Search Results (26,758)

Conventional health risk assessments do not adequately reflect short-term exposure characteristics following chemical accidents. We aimed to evaluate the efficacy of existing assessment methods and propose a more suitable risk assessment approach for short-term exposure to hazardous chemicals. We analyzed foundational studies used to derive reference concentration (RfC), reference dose (RfD), and minimal risk level (MRL) values and applied these health guidance values (HGVs) to a hypothetical chemical accident scenario. An analysis of the studies underlying each HGV revealed that, except for the RfC for formaldehyde and the RfD for toluene, all values were derived under research conditions comparable to their respective exposure durations. Given the differing toxicity mechanisms between acute and chronic exposures, MRLs that were aligned with the corresponding exposure durations supported more appropriate risk management decisions. The health risk assessment results showed that RfC/RfD-based hazard quotients (HQs) were consistently higher than MRL-based HQs across all age groups and both substances, indicating that RfC/RfD values tend to yield more conservative risk estimates. For formaldehyde, the use of RfC instead of MRL resulted in an additional 208 tiles (2.08 km²) being classified as areas of potential concern (HQ > 1) relative to the MRL-based evaluation. These findings highlighted that the selection of HGVs can significantly influence the spatial extent of areas of potential concern, potentially altering health risk determinations for large population groups. This study provides a scientific basis for improving exposure and risk assessment frameworks under short-term exposure conditions. It also serves as valuable foundational data for developing effective and rational risk management strategies during actual chemical accidents. To the best of our knowledge, this is the first study to apply MRLs to a short-term chemical accident scenario and directly compare them with traditional reference values. Full article

Cognitive tests measure psychological constructs that predict the development of academic skills. Research on cognitive–reading achievement relations has primarily been completed with single-test batteries and samples, resulting in inconsistencies across studies. The current study developed a consensus model of cognitive–reading achievement relations using meta-structural equation modeling (meta-SEM) through a cross-sectional analysis of subtest correlations from English-language norm-referenced tests. The full dataset used for this study included 49,959 correlations across 599 distinct correlation matrices. These included correlations among 1112 subtests extracted from 137 different cognitive and achievement test batteries. The meta-SEM approach allowed for increased sampling of cognitive and academic reading skills measured by various test batteries to better inform the validity of construct relations. The findings were generally consistent with previous research, suggesting that cognitive abilities are important predictors of reading skills and generalize across different test batteries and samples. The findings are also consistent with integrated cognitive–reading models and have implications for assessment and intervention frameworks. Full article

Sustainable energy entrepreneurs promote sustainable development by focusing more on energy efficiency. This study examines the interdependence and driving–dependent relationships among the socioeconomic factors (SEFs) influencing sustainable energy enterprises (SEEs). A mixed-methods approach is used, beginning with a literature review and expert consensus, followed by total interpretive structural modeling (TISM) and cross-impact matrix multiplication applied to classification (MICMAC) analysis. Seven key SEFs are finalized through interviews with 12 experts. Data are then collected from 11 SEEs. The study reveals that the regulatory and institutional framework emerges as the primary driving factor influencing other SEFs, including financial accessibility, market demand, technological innovation, and infrastructure readiness. Social and cultural acceptance is identified as the most dependent factor. The study proposes future research directions by identifying the United Nations sustainable development goals (SDGs) related to the antecedents, decisions, and outcomes with theoretical linkages through the Antecedents–Decisions–Outcomes (ADO) framework. The major SDGs identified are SDG 4 (education), SDG 7 (energy), SDG 9 (industry), SDG 11 (communities), and SDG 13 (climate). The study highlights that regulatory support, funding access, skill development, and technology transfer are required areas for strategic focus. Understanding the hierarchy of SEs supports business model innovation, investment planning, and risk management. Full article

This paper introduces an innovative artificial neural networks-based analytical solver for fractional partial differential equations (fPDEs), combining neural networks (NNs) with symbolic computation. Leveraging the powerful function approximation ability of NNs and the exactness of symbolic methods, our approach achieves notable improvements in both computational speed and solution precision. The efficacy of the proposed method is validated through four numerical examples, with results visualized using three-dimensional surface plots, contour mappings, and density distributions. Numerical experiments demonstrate that the proposed framework successfully derives exact solutions for fPDEs without relying on data samples. This research provides a novel methodological framework for solving fPDEs, with broad applicability across scientific and engineering fields. Full article

Fatigue in elite soccer is a multifaceted phenomenon involving physical, metabolic, psychological, and neuromuscular stressors that accumulate over training and competition. Traditional monitoring tools, while informative, are often invasive, impractical during play, or fail to provide real-time insights. This narrative review synthesizes sweat-based biomarkers linked to fatigue in elite soccer, with a focus on multi-modal domains (neuromuscular, metabolic, inflammatory, psychological). Using an integrative approach, we reviewed studies published across databases including PubMed, Scopus, and Web of Science that evaluate sweat biomarkers of different types of fatigue in soccer. We identified key candidates—lactate, sodium, cortisol, IL-6, and hypoxanthine—and evaluated their potential in non-invasive monitoring. Youth-specific and female populations remain underrepresented. We also assessed each biomarker’s technological maturity using a sweat-specific Technology Readiness Level (TRL) framework. Based on these findings, we propose a translational framework for practitioners and outline priorities for future research and validation in real-world sport settings. Full article

Benzene, a well-established human carcinogen and major industrial pollutant, poses significant health risks through occupational exposure due to its no-threshold effect, leading to multi-system damage involving the hematopoietic, nervous, and immune systems. This makes the investigation of its toxic mechanisms crucial for precise prevention and control of its health impacts. Programmed cell death (PCD), an orderly and regulated form of cellular demise controlled by specific intracellular genes in response to various stimuli, has emerged as a key pathway where dysfunction may underlie benzene-induced toxicity. This review systematically integrates evidence linking benzene toxicity to PCD dysregulation, revealing that benzene and its metabolites induce abnormal subtypes of PCD (apoptosis, autophagy, ferroptosis) in hematopoietic cells. This occurs through mechanisms including activation of Caspase pathways, regulation of long non-coding RNAs, and epigenetic modifications, with recent research highlighting the IRP1-DHODH-ALOX12 ferroptosis axis and oxidative stress–epigenetic interactions as pivotal. Additionally, this review describes a comprehensive monitoring system for early toxic effects comprising benzene exposure biomarkers (urinary t,t-muconic acid (t,t-MA), S-phenylmercapturic acid (S-PMA)), PCD-related molecules (Caspase-3, let-7e-5p, ACSL1), oxidative stress indicators (8-OHdG), and genetic damage markers (micronuclei, p14ARF methylation), with correlative analyses between PCD mechanisms and benzene toxicity elaborated to underscore their integrative roles in risk assessment. Furthermore, the review details analytical techniques for these biomarkers, including direct benzene detection methods—direct headspace gas chromatography with flame ionization detection (DHGC-FID), liquid chromatography-tandem mass spectrometry (LC-MS/MS), and portable headspace sampling (Portable HS)—alongside molecular imprinting and fluorescence probe technologies, as well as methodologies for toxic effect markers such as live-cell imaging, electrochemical techniques, methylation-specific PCR (MSP), and Western blotting, providing technical frameworks for mechanistic studies and translational applications. By synthesizing current evidence and mechanistic insights, this work offers novel perspectives on benzene toxicity through the PCD lens, identifies potential therapeutic targets associated with PCD dysregulation, and ultimately establishes a theoretical foundation for developing interventional strategies against benzene-induced toxicity while emphasizing the translational value of mechanistic research in occupational and environmental health. Full article

Aflatoxins (AFs), harmful secondary metabolites produced by the genus Aspergillus, particularly Aspergillus flavus and Aspergillus parasiticus, are one of the best-known potent mycotoxins, posing a significant risk to public health. The primary type, especially aflatoxin B₁ (AFB₁), is a potent carcinogen associated with liver cancer, immunosuppression, and other health problems. Environmental factors such as high temperatures, humidity, and inadequate storage conditions promote the formation of aflatoxin in staple foods such as maize, peanuts, and rice. Immunocompromised individuals, including those with HIV/AIDS, hepatitis, cancer, or diabetes, are at increased risk due to their reduced detoxification capacity and weakened immune defenses. Chronic exposure to AF in these populations exacerbates liver damage, infection rates, and disease progression, particularly in developing countries and moderate-income populations where food safety regulations are inadequate and reliance on contaminated staple foods is widespread. Biomarkers such as aflatoxin-albumin complexes, urinary aflatoxin M₁, and aflatoxin (AF) DNA adducts provide valuable insights but remain underutilized in resource-limited settings. Despite the globally recognized health risk posed by AF, research focused on monitoring human exposure remains limited, particularly among immunocompromised individuals. This dynamic emphasizes the need for targeted studies and interventions to address the particular risks faced by immunocompromised individuals. This review provides an up-to-date overview of AF exposure in immunocompromised populations, including individuals with cancer, hepatitis, diabetes, malnutrition, pregnant women, and the elderly. It also highlights exposure pathways, biomarkers, and biomonitoring strategies, while emphasizing the need for targeted interventions, advanced diagnostics, and policy frameworks to mitigate health risks in these vulnerable groups. Addressing these gaps is crucial to reducing the health burden and developing public health strategies in high-risk regions. Full article

Hibiscus sabdariffa (H. sabdariffa) is a high-value economic and functional crop, limited by agroclimatic conditions and low technological adoption. This systematic review examines the current state of artificial intelligence applications in agricultural management, analyzing 2111 records, selecting 82, and synthesizing 22 studies that meet the inclusion criteria. This review adopts a holistic framework aligned with three priority areas in agriculture—resource and climate management, crop productivity and quality, and sustainability—to explore how AI addresses key challenges in the cultivation and post-harvest processing of Hibiscus sabdariffa. The results show a predominance of classical machine learning techniques, with limited implementation of deep learning models. The most common applications include image classification, yield prediction, and analysis of bioactive compounds. However, limitations remain in the availability of open data, reproducible code, and standardized metrics. The narrative synthesis identified clear opportunities to integrate emerging technologies, such as deep neural networks and the Internet of Things (IoT), particularly in water management and stress monitoring. The review concludes that strengthening interdisciplinary research and promoting data openness is key to achieving a more resilient, sustainable, and technologically advanced crop. Full article

Simulators are an effective tool for improving tram driver training. In urban rail transportation, the fidelity of reproducing the driver’s working environment is crucial due to the high diversity of vehicle models. This study presents a structured assessment model for evaluating the mapping of a tram driver’s console in a universal simulator. The model is based on expert judgment and utilizes fuzzy logic to evaluate four key criteria: perspective, button placement, functionality, and time required to locate safety buttons. A group of 30 experts, including experienced tram drivers and technical specialists, assessed the fidelity of the simulated consoles for three tram types: Solaris Tramino S105p, Moderus Gamma LF 06 AC, and Škoda 16T RK. The results enable the classification of console fidelity levels (low, moderate, high) and support the identification of design inconsistencies. The proposed model provides a standardized tool for assessing simulator realism, which can be applied by transport operators, manufacturers, and training centers to improve simulator configurations. Researchers may also use the model as a methodological framework for further evaluation studies involving human–machine interface fidelity. Full article

The question of the relationship between the Armenian and Byzantine churches has always interested researchers, often becoming a problem of study. Since the chosen problem concerns not only the mentioned churches but was also a fierce problem of the entire Christian world in the context of the debate between the supporters of Monophysitism and Dyophysitism, we set ourselves the goal of studying the issue in this context within the framework of the end of the 9th century and in the 10th century, when particularly important development took place. One of the main results of the article is that despite the accepted opinion that the Armenian Church has always insisted on its confession, based on political considerations, the Armenian political and religious leaders sometimes expressed readiness for a church union with Byzantium. The main method of this article is the genetic method, with the help of which the origin, sequence of events, and patterns of development of the phenomenon under research are studied. Full article

Rapid urbanization exerts immense pressure on cultivated land. Among these, slope-classified cultivated land (referring to cropland categorized by slope gradients) is especially vulnerable to fragmentation due to its ecological fragility, challenging utilization, and critical role in soil conservation and sustainable agriculture. This study explores the spatiotemporal dynamics and driving mechanisms of slope-classified cultivated land fragmentation (SCLF) in Guangdong Province, China, from 2000 to 2020. Using multi-temporal geospatial data, machine learning interpretation, and socioeconomic datasets, this research quantifies the spatiotemporal changes in SCLF, identifies key drivers and their interactions, and proposes differentiated protection strategies. The results reveal the following: (1) The SCLF decreased in the Pearl River Delta, exhibited “U-shaped” fluctuations in the west and east, and increased steadily in northern Guangdong. (2) The machine learning interpretation highlights significantly amplified synergistic effects among drivers, with socioeconomic factors, particularly agricultural mechanization and non-farm employment rates, exerting dominant influences on fragmentation patterns. (3) A “core–transitional–marginal” protection framework is proposed, intensifying the land use efficiency and ecological resilience in core areas, coupling land consolidation with green infrastructure in transitional zones, and promoting agroecological diversification in marginal regions. This research proposed a novel framework for SCLF, contributing to cultivated land protection and informing differentiated spatial governance in rapidly urbanizing regions. Full article

Hand hygiene is a key measure to prevent healthcare-associated infections (HAIs), yet compliance remains low in Sub-Saharan Africa (SSA), due to limited resources, insufficient training, and behavioral challenges. Simulation-based education offers a promising approach to enhance technical and non-technical skills in safe learning environments, promoting behavioral change and patient safety. This study aimed to develop and pilot a contextually adapted hand hygiene simulation-based learning scenario for nursing students in SSA. Grounded in the Medical Research Council (MRC) Framework and Design-Based Research principles, a multidisciplinary team from European and African higher education institutions (HEIs) co-created this scenario, integrating international and regional hand hygiene guidelines. Two iterative pilot cycles were conducted with expert panels, educators, and students. Data from structured observation and post-simulation questionnaires were analyzed using descriptive statistics. The results confirm the scenario’s feasibility, relevance, and educational value. The participants rated highly the clarity of learning objectives (M = 5.0, SD = 0.0) and preparatory materials (M = 4.6, SD = 0.548), reporting increased knowledge/skills and confidence and emphasizing the importance of clear roles, structured facilitation, and real-time feedback. These findings suggest that integrating simulation in health curricula could strengthen HAI prevention and control in SSA. Further research is needed to evaluate long-term outcomes and the potential for wider implementation. Full article

Introduction: Polio supplementary immunisation activities (SIA) are implemented to rapidly increase vaccination coverage and interrupt the transmission of poliovirus in a specified geographical area. Polio SIA complements routine immunisation and is crucial for the eradication of the disease by increasing population immunity. However, several contextual factors (i.e., implementation determinants) can influence the success or failure of polio SIA implementation; as such, understanding their dynamics can enhance proactive planning for practice improvement. This study aimed to explore and map the contextual factors of polio SIA implementation in the African region using a critical systems thinking approach. Methods: A rapid review of published and grey literature was conducted. The search included the Global Polio Eradication Initiative library for programmatic reports and two databases (PubMed and Google Scholar). Data extraction was performed using a structured tool. Thematic analysis was performed to categorise the identified contextual factors according to the domains and constructs of the Consolidated Framework for Implementation Research (CFIR). Then, a causal loop diagram (CLD) was used to map the linkages between the identified factors. Results: A total of seventy-eight contextual factors across the five CFIR domains were identified: three for innovation, twenty for outer setting, sixteen for inner setting, twenty-six for individuals, and thirteen for the implementation process. A system map of all the factors using CLD revealed multiple contingent connections, with eleven reinforcing loops and four balancing loops. Conclusions: This study identified the multilevel nature of the contextual factors that influence polio SIA, including their dynamics. The integration of CLD and CFIR in this study offers critical insights into the potential feedback loops that exists between the contextual factors which can be used as leverage points for policy and practice improvements, including tailoring strategies to enhance polio campaign implementation effectiveness, especially with the expanded use of the novel Oral Polio Vaccine type 2 (nOPV2) across countries in the region. Full article

Prime editing (PE), a novel “search-and-replace” genome editing technology, demonstrates significant potential for crop genetic improvement due to its precision and versatility. However, since its initial application in plants, PE technology has consistently faced challenges of low and variable editing efficiency, representing a major bottleneck hindering its broader application. Therefore, this study conducted a systematic review following the PRISMA 2020 guidelines. We systematically searched databases—Web of Science, PubMed, and Google Scholar—for studies published up to June 2025 focusing on enhancing PE performance in crops. After a rigorous screening process, 38 eligible primary research articles were ultimately included for comprehensive analysis. Our analysis revealed that early PE systems such as PE2 could perform diverse edits, including all 12 base substitutions and small insertions or deletions (indels), but their efficiency was highly variable across species, targets, and edit types. To overcome this bottleneck, researchers developed four major optimization strategies: (1) engineering core components such as Cas9, reverse transcriptase (RT), and editor architecture; (2) enhancing expression and delivery via optimized promoters and vectors; (3) improving reaction processes by modulating DNA repair pathways or external conditions; and (4) enriching edited events through selectable or visual markers. These advancements broadened PE’s targeting scope with novel Cas9 variants and enabled complex, kilobase-scale DNA insertions and rearrangements. The application of PE technology in plants has evolved from basic functional validation, through systematic optimization for enhanced efficiency, to advanced stages of functional expansion. This review charts this trajectory and clarifies the key strategies driving these advancements. We posit that future breakthroughs will increasingly depend on synergistically integrating these strategies to enable the efficient, precise, and predictable application of PE technology across diverse crops and complex breeding objectives. This study provides an important theoretical framework and practical guidance for subsequent research and application in this field. Full article

This study delves into the response characteristics of core grounding current signals in power transformers across different operating conditions, aiming to enhance the accuracy of transformer condition assessment. Existing detection technologies often rely on single-parameter methods, which fall short in providing a comprehensive evaluation of transformer conditions. To address this limitation, this research develops a wideband circuit model based on multi-conductor transmission line theory and backed by experimental validation. The model systematically investigates the response mechanisms of core grounding current to various electrical stresses, including impulse voltages, power-frequency harmonics, and partial discharges. The findings reveal distinct response characteristics of core grounding current under different stresses. Under impulse voltage excitation, the core current exhibits high-frequency oscillatory decay with characteristics linked to voltage waveform parameters. In harmonic conditions, the current spectrum shows linear correspondence with excitation voltages, with no resonance below 1 kHz. Partial discharges induce high-frequency oscillations in the grounding current due to multi-resonant networks formed by distributed winding-core parameters. This study establishes a new theoretical framework for transformer condition assessment based on core grounding current analysis, offering critical insights for optimizing detection technologies and overcoming the limitations of traditional methods. Full article