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Keywords = radiation plasma dynamics

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15 pages, 3786 KiB  
Article
Atomistic Mechanisms and Temperature-Dependent Criteria of Trap Mutation in Vacancy–Helium Clusters in Tungsten
by Xiang-Shan Kong, Fang-Fang Ran and Chi Song
Materials 2025, 18(15), 3518; https://doi.org/10.3390/ma18153518 - 27 Jul 2025
Viewed by 272
Abstract
Helium (He) accumulation in tungsten—widely used as a plasma-facing material in fusion reactors—can lead to clustering, trap mutation, and eventual formation of helium bubbles, critically impacting material performance. To clarify the atomic-scale mechanisms governing this process, we conducted systematic molecular statics and molecular [...] Read more.
Helium (He) accumulation in tungsten—widely used as a plasma-facing material in fusion reactors—can lead to clustering, trap mutation, and eventual formation of helium bubbles, critically impacting material performance. To clarify the atomic-scale mechanisms governing this process, we conducted systematic molecular statics and molecular dynamics simulations across a wide range of vacancy cluster sizes (n = 1–27) and temperatures (500–2000 K). We identified the onset of trap mutation through abrupt increases in tungsten atomic displacement. At 0 K, the critical helium-to-vacancy (He/V) ratio required to trigger mutation was found to scale inversely with cluster size, converging to ~5.6 for large clusters. At elevated temperatures, thermal activation lowered the mutation threshold and introduced a distinct He/V stability window. Below this window, clusters tend to dissociate; above it, trap mutation occurs with near certainty. This critical He/V ratio exhibits a linear dependence on temperature and can be described by a size- and temperature-dependent empirical relation. Our results provide a quantitative framework for predicting trap mutation behavior in tungsten, offering key input for multiscale models and informing the design of radiation-resistant materials for fusion applications. Full article
(This article belongs to the Section Materials Simulation and Design)
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23 pages, 9331 KiB  
Article
Non-Ideal Hall MHD Rayleigh–Taylor Instability in Plasma Induced by Nanosecond and Intense Femtosecond Laser Pulses
by Roman S. Zemskov, Maxim V. Barkov, Evgeniy S. Blinov, Konstantin F. Burdonov, Vladislav N. Ginzburg, Anton A. Kochetkov, Aleksandr V. Kotov, Alexey A. Kuzmin, Sergey E. Perevalov, Il’ya A. Shaikin, Sergey E. Stukachev, Ivan V. Yakovlev, Alexander A. Soloviev, Andrey A. Shaykin, Efim A. Khazanov, Julien Fuchs and Mikhail V. Starodubtsev
Plasma 2025, 8(2), 23; https://doi.org/10.3390/plasma8020023 - 10 Jun 2025
Viewed by 1355
Abstract
A pioneering detailed comparative study of the dynamics of plasma flows generated by high-power nanosecond and high-intensity femtosecond laser pulses with similar fluences of up to 3×104 J/cm2 is presented. The experiments were conducted on the petawatt laser facility [...] Read more.
A pioneering detailed comparative study of the dynamics of plasma flows generated by high-power nanosecond and high-intensity femtosecond laser pulses with similar fluences of up to 3×104 J/cm2 is presented. The experiments were conducted on the petawatt laser facility PEARL using two types of high-power laser radiation: femtosecond pulses with energy exceeding 10 J and a duration less than 60 fs, and nanosecond pulses with energy exceeding 10 J and a duration on the order of 1 ns. In the experiments, high-velocity (>100 km/s) flows of «femtosecond» (created by femtosecond laser pulses) and «nanosecond» plasmas propagated in a vacuum across a uniform magnetic field with a strength over 14 T. A significant difference in the dynamics of «femtosecond» and «nanosecond» plasma flows was observed: (i) The «femtosecond» plasma initially propagated in a vacuum (no B-field) as a collimated flow, while the «nanosecond» flow diverged. (ii) The «nanosecond» plasma interacting with external magnetic field formed a quasi-spherical cavity with Rayleigh–Taylor instability flutes. In the case of «femtosecond» plasma, such flutes were not observed, and the flow was immediately redirected into a narrow plasma sheet (or «tongue») propagating across the magnetic field at an approximately constant velocity. (iii) Elongated «nanosecond» and «femtosecond» plasma slabs interacting with a transverse magnetic field broke up into Rayleigh–Taylor «tongues». (iv) The ends of these «tongues» in the femtosecond case twisted into vortex structures aligned with the ion motion in the external magnetic field, whereas the «tongues» in the nanosecond case were randomly oriented. It was suggested that the twisting of femtosecond «tongues» is related to Hall effects. The experimental results are complemented by and consistent with numerical 3D magnetohydrodynamic simulations. The potential applications of these findings for astrophysical objects, such as short bursts in active galactic nuclei, are discussed. Full article
(This article belongs to the Special Issue New Insights into Plasma Theory, Modeling and Predictive Simulations)
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18 pages, 5983 KiB  
Article
Plasma and Fecal Metabolites Combined with Gut Microbiome Reveal Systemic Metabolic Shifts in 60Co Gamma-Irradiated Rats
by Jie Zong, Haiyang Wu, Xuan Hu, Ami Yao, Wenhua Zhu, Guifang Dou, Shuchen Liu, Xiaoxia Zhu, Ruolan Gu, Yunbo Sun, Zhuona Wu, Shanshan Wang and Hui Gan
Metabolites 2025, 15(6), 363; https://doi.org/10.3390/metabo15060363 - 29 May 2025
Viewed by 570
Abstract
Background: High-dose γ-ray exposure (≥7 Gy) in nuclear emergencies induces life-threatening acute radiation syndrome, characterized by rapid hematopoietic collapse (leukocytes <0.5 × 10⁹/L) and gastrointestinal barrier failure. While clinical biomarkers like leukocyte depletion guide current therapies targeting myelosuppression, the concomitant metabolic disturbances [...] Read more.
Background: High-dose γ-ray exposure (≥7 Gy) in nuclear emergencies induces life-threatening acute radiation syndrome, characterized by rapid hematopoietic collapse (leukocytes <0.5 × 10⁹/L) and gastrointestinal barrier failure. While clinical biomarkers like leukocyte depletion guide current therapies targeting myelosuppression, the concomitant metabolic disturbances and gut microbiota dysbiosis—critical determinants of delayed mortality—remain insufficiently profiled across the 28-day injury-recovery continuum. Methods: This study investigates the effects of 60Co γ-ray irradiation on metabolic characteristics and gut microbiota in Sprague Dawley rats using untargeted metabolomics and 16S rRNA sequencing. Meanwhile, body weight and complete blood counts were measured. Results: Body weight exhibited significant fluctuations, with the most pronounced deviation observed at 14 days. Blood counts revealed a rapid decline in white blood cells, red blood cells, and platelets post-irradiation, reaching nadirs at 7–14 days, followed by gradual recovery to near-normal levels by 28 days. Untargeted metabolomics identified 32 upregulated and 33 downregulated plasma metabolites at 14 days post-irradiation, while fecal metabolites showed 47 upregulated and 18 downregulated species at 3 days. Key metabolic pathways impacted included Glycerophospholipid metabolism, alpha-linolenic acid metabolism, and biosynthesis of unsaturated fatty acids. Gut microbiota analysis demonstrated no significant change in α-diversity but significant β-diversity shifts (p < 0.05), indicating a marked alteration in the compositional structure of the intestinal microbial community following radiation exposure. Principal coordinate analysis confirmed distinct clustering between control and irradiated groups, with increased abundance of Bacteroidota and decreased Firmicutes in irradiated rats. These findings highlight dynamic metabolic and microbial disruptions post-irradiation, with recovery patterns suggesting a 28-day restoration cycle. Spearman’s rank correlation analysis explored associations between the top 20 fecal metabolites and 50 abundant bacterial taxa. Norank_f_Muribaculaceae, Prevotellaceae_UCG-001, and Bacteroides showed significant correlations with various radiation-altered metabolites, highlighting metabolite–microbiota relationships post-radiation. Conclusions: This study provides insights into potential biomarkers for radiation-induced physiological damage and underscores the interplay between systemic metabolism and gut microbiota in radiation response. Full article
(This article belongs to the Section Advances in Metabolomics)
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16 pages, 861 KiB  
Article
Theoretical Study of the Pre-Plasma Density Scale Length’s Influence on the Absorption Efficiency in Laser–Solid Interaction at Relativistic Laser Intensities for PW-Class Lasers
by Iuliana-Mariana Vladisavlevici, Michael Ehret, Evgeny Filippov, Enrique García-García, Cruz Mendez, Marta Olivar Ruíz, Óscar Varela, Luca Volpe and Jose Antonio Pérez-Hernández
Photonics 2025, 12(1), 71; https://doi.org/10.3390/photonics12010071 - 15 Jan 2025
Cited by 1 | Viewed by 1417
Abstract
This work studied the pre-plasma that builds up in interactions of focused high-power PW-class lasers with solid targets at the target surface facing the laser beam, and its impact on the global laser absorption efficiency as well as on the spectral cut-off energy [...] Read more.
This work studied the pre-plasma that builds up in interactions of focused high-power PW-class lasers with solid targets at the target surface facing the laser beam, and its impact on the global laser absorption efficiency as well as on the spectral cut-off energy of laser-generated proton beams. Our practical heuristic estimates were derived from the example of the VEGA-3 laser at CLPU. Our modeling results for the pre-plasma expansion due to the laser pedestal of VEGA-3 were benchmarked by hydrodynamic simulations, revealing good agreement for the evolution before the arrival of the main Gaussian laser intensity peak. Our detailed numerical two-dimensional Particle-in-Cell simulations showed the impact of different pre-plasma scale lengths on the absorption efficiency of laser energy into electrons, relevant for the seeding of other types of radiation. It was shown that the absorption can increase manyfold when increasing the pre-plasma scale length. This effect can be beneficial for the spectral cut-off energy of accelerated protons, where a trade-off between absorption and electron dynamics yields an optimum pre-plasma scale length. The findings can be applied to other PW-class laser facilities. Full article
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12 pages, 7215 KiB  
Article
Radio Spectrum Observations and Studies of the Solar Broadband Radio Dynamic Spectrometer (SBRS)
by Jing Huang and Baolin Tan
Universe 2024, 10(12), 440; https://doi.org/10.3390/universe10120440 - 29 Nov 2024
Viewed by 908
Abstract
Solar radio spectral observation is one of the essential approaches for solar physics research, which helps us study the plasma dynamics in the solar atmosphere. The Solar Broadband Radio Dynamic Spectrometer (SBRS) started observing the Sun at Huairou Solar Observing Station in Beijing, [...] Read more.
Solar radio spectral observation is one of the essential approaches for solar physics research, which helps us study the plasma dynamics in the solar atmosphere. The Solar Broadband Radio Dynamic Spectrometer (SBRS) started observing the Sun at Huairou Solar Observing Station in Beijing, China, in 1999. It has obtained a large amount of high-quality observation data of solar radio dynamic spectra in the centimeter–decimeter wavelengths (1.10–7.60 GHz). In particular, the observations with high-temporal resolution of millisecond and high-frequency resolution of MHz display plenty of superfine structures in the dynamic spectrum, which provide crucial information on the radiation process of various radio bursts. We review the past history of solar radio spectral observation and scientific results of SBRS. It is meaningful and will undoubtedly help us inspire new ideas for future research. The understanding of the basic plasma processes in solar plasma could also promote the development of solar physics, astrophysics, and space weather. To broaden the observation frequency range, we propose a new spectrometer at millimeter wavelengths (20–100 GHz) with ultra-wideband and high time–frequency resolution to study the physical processes in the solar transition region. This will open a new window for solar physics research and will provide crucial observational evidence for exploring a series of major issues in solar physics, including coronal heating, solar eruptions, and the origin of solar winds. Full article
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15 pages, 279 KiB  
Review
Plasmas Containing Quasimonochromatic Electric Fields (QEFs): Review of the General Principles of Their Spectroscopy and Selected Applications
by Eugene Oks
Atoms 2024, 12(10), 49; https://doi.org/10.3390/atoms12100049 - 27 Sep 2024
Viewed by 1024
Abstract
We review the general principles of the spectroscopy of plasmas containing quasimonochromatic electric fields (QEFs). We demonstrate that the underlying physics is very rich due to the complicated entanglement of four characteristic times: the typical time required for the formation of the quasienergy [...] Read more.
We review the general principles of the spectroscopy of plasmas containing quasimonochromatic electric fields (QEFs). We demonstrate that the underlying physics is very rich due to the complicated entanglement of four characteristic times: the typical time required for the formation of the quasienergy states, the lifetime of the excited state of the radiator, the typical time of the formation of the homogeneous Stark broadening by the electron microfield, and the typical time of the formation of the homogeneous Stark broadening by the dynamic part of the ion microfield. We exemplified how the shape and shift of spectral lines are affected by the mutual interactions of the three subsystems. Specifically, the interaction of the radiator with the plasma can be substantially influenced by the interaction of the radiator with the QEF, and vice versa, as well as by the interaction of the QEF and the plasma with each other. We also provide some applications of these various effects. Finally, we outline directions for future research. Full article
15 pages, 1472 KiB  
Article
A Preliminary Assessment of the Usability of Magnetoplasma Compressors in Scientific and Technical Applications
by Victor V. Kuzenov, Aleksey Yu. Varaksin and Sergei V. Ryzhkov
Symmetry 2024, 16(9), 1200; https://doi.org/10.3390/sym16091200 - 12 Sep 2024
Cited by 5 | Viewed by 699
Abstract
This paper presents a preliminary analysis of the plasma dynamic modes of operation of end-type magnetoplasma compressor (MPC) discharges. The characteristic methods used to organize the optical pumping of a photodissociation gas laser using an MPC discharge are briefly described. The kinetic and [...] Read more.
This paper presents a preliminary analysis of the plasma dynamic modes of operation of end-type magnetoplasma compressor (MPC) discharges. The characteristic methods used to organize the optical pumping of a photodissociation gas laser using an MPC discharge are briefly described. The kinetic and energy characteristics of photodissociation gas optical quantum generators (OQGs) with optical pumping by an MPC discharge were evaluated. Based on the numerical calculations, an analysis of the radiation–plasma dynamic structures and the spectral brightness characteristics of the MPC discharge in the ohmic mode of plasma heating was carried out. Full article
(This article belongs to the Special Issue Symmetry in High Voltage and Insulation Technology)
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17 pages, 42688 KiB  
Article
The Multi-Detectors System of the PANDORA Facility: Focus on the Full-Field Pin-Hole CCD System for X-ray Imaging and Spectroscopy
by David Mascali, Eugenia Naselli, Sandor Biri, Giorgio Finocchiaro, Alessio Galatà, Giorgio Sebastiano Mauro, Maria Mazzaglia, Bharat Mishra, Santi Passarello, Angelo Pidatella, Richard Rácz, Domenico Santonocito and Giuseppe Torrisi
Condens. Matter 2024, 9(2), 28; https://doi.org/10.3390/condmat9020028 - 20 Jun 2024
Cited by 2 | Viewed by 1728
Abstract
PANDORA (Plasmas for Astrophysics Nuclear Decays Observation and Radiation for Archaeometry) is an INFN project aiming at measuring, for the first time, possible variations in in-plasma β-decay lifetimes in isotopes of astrophysical interest as a function of thermodynamical conditions of the in-laboratory [...] Read more.
PANDORA (Plasmas for Astrophysics Nuclear Decays Observation and Radiation for Archaeometry) is an INFN project aiming at measuring, for the first time, possible variations in in-plasma β-decay lifetimes in isotopes of astrophysical interest as a function of thermodynamical conditions of the in-laboratory controlled plasma environment. Theoretical predictions indicate that the ionization state can dramatically modify the β-decay lifetime (even of several orders of magnitude). The PANDORA experimental approach consists of confining a plasma able to mimic specific stellar-like conditions and measuring the nuclear decay lifetime as a function of plasma parameters. The β-decay events will be measured by detecting the γ-ray emitted by the daughter nuclei, using an array of 12 HPGe detectors placed around the magnetic trap. In this frame, plasma parameters have to be continuously monitored online. For this purpose, an innovative, non-invasive multi-diagnostic system, including high-resolution time- and space-resolved X-ray analysis, was developed, which will work synergically with the γ-rays detection system. In this contribution, we will describe this multi-diagnostics system with a focus on spatially resolved high-resolution X-ray spectroscopy. The latter is performed by a pin-hole X-ray camera setup operating in the 0.5–20 keV energy domain. The achieved spatial and energy resolutions are 450 µm and 230 eV at 8.1 keV, respectively. An analysis algorithm was specifically developed to obtain SPhC (Single Photon-Counted) images and local plasma emission spectrum in High-Dynamic-Range (HDR) mode. Thus, investigations of image regions where the emissivity can change by even orders of magnitude are now possible. Post-processing analysis is also able to remove readout noise, which is often observable and dominant at very low exposure times (ms). Several measurements have already been used in compact magnetic plasma traps, e.g., the ATOMKI ECRIS in Debrecen and the Flexible Plasma Trap at LNS. The main outcomes will be shortly presented. The collected data allowed for a quantitative and absolute evaluation of local emissivity, the elemental analysis, and the local evaluation of plasma density and temperature. This paper also discusses the new plasma emission models, implemented on PIC-ParticleInCell codes, which were developed to obtain powerful 3D maps of the X-rays emitted by the magnetically confined plasma. These data also support the evaluation procedure of spatially resolved plasma parameters from the experimental spectra as well as, in the near future, the development of appropriate algorithms for the tomographic reconstruction of plasma parameters in the X-ray domain. The described setups also include the most recent upgrade, consisting of the use of fast X-ray shutters with special triggering systems that will be routinely implemented to perform both space- and time-resolved spectroscopy during transient, stable, and turbulent plasma regimes (in the ms timescale). Full article
(This article belongs to the Special Issue High Precision X-ray Measurements 2023)
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15 pages, 4318 KiB  
Article
Nanosecond-Laser-Induced Breakdown of Aqueous Colloidal Solutions of Dysprosium Nanoparticles: The Influence of Nanoparticle Concentration on the Breakdown Plasma and the Intensity of Physical and Chemical Processes
by Ilya V. Baimler, Alexey S. Baryshev, Anastasiya O. Dikovskaya, Viktor K. Chevokin, Oleg V. Uvarov, Maxim E. Astashev, Sergey V. Gudkov and Aleksander V. Simakin
Physics 2024, 6(2), 529-543; https://doi.org/10.3390/physics6020035 - 9 Apr 2024
Cited by 1 | Viewed by 1455
Abstract
This paper studies the dynamics of the development of laser breakdown plasma in aqueous colloids of dysprosium nanoparticles by analyzing the time patterns of plasma images obtained using a high-speed streak camera. In addition, the distribution of plasma flashes in space and their [...] Read more.
This paper studies the dynamics of the development of laser breakdown plasma in aqueous colloids of dysprosium nanoparticles by analyzing the time patterns of plasma images obtained using a high-speed streak camera. In addition, the distribution of plasma flashes in space and their luminosity were studied, and the amplitude of acoustic signals and the rate of generation of new chemical products were studied depending on the concentration of dysprosium nanoparticles in the colloid. Laser breakdown was initiated by pulsed radiation from a nanosecond Nd:YAG laser. It is shown that the size of the plasma flash, the speed of motion of the plasma–liquid interface, and the lifetime of the plasma flash decrease with an increasing concentration of nanoparticles in the colloid. In this case, the time delay between the beginning of the laser pulse and the moment the plasma flash reaches its maximum intensity increases with increasing concentrations of nanoparticles. Varying the laser fluence in the range from 67 J/cm2 to 134 J/cm2 does not lead to noticeable changes in these parameters, due to the transition of the breakdown plasma to the critical regime. For dysprosium nanoparticles during laser breakdown of colloids, a decrease in the yield of hydrogen peroxide and an increase in the rate of formation of hydroxyl radicals per water molecule, characteristic of nanoparticles of rare earth metals, are observed, which may be due to the participation of nanoparticles and hydrogen peroxide in reactions similar to the Fenton and Haber–Weiss reactions. Full article
(This article belongs to the Section Applied Physics)
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24 pages, 1299 KiB  
Review
Pioneering the Future: A Trailblazing Review of the Fusion of Computational Fluid Dynamics and Machine Learning Revolutionizing Plasma Catalysis and Non-Thermal Plasma Reactor Design
by Muhammad Yousaf Arshad, Anam Suhail Ahmad, Jakub Mularski, Aleksandra Modzelewska, Mateusz Jackowski, Halina Pawlak-Kruczek and Lukasz Niedzwiecki
Catalysts 2024, 14(1), 40; https://doi.org/10.3390/catal14010040 - 6 Jan 2024
Cited by 14 | Viewed by 5525
Abstract
The advancement of plasma technology is intricately linked with the utilization of computational fluid dynamics (CFD) models, which play a pivotal role in the design and optimization of industrial-scale plasma reactors. This comprehensive compilation encapsulates the evolving landscape of plasma reactor design, encompassing [...] Read more.
The advancement of plasma technology is intricately linked with the utilization of computational fluid dynamics (CFD) models, which play a pivotal role in the design and optimization of industrial-scale plasma reactors. This comprehensive compilation encapsulates the evolving landscape of plasma reactor design, encompassing fluid dynamics, chemical kinetics, heat transfer, and radiation energy. By employing diverse tools such as FLUENT, Python, MATLAB, and Abaqus, CFD techniques unravel the complexities of turbulence, multiphase flow, and species transport. The spectrum of plasma behavior equations, including ion and electron densities, electric fields, and recombination reactions, is presented in a holistic manner. The modeling of non-thermal plasma reactors, underpinned by precise mathematical formulations and computational strategies, is further empowered by the integration of machine learning algorithms for predictive modeling and optimization. From biomass gasification to intricate chemical reactions, this work underscores the versatile potential of plasma hybrid modeling in reshaping various industrial processes. Within the sphere of plasma catalysis, modeling and simulation methodologies have paved the way for transformative progress. Encompassing reactor configurations, kinetic pathways, hydrogen production, waste valorization, and beyond, this compilation offers a panoramic view of the multifaceted dimensions of plasma catalysis. Microkinetic modeling and catalyst design emerge as focal points for optimizing CO2 conversion, while the intricate interplay between plasma and catalysts illuminates insights into ammonia synthesis, methane reforming, and hydrocarbon conversion. Leveraging neural networks and advanced modeling techniques enables predictive prowess in the optimization of plasma-catalytic processes. The integration of plasma and catalysts for diverse applications, from waste valorization to syngas production and direct CO2/CH4 conversion, exemplifies the wide-reaching potential of plasma catalysis in sustainable practices. Ultimately, this anthology underscores the transformative influence of modeling and simulation in shaping the forefront of plasma-catalytic processes, fostering innovation and sustainable applications. Full article
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20 pages, 8659 KiB  
Article
Evolution of Irradiation Defects in W and W-Re Systems: A Density Functional Theory and Rate Theory Study
by Tianyuan Xin, Yiying Yang, Yuexia Wang, Lu Wu, Rongjian Pan, Qiu Xu and Xiaoyong Wu
Metals 2023, 13(12), 1990; https://doi.org/10.3390/met13121990 - 7 Dec 2023
Cited by 3 | Viewed by 1473
Abstract
In a fusion environment, tungsten, a plasma-facing material in a reactor, is subject to the irradiation of high-energy neutrons, generating a large amount of displacement damage and transmutation products (such as rhenium, Re). We studied the evolution of defects under irradiation in W [...] Read more.
In a fusion environment, tungsten, a plasma-facing material in a reactor, is subject to the irradiation of high-energy neutrons, generating a large amount of displacement damage and transmutation products (such as rhenium, Re). We studied the evolution of defects under irradiation in W and W-Re systems using the density functional theory (DFT) and rate theory (RT) method. The results indicate that the evolution of irradiation defects is mainly affected by the irradiation dose, dose rate, and temperature. During irradiation, loops form first in W, followed by the generation of voids, which are due to the different migration energies of point defects. Higher dose rates result in a higher density and larger size of defects in tungsten. Higher temperatures cause a decrease in void density and an increase in size. The results obtained at 600 °C were in good agreement with the reported TEM data. In W-Re alloys, it is indicated that the formation of loops is delayed because Re suppresses the nucleation of loops. The dynamic introduction of Re in W stabilizes the growth of defects compared to W-Re alloys, suggesting that transmuting elements have less detrimental effects on irradiation than alloying. As defect densities and sizes were quantified under different irradiation conditions, the results provide data for the multi-scale simulation of the radiation damage and thermal/mechanical properties in plasma-facing materials under fusion conditions. Full article
(This article belongs to the Section Computation and Simulation on Metals)
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17 pages, 6286 KiB  
Article
Metabolomic Signatures Associated with Radiation-Induced Lung Injury by Correlating Lung Tissue to Plasma in a Rat Model
by Liming Gu, Wenli Wang, Yifeng Gu, Jianping Cao and Chang Wang
Metabolites 2023, 13(9), 1020; https://doi.org/10.3390/metabo13091020 - 17 Sep 2023
Cited by 3 | Viewed by 2195
Abstract
The lung has raised significant concerns because of its radiosensitivity. Radiation-induced lung injury (RILI) has a serious impact on the quality of patients’ lives and limits the effect of radiotherapy on chest tumors. In clinical practice, effective drug intervention for RILI remains to [...] Read more.
The lung has raised significant concerns because of its radiosensitivity. Radiation-induced lung injury (RILI) has a serious impact on the quality of patients’ lives and limits the effect of radiotherapy on chest tumors. In clinical practice, effective drug intervention for RILI remains to be fully elucidated. Therefore, an in-depth understanding of the biological characteristics is essential to reveal the mechanisms underlying the complex biological processes and discover novel therapeutic targets in RILI. In this study, Wistar rats received 0, 10, 20 or 35 Gy whole-thorax irradiation (WTI). Lung and plasma samples were collected within 5 days post-irradiation. Then, these samples were processed using liquid chromatography–mass spectrometry (LC-MS). A panel of potential plasma metabolic markers was selected by correlation analysis between the lung tissue and plasma metabolic features, followed by the evaluation of radiation injury levels within 5 days following whole-thorax irradiation (WTI). In addition, the multiple metabolic dysregulations primarily involved amino acids, bile acids and lipid and fatty acid β-oxidation-related metabolites, implying disturbances in the urea cycle, intestinal flora metabolism and mitochondrial dysfunction. In particular, the accumulation of long-chain acylcarnitines (ACs) was observed as early as 2 d post-WTI by dynamic plasma metabolic data analysis. Our findings indicate that plasma metabolic markers have the potential for RILI assessment. These results reveal metabolic characteristics following WTI and provide new insights into therapeutic interventions for RILI. Full article
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19 pages, 6198 KiB  
Systematic Review
The Metabolic Footprint of Systemic Effects in the Blood Caused by Radiotherapy and Inflammatory Conditions: A Systematic Review
by Karol Jelonek, Katarzyna Mrowiec, Dorota Gabryś and Piotr Widłak
Metabolites 2023, 13(9), 1000; https://doi.org/10.3390/metabo13091000 - 9 Sep 2023
Cited by 3 | Viewed by 1874
Abstract
Response to radiotherapy (RT) includes tissue toxicity, which may involve inflammatory reactions. We aimed to compare changes in metabolic patterns induced at the systemic level by radiation and inflammation itself. Patients treated with RT due to head and neck cancer and patients with [...] Read more.
Response to radiotherapy (RT) includes tissue toxicity, which may involve inflammatory reactions. We aimed to compare changes in metabolic patterns induced at the systemic level by radiation and inflammation itself. Patients treated with RT due to head and neck cancer and patients with inflammation-related diseases located in the corresponding anatomical regions were selected. PubMed and Web of Science databases were searched from 1 January 2000 to 10 August 2023. Twenty-five relevant studies where serum/plasma metabolic profiles were analyzed using different metabolomics approaches were identified. The studies showed different metabolic patterns of acute and chronic inflammatory diseases, yet changes in metabolites linked to the urea cycle and metabolism of arginine and proline were common features of both conditions. Although the reviewed reports showed only a few specific metabolites common for early RT response and inflammatory diseases, partly due to differences in metabolomics approaches, several common metabolic pathways linked to metabolites affected by radiation and inflammation were revealed. They included pathways involved in energy metabolism (e.g., metabolism of ketone bodies, mitochondrial electron transport chain, Warburg effect, citric acid cycle, urea cycle) and metabolism of certain amino acids (Arg, Pro, Gly, Ser, Met, Ala, Glu) and lipids (glycerolipids, branched-chain fatty acids). However, metabolites common for RT and inflammation-related diseases could show opposite patterns of changes. This could be exemplified by the lysophosphatidylcholine to phosphatidylcholine ratio (LPC/PC) that increased during chronic inflammation and decreased during the early phase of response to RT. One should be aware of dynamic metabolic changes during different phases of response to radiation, which involve increased levels of LPC in later phases. Hence, metabolomics studies that would address molecular features of both types of biological responses using comparable analytical and clinical approaches are needed to unravel the complexities of these phenomena, ultimately contributing to a deeper understanding of their impact on biological systems. Full article
(This article belongs to the Special Issue Recent Advances in Radiation Research)
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13 pages, 5812 KiB  
Article
Explosion and Dynamic Transparency of Low-Density Structured Polymeric Targets Irradiated by a Long-Pulse KrF Laser
by Vladimir D. Zvorykin, Natalia G. Borisenko, Kirill S. Pervakov, Alexey V. Shutov and Nikolay N. Ustinovskii
Symmetry 2023, 15(9), 1688; https://doi.org/10.3390/sym15091688 - 2 Sep 2023
Cited by 2 | Viewed by 1251
Abstract
The hydrodynamics of plasma formed in the interaction of 100 ns UV KrF laser pulses with foam targets with volume densities from 5 to 500 mg/cm3 was studied. Initial and dynamic transmittance at 248 nm wavelength were measured. At intensities of about [...] Read more.
The hydrodynamics of plasma formed in the interaction of 100 ns UV KrF laser pulses with foam targets with volume densities from 5 to 500 mg/cm3 was studied. Initial and dynamic transmittance at 248 nm wavelength were measured. At intensities of about 1012 W/cm2, the propagation rates of radiation through foam targets reached 80 km/s, while plasma stream velocities from both the front and rear sides of targets were approximately the same, ~ 75 km/s, which confirms a volumetric absorption of radiation within the target thickness and the explosive nature of the plasma formation and expansion. Full article
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13 pages, 3652 KiB  
Article
Extreme Ultraviolet Radiation Sources from Dense Plasmas
by Klaus Bergmann
Atoms 2023, 11(9), 118; https://doi.org/10.3390/atoms11090118 - 31 Aug 2023
Cited by 4 | Viewed by 2267
Abstract
The concept of dense and hot plasmas can be used to build up powerful and brilliant radiation sources in the soft X-ray and extreme ultraviolet spectral range. Such sources are used for nanoscale imaging and structuring applications, such as EUV lithography in the [...] Read more.
The concept of dense and hot plasmas can be used to build up powerful and brilliant radiation sources in the soft X-ray and extreme ultraviolet spectral range. Such sources are used for nanoscale imaging and structuring applications, such as EUV lithography in the semiconductor industry. An understanding of light-generating atomic processes and radiation transport within the plasma is mandatory for optimization. The basic principles and technical concepts using either a pulsed laser or a gas discharge for plasma generation are presented, and critical aspects in the ionization dynamics are outlined within the framework of a simplified atomic physics model. Full article
(This article belongs to the Special Issue Atomic Physics in Dense Plasmas)
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