Search Results (2,209)

The ultra-precision machining of micro-optics from low glass transition temperature (T_g) hydrophobic polymers is frequently compromised by thermal instability and kinematic constraints imposed by on-axis turning. To address these challenges, this study presents a novel clamping–cooling system engineered for the off-axis diamond turning of low-T_g polymers. The design integrates vacuum clamping for workpiece stabilization with an embedded microchannel network for efficient thermal management. Strategic material selection effectively balances thermal insulation with mechanical stability. Performance evaluations demonstrated robust thermal regulation: lens blank surface temperatures stabilized at 6 °C during stationary testing, and the system was able to drop below 0 °C under maximum cooling targets. This strict thermal control enabled achieving nanometer surface roughness. Ultimately, this modular system facilitates the scalable, simultaneous production of high-quality, polishing-free intraocular lenses (IOLs), advancing manufacturing capabilities for complex precision optics. Full article

Traditional cancer therapies such as surgery, chemotherapy, and antibody-based treatments often face significant barriers, including systemic toxicity, a lack of selectivity, and the emergence of drug resistance. These issues demand innovative and targeted solutions. Peptide-based therapeutics have gained prominence for their ability to disrupt cancer pathways and facilitate targeted drug delivery, offering structural flexibility, precise targeting, and low immunogenicity with minimal effects on healthy tissues. Concurrently, aptamers, which are structured nucleic acid molecules capable of high-affinity molecular recognition, are being developed as both direct therapeutic agents and as targeting ligands for the improved delivery of anticancer drugs. Combining peptide and aptamer technologies with engineered exosomes provides a modular drug delivery system that enhances targeting specificity, stability, and the ability to cross complex biological barriers such as the blood–brain barrier. The emergence of peptide-decorated, aptamer-decorated exosomes represents a new frontier in precision oncology, promising highly selective, biocompatible, and tunable cancer therapies. Further advances are required to overcome challenges in pharmacokinetics, scalable production, and regulatory compliance, but ongoing bioengineering and nanotechnology research continues to accelerate the translation of these innovative strategies toward improved cancer diagnostics and treatment outcomes. This review discusses the synergistic integration of peptides and aptamers with exosome-based delivery systems, highlighting their current applications and future possibilities. Full article

Robust vehicle detection in real-world traffic surveillance remains challenging due to degraded imagery caused by motion blur, adverse weather, and low illumination, which significantly increases detector sensitivity to hyperparameter configurations. This study proposes a “Frugal AI” distributed multi-GPU framework that optimizes hyperparameters via a stochastic simplex-based search coupled with five-fold cross-validation. Utilizing three low-cost NVIDIA GTX 1050 Ti GPUs, the framework performs parallel candidate exploration with an asynchronous model-level exchange mechanism to escape local optima without the overhead of gradient synchronization. Seven CNN backbones—VGG16, VGG19, GoogLeNet, MobileNetV2, ResNet18, ResNet50, and ResNet101—were evaluated within YOLOv2 and Faster R-CNN detectors. To address memory constraints (4 GB VRAM), YOLOv2 was selected for extensive benchmarking. Performance was measured using a harmonic precision–recall-based cost metric to strictly penalize imbalanced outcomes. Experimental results demonstrate that under identical wall-clock time budgets, the proposed framework achieves an average 1.38% reduction in aggregated cost across all models, with the highly sensitive VGG19 backbone showing a 4.00% improvement. Benchmarking against Bayesian optimization, genetic algorithms, and random search confirms that our method achieves superior optimization quality with statistical significance ($p < 0.05$). Under a rigorous IoU = 0.75 threshold, the optimized models consistently yielded F1-scores 0.8444 $\pm$ 0.0346. Ablation studies further validate that the collaborative model exchange is essential for accelerating convergence in rugged loss landscapes. This research offers a practical, scalable, and cost-efficient solution for deploying robust AI surveillance in resource-constrained smart city infrastructure. Full article

The deployment of Convolutional Neural Networks (CNNs) on entry-level Edge FPGAs is severely constrained by the scarcity of Digital Signal Processing (DSP) blocks, a phenomenon termed the “DSP Wall”. To circumvent this bottleneck, this paper presents AEMAC, a Software–Hardware Co-Designed accelerator architecture that decouples arithmetic computation from DSP availability. The proposed methodology synergizes a software-level Dynamic Integer Scaling strategy with a hardware-level Adaptive Error-Compensated Multiply-Accumulate unit. By mapping floating-point activations to an optimal integer domain and employing a DSP-free, LUT-based tri-mode datapath, the architecture achieves extreme resource efficiency. To mitigate the precision loss inherent in logic-based truncation, a statistical bias compensation mechanism is integrated into the accumulator chain. Experimental validation on a Xilinx Zynq-7020 FPGA demonstrates a strictly zero-DSP implementation with minimal logic utilization (100 LUTs). Post-implementation timing simulations confirm a dynamic power of 0.490 W for a 64-core cluster under worst-case random workloads, yielding a verified energy efficiency of 26.1 GOPS/W. Micro-level analysis confirms a 16.7% reduction in arithmetic Mean Absolute Error (MAE) compared to naive truncation. Furthermore, macro-level evaluation on the CIFAR-10 dataset reveals that the co-design strategy recovers system accuracy to 64.74%, outperforming the uncompensated baseline by 0.55% and achieving statistical comparability to floating-point baselines. To ensure absolute internal consistency, all hardware metrics are strictly validated via SAIF-based post-implementation simulations. Based on a conservative full-chip projection that incorporates a routing derating model, these internally consistent results establish AEMAC as a highly scalable and reliable solution for breaking the DSP wall in resource-constrained edge intelligence. Full article

Soil health monitoring is critical for the sustainable management of the black soil region, a key resource for global food security. However, traditional field surveys are constrained by high operational costs, limited spatial coverage, and low temporal frequency, making them inadequate for high-resolution and time-sensitive soil monitoring. The recently launched ZY1-02E satellite, equipped with an advanced hyperspectral imager, offers a new potential data source, yet its capability for quantitative soil modelling requires rigorous cross-sensor validation. This study conducts a cross-sensor evaluation of ZY1-02E and its predecessor, ZY1-02D, for mapping soil organic matter (SOM) and soil texture (sand, silt, and clay) in Northeast China. Optimal spectral indices were constructed through exhaustive band combination and correlation screening, and quantitative inversion models were established using a hybrid framework integrating Random Frog feature selection with Gaussian Process Regression (GPR) and Boosting Trees, based on synchronous ground observations. Results demonstrate strong cross-sensor consistency, with spectral indices showing significant linear correlations (${\mathrm{R}}^2>0.65$) between ZY1-02E and ZY1-02D. Furthermore, the quantitative retrieval models applied to ZY1-02E imagery achieved robust performance, with cross-sensor retrieval consistency exceeding ${\mathrm{R}}^2=0.60$ for all parameters and SOM exhibiting the highest agreement (${\mathrm{R}}^2=0.74$). These findings confirm the radiometric stability and algorithm transferability of ZY1-02E, demonstrating its capability to generate soil parameter products comparable to ZY1-02D without extensive model recalibration. The validated interoperability of the twin-satellite constellation substantially enhances temporal observation capacity during the narrow bare-soil window, effectively mitigating cloud-induced data gaps in high-latitude agricultural regions. Importantly, the enhanced monitoring framework provides a scalable technical paradigm for high-frequency hyperspectral soil mapping, offering critical spatial decision support for precision fertilization, soil degradation mitigation, and conservation tillage management in the Mollisol belt. Full article

Automated pig-welfare monitoring needs scalable, non-invasive signals that work across ages and individuals. A key methodological contribution of this study is the use of subject-wise validation, which ensures generalization to unseen animals and prevents inflated accuracy caused by growth-related and individual ‘voice’ differences. Vocalizations can help, but growth and individual “voice” differences can confound distress patterns and overstate accuracy without subject-wise validation. In our study, we explicitly accounted for individual variability by including animal identity as a random effect in mixed models and by using grouped cross-validation, where models were tested only on pigs not seen during training. This approach ensures that the reported accuracy reflects generalization across different individuals rather than memorization of specific vocal signatures. We analyzed 2221 vocal samples from 40 pigs (20 males, 20 females) recorded across four growth phases (farrowing, nursery, growing, finishing) under six conditions (pain, hunger, thirst, cold stress, heat stress, normal). Acoustic features extracted in Praat included energy, duration, intensity, pitch, and formants (F1–F4). Using blockwise variance decomposition, we quantified contributions of distress exposure, growth phase, and sex, and estimated the additional variance explained by animal identity. Distress exposure dominated intensity and spectral traits, particularly Formant 2, whereas the growth phase produced systematic shifts in duration and pitch. Animal identity added a modest but consistent increment in explained variance (~+0.02–0.03 R² beyond sex, phase, and distress). For prediction, we used 5-fold cross-validation grouped by animal. A Random Forest achieved a modest balanced accuracy of 0.609 and macro-F1 of 0.597; pain was most separable (recall 0.825), while other states showed moderate recall, indicating overlap. These results support hierarchical acoustic encoding of distress and establish a benchmark for precision welfare monitoring. Furthermore, they highlight that resolving complex physiological overlaps, such as heat stress and resource competition, requires a shift from unimodal acoustic models to multimodal Precision Livestock Farming (PLF) systems that integrate bioacoustics with continuous environmental and behavioral data streams. Full article

Against the background of highly interconnected global capital markets and rapidly propagating cross-lingual information streams, traditional anomaly detection paradigms based solely on single-modality numerical time-series sensors are insufficient for forward-looking risk sensing. From the perspective of artificial intelligence-driven sensing, this study proposes a multilingual semantic–numerical collaborative Transformer framework to construct a unified multimodal financial sensing architecture for intelligent anomaly sensing and risk perception. Within the proposed sensing paradigm, multilingual texts are conceptualized as semantic sensors that continuously emit event-driven sensing signals, while market prices, trading volumes, and order book dynamics are modeled as heterogeneous numerical sensor streams reflecting behavioral market sensing responses. These heterogeneous sensors are jointly integrated through a cross-modal sensor fusion architecture. A cross-modal temporal alignment attention mechanism is designed to explicitly model dynamic lag structures between semantic sensing signals and numerical sensor responses, enabling temporally adaptive sensor-level alignment and fusion. To enhance sensing robustness, a multilingual semantic noise-robust encoding module is introduced to suppress unreliable textual sensor noise and stabilize cross-lingual semantic sensing representations. Furthermore, a semantic–numerical collaborative risk fusion module is constructed within a shared latent sensing space to achieve adaptive sensor contribution weighting and cross-sensor feature coupling, thereby improving anomaly sensing accuracy and robustness under complex multimodal sensing environments. Extensive experiments conducted on real-world multi-market financial sensing datasets demonstrate that the proposed artificial intelligence-driven sensing framework significantly outperforms representative statistical and deep learning baselines. The framework achieves a Precision of $0.852$, Recall of $0.781$, F1-score of $0.815$, and an AUC of $0.892$, while substantially improving early warning time in practical risk sensing scenarios. In cross-market transfer settings, the proposed sensing architecture maintains stable anomaly sensing performance under bidirectional domain shifts, with AUC consistently exceeding $0.86$, indicating strong structural generalization across heterogeneous sensing environments. Ablation analysis further verifies that temporal sensor alignment, semantic sensor denoising, and collaborative cross-sensor risk coupling contribute independently and synergistically to the overall sensing performance. Overall, this study establishes a scalable multimodal intelligent sensing framework for dynamic financial anomaly sensing, providing an effective artificial intelligence-driven sensing solution for cross-market risk surveillance and adaptive financial signal sensing. Full article

Accurate and scalable body condition scoring (BCS) is important for health monitoring and productivity management in precision livestock farming. However, manual scoring is subjective, labor-intensive, and difficult to standardize, while many automated methods are too computationally demanding for edge deployment in real farm environments. This study proposes EdgeBCS-YOLO, a lightweight object detection framework for real-time beef cattle BCS in unstructured farming scenarios. Built on YOLO11n, it combines Position-Sensitive Feature Fusion (PSFF), a Texture-Aware Star Module (TASM), an Efficient Grouped Detection Head (EGDH), and a Focal and Global Knowledge Distillation (FGD)-based distillation strategy. On a dynamic blurring dataset, EdgeBCS-YOLO achieved 90.8% precision, 82.7% recall, and 88.9% mAP@50. On the NVIDIA Jetson Orin NX Super, it achieved a model size of 3.95 MB, a system FPS of 33.35, and an average inference latency of 13.26 ms. These results suggest that it is a practical and potentially efficient solution for automated BCS on edge devices. Full article

The rapid advancement of global urbanization has rendered Impervious Surface Area (ISA) a critical indicator for monitoring urban ecological and thermal environments. However, traditional sub-pixel ISA estimation methods, such as Spectral Mixture Analysis (SMA) and machine learning regression, are significantly constrained by spectral variability and a scarcity of high-quality training samples. To address these limitations, this study proposes a novel sub-pixel Impervious Surface Fraction (ISF) retrieval framework leveraging high-resolution airborne hyperspectral data. By simulating physically consistent multispectral reflectance and generating high-accuracy reference ISF via spatial aggregation, we construct a robust and noise-resistant training dataset. Experimental results on Landsat data demonstrate that this simulation-based approach effectively mitigates sample uncertainty, significantly enhances retrieval accuracy, and accurately preserves spatial details and boundary structures. Theoretically, the framework exhibits strong cross-sensor adaptability, as it allows for the generation of sensor-consistent training datasets for various medium-resolution satellite platforms by simply substituting the target sensor’s spectral response functions. Combined with this inherent scalability and the potential for cross-sensor model migration, this method provides a reliable and systematic paradigm for long-term, high-precision ISF mapping across multiple satellite constellations. Full article

Background: Efficient parking navigation in large and dynamic parking areas requires systems that can adapt to real-time conditions and provide precise vehicle localization. Methods: This paper presents a smart car parking navigation module that integrates camera-based vehicle perception, homography-based ground-plane localization, mobile GNSS positioning, and dynamic route planning into a unified framework. Instance segmentation (YOLOv8n-seg) is used to detect vehicles and extract ground-contact regions, which are associated with parking slots defined in a GeoJSON-based site model. Mobile GNSS data are fused with visual observations via spatio-temporal proximity scoring to enable robust user–vehicle matching without optical identification. An A* routing algorithm dynamically computes and updates navigation paths, adapting to lane obstructions and slot availability in real time. Results: Experimental evaluation on a real six-camera parking facility shows that the proposed segmentation-based localization reduces mean error from 0.732 m to 0.283 m (61.3% improvement), with the 95th-percentile error dropping from 1.892 m to 0.908 m, and outperforming the bounding-box baseline in 85.3% of detections. Conclusions: These results demonstrate that sub-meter vehicle localization and reliable user–vehicle association are achievable using standard surveillance cameras without specialized infrastructure, offering a scalable and cost-effective solution for intelligent parking navigation. Full article

Regenerative medicine is becoming more widely integrated with longevity-oriented and preventive care as populations age and chronic degenerative diseases burden healthcare systems. Mesenchymal stem cell (MSC) therapies have progressed from experimental interventions to approved products, yet scalability, safety, cost, and regulatory complexity constrain widespread implementation in medical wellness contexts. The predominant therapeutic effects of MSCs are mediated via paracrine mechanisms, leading to cell-free approaches based on the MSC secretome—a complex mixture of bioactive factors including all types of biomolecules and assemblies thereof, such as exosomes. These acellular products offer compelling advantages: multiple batches from single-donor sources, standardized dosing, reduced allogeneic cell risks, and shorter outpatient-compatible administration. Preclinical and clinical data indicate that secretome-based products exert potent regenerative effects in osteoarthritis, chronic wounds, stroke, traumatic brain injury, and neurodegenerative diseases. This review examines the evolution from cell-based to cell-free regenerative strategies, focusing on human umbilical cord Wharton’s jelly MSC secretome for precision longevity medicine. It compares MSC therapies with secretome- and exosome-based formulations across mechanistic, manufacturing, safety, practical and regulatory dimensions. Regional perspectives highlight Southeast Asia, and especially Thailand, as an emerging regenerative-longevity hub. Finally, it outlines the preventive patient journey integrating cell-free interventions within multi-modal programs aimed at extending healthspan. Full article

Pruning is a critical horticultural practice that requires continuous interpretation of plant structure to maintain crop health and prevent disease. Manual identification of pruning-relevant regions is labor-intensive and limits scalability in precision agriculture. This study presents a cognitive vision-based pruning region identification system using a You Only Look Once version 9 model to detect lateral branches, lower leaves, and diseased leaves in Solanum lycopersicum. A custom dataset of 4905 augmented images was used for training and evaluation. The model achieved 82.86% precision, 77.24% recall, 79.96% F1-score, and 83.21% mAP. Deployment on Raspberry Pi 5 demonstrated real-time, cloud-independent edge inference, indicating the feasibility of low-cost cognitive vision systems for smart agriculture. Full article

This paper presents an onboard, markerless perching system for a quadrotor UAV, validated in outdoor flight experiments, to reduce hovering energy during long-endurance unmanned missions. Existing autonomous landing research predominantly focuses on planar surfaces, cooperative environments with visual markers, or specialized hardware, limiting scalability to scenarios requiring detection and perching on thin rod-like targets in uncooperative outdoor settings. This study proposes a markerless perching system for autonomously perching a drone on a hurdle’s horizontal bar. The system employs a single-axis gimbal camera, altitude LiDAR, and ToF sensor, integrating perception, post-processing, and control. On the perception side, we augment a YOLOv12n-based segmentation model with a high-resolution P2 pathway for small-object detection and apply module compression for real-time inference on edge devices. Robustness is improved by jointly utilizing the full hurdle and horizontal bar while constructing negative samples to suppress false positives. On the control side, a state machine controller leverages centroid coordinates, orientation, and distance measurements to achieve a stable long-range approach and precise close-range alignment. Experiments on a Jetson Orin NX-based system demonstrate successful perching in all six outdoor flight tests. Ablation studies quantitatively analyze each component’s contribution to perching success rate and completion time. This research validates perching technology’s practical applicability through outdoor markerless perching on thin 3D structures. Full article

Large-scale aerospace components (e.g., wings, fuselage sections, wing boxes, and rocket segments) feature large dimensions, low stiffness, complex interfaces, and strict assembly tolerances. Traditional rigid tooling and manual alignment struggle to meet the demands of high precision, efficiency, and flexibility in modern aerospace manufacturing. This paper presents a structured literature review on the automated assembly of large-scale aerospace components, summarizing advances in three core domains: pose adjustment and positioning mechanisms, digital measurement technologies, and trajectory planning and control. Particular emphasis is placed on two cross-cutting themes: measurement uncertainty analysis and flexible assembly, which are critical for high-quality docking. The review classifies pose adjustment mechanisms into four categories (NC positioners, parallel kinematic machines, industrial robots, and novel mechanisms) and digital measurement into five branches (vision metrology, large-scale metrology, measurement field construction, uncertainty analysis, and auxiliary techniques). It also outlines five trajectory planning and control routes, covering traditional methods, multi-sensor fusion, digital twins, flexible assembly, and emerging intelligent approaches. The analysis reveals that current research suffers from fragmentation among mechanism design, metrology, and control, with insufficient integration of uncertainty propagation and flexible deformation modeling. Future systems will rely on heterogeneous equipment collaboration, uncertainty-aware closed-loop control, high-fidelity flexible modeling, and digital twin-driven decision-making. This review provides a unified framework and a technical reference for developing reliable, flexible, and scalable automated assembly systems for next-generation aerospace structures. Full article

Coral reef ecosystems are declining rapidly due to climate change, disease, and anthropogenic stressors, driving the expansion of land-based coral propagation for reef restoration. A major bottleneck in these efforts is the manual measurement of coral recruit tissue area from microscopy images, which requires 2–7 min per image and limits scalability. We present a hierarchical deep learning pipeline that automates this measurement by integrating YOLO-based detection with Segment Anything Model (SAM) segmentation. YOLO localizes recruits and classifies them by developmental stage; stage-specific fine-tuned SAM models then segment live tissue using bounding box and background point prompts to suppress segmentation leakage and improve boundary precision. Surface area is computed directly from the segmented masks using pixel size extracted from image metadata. The pipeline reduces processing time to approximately 3–5 s per image—a 24–140× speedup over manual tracing. Evaluated on 3668 microscopy images from two national coral research facilities, the system achieves a mean IoU exceeding 95% and an auto-acceptance rate (AAR) of 71.51%, where predicted-to-ground-truth area ratios fall within a ±5% tolerance of expert annotation, substantially reducing manual workload while maintaining measurement reliability across species, developmental stages, and imaging conditions. This workflow addresses a critical bottleneck in restoration research and demonstrates the broader applicability of AI-based image analysis in marine ecology. Full article