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Search Results (5,118)

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Keywords = signaling interference

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21 pages, 4517 KiB  
Article
A Method Integrating the Matching Field Algorithm for the Three-Dimensional Positioning and Search of Underwater Wrecked Targets
by Huapeng Cao, Tingting Yang and Ka-Fai Cedric Yiu
Sensors 2025, 25(15), 4762; https://doi.org/10.3390/s25154762 (registering DOI) - 1 Aug 2025
Abstract
In this paper, a joint Matching Field Processing (MFP) Algorithm based on horizontal uniform circular array (UCA) is proposed for three-dimensional position of underwater wrecked targets. Firstly, a Marine search and rescue position model based on Minimum Variance Distortionless Response (MVDR) and matching [...] Read more.
In this paper, a joint Matching Field Processing (MFP) Algorithm based on horizontal uniform circular array (UCA) is proposed for three-dimensional position of underwater wrecked targets. Firstly, a Marine search and rescue position model based on Minimum Variance Distortionless Response (MVDR) and matching field quadratic joint Algorithm was proposed. Secondly, an MVDR beamforming method based on pre-Kalman filtering is designed to refine the real-time DOA estimation of the desired signal and the interference source, and the sound source azimuth is determined for prepositioning. The antenna array weights are dynamically adjusted according to the filtered DOA information. Finally, the Adaptive Matching Field Algorithm (AMFP) used the DOA information to calculate the range and depth of the lost target, and obtained the range and depth estimates. Thus, the 3D position of the lost underwater target is jointly estimated. This method alleviates the angle ambiguity problem and does not require a computationally intensive 2D spectral search. The simulation results show that the proposed method can better realise underwater three-dimensional positioning under certain signal-to-noise ratio conditions. When there is no error in the sensor coordinates, the positioning error is smaller than that of the baseline method as the SNR increases. When the SNR is 0 dB, with the increase in the sensor coordinate error, the target location error increases but is smaller than the error amplitude of the benchmark Algorithm. The experimental results verify the robustness of the proposed framework in the hierarchical ocean environment, which provides a practical basis for the deployment of rapid response underwater positioning systems in maritime search and rescue scenarios. Full article
(This article belongs to the Special Issue Sensor Fusion in Positioning and Navigation)
15 pages, 3678 KiB  
Article
Virtual Signal Processing-Based Integrated Multi-User Detection
by Dabao Wang and Zhao Li
Sensors 2025, 25(15), 4761; https://doi.org/10.3390/s25154761 (registering DOI) - 1 Aug 2025
Abstract
The demand for high data rates and large system capacity has posed significant challenges for medium access control (MAC) methods. Successive interference cancellation (SIC) is a classical multi-user detection (MUD) method; however, it suffers from an error propagation problem. To address this deficiency, [...] Read more.
The demand for high data rates and large system capacity has posed significant challenges for medium access control (MAC) methods. Successive interference cancellation (SIC) is a classical multi-user detection (MUD) method; however, it suffers from an error propagation problem. To address this deficiency, we propose a method called Virtual Signal Processing-Based Integrated Multi-User Detection (VSP-IMUD). In VSP-IMUD, the received mixed multi-user signals are treated as an equivalent signal. The channel ambiguity corresponding to each user’s signal is then examined. For channels with non-zero ambiguity values, the signal components are detected using zero-forcing (ZF) reception. Next, the detected ambiguous signal components are reconstructed and subtracted from the received mixed signal using SIC. Once all the ambiguous signals are detected, the remaining signal components with zero ambiguity values are equated to a virtual integrated signal, to which a matched filter (MF) is applied. Finally, by selecting the signal with the highest channel gain and adopting its data as the reference symbol, the remaining signals’ dataset can be determined. Our theoretical analysis and simulation results demonstrate that VSP-IMUD effectively reduces the frequency of SIC applications and mitigates its error propagation effects, thereby improving the system’s bit-error rate (BER) performance. Full article
(This article belongs to the Section Intelligent Sensors)
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26 pages, 3787 KiB  
Review
Insights to Resistive Pulse Sensing of Microparticle and Biological Cells on Microfluidic Chip
by Yiming Yao, Kai Zhao, Haoxin Jia, Zhengxing Wei, Yiyang Huo, Yi Zhang and Kaihuan Zhang
Biosensors 2025, 15(8), 496; https://doi.org/10.3390/bios15080496 (registering DOI) - 1 Aug 2025
Abstract
Since the initial use of biological ion channels to detect single-stranded genomic base pair differences, label-free and highly sensitive resistive pulse sensing (RPS) with nanopores has made remarkable progress in single-molecule analysis. By monitoring transient ionic current disruptions caused by molecules translocating through [...] Read more.
Since the initial use of biological ion channels to detect single-stranded genomic base pair differences, label-free and highly sensitive resistive pulse sensing (RPS) with nanopores has made remarkable progress in single-molecule analysis. By monitoring transient ionic current disruptions caused by molecules translocating through a nanopore, this technology offers detailed insights into the structure, charge, and dynamics of the analytes. In this work, the RPS platforms based on biological, solid-state, and other sensing pores, detailing their latest research progress and applications, are reviewed. Their core capability is the high-precision characterization of tiny particles, ions, and nucleotides, which are widely used in biomedicine, clinical diagnosis, and environmental monitoring. However, current RPS methods involve bottlenecks, including limited sensitivity (weak signals from sub-nanometer targets with low SNR), complex sample interference (high false positives from ionic strength, etc.), and field consistency (solid-state channel drift, short-lived bio-pores failing POCT needs). To overcome this, bio-solid-state fusion channels, in-well reactors, deep learning models, and transfer learning provide various options. Evolving into an intelligent sensing ecosystem, RPS is expected to become a universal platform linking basic research, precision medicine, and on-site rapid detection. Full article
(This article belongs to the Special Issue Advanced Microfluidic Devices and Lab-on-Chip (Bio)sensors)
13 pages, 1217 KiB  
Article
Optimization Scheme for Modulation of Data Transmission Module in Endoscopic Capsule
by Meiyuan Miao, Chen Ye, Zhiping Xu, Laiding Zhao and Jiafeng Yao
Sensors 2025, 25(15), 4738; https://doi.org/10.3390/s25154738 (registering DOI) - 31 Jul 2025
Abstract
The endoscopic capsule is a miniaturized device used for medical diagnosis, which is less invasive compared to traditional gastrointestinal endoscopy and can reduce patient discomfort. However, it faces challenges in communication transmission, such as high power consumption, serious signal interference, and low data [...] Read more.
The endoscopic capsule is a miniaturized device used for medical diagnosis, which is less invasive compared to traditional gastrointestinal endoscopy and can reduce patient discomfort. However, it faces challenges in communication transmission, such as high power consumption, serious signal interference, and low data transmission rate. To address these issues, this paper proposes an optimized modulation scheme that is low-cost, low-power, and robust in harsh environments, aiming to improve its transmission rate. The scheme is analyzed in terms of the in-body channel. The analysis and discussion for the scheme in wireless body area networks (WBANs) are divided into three aspects: bit error rate (BER) performance, energy efficiency (EE), and spectrum efficiency (SE), and complexity. These correspond to the following issues: transmission rate, communication quality, and low power consumption. The results demonstrate that the optimized scheme is more suitable for improving the communication performance of endoscopic capsules. Full article
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28 pages, 4107 KiB  
Article
Channel Model for Estimating Received Power Variations at a Mobile Terminal in a Cellular Network
by Kevin Verdezoto Moreno, Pablo Lupera-Morillo, Roberto Chiguano, Robin Álvarez, Ricardo Llugsi and Gabriel Palma
Electronics 2025, 14(15), 3077; https://doi.org/10.3390/electronics14153077 (registering DOI) - 31 Jul 2025
Abstract
This paper introduces a theoretical large-scale radio channel model for the downlink in cellular systems, aimed at estimating variations in received signal power at the user terminal as a function of device mobility. This enables applications such as direction-of-arrival (DoA) estimation, estimating power [...] Read more.
This paper introduces a theoretical large-scale radio channel model for the downlink in cellular systems, aimed at estimating variations in received signal power at the user terminal as a function of device mobility. This enables applications such as direction-of-arrival (DoA) estimation, estimating power at subsequent points based on received power, and detection of coverage anomalies. The model is validated using real-world measurements from urban and suburban environments, achieving a maximum estimation error of 7.6%. In contrast to conventional models like Okumura–Hata, COST-231, Third Generation Partnership Project (3GPP) stochastic models, or ray-tracing techniques, which estimate average power under static conditions, the proposed model captures power fluctuations induced by terminal movement, a factor often neglected. Although advanced techniques such as wave-domain processing with intelligent metasurfaces can also estimate DoA, this model provides a simpler, geometry-driven approach based on empirical traces. While it does not incorporate infrastructure-specific characteristics or inter-cell interference, it remains a practical solution for scenarios with limited information or computational resources. Full article
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24 pages, 4753 KiB  
Article
A Secure Satellite Transmission Technique via Directional Variable Polarization Modulation with MP-WFRFT
by Zhiyu Hao, Zukun Lu, Xiangjun Li, Xiaoyu Zhao, Zongnan Li and Xiaohui Liu
Aerospace 2025, 12(8), 690; https://doi.org/10.3390/aerospace12080690 (registering DOI) - 31 Jul 2025
Abstract
Satellite communications are pivotal to global Internet access, connectivity, and the advancement of information warfare. Despite these importance, the open nature of satellite channels makes them vulnerable to eavesdropping, making the enhancement of interception resistance in satellite communications a critical issue in both [...] Read more.
Satellite communications are pivotal to global Internet access, connectivity, and the advancement of information warfare. Despite these importance, the open nature of satellite channels makes them vulnerable to eavesdropping, making the enhancement of interception resistance in satellite communications a critical issue in both academic and industrial circles. Within the realm of satellite communications, polarization modulation and quadrature techniques are essential for information transmission and interference suppression. To boost electromagnetic countermeasures in complex battlefield scenarios, this paper integrates multi-parameter weighted-type fractional Fourier transform (MP-WFRFT) with directional modulation (DM) algorithms, building upon polarization techniques. Initially, the operational mechanisms of the polarization-amplitude-phase modulation (PAPM), MP-WFRFT, and DM algorithms are elucidated. Secondly, it introduces a novel variable polarization-amplitude-phase modulation (VPAPM) scheme that integrates variable polarization with amplitude-phase modulation. Subsequently, leveraging the VPAPM modulation scheme, an exploration of the anti-interception capabilities of MP-WFRFT through parameter adjustment is presented. Rooted in an in-depth analysis of simulation data, the anti-scanning capabilities of MP-WFRFT are assessed in terms of scale vectors in the horizontal and vertical direction. Finally, exploiting the potential of the robust anti-scanning capabilities of MP-WFRFT and the directional property of antenna arrays in DM, the paper proposes a secure transmission technique employing directional variable polarization modulation with MP-WFRFT. The performance simulation analysis demonstrates that the integration of MP-WFRFT and DM significantly outperforms individual secure transmission methods, improving anti-interception performance by at least an order of magnitude at signal-to-noise ratios above 10 dB. Consequently, this approach exhibits considerable potential and engineering significance for its application within satellite communication systems. Full article
(This article belongs to the Section Astronautics & Space Science)
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31 pages, 18320 KiB  
Article
Penetrating Radar on Unmanned Aerial Vehicle for the Inspection of Civilian Infrastructure: System Design, Modeling, and Analysis
by Jorge Luis Alva Alarcon, Yan Rockee Zhang, Hernan Suarez, Anas Amaireh and Kegan Reynolds
Aerospace 2025, 12(8), 686; https://doi.org/10.3390/aerospace12080686 (registering DOI) - 31 Jul 2025
Viewed by 34
Abstract
The increasing demand for noninvasive inspection (NII) of complex civil infrastructures requires overcoming the limitations of traditional ground-penetrating radar (GPR) systems in addressing diverse and large-scale applications. The solution proposed in this study focuses on an initial design that integrates a low-SWaP (Size, [...] Read more.
The increasing demand for noninvasive inspection (NII) of complex civil infrastructures requires overcoming the limitations of traditional ground-penetrating radar (GPR) systems in addressing diverse and large-scale applications. The solution proposed in this study focuses on an initial design that integrates a low-SWaP (Size, Weight, and Power) ultra-wideband (UWB) impulse radar with realistic electromagnetic modeling for deployment on unmanned aerial vehicles (UAVs). The system incorporates ultra-realistic antenna and propagation models, utilizing Finite Difference Time Domain (FDTD) solvers and multilayered media, to replicate realistic airborne sensing geometries. Verification and calibration are performed by comparing simulation outputs with laboratory measurements using varied material samples and target models. Custom signal processing algorithms are developed to extract meaningful features from complex electromagnetic environments and support anomaly detection. Additionally, machine learning (ML) techniques are trained on synthetic data to automate the identification of structural characteristics. The results demonstrate accurate agreement between simulations and measurements, as well as the potential for deploying this design in flight tests within realistic environments featuring complex electromagnetic interference. Full article
(This article belongs to the Section Aeronautics)
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22 pages, 5254 KiB  
Article
Exploring Simulation Methods to Counter Cyber-Attacks on the Steering Systems of the Maritime Autonomous Surface Ship (MASS)
by Igor Astrov, Sanja Bauk and Pentti Kujala
J. Mar. Sci. Eng. 2025, 13(8), 1470; https://doi.org/10.3390/jmse13081470 - 31 Jul 2025
Viewed by 57
Abstract
This paper presents a simulation-based investigation into control strategies for mitigating the consequences of cyber-assault on the steering systems of the Maritime Autonomous Surface Ships (MASS). The study focuses on two simulation experiments conducted within the Simulink/MATLAB environment, utilizing the catamaran “Nymo” MASS [...] Read more.
This paper presents a simulation-based investigation into control strategies for mitigating the consequences of cyber-assault on the steering systems of the Maritime Autonomous Surface Ships (MASS). The study focuses on two simulation experiments conducted within the Simulink/MATLAB environment, utilizing the catamaran “Nymo” MASS mathematical model to represent vessel dynamics. Cyber-attacks are modeled as external disturbances affecting the rudder control signal, emulating realistic interference scenarios. To assess control resilience, two configurations are compared during a representative turning maneuver to a specified heading: (1) a Proportional–Integral–Derivative (PID) regulator augmented with a Least Mean Squares (LMS) adaptive filter, and (2) a Nonlinear Autoregressive Moving Average with Exogenous Input (NARMA-L2) neural network regulator. The PID and LMS configurations aim to enhance the disturbance rejection capabilities of the classical controller through adaptive filtering, while the NARMA-L2 approach represents a data-driven, nonlinear control alternative. Simulation results indicate that although the PID and LMS setups demonstrate improved performance over standalone PID in the presence of cyber-induced disturbances, the NARMA-L2 controller exhibits superior adaptability, accuracy, and robustness under adversarial conditions. These findings suggest that neural network-based control offers a promising pathway for developing cyber-resilient steering systems in autonomous maritime vessels. Full article
(This article belongs to the Special Issue Advanced Control Strategies for Autonomous Maritime Systems)
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22 pages, 2437 KiB  
Article
Anomaly Detection of Acoustic Signals in Ultra-High Voltage Converter Valves Based on the FAVAE-AS
by Shuyan Pan, Mingzhu Tang, Na Li, Jiawen Zuo and Xingpeng Zhou
Sensors 2025, 25(15), 4716; https://doi.org/10.3390/s25154716 (registering DOI) - 31 Jul 2025
Viewed by 72
Abstract
The converter valve is the core component of the ultra-high voltage direct current (UHVDC) transmission system, and its fault detection is very important to ensure the safe and stable operation of the transmission system. However, the voiceprint signals collected by converter stations under [...] Read more.
The converter valve is the core component of the ultra-high voltage direct current (UHVDC) transmission system, and its fault detection is very important to ensure the safe and stable operation of the transmission system. However, the voiceprint signals collected by converter stations under complex operating conditions are often affected by background noise, spikes, and nonlinear interference. Traditional methods make it difficult to achieve high-precision detection due to the lack of feature extraction ability and poor noise robustness. This paper proposes a fault-aware variational self-encoder model (FAVAE-AS) based on a weak correlation between attention and self-supervised learning. It extracts probability features via a conditional variational autoencoder, strengthens feature representation using multi-layer convolution and residual connections, and introduces a weak correlation attention mechanism to capture global time point relationships. A self-supervised learning module with six signal transformations improves generalization, while KL divergence-based correlation inconsistency quantization with dynamic thresholds enables accurate anomaly detection. Experiments show that FAVAE-AS achieves 0.925 accuracy in fault detection, which is 5% higher than previous methods, and has strong robustness. This research provides critical technical support for UHVDC system safety by addressing converter valve acoustic anomaly detection. It proposes an extensible framework for industrial intelligent maintenance. Full article
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22 pages, 20436 KiB  
Article
An Adaptive Decomposition Method with Low Parameter Sensitivity for Non-Stationary Noise Suppression in Magnetotelluric Data
by Zhenyu Guo, Cheng Huang, Wen Jiang, Tao Hong and Jiangtao Han
Minerals 2025, 15(8), 808; https://doi.org/10.3390/min15080808 - 30 Jul 2025
Viewed by 79
Abstract
Magnetotelluric (MT) sounding is a crucial technique in mineral exploration. However, MT data are highly susceptible to various types of noise. Traditional data processing methods, which rely on the assumption of signal stationarity, often result in severe distortion when suppressing non-stationary noise. In [...] Read more.
Magnetotelluric (MT) sounding is a crucial technique in mineral exploration. However, MT data are highly susceptible to various types of noise. Traditional data processing methods, which rely on the assumption of signal stationarity, often result in severe distortion when suppressing non-stationary noise. In this study, we propose a novel, adaptive, and less parameter-dependent signal decomposition method for MT signal denoising, based on time–frequency domain analysis and the application of modal decomposition. The method uses Variational Mode Decomposition (VMD) to adaptively decompose the MT signal into several intrinsic mode functions (IMFs), obtaining the instantaneous time–frequency energy distribution of the signal. Subsequently, robust statistical methods are introduced to extract the independent components of each IMF, thereby identifying signal and noise components within the decomposition results. Synthetic data experiments show that our method accurately separates high-amplitude non-stationary interference. Furthermore, it maintains stable decomposition results under various parameter settings, exhibiting strong robustness and low parameter dependency. When applied to field MT data, the method effectively filters out non-stationary noise, leading to significant improvements in both apparent resistivity and phase curves, indicating its practical value in mineral exploration. Full article
(This article belongs to the Special Issue Novel Methods and Applications for Mineral Exploration, Volume III)
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24 pages, 3953 KiB  
Article
A New Signal Separation and Sampling Duration Estimation Method for ISRJ Based on FRFT and Hybrid Modality Fusion Network
by Siyu Wang, Chang Zhu, Zhiyong Song, Zhanling Wang and Fulai Wang
Remote Sens. 2025, 17(15), 2648; https://doi.org/10.3390/rs17152648 - 30 Jul 2025
Viewed by 159
Abstract
Accurate estimation of Interrupted Sampling Repeater Jamming (ISRJ) sampling duration is essential for effective radar anti-jamming. However, in complex electromagnetic environments, the simultaneous presence of suppressive and deceptive jamming, coupled with significant signal overlap in the time–frequency domain, renders ISRJ separation and parameter [...] Read more.
Accurate estimation of Interrupted Sampling Repeater Jamming (ISRJ) sampling duration is essential for effective radar anti-jamming. However, in complex electromagnetic environments, the simultaneous presence of suppressive and deceptive jamming, coupled with significant signal overlap in the time–frequency domain, renders ISRJ separation and parameter estimation considerably challenging. To address this challenge, this paper proposes a method utilizing the Fractional Fourier Transform (FRFT) and a Hybrid Modality Fusion Network (HMFN) for ISRJ signal separation and sampling-duration estimation. The proposed method first employs FRFT and a time–frequency mask to separate the ISRJ and target echo from the mixed signal. This process effectively suppresses interference and extracts the ISRJ signal. Subsequently, an HMFN is employed for high-precision estimation of the ISRJ sampling duration, offering crucial parameter support for active electromagnetic countermeasures. Simulation results validate the performance of the proposed method. Specifically, even under strong interference conditions with a Signal-to-Jamming Ratio (SJR) of −5 dB for deceptive jamming and as low as −10 dB for suppressive jamming, the regression model’s coefficient of determination still reaches 0.91. This result clearly demonstrates the method’s robustness and effectiveness in complex electromagnetic environments. Full article
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31 pages, 17812 KiB  
Article
Deep Learning-Based Source Localization with Interference Striation of a Towed Horizontal Line Array
by Zhengchao Huang, Yanfa Deng, Peng Qian, Zhenglin Li and Peng Xiao
Electronics 2025, 14(15), 3053; https://doi.org/10.3390/electronics14153053 - 30 Jul 2025
Viewed by 113
Abstract
The aperture of the towed horizontal line array is limited and the received signal is unstable in a complex ocean environment, making it difficult to distinguish the location of the sound source. To address this challenge, this paper presents a MoELocNet (Mixture of [...] Read more.
The aperture of the towed horizontal line array is limited and the received signal is unstable in a complex ocean environment, making it difficult to distinguish the location of the sound source. To address this challenge, this paper presents a MoELocNet (Mixture of Experts Localization Network) for deep-sea sound source localization, leveraging interference structures in range-frequency domain signals from a towed horizontal line array. Unlike traditional correlation-based methods constrained by time-varying ocean environments and low signal-to-noise ratios, the model employs multi-expert and multi-task learning to extract interference periods from single-frame data, enabling robust estimation of source range and depth. Simulation results demonstrate its superior performance in the deep-sea shadow zone, achieving a range localization error of 0.029 km and a depth error of 0.072 m. The method exhibits strong noise robustness and delivers satisfactory results across diverse deep-sea zones, with optimal performance in shadow zones and secondary effectiveness in the direct arrival zone. Full article
(This article belongs to the Special Issue Low-Frequency Underwater Acoustic Signal Processing and Applications)
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14 pages, 1161 KiB  
Article
Multipath Interference Impact Due to Fiber Mode Coupling in C+L+S Multiband Transmission Reach
by Luís Cancela and João Pires
Photonics 2025, 12(8), 770; https://doi.org/10.3390/photonics12080770 - 30 Jul 2025
Viewed by 75
Abstract
Multiband transmission is, nowadays, being implemented worldwide to increase the optical transport network capacity, mainly because it uses the already-installed single-mode fiber (SMF). The G.654E SMF, due to its attributes (e.g., low-loss, and large-effective area in comparison with the standard G.652 SMF), can [...] Read more.
Multiband transmission is, nowadays, being implemented worldwide to increase the optical transport network capacity, mainly because it uses the already-installed single-mode fiber (SMF). The G.654E SMF, due to its attributes (e.g., low-loss, and large-effective area in comparison with the standard G.652 SMF), can also increase network capacity and can also be used for multiband (MB) transmission. Nevertheless, in MB transmission, power mode coupling arises when bands with wavelengths below the cut-off wavelength are used, inducing multipath interference (MPI). This work investigates the impact of the MPI, due to mode coupling from G.654E SMF, in the transmission reach of a C+L+S band transmission system. Our results indicate that for the S-band scenario, the band below the wavelength cut-off, an approximately 25% reach decrease is observed when the MPI/span increases to −26 dB/span, considering quadrature phase-shift keying (QPSK) signals with a 64 GBaud symbol rate. We also concluded that if the L-band were not above the wavelength cut-off, it would be much more affected than the S-band, with an approximately 52% reach decrease due to MPI impact. Full article
(This article belongs to the Section Optical Communication and Network)
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16 pages, 2701 KiB  
Article
The Lysine at Position 177 Is Essential to Limit the Inhibitory Capacities of Sprouty4 Protein in Normal and Cancer-Derived Cells
by Maximilian Schiwek, Kathrin Ruhdorfer, Christoph Pfurner and Hedwig Sutterlüty
Int. J. Mol. Sci. 2025, 26(15), 7353; https://doi.org/10.3390/ijms26157353 - 30 Jul 2025
Viewed by 171
Abstract
The Sprouty (Spry) proteins modulate signalling and regulate processes like cellular migration and proliferation. Here, we investigated a Spry4 alteration substituting a lysine at position 177 to an arginine, based on a mutation found in Kallmann syndrome, a genetically heterogeneous disease connected to [...] Read more.
The Sprouty (Spry) proteins modulate signalling and regulate processes like cellular migration and proliferation. Here, we investigated a Spry4 alteration substituting a lysine at position 177 to an arginine, based on a mutation found in Kallmann syndrome, a genetically heterogeneous disease connected to reduced fibroblast growth factor receptor1 (FGFR) signalling. Using growth curves to evaluate proliferative and scratch assays to determine migrative capacities of the cells, in normal fibroblasts as well as in osteosarcoma-derived cells, we demonstrate that the modified Spry4K177R version hinders both processes, which the unaltered protein cannot do under the same conditions. The inhibition of these processes was accompanied by lower relative phospho-extracellular-signal-regulated kinases (pERK) levels in response to serum induction, indicating that activation of MAPK was less efficient. In contrast to the situation in these cells of mesenchymal origin, in lung cancer-derived cell lines both variants of Spry4 were able to interfere with proliferation of tested cells, and in the cells with elevated FGFR1 expression the Spry4 proteins with an alteration at codon 177 were even more effective. In summary, these data indicate that the lysine at position 177 restricts the ability of Spry4 to inhibit signal transduction at least in cells with high FGFR1 levels. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Sprouty Proteins in Cancer)
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27 pages, 12922 KiB  
Article
A Nasal Resistance Measurement System Based on Multi-Sensor Fusion of Pressure and Flow
by Xiaoqin Lian, Guochun Ma, Chao Gao, Chunquan Liu, Yelan Wu and Wenyang Guan
Micromachines 2025, 16(8), 886; https://doi.org/10.3390/mi16080886 - 29 Jul 2025
Viewed by 102
Abstract
Nasal obstruction is a common symptom of nasal conditions, with nasal resistance being a crucial physiological indicator for assessing severity. However, traditional rhinomanometry faces challenges with interference, limited automation, and unstable measurement results. To address these issues, this research designed a nasal resistance [...] Read more.
Nasal obstruction is a common symptom of nasal conditions, with nasal resistance being a crucial physiological indicator for assessing severity. However, traditional rhinomanometry faces challenges with interference, limited automation, and unstable measurement results. To address these issues, this research designed a nasal resistance measurement system based on multi-sensor fusion of pressure and flow. The system comprises lower computer hardware for acquiring raw pressure–flow signals in the nasal cavity and upper computer software for segmenting and filtering effective respiratory cycles and calculating various nasal resistance indicators. Meanwhile, the system’s anti-interference capability was assessed using recall, precision, and accuracy rates for respiratory cycle recognition, while stability was evaluated by analyzing the standard deviation of nasal resistance indicators. The experimental results demonstrate that the system achieves recall and precision rates of 99% and 86%, respectively, for the recognition of effective respiratory cycles. Additionally, under the three common interference scenarios of saturated or weak breaths, breaths when not worn properly, and multiple breaths, the system can achieve a maximum accuracy of 96.30% in identifying ineffective respiratory cycles. Furthermore, compared to the measurement without filtering for effective respiratory cycles, the system reduces the median within-group standard deviation across four types of nasal resistance measurements by 5 to 18 times. In conclusion, the nasal resistance measurement system developed in this research demonstrates strong anti-interference capabilities, significantly enhances the automation of the measurement process and the stability of the measurement results, and offers robust technical support for the auxiliary diagnosis of related nasal conditions. Full article
(This article belongs to the Section B:Biology and Biomedicine)
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