). Skin permeation studies showed a significantly enhanced flux (10.81 (4.55) µg/cm²/h) and cumulative permeation (12.94 (2.06) µg/cm²) compared to topical E2V-NPs and suspension, along with increased skin accumulation (38.55 (0.10) µg). Cytotoxicity studies confirmed that E2V and E2V-NPs were biocompatible (>80% viability), while PBs showed concentration-dependent cytotoxicity. Conclusions: Overall, this integrated platform combining design of experiment, nanoparticles, microneedles, and LCD 3D printing offered a promising strategy for enhancing transdermal drug delivery efficiency and reproducibility. Full article

Background: Epidemiological data link hard and chlorinated water to atopic dermatitis (AD), but experimental evidence on their effect and on dermocosmetic benefit remains limited. Objectives: We aimed to compare the effects of soft, hard, and chlorinated water on atopic skin and assess whether a dermocosmetic routine mitigates these effects. Methods: In a 3-day, open-label, intra-individual study, 66 adults with atopic skin underwent repeated forearm immersions (five cycles/day) in soft, hard, or chlorinated water. One forearm received a cleansing-oil and moisturising-balm routine after each cycle; the contralateral forearm served as untreated control. TEWL, hydration, and global discomfort were assessed. In a 21-day real-life study, adults with AD regularly exposed to hard domestic or swimming-pool water used the routine daily. Discomfort and quality of life were recorded. Results: Water immersion induced modest, inconsistent TEWL changes, increased hydration and slightly reduced discomfort, without differences between water types. The routine reduced TEWL, increased hydration, and decreased discomfort for all water types. In real life, it produced immediate and sustained improvements in discomfort and quality of life. Conclusions: Under controlled exposure, soft, hard, and chlorinated water exert comparable, limited effects on atopic skin. The dermocosmetic routine consistently improves barrier-related parameters and comfort, independently of water type. Full article

This paper focuses on the significant potential of specific optical non-invasive methods, such as digital holographic microscopy, digital speckle pattern interferometry, and digital holographic interferometry, as scientific and technological tools for retrieving physical and biomechanical parameters embedded in the optical phase of laser-illuminated biomedical samples. These techniques take advantage of the laser speckle phenomena observed when non-specular surfaces are illuminated, enabling whole-field measurements and reconstruction of 3D images. Their versatility in implementation and application has led to advances in various fields of research and has broadened our understanding in both the basic and applied sciences. In clinical environments, the aforementioned quantitative optical studies are particularly valuable for understanding the behavior of biological samples, as they allow precise characterization of deformations, displacements, stress, strain, refractive index, and morphological features. Applications presented span from soft to hard tissues at both micro- and macro-scales, with results obtained from vocal cords, skin tissues, melanoma cells, and teeth. Furthermore, this overview provides a general perspective of some current speckle-based approaches and their growing relevance in biomedical research. Full article

This review summarizes the research on the end effectors of agricultural harvesting robots (2010–2025) and extracts two core design principles. First of all, the selection of end effectors must follow the biological characteristics of fruits: rigid grippers are suitable for hard skinned and regular fruits; soft grippers can reduce the damage of fragile crops to a certain extent; suction cups are suitable for smooth, barrier free surfaces; the envelope type is suitable for soft and lossless picking scenes; the combined suction and grip design is more suitable for unstructured environments. Secondly, the separation mode should match the characteristics of the stem: motion separation (torsion/pull) is suitable for weak stems, while cutting is mainly used for hard stems. Unlike previous literature, this review provides a field deployability checklist (including dust/water proofing, cleanliness, maintenance, aging prevention, and aspiration prevention) to narrow the results of the laboratory and the real field environment. The three future directions of multimodal perception, variable stiffness driving and reinforcement learning are logically related to the analysis in this paper: multimodal perception optimizes the perception limit, variable stiffness solves the rigid–flexible trade-off, and reinforcement learning provides adaptive strategies for different crops. This framework can match the end effector design with the crop-specific field conditions. Full article

Face recognition under uncontrolled lighting remains challenging due to variations in brightness, background noise, and low-quality features. This paper presents a unified deep learning model that integrates illumination normalization, skin-aware spatial modulation, and quality-based margin learning within a single inference process. Unlike earlier methods that treat relighting or segmentation as preprocessing, this approach directly integrates mask-guided feature modulation into embedding learning. The system comprises RetinaFace detection, photometric augmentation during training, lightweight neural relighting at inference, U-Net-based skin segmentation, and identity embeddings trained with ArcFace, AdaFace, or MagFace losses, with angular margins adapted to feature quality. Experiments on Labeled Faces in the Wild (LFW), Celebrities in Frontal-Profile (CFP-FP), Age Database 30 (AgeDB-30), and a custom illumination dataset demonstrate steady enhancements in difficult lighting conditions. The model reaches a competitive 99.8% accuracy on LFW and shows notable improvements on pose-hard CFP-FP and the custom dataset, such as a +2.6% increase in TPR at 1 ${\times 10}^{-4}$ FPR. The key innovations include: (i) mask-guided embedding modulation that embeds segmentation into feature learning, (ii) a dual strategy combining training-time photometric data augmentation with inference-time neural relighting, and (iii) joint spatial–quality margin learning via AdaFace/MagFace. Finally, results confirm consistent gains under challenging illumination and pose variations. Full article

Environmental concerns over plastic-based adhesives highlight the urgent need for biodegradable alternatives. This study transforms milkfish (Chanos chanos) skin waste from the fishery industry into a collagen–polyvinylpyrrolidone (PVP) biohybrid adhesive stick for paper bonding. Milkfish showed the highest adhesive strength among twenty species, requiring ≥213.7 mg/g hydroxyproline for optimal performance. Type I collagen was confirmed via Fourier transform infrared (FTIR) and amino acid composition, and the extraction yield reached 68.82%. The fish skin collagen–PVP glue stick demonstrated paper adhesion and physicochemical properties comparable to starch-based and commercial glues, with lower hardness and more dry adhesive per unit area. Sensory evaluation using quantitative descriptive analysis revealed no significant differences (p < 0.05) compared to commercial glue sticks, except for increased glue consumption and reduced shape retention. The shelf life exceeded 70 days. Collagen adhesive from fish skin offers comparable efficiency to chemical and other bio-based adhesives, providing a sustainable solution that promotes the circular economy and green innovation. Full article

Background and Clinical Significance: Conventional hard sockets are reported to result in skin breakdown for almost half of transtibial prosthesis users. Adjustable sockets have been developed to better accommodate residual limb shape and volume changes. They have demonstrated optimal skin health in prospective adult clinical studies. Case Presentation: We present the case of a 57-year-old male with a transtibial amputation who enrolled in a research study at the University of Pennsylvania. In the year before enrollment, he experienced frequent, near-constant skin breakdown of the distal residual limb at the anterior tibia due to limb volume fluctuations and excessive pressure from a conventional hard socket and was frequently unable to use his socket due to skin breakdown. The subject was fit with an adjustable, immediate fit transtibial prosthesis (iFIT Prosthetics^®). After a two-week home trial, he rated the adjustable prosthesis 62 out of 70 on an adapted Prosthetic Evaluation Questionnaire, compared with a score of 20 for his conventional prosthesis. Due to improved comfort, he discontinued the use of his conventional device. The subject was followed for over one year and wore the adjustable prosthesis exclusively without a recurrence of skin breakdown. Residual limb volume changes commonly lead to poor socket fit and skin irritation in conventionally fabricated hard sockets, often progressing to skin breakdown. In individuals with diabetes, wound healing can be prolonged and functionally limiting. In this case, an adjustable prosthesis successfully eliminated anterior tibial skin breakdown in a subject predisposed to this injury when using conventional hard sockets. Conclusions: Adjustable sockets can prevent skin breakdown in individuals with transtibial limb loss. Full article

Cutaneous fibrosis is characterized by aberrant wound healing with excessive extracellular matrix deposition, sustained inflammation, and oxidative stress, while currently available therapies show limited efficacy and safety. A Dual Hyaluronic Acid Compound (DHC), consisting of high-molecular-weight, low-molecular-weight, and minimally cross-linked hyaluronic acid, has demonstrated regenerative and antioxidant properties, but its anti-fibrotic effects have not been fully explored. This study investigated the anti-fibrotic potential of DHC using a bleomycin-induced murine dermal fibrosis model and a UVB-irradiated ex vivo human skin model. In C57BL/6 mice, dermal fibrosis was induced by daily bleomycin injections for three weeks, followed by intradermal DHC administration. Histological and biomechanical analyses showed that DHC significantly reduced dermal thickness, collagen deposition, and skin hardness compared with untreated fibrotic controls. DHC decreased α-SMA expression and increased MMP1 levels, indicating attenuation of myofibroblast activation and enhanced matrix remodeling. It also reduced macrophage markers (CD68, CD163) and pro-inflammatory cytokines (IL-1β, TNF-α). Furthermore, DHC restored superoxide dismutase (SOD) and catalase (CAT) activity and upregulated NRF2, HO-1, and NQO1 expression in the in vivo model. Similarly, DHC upregulated SOD and CAT activity and reduced pro-inflammatory cytokines (IL-6, TNF-α) in the ex vivo human skin model. These findings suggest that DHC exerts multimodal anti-fibrotic effects through coordinated regulation of fibroblast activation, inflammation, and oxidative stress, supporting its potential as a therapeutic approach for cutaneous fibrosis. Full article

This study aimed to compare carcass composition and selected meat quality traits of guinea fowl (Numida meleagris) and common pheasant (Phasianus colchicus L.) reared under the production conditions applied in this experiment. The study material consisted of 32 birds, including 16 male common pheasants and 16 male guinea fowl, all slaughtered at 13 weeks of age. The analysis revealed significant differences (p < 0.05) between the two groups in carcass composition and several meat quality parameters. Under the given rearing conditions, guinea fowl were characterized by higher body and carcass weight, as well as weights of individual carcass components, compared to pheasants. They also showed higher carcass yield and greater proportions of certain elements, including leg muscles, skin with subcutaneous fat, and wings, whereas pheasants exhibited a higher proportion of breast muscles and neck. Guinea fowl had higher absolute masses of meat, fat, and bones, but a lower meat-to-fat ratio. No significant differences between groups were observed for the meat-and-fat-to-bone ratio or the meat-to-bone ratio. The highest protein content was recorded in the breast muscles of pheasants (27.1%), while the lowest was found in the leg muscle of guinea fowl (22.1%). Differences between the groups were also observed in intramuscular fat and water content in both breast and leg muscles, as well as in collagen content in the breast muscle. Regardless of group, breast muscles were characterized by higher protein content and lower fat and collagen levels than leg muscles. Differences were further noted in electrical conductivity (EC) and the a* and b* color parameters in both muscle types. Breast muscles exhibited lower pH and a* values but higher EC and L* values than leg muscles in both groups. Textural traits of the breast muscles, including cohesiveness, springiness, and chewiness, were higher in guinea fowl, whereas hardness and Warner–Bratzler shear force (WB) were lower compared to pheasants. However, these differences should be interpreted with caution, as the birds were reared under different feeding and management systems, which may have contributed to the observed variation. Overall, the results provide comparative data on carcass composition and meat quality of guinea fowl and pheasants under the studied production conditions. These findings may serve as a basis for further controlled studies designed to more clearly isolate species effects and to evaluate their potential relevance for poultry production. Full article

Objectives: To strengthen the recognition of juvenile xanthogranuloma (JXG) by analyzing ultrasound findings. Methods: This study retrospectively enrolled these patients with pathologically confirmed JXG from January 2011 to March 2025. The clinical, imaging, pathological features, and prognosis of all included patients were analyzed. All the imaging features were evaluated in consensus by two radiologists. Results: Fourteen patients were included in the study. A total of 78.6% presented with solitary masses. The age of the patients ranged from 2 months to 48 years. Those aged ≤1 year accounted for 64.3% of the sample. The lesions were predominantly located on the head and face, and the skin of most patients was yellowish-orange. The ultrasound manifestations are mostly hypoechoic masses with clear boundaries and regular shapes. Contrast-enhanced ultrasound shows a slight homogeneous enhancement, and on shear wave elastography, it appears to be relatively hard. Conclusions: JXGs are more common in infants or young children and present with yellowish-orange, cutaneous lesions. Ultrasound revealed homogeneous, well-circumscribed, regular hypoechoic nodules. Multimodal imaging may be helpful for preoperative diagnosis. Full article

The purpose of this investigation was to develop and physicochemically characterize two natural O/W cosmetic cream prototypes (LC1, LC2) containing 5% (w/w) of a Vaccinium vitis-idaea (lingonberry) fruit extract (LE) together with their corresponding blank formulations (LC1-BL, LC2-BL). The extract was obtained by hydroalcoholic maceration followed by solvent removal and was characterized for total phenolic, flavonoid, and monomeric anthocyanin content. Its antioxidant capacity was evaluated using DPPH, FRAP, CUPRAC, and ABTS assays. The phenolic profile was further explored by HPLC–DAD–ESI(+), enabling tentative identification of phenolic subclasses previously reported in the literature to be associated with antioxidant properties. The prepared creams were evaluated for qualitative organoleptic properties, pH, texture (hardness, adhesiveness, and spreadability), viscosity, and accelerated conditions of stability. All formulations were stable, and no phase separation occurred; however, the addition of the extract modified their color and odor and decreased the pH to values within the physiological skin pH range. An in-silico safety evaluation of the constituents (MoS and TTC) found a good toxicological profile at concentrations employed. Overall, the results support the feasibility of incorporating lingonberry fruit extract into O/W cosmetic cream systems and demonstrate that appropriate formulation design allows the development of stable products with defined physicochemical and mechanical characteristics. Full article

Mechanical harvesting damage is a critical factor constraining potato quality and storage performance. Field curing is a commonly employed pre-treatment prior to mechanical picking of potatoes, which promotes skin suberization and reduces mechanical damage; however, the determination of optimal curing duration lacks a theoretical basis. This study investigated ‘Xisen No. 6’ potatoes at harvest maturity. Curing was performed by field sun-drying (open-air exposure) immediately after mechanical excavation, with five duration gradients (0, 1, 2, 3, and 4 h) established under the recorded meteorological conditions. Twenty-two physical–mechanical and damage parameters were measured, and principal component analysis (PCA) was employed for comprehensive evaluation. The results demonstrated that curing induced a transformation of tubers from “soft-elastic bodies” to “hard-brittle bodies”. This study first revealed the contradictory evolution pattern between skin abrasion damage and tissue impact damage, which exhibited a strong negative correlation (r = −0.89, p < 0.01). PCA indicated that a 3 h curing duration could effectively balance the control of both damage types. These findings provide a quantitative solution to the dilemma of reducing skin damage while controlling impact damage during mechanical potato harvesting, offering significant guidance for optimizing harvesting process parameters and reducing postharvest losses. Full article

This paper presents a breakthrough in activating the skin effect at conventional broaching speeds (1–8 m/min) by using laser defocus gradient modification to induce surface embrittlement in martensitic stainless steel Z10C13. Through controlled defocusing, a 50 μm gradient remelting layer was created, which features ultrafine grains (0.8 μm) and a high-density geometrically necessary dislocation (GND) zone (ρGND = 2.27 μm⁻³). The quasi-cleavage fracture was triggered via dislocation pinning by non-oriented low-angle grain boundaries (28.4% LAGBs). Multiscale characterization confirms that this microstructural transformation enhances surface hardness by 12.95% (reaching 31.4 HRC), reduces cutting force by 34.07%, and improves surface roughness by 63.74% (Sz = 28.80 μm). Simultaneously, a parallel crack-deflection mechanism restricts subsurface damage propagation, resulting in a crack-free subsurface zone. These results demonstrate the effectiveness of the embrittlement–toughening dichotomy for precision machining of difficult-to-cut materials under low-speed constraints. Full article

To promote sustainable food production, the effective valorization of agricultural byproducts is essential. This study investigated the potential of underutilized chestnut inner skin (CIS) and thinned young persimmon fruit (YPF) extracts as functional ingredients in pudding gels, selected as a complex model system utilizing heat-induced egg gelation with milk and sugar. Puddings were prepared by replacing water with 10% or 50% CIS or YPF extracts. We comprehensively evaluated the physicochemical properties (texture, color, viscosity), microstructure (SEM), and sensory quality. Additionally, immunoreactive allergenic proteins (ovalbumin, casein, β-lactoglobulin) were quantified using ELISA, and antioxidant activity was measured via DPPH and H-ORAC assays. Results indicated that while high extract concentrations (50%) negatively impacted texture by increasing hardness and forming air pockets, the 10% YPF treatment yielded a smooth, homogeneous microstructure comparable to the control. Crucially, the 10% YPF extract significantly reduced the concentration of detectable allergenic proteins, attributed to the formation of insoluble tannin–protein complexes, without compromising sensory acceptance. Furthermore, the addition of these extracts significantly enhanced the antioxidant activity of the puddings in a concentration-dependent manner. These findings demonstrate that 10% YPF is a promising candidate for developing sustainable, hypoallergenic, and antioxidant-rich functional food products. Full article