Search Results (178)

With the rising performance demands in road engineering, traditional experiments often fail to reveal the microscopic mechanisms behind asphalt behavior. Molecular dynamics (MD) simulation has emerged as a valuable complement, enabling molecular-level insights into asphalt’s composition, structure, and aging mechanisms. This review summarizes the recent advances in applying MD to asphalt research. It first outlines molecular model construction approaches, including average models, three- and four-component systems, and modified models incorporating SBS, SBR, PU, PE, and asphalt–aggregate interfaces. It then analyzes how MD reveals the key performance aspects—such as high-temperature stability, low-temperature flexibility, self-healing behavior, aging processes, and interfacial adhesion—by capturing the molecular interactions. While MD offers significant advantages, challenges remain: idealized modeling, high computational demands, limited chemical reaction simulation, and difficulties in multi-scale coupling. This paper aims to provide theoretical insights and methodological support for future studies on asphalt performance and highlights MD simulation as a promising tool in pavement material science. Full article

Asphalt pavement cracking is an important factor affecting its service life. Under certain conditions, the self-healing behavior of asphalt itself can repair pavement cracks. However, the self-healing ability of asphalt itself is limited. In order to strengthen the self-healing ability of asphalt, the microcapsule wrapped with a repair agent is pre-mixed into the asphalt mixture. When the crack occurs and spreads to the surface of the microcapsule, the microcapsule ruptures and the healing agent flows out to realize the self-healing of the crack. Current microcapsules are mostly prepared with healing agents and bio-oil as core materials, and their high-temperature resistance to rutting is poor. While the epoxy resin contains a three-membered cyclic ether, it can undergo ring-opening polymerization to bond and repair the asphalt matrix. In addition, research on microcapsules mainly focuses on the self-healing properties of microcapsule-modified asphalt. In fact, before adding microcapsules to asphalt to improve its self-healing performance, it is necessary to ensure that the asphalt has a good road performance. On this basis, the self-healing performance of asphalt is improved, thereby extending the service life of asphalt pavement. Therefore, two-component epoxy self-healing microcapsules (E-mic and G-mic) were first prepared in this paper. Then, a temperature scanning test, rheological test of bending beams, and linear amplitude scanning test were, respectively, conducted for the microcapsule/asphalt to evaluate its road performance, including the high-temperature performance, low-temperature crack resistance, and fatigue performance. Finally, the self-healing performance of microcapsules/asphalt was tested. The results showed that the self-developed epoxy self-healing microcapsules were well encapsulated and presented as spherical micron-sized particles. The average particle size of the E-mic was approximately 23.582 μm, while the average particle size of the G-mic was approximately 22.440 μm, exhibiting a good normal distribution. In addition, they can remain intact and unbroken under high-temperature conditions. The results of road performance tests indicated that the microcapsule/asphalt mixture exhibits an excellent high-temperature resistance to permanent deformation, low-temperature crack resistance, and fatigue resistance. The self-healing test demonstrated that the microcapsule/asphalt exhibited an excellent self-healing performance. When the microcapsule content was 4%, the self-healing rate reached its optimal level of 67.8%, which was 149.2% higher than that of the base asphalt. Full article

The rapid growth in large-scale distributed video conferencing, remote education, and real-time broadcasting poses significant challenges to traditional centralized streaming systems, particularly regarding scalability, cost, and reliability under high concurrency. Centralized approaches often encounter bottlenecks, increased bandwidth expenses, and diminished fault tolerance. This paper proposes a novel decentralized real-time broadcasting system employing a peer-to-peer (P2P) chain topology based on IPv6 networking and the Secure Reliable Transport (SRT) protocol. By exploiting the global addressing capability of IPv6, our solution simplifies direct node interconnections, effectively eliminating complexities associated with Network Address Translation (NAT). Furthermore, we introduce an innovative chain-relay transmission method combined with distributed node management strategies, substantially reducing reliance on central servers and minimizing deployment complexity. Leveraging SRT’s low-latency UDP transmission, packet retransmission, congestion control, and AES-128/256 encryption, the proposed system ensures robust security and high video stream quality across wide-area networks. Additionally, a WebSocket-based real-time fault detection algorithm coupled with a rapid fallback self-healing mechanism is developed, enabling millisecond-level fault detection and swift restoration of disrupted links. Extensive performance evaluations using Video Multi-Resolution Fidelity (VMRF) metrics across geographically diverse and heterogeneous environments confirm significant performance gains. Specifically, our approach achieves substantial improvements in latency, video quality stability, and fault tolerance over existing P2P methods, along with over tenfold enhancements in frame rates compared with conventional RTMP-based solutions, thereby demonstrating its efficacy, scalability, and cost-effectiveness for real-time video streaming applications. Full article

SLE is characterized by the generation of a variety of autoantibodies including anti-dsDNA autoantibodies, causing damage in various organs. If autoimmunity is defined by the generation of a variety of autoantibodies against the self, SLE is the only disease to qualify. Identification of the SLE-causing factor must fulfill the following criteria: (i) the factor induces SLE, (ii) the factor is operating in active SLE and (iii) SLE heals after removal of the factor. All candidate factors are reviewed from this viewpoint in this review. As to the cause of SLE, high levels of interferon α can induce SLE; however, interferon α in most patients did not reach this high level. BAFF (B cell activating factor of the TNF family) is increased in SLE. BAFF itself induced some manifestation of SLE, whereas removal of interferon α or BAFF by an antibody (Ab) did not heal SLE. BXSB male mice with a duplicated TLR7 gene develop SLE; however, the gene Sle1 is also required for the development of SLE. In addition, sanroque mice develop a variety of autoantibodies and SLE; the sanroque mutation, which disrupts one of the repressors of ICOS, results in increased CCR7^lo CXCR5⁺Tfh cells, IL-21 and SLE. ICOS⁺T follicular helper (Tfh) cells increase in SLE and SLE-model (NZBxNZW)F1 mice, and the blockade of Tfh development ameliorated SLE, indicating the importance of Tfh cells in the pathogenesis of SLE. Self-organized criticality theory shows that SLE is caused by repeated infection, wherein SLE-inducing pathogens can vary individually depending on one’s HLA; however, the pathogen presented on HLA stimulates the T cell receptor (TCR) strongly beyond self-organized criticality. This stimulation generates TCR-revised, autoreactive DOCK8⁺Tfh cells, which induced a variety of autoantibodies and SLE. The SARS-CoV-2 virus is an example pathogen because SLE occurs after SARS-CoV-2 infection and vaccination. DOCK8⁺Tfh cells and SLE decreased after conventional or anti-DOCK Ab therapies. Thus, DOCK8⁺Tfh cells newly generated after repeated infection fulfill the criteria (i), (ii) and (iii) as the cause of SLE. Full article

To address the challenges of prolonged current isolation times and high dependency on varistors in traditional flexible short-circuit fault isolation schemes for DC systems, this paper proposes a rapid fault isolation circuit design based on an adaptive solid-state circuit breaker (SSCB). By introducing an adaptive current-limiting branch topology, the proposed solution reduces the risk of system oscillations induced by current-limiting inductors during normal operation and minimizes steady-state losses in the breaker. Upon fault occurrence, the current-limiting inductor is automatically activated to effectively suppress the transient current rise rate. An energy dissipation circuit (EDC) featuring a resistor as the primary energy absorber and an auxiliary varistor (MOV) for voltage clamping, alongside a snubber circuit, provides an independent path for inductor energy release after faults. This design significantly alleviates the impact of MOV capacity constraints on the fault isolation process compared to traditional schemes where the MOV is the primary energy sink. The proposed topology employs a symmetrical bridge structure compatible with both pole-to-pole and pole-to-ground fault scenarios. Parameter optimization ensures the IGBT voltage withstand capability and energy dissipation efficiency. Simulation and experimental results demonstrate that this scheme achieves fault isolation within 0.1 ms, reduces the maximum fault current-to-rated current ratio to 5.8, and exhibits significantly shorter isolation times compared to conventional approaches. This provides an effective solution for segment switches and tie switches in millisecond-level self-healing systems for both low-voltage (LVDC, e.g., 750 V/1500 V DC) and medium-voltage (MVDC, e.g., 10–35 kV DC) smart DC distribution grids, particularly in applications demanding ultra-fast fault isolation such as data centers, electric vehicle (EV) fast-charging parks, and shipboard power systems. Full article

When individuals transition from homelessness into housing, their new home should serve as a place of healing and dignity. This paper presents empirical evidence on the impact of trauma-informed design (TID), an approach to designing affordable housing that supports the health and well-being of people with lived experience of homelessness. The study used a mixed-methods, quasi-experimental design across five permanent supportive housing (PSH) sites—three with TID features and two without. Residents completed surveys at two timepoints, and both the residents and the staff participated in semi-structured interviews. The quantitative results revealed a complex pattern: while some aspects of relationships and self-awareness improved at TID sites, measures of psychological safety and compassion declined. Additionally, conflict, psychological aggression, physical aggression, and mild violence increased over the same period. Qualitative findings highlight that safety is a nuanced, context-dependent experience that exists along a spectrum. The residents at the TID sites described opportunities to experience higher levels of safety. Together, the quantitative and qualitative data paint a complex picture of life in PSH. A key finding is that safety, conflict, and relationships are interwoven, evolving over time as the residents adapt to their environment. Full article

To improve the consumption rate of distributed energy and enhance the self-healing performance of distribution networks, this paper proposes a distribution network optimization method considering carbon emissions and dynamic reconfiguration. Firstly, various measures such as dynamic reconfiguration and distributed energy scheduling are used in upper-level optimization to reduce the network loss and solar curtailment cost of the system and to realize the optimal economic operation of the distribution network. Secondly, based on carbon emission flow theory in lower-level optimization, a low-carbon demand response model with a dynamic carbon emission factor as the guiding signal is established to promote carbon emission reduction on the user side. Then, the second-order cone planning and improved dung beetle optimization algorithm are used to solve the model. Finally, it is verified on the test system that the method can effectively reduce the risk of voltage overruns and enhance the low-carbonization and economy of distribution network operation. Full article

Nanofibers have emerged as transformative materials in the field of energy storage, offering unique physicochemical properties such as high surface area, porosity, and tunable morphology. Recent advancements have also introduced genetically modified fibers—engineered at the biological level to produce functionalized nanostructures with customizable properties. These bioengineered nanofibers add a sustainable and potentially self-healing component to energy storage materials. This paper reviews key applications of conventional and genetically modified nanofibers in lithium-ion and sodium-ion batteries, supercapacitors, hybrid systems, and flexible energy storage with a focus on how genetic and molecular engineering of fibrous materials enables new capabilities in ion transport, electrode architecture, and device longevity. Together, these advances contribute to the development of next-generation energy storage systems with enhanced performance, biocompatibility, and sustainability. This review therefore critically examines the current state, advantages, and limitations of both synthetic and biopolymer-based materials in energy storage applications. It discusses recent technological innovations, such as polymer–nanoparticle composites, functionalized polymer matrices, and next-generation polymer electrolytes. Future research should prioritize enhancing conductivity, improving scalability, and reducing environmental impact, ensuring that polymer-based materials contribute to the development of more efficient and sustainable energy storage technologies. Full article

In the face of the growing challenges of the Anthropocene—marked by climate change, biodiversity loss, and increasing rates of disease and despair—this paper explores the need for holistic solutions that integrate cultural and spiritual transformation as essential dimensions of change. Recognizing that the interconnected challenges to planetary health stem from destructive socio-political agendas and unhealthy economic structures, we underscore the importance of worldviews and value systems as root causes of social and ecological injustices. Solutions require an understanding of the complex interdependence of systems, fostering mutualistic mindsets, and healing the ‘relationship crisis’ between humans and the natural world by cultivating a deeper level of consciousness. In response to these urgent needs, we describe Earthrise—a community of engaged contemplative practice led by the Nova Institute for Health in collaboration with the Planetary Health Alliance—dedicated to spiritual and cultural transformation in the face of today’s complex crises. Through intentional spiritual relationships—with ourselves, each other, and the natural world—our community emphasizes the power of narrative co-creation in building social cohesion and collective action for environmental stewardship. Our work is not solely contemplative, but also relational and integrative—embodying values through lived practice, community, and ecological engagement. Our activities focus on developing cultural capacities and self-awareness as essential foundations for fair and sustainable social transformation. By integrating diverse perspectives, including ancestral wisdom and Indigenous knowledge systems, we enrich worldviews and deepen our connection to the planet. The Earthrise community seeks to cultivate a sense of belonging, nurturing the meaningful relationships that foster compassion and care. Central to our approach is the use of creative emergence, leveraging the arts to inspire change and catalyze new paradigms. Through this exploration of interconnected themes, we contend that spiritual and cultural transformation is vital to advancing a thriving future, where human flourishing and planetary health are understood as inseparable and interconnected goals. Full article

Fatigue is a common consequence of traumatic brain injury, neurological diseases or developmental disorders, and systemic inflammatory diseases, including autoimmune conditions that affect the brain. This condition is characterized by reduced endurance for cognitive tasks, diminished quality of life, and impaired work capacity. In addition to cognitive difficulties, individuals often experience disproportionately long recovery times after demanding tasks, emotional instability, stress sensitivity, sensory sensitivity, impaired ability to initiate activities, and sleep disturbances. Tension headaches frequently occur when the brain is excessively activated by mental activity. In this paper, we propose the term “Brain Fatigue Syndrome” (BFS) as a collective name for the symptoms closely associated with this pathological fatigue resulting from brain impact. BFS can be identified through interviews and measured using the self-assessment instrument, the Mental Fatigue Scale (MFS). We suggest potential underlying mechanisms at the cellular level for the BFS symptom complex, including astrocyte dysfunction with impaired glutamate signaling and glucose uptake, mitochondrial dysfunction, blood–brain barrier dysfunction, and the activation of microglia and mast cells. In conclusion, BFS suggests a general brain impact. The symptoms associated with BFS typically resolve when the injury or disease heals. However, in some individuals, BFS persists even after the injury or illness has ostensibly healed. Full article

Carbon dioxide-based copolymers such as polypropylene carbonate (PPC) can offer the double environmental benefit of capturing CO₂ and replacing oil-based raw materials in the plastics industry with renewable ones. However, their production at an industrial level is still limited by the range of applications in which their physicochemical properties are competitive and ideally surpass those of fossil-based polymeric commodities. This work introduces PPC materials with high-stretch and self-healing properties that were prepared by copolymerization of CO₂ and propylene oxide using tailored Zn glutarate catalysts. The PPC materials were analyzed in terms of composition, molecular weight, thermal and mechanical behavior, particularly focusing on their tensile properties, strain recovery, creep response, and self-healing ability. All the prepared PPC materials showed good ductility and self-healing properties. The most promising ones achieved excellent and fast recovery of extremely high elongations (>700%), still reaching remarkable values (>600%) after proper self-healing. These high-stretch and self-healing PPC materials are completely amorphous, present good optical transparency, and can be processed using techniques normally used for other thermoplastics. Therefore, they are promising for a variety of applications, including shrink films and self-healing packaging, thus providing new, valuable perspectives for the industrialization of these CO₂-based polymers. Full article

It has been well known for the past decade that the accumulation of food E-preservatives in the human body has harmful consequences for human health. Furthermore, scientists have realized that despite the convenience offered by petrochemical-derived polymers, a circular economy and sustainability are two current necessities; thus, the use of biodegradable alternative materials is imposed. The food packaging sector is one of the most rapidly changing sectors in the world. In recent years, many studies have focused on the development of active packaging films to replace old non-ecofriendly techniques with novel environmentally friendly methods. In this study, a novel self-healable, biodegradable active packaging film was developed using poly(lactic acid) (PLA) as a biopolymer, which was incorporated with a nanohybrid solid material as a natural preservative. This nanohybrid was derived via the absorption of carvacrol (CV) essential oil in an activated carbon (AC) nanocarrier. A material with a high carvacrol load of 71.3%wt. into AC via a vacuum-assisted adsorption method, functioning as a natural antioxidant and an antibacterial agent. The CV@AC nanohybrid was successfully dispersed in a PLA/triethyl citrate (TEC) matrix via melt extrusion, and a final PLA/TEC/xCV@AC nanocomposite film was developed. The study concluded that x = 10%wt. CV@AC was the optimum nanohybrid amount incorporated in the self-healable PLA/TEC and exhibited 277% higher ultimate strength and 72% higher water barrier compared to the pure PLA/TEC. Moreover, it remained ductile enough to show the slowest CV release rate, highest antioxidant activity, and significant antibacterial activity against Staphylococcus aureus and Salmonella enterica ssp. enterica serovar Typhimurium. This film extended the shelf life of fresh minced pork by four days, according to total viable count measurements, and decreased its lipid oxidation rate. Finally, this novel film preserved the nutritional value of porkby maintaining a higher heme iron content and showed a higher level of sensory characteristics compared to commercial packaging paper. Full article

Leishmania is a protozoan parasite causing a spectrum of pathologies in humans grouped under the name leishmaniasis. Clinical outcomes range from the self-healing cutaneous form to the visceral one that is fatal in the absence of treatment. The leishmaniases are endemic in 98 countries in the tropics, subtropics, and Southern Europe, where 3 million new cases and more than 50,000 deaths are recorded yearly. Control of this disease is challenging as there is no approved vaccine coupled with toxic chemotherapeutics and the development of parasite resistance to some available drugs. It is, therefore, evident that the identification of new control methods, including new therapeutics, should be strongly encouraged. In the present study, thiol organic compounds were synthesized and tested for their activity against Leishmania major, the causative agent of human cutaneous leishmaniasis. Of the 21 compounds tested, 13 were active against L. major promastigotes in vitro at 100 μg/mL. Selected compounds tested in a dose-response assay showed activity at concentration as low as 25 μg/mL, a level of activity similar to that of Amphotericin B, a drug of choice for the treatment of human leishmaniasis. Structure–activity analysis shows that the addition of certain substituents, such as a methoxy group, to a compound that is biologically active renders it inactive. Together, our data demonstrate that functionalized thiols have an in vivo anti-Leishmania activity that is directly linked to their chemical structure. Full article

Background: The COVID-19 pandemic significantly increased public interest in e-health literacy, especially among university students. However, gaps remain in their ability to find and use credible online health information. Purpose: This study explores the effects of public health emergencies on e-health literacy among Chinese university students, aiming to identify influencing factors and propose solutions to improve digital health education. Methods: A structured survey using the eHEALS scale and additional questionnaires was administered to 300 students in Northern China. Statistical analysis was conducted using SPSS 25.0, focusing on literacy levels and their determinants. Results: The pandemic heightened interest in e-health, leading to modest improvements in literacy levels. However, challenges persist, including evaluating the credibility of information and addressing privacy concerns. Apps emerged as the most widely used e-health tools. Discussion: Findings highlight the importance of targeted health education programs to bridge gaps in e-health literacy and support students in effectively using digital health tools. The results emphasize integrating privacy safeguards and enhancing user trust in e-health systems. Conclusions: Enhancing e-health literacy can empower students to make informed health decisions, fostering better self-management and resilience during public health crises. Full article

The efficient management of IoT systems is fundamental to advancing smart cities while enabling the seamless integration of technologies that enhance urban sustainability and resilience. This paper introduces a Hierarchical Resource Management System (HRMS) tailored for IoT-enabled smart cities, emphasizing a decentralized architecture at the building level and scaling up to city-wide applications. At its core, the system integrates the Adaptive Resilient Node (ARN), designed to autonomously manage energy resources and ensure continuous operation through self-healing capabilities. This study outlines the HRMS architecture, operational workflows, and core functionalities, demonstrating how the hierarchical framework supports real-time decision-making, fault tolerance, and scalable resource allocation. The proposed system’s lightweight inter-node communication enhances workload balancing and system responsiveness, addressing critical challenges in urban energy management. Experimental evaluations show that the system achieves up to a 50% improvement in energy efficiency and a 30% reduction in downtime across various urban environments, highlighting its transformative potential for sustainable and resilient urban growth. Full article