Search Results (794)

The mental and physical health of college students, especially in urban environments like Shanghai, is crucial given the high academic and urban stressors, which were intensified by the COVID-19 lockdown. Prior research has shown gender differences in health impacts during public health crises, with females often more vulnerable to mental health issues. Objective: This study aimed to comprehensively assess the physical and psychological health of Chinese college students post-lockdown, focusing on the relationship between stress, anxiety, depression, sleep patterns, and physical health, with a particular emphasis on gender differences. Methods: We conducted a cross-sectional study involving 116 students in Shanghai, utilizing psychological scales (HAMA, IPAQ, PSQI, SDS, FS 14, PSS, SF-36) and physical fitness tests (resting heart rate, blood pressure, hand grip, forced vital capacity, standing long jump, sit-and-reach, one-minute sit-up test and the one-minute squat test, single-leg stand test with eyes closed), to analyze health and behavior during the pandemic lockdown. All students have undergone the same life habits during the pandemic. Results: The HAMA scores indicated no significant levels of physical or mental anxiety. The PSS results (42.45 ± 8.93) reflected a high overall stress level. Furthermore, the PSQI scores (5.4 ± 2.91) suggested that the participants experienced mild insomnia. The IPAQ scores indicated higher levels of job-related activity (1261.49 ± 2144.58), transportation activity (1253.65 ± 987.57), walking intensity (1580.78 ± 1412.20), and moderate-intensity activity (1353.03 ± 1675.27) among college students following the lockdown. Hand grip strength (right) (p = 0.001), sit-and-reach test (p = 0.001), standing long jump (p = 0.001), and HAMA total score (p = 0.033) showed significant differences between males and females. Three principal components were identified in males: HAMA, FS14, and PSQI, explaining a total variance of 70.473%. Similarly, three principal components were extracted in females: HAMA, PSQI, and FS14, explaining a total variance of 69.100%. Conclusions: Our study underscores the complex interplay between physical activity (PA), mental health, and quality of life, emphasizing the need for gender-specific interventions. The persistent high stress, poor sleep quality, and reduced PA levels call for a reorganized teaching schedule to enhance student well-being without increasing academic pressure. Full article

Objectives: The aim of this study was to assess the safety and feasibility of resistance training (RT) in middle-aged and young individuals by examining cardiocirculatory and metabolic responses to squat performed under low and high external loads as per current exercise prescription guidelines. Methods: Eighteen RT-trained individuals (nine middle-aged individuals, including eight women who were equally distributed) performed a cycling incremental test for the determination of their maximal aerobic capacity and three sessions of RT, respectively, to determine their one repetition maximum (1RM) of squat and their physiological responses during different training protocols of squat with equal training loads (3 × 12 at 55% 1RM vs. 5 × 5 at 80% 1RM). Whole-body metabolic (oxygen update and blood lactate) and cardiocirculatory (heart rate and blood pressure) responses and rate of perceived exertion (RPE) were compared across age groups and % 1RM to determine the metabolic stimulus and cardiovascular strain imposed by this form of training. Results: Young and middle-aged individuals exhibited similar cardiocirculatory responses to RT, with the only exception being a higher diastolic response in the middle-aged group for both protocols (present also at rest). No difference was found between the two age groups in terms of metabolic response and RPE. 80% 1RM induced a similar cardiocirculatory response and a higher RPE but a lower metabolic response compared to 55% 1RM. Conclusions: While no difference in physiological responses was found between the groups, the lower-load and higher-repetition training scheme demonstrated better time efficiency, metabolic activation, and perceived effort with equivalent cardiocirculatory strain. These findings support the safety of RT and can guide practitioners in the design of training protocols. Full article

Objectives: This study examined the impact of a low-sugar flavored beverage on total fluid intake and hydration biomarkers during intermittent exercise in a hot environment among healthy children. Methods: Twenty-one children (11 girls, 8–10 y) completed a randomized, crossover study with two trials. Each trial involved three bouts of 10 min walking, 5 min rest, 10 min walking, and 35 min rest for a total of 3 h in a hot (29.9 ± 0.6 °C) and dry environment (26 ± 7% relative humidity). Walking intensity was 69 ± 7% of age-predicted maximum heart rate. Participants consumed either plain water (W) or a low-sugar flavored beverage (FB). Body weight, fluid intake, urine samples, and perceptual ratings were collected. Results: Total ad libitum fluid intake was significantly higher with the FB (946 ± 535 mL) than with W (531 ± 267 mL; p < 0.05). This difference was 128% higher for FB compared to W, with 19 out of the 21 children ingesting more fluids in FB versus W. Children rated the FB as more likable across all time points (p < 0.05). Net fluid balance was better with FB at 60, 70, 85, 135, and 145 min (p < 0.05), though not different at the 3 h mark. Urine volume was higher with FB (727 ± 291 mL) than with W (400 ± 293 mL; p < 0.05). Urine osmolality was significantly higher in the W trial at 120 and 180 min (p < 0.05). Conclusions: A flavored, low-sugar beverage enhanced ad libitum fluid intake and improved hydration markers compared to water during exercise in the heat, supporting its potential as a practical rehydration strategy for children. Full article

Background/Objectives: Patients with normal sinus rhythms undergoing cardiac resynchronization therapy defibrillator (CRT-D) implantation may benefit from a novel two-lead CRT-D system (CRT-DX), which features an atrial sensing dipole integrated into the right ventricular lead. This single-arm, international, non-controlled investigation focused on the safety and clinical efficacy of CRT-DX devices in CRT-D candidates who do not require atrial pacing. Methods: Patients indicated for CRT-D implantation (resting heart rates > 40 bpm and ≥100 bpm during exercise, no second or higher-degree AV block, and no history of persistent or permanent atrial fibrillation) were enrolled across 21 sites in four European countries. The primary endpoint was the need for an additional RA lead implantation within 12 months. Secondary endpoints comprised any invasive re-intervention to the CRT-DX system or infection. Results: Among the 110 patients (mean age 62 years, 70% male), 60% had an underlying non-ischemic cardiac disease. During 12 months of follow-up, RA lead implantation was required in two patients for atrial undersensing or chronotropic incompetence (RA lead implantation-free rate: 98.2% (95% CI: 92.7–99.5%)). Atrial sensing amplitudes were stable (mean: 4.7 ± 1.7 mV), AV-synchrony was maintained at >99%, and the median percentage of biventricular pacing exceeded 98%. The left ventricular ejection fraction improved by an absolute 14.7%. Conclusions: Using simple, clinically applicable inclusion criteria, the two-lead CRT-DX system demonstrated a low rate of subsequent RA lead implantations (1.8%) and maintained adequate RA sensing amplitudes throughout the observation period. The two-lead CRT-DX concept appears to be a feasible alternative for patients with preserved chronotropic competence. Full article

Introduction: Rapid ascent to altitudes of over 5000 m above sea level are associated with dramatic changes in adaptive physiology. The effects of a gradual ascent on symptoms, oximetry, and heart rate are described and compared with the effects of a rapid ascent to the same altitude by a comparable cohort. Methods: A group of 13 individuals (six females) representing 10 countries from five continents ascended gradually from Lukla (2300 m) to Everest Base Camp (5300 m) in Nepal over an 8-day period, then descended over a further 4 days. All symptoms and medication were recorded, along with pulse oximetry (SpO₂) and heart rate (HR) every 500 m of ascent. The results were then compared with those obtained at equivalent altitudes using similar methodology from a fast ascent of Mount Kilimanjaro to an equivalent altitude by a comparable cohort over 4 days. Results: The gradual ascent group had a median age of 33 years (range 25–66), and all successfully completed the trek. No severe headache, vomiting, orthopnoea, or productive cough occurred, although minor nausea and mild headache were common. Baseline oximetry fell from a median of 96% (93–97%) to a median of 78% (53–86%) at 8 days but recovered to 94% (89–99%) inside 4 days. Corresponding HR rose from a baseline median of 72 bpm (57–85) to a median of 103 bpm (78–115) at 8 days, then recovered to 80 bpm (54–94) after 4 days. Neither age nor gender correlated with outcomes. Individually, HR correlated inversely with oximetry, but there was no group correlation between these two variables. By contrast, a more rapid 4-day ascent from the same starting height, with similar baseline values for HR and oximetry, to the same final altitude was associated with more severe headache, breathlessness, and vomiting. Fast ascent was associated with a significantly more marked reduction in oximetry to a median of 71% (52–76) and an increase in HR to a median of 110 bpm (88–140). The fast ascent group also required significantly more medication, rated their experience as less enjoyable, and had a 100% incidence of acute mountain sickness compared to 0% in the slow ascent group. Discussion: Oxygen desaturation and tachycardia are inevitable consequences of ascending above 5000 m, but the degree to which this occurs can be reduced by slowing ascent times and taking rest days every 1000 m of ascent. This practice is associated with fewer symptoms and greater safety, with less need for either prophylactic or therapeutic medication. Careful consideration should be given to rates of ascent when climbing to altitudes at or above 5000 m. Full article

Cockpit noise, as a critical environmental factor affecting flight safety, may impair pilots’ cognitive functions, leading to a decreased operational performance and decision-making errors, thereby posing potential threats to aviation safety. In order to reveal the relationship between the cockpit noise sound pressure level and pilot physiological indicators, and provide a scientific basis for cockpit noise airworthiness standards, this experiment takes pilot trainees as the research subject. Based on the principle of multimodal data synchronization, a sound field reconstruction system is used to reconstruct the cockpit sound field. Electroencephalogram (EEG), electrocardiogram (ECG), and electrodermal activity (EDA) measurements are carried out in different sound pressure level noise operating environments. The results show that with the increase in the sound pressure level, the significant suppression of α-wave activity in the occipital and parietal regions suggests that the cortical resting state is lifted and visual attention is enhanced; the enhancement of the β-wave in the frontal regions reflects the enhancement of alertness and prefrontal executive control, and the suppression of θ-wave activity in the frontal and temporal regions may indicate that cognitive tuning is suppressed, which reflects the brain’s rapid adaptive response to external noise stimuli in a high-noise environment; noise exposure triggers sustained sympathetic nerve hyperactivity, which is manifested by a significant acceleration of the heart rate and a significant increase in the mean value of skin conductance when the noise sound pressure level exceeds 70 dB(A). The correlation analysis between physiological indicators shows that cockpit noise has a multi-system synergistic effect on human physiological indicators. The experimental results indicate that noise has a significant impact on EEG, ECG, and EDA indicators. Full article

Propranolol, a nonselective beta-adrenergic antagonist, has shown potential for improving anxiety in autistic individuals. Heart rate variability (HRV), a noninvasive cardiac marker of autonomic nervous system functioning, may help identify individuals most likely to benefit from propranolol. Objectives: Determine if baseline resting HRV and other cardiac measures predict the response to propranolol for anxiety and core autism symptomology in autistic children and young adults. Methods: Sixty-two autistic individuals (ages 7–24) participated in a two-phase (i.e., a 12-week randomized controlled trial and a 12-week open-label extension) trial of propranolol. Baseline (i.e., resting state, prior to treatment) HRV and other cardiac measures were obtained from an electrocardiogram. Clinical global impression for anxiety symptoms and overall behavioral treatment impact were assessed after the 12-week trial period. Group-level (i.e., all participants) and responder groups (i.e., strong, minimal, and non-responders to propranolol) were analyzed for treatment effects. Results: HRV variables predicted group-level anxiety response to propranolol, particularly for strong responders. Also, lower baseline values of parasympathetic HRV indices were significantly correlated with greater behavioral improvement after treatment with propranolol. Last, several baseline cardiac variables were associated with improvement in multiple behavioral domains after treatment with propranolol. Conclusions: HRV may be a potential biomarker for predicting reduced anxiety and behavioral symptoms in response to propranolol in autistic children and young adults. Identifying autonomic profiles associated with positive treatment outcomes could guide future personalized interventions in autism. The results presented herein should be regarded as preliminary until the findings are replicated in future clinical trials. Full article

This study evaluates the accuracy of a low-cost wearable system for the continuous monitoring of vital signs, including heart rate, blood oxygen saturation (Sp${\mathrm{O}}_2$), blood pressure trend (BPT), and body temperature. The prototype was built using the nRF52840 microcontroller, which integrates photoplethysmography and infrared sensors. The heart rate and Sp${\mathrm{O}}_2$ data were collected under three body positions (Rest, Sitting, and Standing), while all measurements were performed using both anatomical configurations: BPT-Finger and BPT-Earlobe. Results were compared against validated commercial devices: UT-100 for heart rate and Sp${\mathrm{O}}_2$, G-TECH LA800 for blood pressure, and G-TECH THGTSC3 for body temperature. Ten participants were monitored over a ten-day period. Bland–Altman analysis revealed clinically acceptable agreement thresholds of ±5 mmHg for blood pressure, ±5–10 bpm for heart rate, ±4% for Sp${\mathrm{O}}_2$, and ±0.5 °C for temperature. Both wearable configurations demonstrated clinically acceptable agreement across all vital signs. The BPT-Earlobe configuration exhibited superior stability and lower variability in the Rest and Sitting positions, likely due to reduced motion artifacts. Conversely, the BPT-Finger configuration showed higher Sp${\mathrm{O}}_2$ accuracy in the Standing position, with narrower limits of agreement. These findings highlight the importance of sensor placement in maintaining measurement consistency across physiological conditions. With an estimated cost of only ~USD 130—compared to ~USD 590 for the commercial alternatives—the proposed system presents a cost-effective, scalable, and accessible solution for decentralized health monitoring, particularly in underserved or remote environments. Full article

(1) Eating disorders (EDs), characterized by symptoms such as restrictive eating, binge eating, compensatory behaviors, and emotional dysregulation, are associated with autonomic nervous system dysregulation, which may contribute to cardiovascular complications. This review systematically examines the relationship between heart rate variability (HRV) and core ED symptoms to identify specific autonomic patterns linked to behaviors like fasting, binge eating, and emotional dysregulation. (2) A total of 16 cross-sectional and longitudinal studies were narratively synthesized following PRISMA guidelines. All studies were selected from the Science Direct, PubMed, Web of Science, and Scopus databases. (3) Findings indicate that individuals with anorexia nervosa exhibit blunted sympathetic reactivity and reduced parasympathetic flexibility, particularly during stress or physical activity, with HRV measures normalizing after weight restoration. In contrast, binge eating and loss-of-control eating are associated with lower resting HRV, which correlates with the severity of eating behaviors. Reactive HRV also varies with food cues and emotional states, showing complex autonomic responses in individuals with EDs. Emotional dysregulation, consistently marked by reduced high-frequency HRV, is a key feature across these disorders. (4) These results suggest that HRV patterns may serve as physiological markers of ED symptomatology, offering insights for targeted interventions aimed at improving both emotional regulation and cardiovascular health in affected individuals. Full article

We examined heart rate (HR) and heart rate variability (HRV) in young and middle-aged men after a period of detraining that immediately followed the completion of an exercise training program. Eight young (27.8 ± 3.8 years) and ten middle-aged (41.9 ± 3.8 years) men were randomly assigned to complete an 8-week exercise training program that included either aerobic (young: n = 3; middle-aged: n = 2), resistance (young: n = 3; middle-aged: n = 3), or combined (aerobic/resistance) (young: n = 2; middle-aged: n = 5) exercise. Thereafter, participants ceased all planned exercise training activities during an 8-week detraining period. Resting HR and HRV were assessed at baseline, after exercise training, and after detraining. An analysis of mean differences between age groups at each time-point revealed a significantly higher standard deviation of normal RR intervals (SDNN), square root of the mean of squared differences between successive RR intervals (RMSSD), high-frequency (HF) band (0.15–0.40 Hz), and cardiac vagal index (CVI) in young participants when compared to middle-aged participants at baseline (p ≤ 0.019) and after detraining (p ≤ 0.045), but not after the 8-week exercise training intervention (p ≥ 0.057). Additionally, in middle-aged participants, we observed a significant negative association between the percent change in HRV indices (RMSSD, HF, and CVI) and systolic blood pressure in response to detraining (p < 0.05). In conclusion, young participants had higher levels of HRV indices at baseline, reflecting greater cardiac vagal modulation when compared to middle-aged participants. We showed that these age-related differences in HRV are diminished following exercise training but are reestablished following 8 weeks of detraining. Given that age-related attenuations in HRV may reflect changes in cardiovascular health, it is important to further investigate the relationships between HRV, exercise training and detraining, aging, and the risk of poor health outcomes. Full article

Dynamic oxygen uptake (VO₂) reflects moment-to-moment changes in oxygen consumption during exercise and underpins training design, performance enhancement, and clinical decision-making. We tackled two key obstacles—the limited fusion of heterogeneous sensor data and inadequate modeling of long-range temporal patterns—by integrating wearable accelerometer and heart-rate streams with a convolutional neural network–LSTM (CNN-LSTM) architecture and optional attention modules. Physiological signals and VO₂ were recorded from 21 adults through resting assessment and cardiopulmonary exercise testing. The results showed that pairing accelerometer with heart-rate inputs improves prediction compared with considering the heart rate alone. The baseline CNN-LSTM reached R² = 0.946, outperforming a plain LSTM (R² = 0.926) thanks to stronger local spatio-temporal feature extraction. Introducing a spatial attention mechanism raised accuracy further (R² = 0.962), whereas temporal attention reduced it (R² = 0.930), indicating that attention success depends on how well the attended features align with exercise dynamics. Stacking both attentions (spatio-temporal) yielded R² = 0.960, slightly below the value for spatial attention alone, implying that added complexity does not guarantee better performance. Across all models, prediction errors grew during high-intensity bouts, highlighting a bottleneck in capturing non-linear physiological responses under heavy load. These findings inform architecture selection for wearable metabolic monitoring and clarify when attention mechanisms add value. Full article

Background/Objectives: The use of buoyant equipment in water fitness sessions appears to elicit a more intense physiological response in water exercises. However, it remains unknown whether the shape of the equipment influences these responses. The present study aimed to analyze and compare the physiological responses and perceived effort while older women using different buoyant dumbbells during horizontal adduction/abduction of the upper limbs (HA exercise). Methods: Ten older women (76.1 ± 5.3 years of age) attended two assessment sessions to perform HA exercise at a music cadence of 120 bpm with different buoyant dumbbells (one pair for each session): round hydro and hydro crystal. Mean heart rate (HR), systolic and diastolic blood pressures (SBP and DBP, respectively), double product (DPr), blood lactate concentration ([La⁻), and rate of perceived effort (RPE) were assessed according to pre-exercise (rest), warm-up and the HA exercise (five min effort). Results: The mean HR was also analyzed according to the percentage (%) of the predicted maximal theoretical HR (HRmax). Older women reached ~56 and 61% of HRmax using crystal and round dumbbells, respectively. Differences were found in mean HR, [La⁻], and RPE with the round dumbbell showing greater values than the crystal dumbbell. Although no differences were found in SBP and DBP, DPr was higher when women used the round dumbbells. Conclusions: The shape of buoyant dumbbells seems to define acute responses of older women as the round dumbbell promotes a more intense physiological response and perceived effort when compared to the crystal dumbbell. Full article

The physiological capabilities of horses begin to decline after they reach 15 years of age. However, some exceptionally talented horses can continue their sports careers beyond this age, raising concerns about their welfare. This study investigated animal welfare by observing resting heart rate (HR) and heart rate variability (HRV) metrics in geriatric horses participating in similar training or physical activities compared to younger adult horses over 30 min periods. Forty-six horses of varying ages and activity levels were divided into four groups, including horses under 15 years practising structured training for dressage (AL-1; N = 13) and school riding (AL-2; N = 13) and horses aged between 15 and 20 years participating in AL-1 (N = 10) and AL-2 (N = 10). In adult horses, the HR decreased in those performing AL-1, which was observed alongside an increased RR interval compared to those participating in AL-2 (p < 0.05 for both). Meanwhile, HRV increased in adult horses (measured by pNN50) but decreased in geriatric horses (measured by SDANN, SDNNI, DC, and SD2) participating in AL-1 when compared to their counterparts in AL-2 (p < 0.05 for all). Adult horses exhibited better autonomic regulation while engaged in structured dressage training than geriatric horses. These findings underscore the necessity for the careful management of physical activities to ensure the well-being of all horses, particularly older ones. Full article

Persons with personality type D are characterized by an “unhealthy lifestyle”, which is manifested by low physical activity, less healthy eating behavior, and failure to comply with doctors’ recommendations. Persons with personality type D have an inadequate response of hemodynamic parameters to psychoemotional stress; the response of other parameters has not been sufficiently studied. The aim of this study was to investigate the association of personality type D with various psychophysiological parameters of the body during mental stress in healthy individuals. Material and Methods: The study involved 79 students of Kemerovo State Medical University aged 18 to 32 years (mean age 20.7 ± 2.4 years). Psychophysiological diagnostics was carried out using the BOSLAB complex; electromyogram, electrocardiogram, body temperature, respiration, galvanic skin response, and photoplethysmogram data were recorded. The stress testing protocol included cognitive tasks and recovery phases. Additionally, the presence of personality type D in students was assessed using the DS-14 questionnaire. The results of stress tests were compared in groups with the presence/absence of type D. Results: The frequency of detection of type D was high (54.4%). When examining the response of psychophysiological parameters, the most pronounced response to stress tests with mental load was noted for heart rate variability and respiratory system parameters. Individuals with type D personality showed more pronounced sympathetic activation in response to mental stress and a slower recovery at rest. Among the studied parameters, association with personality type D was noted for the following indicators during the mental arithmetic test: heart rate (p = 0.022), the Baevsky strain index (p = 0.004), respiratory rate (p = 0.020), and an indicator of regulatory process adequacy (p < 0.001). Conclusion: In the present study, we found differences in the reaction of psychophysiological parameters to mental stress in healthy individuals depending on the presence or absence of personality type D. These data can be useful for developing stress resistance programs and biofeedback training. The possibility of using the above psychophysiological parameters in biofeedback training programs for individuals with personality type D requires further research. Full article

Cardioprotection against ischemia is achieved using openers of mitochondrial ATP-sensitive K⁺ (mitoKATP) channels such as diazoxide (DZX), leading to pharmacological preconditioning (PPC). We previously reported that PPC decreases the abundance of ventricular Cav1.2 channels, but PPC’s effects on other channels remain largely unexplored. In this study, we hypothesized that DZX regulates the expression of hyperpolarization-activated cyclic nucleotide potassium channel 4 (HCN4) channels in sinoatrial node cells (SANCs), the specialized cardiomyocytes that generate the heartbeat. DZX increased the heart rate in intact adult rats. Patch-clamp experiments revealed an increase in the magnitude of ionic currents through HCN4 channels, which was abolished by the reactive oxygen species (ROS) scavenger N-acetylcysteine (NAC) and the selective mitoKATP channel inhibitor 5-hydroxydecanoate (5-HD). Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and Western blot assays showed that DZX increased HCN4 channel expression at the mRNA and protein levels. Immunofluorescence analyses revealed that PPC increased HCN4 fluorescence, which was abolished by NAC. DZX increased nuclear translocation of c-Fos and decreased protein abundance of RE1 silencing transcription factor (REST)/neuron-restrictive silencer factor (NRSF), suggesting the involvement of these factors. Our results suggest that PPC increases the heart rate by upregulating HCN4 channel expression through a mechanism involving c-Fos, REST, and ROS. Full article