Search Results (6,899)

Background: The transition to renewable energy is intensifying demand for lithium-ion batteries (LIBs), thereby increasing the need for sustainable lithium sourcing. Traditional mining practices pose environmental and health risks, which can be mitigated through efficient end-of-life recycling systems. Methods: This study proposes a modified lithium reverse logistics network that decentralizes black-mass production at distributed facilities before centralized extraction, contrasting with conventional models that transport raw LIBs directly to central processing sites. Using the United States as a case study, two mathematical optimization (mixed-integer linear programming) models were developed to compare the traditional and modified networks in terms of cost efficiency and carbon emissions. Results: The model indicates that the proposed network significantly reduces both operational costs and emissions. Conclusions: This study highlights its potential to support a greener economy and inform policy development. Full article

To address the limitations of traditional hardened concrete road surfaces in coal mine tunnels, which are prone to damage and entail high maintenance costs, this study proposes using modular concrete blocks composed of fly ash and coal gangue as an alternative to conventional materials. These blocks offer advantages including ease of construction and rapid, straightforward maintenance, while also facilitating the reuse of substantial quantities of solid waste, thereby mitigating resource wastage and environmental pollution. Initially, the mineral composition of the raw materials was analyzed, confirming that although the physical and chemical properties of Liangshui Well coal gangue are slightly inferior to those of natural crushed stone, they still meet the criteria for use as concrete aggregate. For concrete blocks incorporating 20% fly ash, the steam curing process was optimized with a recommended static curing period of 16–24 h, a temperature ramp-up rate of 20 °C/h, and a constant temperature of 50 °C maintained for 24 h to ensure optimal performance. Orthogonal experimental analysis revealed that fly ash content exerted the greatest influence on the compressive strength of concrete, followed by the additional water content, whereas the aggregate particle size had a comparatively minor effect. The optimal mix proportion was identified as 20% fly ash content, a maximum aggregate size of 20 mm, and an additional water content of 70%. Performance testing indicated that the fabricated blocks exhibited a compressive strength of 32.1 MPa and a tensile strength of 2.93 MPa, with strong resistance to hydrolysis and sulfate attack, rendering them suitable for deployment in weakly alkaline underground environments. Considering the site-specific conditions of the Liangshuijing coal mine, ANSYS 2020 was employed to simulate and analyze the mechanical behavior of the blocks under varying loads, thicknesses, and dynamic conditions. The findings suggest that hexagonal coal gangue blocks with a side length of 20 cm and a thickness of 16 cm meet the structural requirements of most underground mine tunnels, offering a reference model for cost-effective paving and efficient roadway maintenance in coal mines. Full article

CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-associated protein 9)-mediated genome editing has emerged as a transformative tool in medicine, offering significant potential for cancer therapy because of its capacity to precisely target and alter the genetic modifications associated with the disease. However, a major challenge for its clinical translation is the safe and efficient in vivo delivery of CRISPR/Cas9 components to target cells. Nanotechnology is a promising solution to this problem. Nanocarriers, owing to their tunable physicochemical properties, can encapsulate and protect CRISPR/Cas9 components, enabling targeted delivery and enhanced cellular uptake. This review provides a comprehensive examination of the synergistic potential of CRISPR/Cas9 and nanotechnology in cancer therapy and explores their integrated therapeutic applications in gene editing and immunotherapy. A critical aspect of in vivo CRISPR/Cas9 application is to achieve effective localization at the tumor site while minimizing off-target effects. Nanocarriers can be engineered to overcome biological barriers, thereby augmenting tumor-specific delivery and facilitating intracellular uptake. Furthermore, their design allows for controlled release of the therapeutic payload, ensuring sustained efficacy and reduced systemic toxicity. The optimization of nanocarrier attributes, including size, shape, surface charge, and composition, is crucial for improving the cellular internalization, endosomal escape, and nuclear localization of CRISPR/Cas9. Moreover, surface functionalization with targeting ligands can enhance the specificity of cancer cells, leading to improved gene-editing accuracy. This review thoroughly discusses the challenges associated with in vivo CRISPR/Cas9 delivery and the innovative nanotechnological strategies employed to overcome them, highlighting their combined potential for advancing cancer treatment for clinical application. Full article

Background: Tobacco use is disproportionately high in rural areas, contributing to elevated cancer mortality, yet it often goes untreated due to limited access to care, high poverty and uninsured rates, and co-occurring substance use disorders (SUDs). This study explored the utility of using rapid qualitative analysis (RQA) to guide the adaptation of a tobacco-free workplace program (TFWP) in Texas healthcare centers serving adults with SUDs in medically underserved areas. Methods: From September–December 2023 and May–July 2024, we conducted 11 pre-implementation, virtual semi-structured group interviews focused on adapting the TFWP to local contexts (N = 69); 7 with providers (n = 34) and managers (n = 12) and 4 with patients (n = 23) in 6 healthcare centers. Two qualified analysts independently summarized transcripts, using RQA templates of key domains drawn from interview guides to summarize and organize data in matrices, enabling systematic comparison. Results: The main themes identified were minimal organizational tobacco cessation support and practices, and attitudinal barriers, as follows: (1) the need for program materials tailored to local populations; (2) limited tobacco cessation practices and partial policies—staff requested guidance on enhancing tobacco screenings and cessation delivery, and integrating new interventions; (3) contradictory views on treating tobacco use that can inhibit implementation (e.g., wanting to quit yet anxious that quitting would cause SUD relapse); and (4) inadequate environmental supports—staff requested treating tobacco-use training, patients group cessation counseling; both requested nicotine replacement therapy. Conclusions: RQA identified key areas requiring capacity development through participants’ willingness to adopt the following adaptations: program content (e.g., trainings and tailored educational materials), delivery methods/systems (e.g., adopting additional tobacco care interventions) and implementation strategies (e.g., integrating tobacco cessation practices into routine care) critical to optimizing TFWP fit and implementation. The study findings can inform timely formative evaluation processes to design and tailor similar intervention efforts by addressing site-specific needs and implementation barriers to enhance program uptake. Full article

Currently, exploring digital immersive experiences is a new trend in the innovation and development of cultural tourism. This study addresses the growing demand for digital immersion in cultural tourism by examining the integration of spatial narrative and digitally gamified architectural scenarios. This study synthesizes an optimized framework for narrative design in digitally gamified architectural scenarios, integrating spatial narrative theory and feedback-informed design. The proposed model comprises four key components: (1) developing spatial narrative design methods for such scenarios; (2) constructing a spatial language system for spatial narratives using linguistic principles to organize narrative expression; (3) building a preliminary digitally gamified scenario based on the “Wuhu Jiaoji Temple Renovation Project” after architectural and environmental enhancements; and (4) optimization through thermal feedback experiments—collecting visitor trajectory heatmaps, eye-tracking heatmaps, and oculometric data. The results show that the optimized design, validated in the original game Dreams of Jiaoji, effectively enhanced spatial narrative execution by refining both on-site and in-game architectural scenarios. Post-optimization visitor feedback confirmed the validity of the proposed optimization strategies and principles, providing theoretical and practical references for innovative digital cultural tourism models and architectural design advancements. In the context of site-specific architectural conservation, this approach achieves two key objectives: the generalized interpretation of architectural cultural resources and their visual representation through gamified interactions. This paradigm not only enhances public engagement through enabling a multidimensional understanding of historical building cultures but also accelerates the protective reuse of heritage sites, allowing heritage value to be maximized through contemporary reinterpretation. The interdisciplinary methodology promotes sustainable development in the digital transformation of cultural tourism, fostering user-centered experiences and contributing to rural revitalization. Ultimately, this study highlights the potential use of digitally gamified architectural scenarios as transformative tools for heritage preservation, cultural dissemination, and rural community revitalization. Full article

Background: Postoperative ventral hernia (POVH) remains a significant complication following laparoscopic colectomy despite minimally invasive approaches. Extraction site selection may influence POVH incidence, yet optimal location remains controversial. Methods: This retrospective cohort study analyzed 550 patients undergoing elective laparoscopic right colectomy (2009–2024) at a single center. After exclusions for anastomotic leak and loss to follow-up, 266 patients were propensity-matched 1:1 comparing paramedian (n = 133) versus midline (n = 133) extraction sites. The primary outcome was POVH incidence at 36 months. Secondary outcomes included risk factor identification using multivariate logistic regression and Firth penalized methods. Results: POVH occurred in 3/133 (2.3%) paramedian versus 15/133 (11.3%) midline patients (p = 0.007). Multivariate analysis identified midline extraction (aOR 30.3, 95% CI: 3.34–969, p < 0.001), chronic cough (aOR 25.6, 95% CI: 3.56–287, p = 0.001), and constipation (aOR 10.1, 95% CI: 1.60–70.7, p = 0.015) as independent POVH predictors. Patient comorbidities showed stronger associations than surgical factors in univariate analysis. The number needed to treat with paramedian extraction to prevent one POVH was 11.1. Conclusions: Paramedian extraction sites significantly reduce POVH incidence compared to midline approaches in laparoscopic right colectomy. The identification of modifiable physiological risk factors, particularly conditions causing increased intra-abdominal pressure (chronic cough, constipation), suggests that comprehensive perioperative optimization targeting these specific factors may further reduce POVH risk. Full article

Background and Objectives: Immunodeficiency associated with aging comorbidities increases the vulnerability of geriatric patients to sepsis. Early recognition and management of sepsis are essential in this population. This study evaluated the relationships between RDW, MPV, and MPV/PLT ratios and mortality in geriatric sepsis patients. Materials and Methods: This retrospective study was conducted between 2020 and 2024 in the Intensive Care Unit of the Department of Anesthesiology and Reanimation at a university hospital. Patients aged ≥ 65 years with a SOFA score of ≥2 were included. Demographic data (sex, age, height, weight, and BMI), hemogram parameters (RDW, MPV, and PLT), blood gas, and biochemical values were analyzed. Furthermore, their comorbidities; site of infection; ICU length of stay; vital signs; and SOFA, APACHE II, and SAPS II scores, recorded within the first 24 h following ICU admission, were evaluated. Statistical analysis was performed using the chi-square test, Student’s t-test, the Mann–Whitney U test, the Monte Carlo exact test, and ROC analysis. A p-value of <0.05 was considered statistically significant. Results: A total of 247 patients were included, with 46.2% (n = 114) classified as non-survivors during the 28-day follow-up period. Among them, 64.9% (n = 74) were male, with a mean age of 78.22 ± 8.53 years. Significant differences were also found in SOFA, APACHE-II, and SAPS-II scores between non-survivors and survivors (SOFA: 7.64 ± 3.16 vs. 6.78 ± 2.78, p = 0.023; APACHE-II: 21.31 ± 6.36 vs. 19.27 ± 5.88, p = 0.009; SAPS-II: 53.15 ± 16.04 vs. 46.93 ± 14.64, p = 0.002). On days 1, 3, and 5, the MPV/PLT ratio demonstrated a statistically significant predictive value for 28-day mortality. The optimal cut-off values were >0.03 on day 1 (AUC: 0.580, 95% CI: 0.516–0.642, sensitivity: 72.81%, specificity: 65.91%, p = 0.027), >0.04 on day 3 (AUC: 0.602, 95% CI: 0.538–0.663, sensitivity: 60.53%, specificity: 60.61%, p = 0.005), and >0.04 on day 5 (AUC: 0.618, 95% CI: 0.554–0.790, sensitivity: 66.14%, specificity: 62.88%, p = 0.001). Conclusions: The MPV and MPV/PLT ratios demonstrated statistically significant but limited predictive value for 28-day mortality in geriatric patients with sepsis. In contrast, the limited prognostic value of RDW may be related to variability in the inflammatory response and other underlying conditions. The correlations found between SOFA, APACHE II, and SAPS II scores highlight their importance in mortality risk prediction. Full article

As with wind turbines, marine tidal turbines are expected to be deployed in arrays of multiple turbines. To optimize these arrays, a more profound understanding of the interactions between turbines is necessary. This paper employs the Actuator Line Method alongside the Lattice Boltzmann Method and Large Eddy Simulation to develop a numerical model of tidal turbine arrays. It studies a vertical-axis turbine manufactured by HydroQuest/CMN that is equipped with two counter-rotating columns, each comprising two rotors. The ambient turbulence and upstream velocity profiles correspond to the characteristics of a tidal site such as the Alderney Race. Six turbine layouts are modeled: three aligned layouts with three turbines and three staggered layouts with four turbines. The spacing between turbines varies depending on the layout. This study yields several observations regarding array configuration. A minimum distance of 300 m, or $12D_{eq}$, between aligned turbines is necessary for full wake recovery. At shorter distances, the accumulation of velocity deficits significantly decreases the efficiency of the third turbine in the array. Pairs of counter-rotating vortices are observed in the wake of turbines. The evolution of these vortices and their influence on the wake depend greatly on the array configuration. An optimal configuration is observed in which the overall averaged power is not impaired by the interactions. Full article

High concentrations of vicine and convicine (v-c) in faba beans can trigger favism in susceptible humans, posing a significant barrier to the broader adoption of faba beans as a food source. While plant breeding and various post-harvest processing methods have been adopted to reduce v-c levels, there is limited understanding of how agronomic practices may assist in reducing v-c levels. This study investigated the effect of sowing time (TOS), soil type, and genotype on v-c levels in faba beans. Twelve faba bean genotypes were evaluated across multiple field sites by applying two sowing times and two diverse soil types. The v-c content was quantified using established chromatographic techniques. Genotypes were identified as the most major factor affecting v-c levels, with significant variation observed in mean vicine and convicine contents. Sowing time also had a significant impact (p < 0.01), with lower v-c levels observed in TOS 1 compared to TOS 2. This reduction may be due to a longer plant development period and extended seed desiccation in TOS 1. Soil conditions, likely linked to nutritional factors, significantly influenced vicine concentrations (p < 0.05) but did not influence convicine levels (p > 0.05). These findings highlight the importance of agronomy practices, such as optimal sowing time, soil nutrition, and moisture management, in minimizing v-c levels; the most effective strategy remains the development of low v-c genotypes combined with farming practices that naturally suppress v-c accumulation. Full article

Alkaline earth elements have emerged as crucial electronic modifiers for regulating active sites in catalytic systems, yet the influence of metal–support interactions (MSIs) between alkaline earth compounds and active metals remains insufficiently understood. This study systematically investigated Pt nanoparticles supported on alkaline earth carbonates (Pt/MCO₃, M = Mg, Ca, Ba) for low-temperature propylene combustion. The Pt/BaCO₃ catalyst exhibited outstanding performance, achieving complete propylene conversion at 192 °C, significantly lower than Pt/MgCO₃ (247 °C) and Pt/CaCO₃ (282 °C). The enhanced activity stemmed from distinct MSI effects among the supports, with Pt/BaCO₃ showing the poorest electron enrichment and lowest propylene adsorption energy. Through kinetic analyses, ¹⁸O₂ isotope labeling, and comprehensive characterization, the reaction was confirmed to follow the Mars–van Krevelen (MvK) mechanism. Pt/BaCO₃ achieves an optimal balance between propylene and oxygen adsorption, a critical factor underlying its superior activity. Full article

Under deep, high-intensity mining conditions, a high mineral pressure develops at the working face, which can easily cause floor heave deformation of the roadway. In this paper, with the geological conditions of Buertai coal mine as the background, through on-site monitoring and numerical simulation, the mechanism of strong dynamic pressure roadway floor heave is clarified and a cooperative control method for roadway floor heave deformation is proposed. The main conclusions are as follows: (1) The overall strength of the floor of this strong dynamic pressure roadway is low, which can easily cause roadway floor heave, and on-site multivariate monitoring of the mine pressure is carried out, which clarifies the evolution law of the mine pressure of the mining roadway and along-the-airway roadway. (2) Combined with FLAC3D numerical simulation software, we analyze the influence of coal seam depth and floor lithology on the stability of the roadway floor and find that both have a significant influence on the stability of the roadway. Under the condition of high-intensity mining, the floor will deteriorate gradually, forming a wide range of floor heave areas. (3) Based on the deformation and damage mechanism of the roadway floor, a synergistic control method of “roof cutting and pressure relief + floor anchor injection” is proposed and various technical parameters are designed. An optimized design scheme is designed for the control of floor heave in Buertai coal mine. Full article

Ultra-high-molecular-weight polyethylene (UHMWPE) is a pivotal material in engineering and biomedical applications due to its exceptional mechanical strength, wear resistance, and impact performance. However, its extreme melt viscosity, caused by extensive chain entanglements, severely limits processability via conventional melt-processing techniques. Recent advances in catalytic synthesis have enabled the production of disentangled UHMWPE (dis-UHMWPE), which exhibits enhanced processability while retaining superior mechanical properties. Notably, heterogeneous catalytic systems, utilizing supported fluorinated bis (phenoxy-imine) titanium (FI) catalysts, polyhedral oligomeric silsesquioxanes (POSS)-modified Z-N catalysts, and other novel catalysts, have emerged as promising solutions, combining structural control with industrial feasibility. Moreover, optimizing polymerization conditions further enhances chain disentanglement while maintaining ultra-high molecular weights. These systems utilize nanoscale supports and ligand engineering to spatially isolate active sites, tailor the chain propagation/crystallization kinetics, and suppress interchain entanglement during polymerization. Furthermore, characterization techniques such as melt rheology and differential scanning calorimetry (DSC) provide critical insights into chain entanglement, revealing distinct reorganization kinetics and bimodal melting behavior in dis-UHMWPE. This development of hybrid catalytic systems opens up new avenues for solid-state processing and industrial-scale production. This review highlights recent advances concerning interaction between catalyst design, polymerization control, and material performance, ultimately unlocking the full potential of UHMWPE for next-generation applications. Full article

Pest management is undergoing a transformative shift with the development of the cutting-edge antisense technologies: RNA interference (RNAi), contact unmodified antisense DNA biotechnology (CUADb), and the CRISPR-associated proteins (CRISPR/Cas). These approaches function by facilitating sequence-specific pairing of nucleic acids followed by nuclease-mediated cleavage, offering exceptional precision for targeted pest control. While RNA-guided mechanisms such as RNAi and CRISPR/Cas were initially characterized in non-insect systems, primarily as innate defenses against viral infections, the DNA-guided CUADb pathway was first identified in insect pests as a functional pest control strategy. Its broader role in ribosomal RNA (rRNA) biogenesis was recognized later. Together, these discoveries have revealed an entirely new dimension of gene regulation, with profound implications for sustainable pest management. Despite sharing a common principle of sequence-specific targeting RNAi, CUADb, and CRISPR/Cas differ in several key aspects, including their mechanisms of action, target specificity, and applicability. Rather than serving as universal solutions, each technology is likely to be optimally effective against specific pest groups. Moreover, these technologies allow for rapid adaptation of control strategies to overcome target-site resistance, ensuring long-term efficacy. This review summarizes the core functional characteristics, potential applications, and current limitations of each antisense technology, emphasizing their complementary roles in advancing environmentally sustainable pest control. By integrating foundational biological discoveries with applied innovations, this work provides a new perspectives on incorporating antisense-based strategies into next-generation integrated pest management systems. Full article

The quality of wine largely depends on the quality of wine grapes, which is determined by their chemical composition. Therefore, measuring parameters related to grape ripeness, such as soluble solids content (SSC), is crucial for harvesting high-quality grapes. Visible–Near-Infrared (Vis/NIR) spectroscopy enables effective, non-destructive detection of SSC in grapes. However, commercial Vis/NIR spectrometers are often expensive, bulky, and power-consuming, making them unsuitable for on-site applications. This article integrated the AS7265X sensor to develop a low-cost handheld IoT multispectral detection device, which can collect 18 variables in the wavelength range of 410–940 nm. The data can be sent in real time to the cloud configuration, where it can be backed up and visualized. After simultaneously removing outliers detected by both Monte Carlo (MC) and principal component analysis (PCA) methods from the raw spectra, the SSC prediction model was established, resulting in an ${\mathrm{R}}_V^2$ of 0.697. Eight preprocessing methods were compared, among which moving average smoothing (MAS) and Savitzky–Golay smoothing (SGS) improved the ${\mathrm{R}}_V^2$ to 0.756 and 0.766, respectively. Subsequently, feature wavelengths were selected using UVE and SPA, reducing the number of variables from 18 to 5 and 6, respectively, further increasing the ${\mathrm{R}}_V^2$ to 0.809 and 0.795. The results indicate that spectral data optimization methods are effective and essential for improving the performance of SSC prediction models. The IoT Vis/NIR Spectroscopic System proposed in this study offers a miniaturized, low-cost, and practical solution for SSC detection in wine grapes. Full article

Autonomous earthwork machinery is gaining traction as a means to boost productivity and safety on space-constrained urban sites, yet the fast-growing literature has not been fully integrated. To clarify current knowledge, we systematically searched Scopus and screened 597 records, retaining 157 peer-reviewed papers (2015–March 2025) that address autonomy, integrated control, or risk mitigation for excavators, bulldozers, and loaders. Descriptive statistics, VOSviewer mapping, and qualitative synthesis show the output rising rapidly and peaking at 30 papers in 2024, led by China, Korea, and the USA. Four tightly linked themes dominate: perception-driven machine autonomy, IoT-enabled integrated control systems, multi-sensor safety strategies, and the first demonstrations of fleet-level collaboration (e.g., coordinated excavator clusters and unmanned aerial vehicle and unmanned ground vehicle (UAV–UGV) site preparation). Advances include centimeter-scale path tracking, real-time vision-light detection and ranging (LiDAR) fusion and geofenced safety envelopes, but formal validation protocols and robust inter-machine communication remain open challenges. The review distils five research priorities, including adaptive perception and artificial intelligence (AI), digital-twin integration with building information modeling (BIM), cooperative multi-robot planning, rigorous safety assurance, and human–automation partnership that must be addressed to transform isolated prototypes into connected, self-optimizing fleets capable of delivering safer, faster, and more sustainable urban construction. Full article