A fully integrated low-dropout (LDO) regulator with improved load regulation and transient responses in 40 nm technology is presented in this paper. Combining adjustable threshold push–pull stage (ATPS) and master–slave power transistors...
In this paper, from linear operator, semigroup and Sturm–Liouville problem theories, an abstract system model for the convection–diffusion (C–D) equation is proposed. The state operator for this abstract system model is here defined...
Mycobacterium tuberculosis is a well-known pathogen due to the emergence of drug resistance associated with it, where transcriptional regulators play a key role in infection, colonization and persistence. The genome of M. tuberculosis encodes many tr...
Climate change is increasing variability in environmental conditions and the frequency and severity of natural hazards such as hurricanes, floods, and wildfires. In this paper, we use general systems theory to describe how disaster management systems...
This manuscript addresses the regulator design in the discrete-time setting for the unstable linearized Saint–Venant–Exner model, which describes the dynamics of a sediment-filled water canal. The proposed regulator ensures the closed-loo...
Originally named for its expression in the posterior hypothalamus in rats and after the Greek word for “appetite”, hypocretin, or orexin, as it is known today, gained notoriety as a neuropeptide regulating feeding behavior, energy homeost...
Most of the reported vortex beam generators with orbital angular momentum (OAM) in the terahertz region only operate in either the reflection mode or the transmission mode, which greatly limits the integration and application in terahertz technology...
The increasing demand for sustainable alternatives to synthetic agrochemicals underscores the need for novel, naturally derived plant growth regulators (PGRs) with high specificity and minimal environmental impact. In this study, we propose agavenin...
Clustered regularly interspaced short palindromic repeats (CRISPR)- CRISPR-associated protein 9 (Cas9) genome editing technology is widely used for gene editing because it provides versatility in genetic manipulation. Several methods for regulating C...
A leading cause of bacterial gastroenteritis, Campylobacter jejuni is also associated with broad sequelae, including extragastrointestinal conditions such as reactive arthritis and Guillain-Barré Syndrome (GBS). CbrR is a C. jejuni response re...
As multicellular organisms grow, spatial and temporal patterns of gene expression are strictly regulated to ensure that developmental programs are invoked at appropriate stages. In this work, we describe a putative transcriptional regulator in Arabid...
In this paper, a new piezoelectric dynamic balance regulator, which can be used in motorised spindle systems, is presented. The dynamic balancing adjustment mechanism is driven by an in-plane bending vibration from an annular piezoelectric stator exc...
The oxygen regulator is the core component of the aircraft life support system, which adjusts the flow and pressure of the breathing gas according to the pilot’s breathing needs. In response to the problem that structural parameters are difficu...
Transcription factors are important regulators of gene expression. They can orchestrate the activation or repression of hundreds or thousands of genes and control diverse processes in a coordinated way. This work explores the effect of a master regul...
The introduction of distributed generation (DG) into distribution systems is expanding due to carbon neutral policies. DG with intermittent output characteristics brings frequent voltage variations in distribution systems. Generally, a step voltage r...
Plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) is a novel epigenetic “reader” that specifically recognises histone post-translational modifications (PTMs) via its Tudor and PHD finger domains, thereby regulating chromatin remo...
PA28γ (also called REGγ, 11Sγ or PSME3) negatively regulates p53 activity by promoting its nuclear export and/or degradation. Here, using the RNA ligase-mediated rapid amplification of cDNA ends (RLM-RACE) method, we identified the transcription star...
Bacillus thuringiensis produces insecticidal crystal proteins encoded by cry or cyt genes and targets a variety of insect pests. We previously found that a strong promoter of a DeoR family transcriptional regulator (HD73_5014) can efficiently drive c...
This paper presents a proposal for a new type of regulator for switched reluctance motor (SRM) drives. The proposed regulator enables a significant extension of the rotational speed range and drive output power. This regulator is characterized by a c...
Clostridium ljungdahlii is a representative autotrophic acetogen capable of producing multiple chemicals from one-carbon gases (CO2/CO). The metabolic and regulatory networks of this carbon-fixing bacterium are interesting, but still remain minimally...
DNA mismatch repair (MMR) is a highly conserved pathway that corrects both base–base mispairs and insertion-deletion loops (IDLs) generated during DNA replication. Defects in MMR have been linked to carcinogenesis and drug resistance. However,...
Generally, utilities regulate the voltage on the long power distribution line within a permissible range by using a step voltage regulator (SVR), which is located around the middle of the line and operates according to the condition of the line curre...
Biofilm formation is a survival strategy by which microorganisms adapt to environmental challenges. It is regulated by various signals, such as the second messenger c-di-GMP. We previously found that the Flm chemosensory pathway could respond to chem...
The article describes the design of a universal simulation model of a voltage regulator for applications compatible with the globally used PSpice program. Users can create a model of any type of integrated switching voltage regulator that is currentl...
Pneumatic booster regulators (PBR) are in great demand in modern pneumatic systems for their energy-saving abilities. A new booster regulator with energy recovery (VBA-R) was proposed, and its energy efficiency was investigated by introducing the con...
An output capacitor-less low-dropout (OCL-LDO) regulator with a wide range of load currents is proposed in this study. The structure of the proposed regulator is based on the flipped-voltage-follower LDO regulator. The feedback loop of the proposed r...
Xanthomonas oryzae pv. oryzicola (Xoc) is a notorious plant pathogen. Like most bacterial pathogens, Xoc has evolved a complex regulatory network to modulate the expression of various genes related to pathogenicity. Here, we have identified TfmR...
Pseudomonas aeruginosa, a human opportunistic pathogen, is a common cause of nosocomial infections. Its ability to survive under different conditions relies on a complex regulatory network engaging transcriptional regulators controlling metabolic pat...
Hepatocyte nuclear factor 4 α (HNF4α) is a master transcriptional regulator essential for the maintenance of epithelial cell identity and function. Beyond its well-established role in controlling metabolic and differentiation programs, re...
The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1s (PGC-1s) can induce the expression of several downstream genes that play pivotal roles in the regulation of mitochondrial biogenesis and metabolism in the heart. Moreover, PGC-1...
Persistent infections with high-risk human papillomavirus (HPV) constitute the main risk factor for cervical cancer development. HPV16 is the most frequent type associated to squamous cell carcinomas (SCC), followed by HPV18. The long control region...
The PACLOBUTRAZOL-RESISTANCE (PRE) gene family encodes a group of atypical helix-loop-helix (HLH) proteins that act as the major hub integrating a wide range of environmental and hormonal signals to regulate plant growth and development. PRE1, as a p...
Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-associated proteins) systems provide acquired heritable protection to bacteria and archaea against selfish DNA elements, such as viruses. These systems must be tightly reg...
Alpha-amylase, the major form of amylase with secondary carbohydrate binding sites, is a crucial enzyme throughout the growth period and life cycle of angiosperm. In rice, alpha-amylase isozymes are critical for the formation of the storage starch gr...
Among the plant nutrients, potassium (K) is one of the vital elements required for plant growth and physiology. Potassium is not only a constituent of the plant structure but it also has a regulatory function in several biochemical processes related...
Background. The genus Streptomyces is known for its capability to produce a wide range of bioactive secondary metabolites. The enzymes required for their synthesis are encoded within biosynthetic gene clusters (BGCs), whose expression can be influenc...
Sustainability is important in voltage regulation control in grids and must be done successfully. In this paper, a novel tilt-fractional order integral-derivative with a second order derivative and low-pass filters controller, referred to as TI&lambd...
LIM and SH3 protein 1 was originally identified as a structural cytoskeletal protein with scaffolding function. However, recent data suggest additional roles in cell signaling and gene expression, especially in tumor cells. These novel functions are...
Ewing’s sarcoma (ES) is caused by a chromosomal translocation leading to the formation of the fused EWSFLI1 gene, which codes for an aberrant transcription factor EWSFLI1. The transcriptional targets of EWSFLI1 have been viewed as promising and novel...
Nucleoredoxin (NXN), an oxidoreductase enzyme, contributes to cellular redox homeostasis by regulating different signaling pathways in a redox-dependent manner. By interacting with seven proteins so far, namely disheveled (DVL), protein phosphatase 2...
The antioxidant defense is critical for the survival of intracellular pathogens such as Mycobacterium tuberculosis complex (MTBC) species, including Mycobacterium bovis, which are often exposed to an oxidative environment caused by reactive oxygen sp...
Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration and cancer, which are closely associated with intracellular signal transducers such as reactive oxygen species (ROS). It has been suggested that ROS is the ups...
Voltage stability has always been a hot topic in power system research. Traditional On-Load Tap-Charger (OLTC) transformer is considered to play a very important role in the system voltage stability. However, in the heavy load of distribution network...
This in situ study presents an analysis of the wear of mobile contacts of switching in an automatic line voltage regulator, regarding the surface wear of the contacts. It is interesting to analyze the contacts of this equipment due to the friction an...
Natural products hold immense therapeutic potential, yet they remain underexplored due to challenges in activating or producing them in laboratory settings. Here, we investigate the regulatory capabilities of a new medium-sized Streptomyces Antibioti...
The nucleosome is the structural and fundamental unit of eukaryotic chromatin. The chromatin remodeling complexes change nucleosome composition, packaging and positioning to regulate DNA accessibility for cellular machinery. SWI2/SNF2-Related 1 Chrom...
A cost-effective light-emitting diode (LED) current balance strategy using a variable voltage regulator (VVR) with low dropout vDS control is proposed. This can regulate the multiple metal-oxide-semiconductor field-effect transistors (MOSFETs) of the...
Toxin-antitoxin (TA) systems are the major mechanism for persister formation in Mycobacterium tuberculosis (Mtb). Previous studies found that HigBA2 (Rv2022c-Rv2021c), a predicted type II TA system of Mtb, could be activated for transcription in resp...
Cyanogenic glucosides are specialized metabolites produced by over 3000 species of higher plants from more than 130 families. The deployment of cyanogenic glucosides is influenced by biotic and abiotic factors in addition to being developmentally reg...
The article is devoted to the study of steady-state conditions of a distribution network containing a thyristor voltage regulator. The thyristor voltage regulator (TVR) is a new controlled semiconductor device developed at Nizhny Novgorod State Techn...
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