Search Results (186)

Background/Objectives: Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by the replacement of healthy bone marrow (BM) with malignant and fibrotic tissue. In a healthy state, bone marrow is composed of approximately 60–70% fat cells, which are replaced as disease progresses. Proton density fat fraction (PDFF), a non-invasive and quantitative MRI metric, enables analysis of BM architecture by measuring the percentage of fat versus cells in the environment. Our objective is to investigate variance in quantitative PDFF-MRI values over time as a marker of disease progression and response to treatment. Methods: We analyzed existing data from three cohorts of mice: two groups with MF that failed to respond to therapy with approved drugs for MF (ruxolitinib, fedratinib), investigational compounds (navitoclax, balixafortide), or vehicle and monitored over time by MRI; the third group consisted of healthy controls imaged at a single time point. Using in-house MATLAB programs, we performed a voxel-wise analysis of PDFF values in lower extremity bone marrow, specifically comparing the variance of each voxel within and among mice. Results: Our findings revealed a significant difference in PDFF values between healthy and diseased BM. With progressive disease non-responsive to therapy, the expansion of hematopoietic cells in BM nearly completely replaced normal fat, as determined by a markedly reduced PDFF and notable reduction in the variance in PDFF values in bone marrow over time. Conclusions: This study validated our hypothesis that the variance in PDFF in BM decreases with disease progression, indicating pathologic expansion of hematopoietic cells. We can conclude that disease progression can be tracked by a decrease in PDFF values. Analyzing variance in PDFF may improve the assessment of disease progression in pre-clinical models and ultimately patients with MF. Full article

In October 2024, a DANA (Isolated Depression at High Levels) triggered torrential rains across the Valencian Community, causing 227 deaths, severe infrastructure damage, and economic losses estimated at €17.8 billion. In this context of crisis, startups, despite having fewer resources and less experience than large corporations, played a significant role in crisis communication, shaping public perception and operational continuity. This study explores the communication strategies adopted by startups during and after the disaster, focusing on their activity on Instagram, TikTok, and Facebook between October 2024 and January 2025. Using a mixed-methods approach, we conducted a quantitative analysis of digital discourse through the Fanpage Karma tool, assessing metrics such as engagement, reach, and posting frequency. Sentiment analysis was performed using GPT-4, an advanced natural language processing model, and in-depth interviews with startup representatives provided qualitative insights into reputational impacts. The findings reveal that startups which aligned their discourse with the social context, prioritizing transparency and emotional proximity, enhanced their visibility and credibility. These results underscore how effective crisis communication not only mitigates reputational risk but also strengthens the local entrepreneurial ecosystem through trust-building and social responsibility. Full article

The hydrological response of a watershed is strongly influenced by the spatiotemporal dynamics of rainfall. Rainfall events of similar magnitude can produce markedly different flood processes due to variations in the spatiotemporal patterns of rainfall, posing significant challenges for flood forecasting under complex rainfall scenarios. Traditional methods typically rely on high-resolution or synthetic rainfall data to characterize the scale, direction and velocity of rainstorms, in order to analyze their impact on the flood process. These studies have shown that storms traveling along the main river channel tend to exert the greatest impact on flood processes. Therefore, tracking the movement of the rainfall center along the flow direction, especially when only rain gauge data are available, can reduce model complexity while maintaining forecast accuracy and improving model applicability. This study proposes a machine learning-based time-variable instantaneous unit hydrograph that integrates rainfall spatiotemporal dynamics using quantitative spatial indicators. To overcome limitations of traditional variable unit hydrograph methods, a pre-training and fine-tuning strategy is employed to link the unit hydrograph S-curve with rainfall spatial distribution. First, synthetic pre-training data were used to enable the machine learning model to learn the shape of the S-curve and its general pattern of variation with rainfall spatial distribution. Then, real flood data were employed to learn the actual runoff routing characteristics of the study area. The improved model allows the unit hydrograph to adapt dynamically to rainfall evolution during the flood event, effectively capturing hydrological responses under varying spatiotemporal patterns. The case study shows that the improved model exhibits superior performance across all runoff routing metrics under spatiotemporal rainfall variability. The improved model increased the simulation qualified rate for historical flood events, with significant rainfall center movement during the event from 63% to 90%. This study deepens the understanding of how rainfall dynamics influence watershed response and enhances hourly-scale flood forecasting, providing support for disaster early warning with strong theoretical and practical significance. Full article

Time-of-flight sensors have emerged as a viable solution for real-time distance sensing in robotic safety applications due to their compact size, fast response, and contactless operation. This study addresses one of the key challenges with time-of-flight sensors, focusing on how they perceive and evaluate the environment, particularly in the presence of complex geometries and reflective surfaces. Using a Universal Robots UR5e arm in a controlled indoor workspace, two different sensors were tested across eight scenarios involving objects of varying shapes, sizes, materials, and reflectivity. Quantitative metrics including the root mean square error, mean absolute error, area difference, and others were used to evaluate measurement accuracy. Results show that the sensor’s field of view and operating principle significantly affect its spatial resolution and object boundary detection, with narrower fields of view providing more precise measurements and wider fields of view demonstrating greater resilience to specular reflections. These findings offer valuable insights into selecting appropriate ToF sensors for integration into robotic safety systems, particularly in environments with reflective surfaces and complex geometries. Full article

Increasing frequency and severity of urban flooding, driven by climate change and urban population growth, present major challenges. Traditional flood control infrastructure alone cannot fully prevent flood damage, highlighting the need for a comprehensive and multi-dimensional disaster management approach. This study proposes the Flood Risk Index for Building (FRIB)—a building-level assessment framework that integrates vulnerability, hazard, and exposure. FRIB assigns customized risk levels to individual buildings and evaluates the effectiveness of a multi-dimensional method. Compared to traditional indicators like flood depth, FRIB more accurately identifies high-risk areas by incorporating diverse risk factors. It also enables efficient resource allocation by excluding low-risk buildings, focusing efforts on high-risk zones. For example, in a case where 5124 buildings were targeted based on 1 m flood depth, applying FRIB excluded 24 buildings with “low” risk and up to 530 with “high” risk, reducing unnecessary interventions. Moreover, quantitative metrics like entropy and variance showed that as FRIB levels rise, flood depth distributions become more balanced—demonstrating that depth alone does not determine risk. In conclusion, while qualitative labels such as “very low” to “very high” aid intuitive understanding, FRIB’s quantitative, multi-dimensional approach enhances precision in urban flood management. Future research may expand FRIB’s application to varied regions, supporting tailored flood response strategies. Full article

Since the mid-1980s, the Mediterranean Sea’s surface and deeper layers have warmed at unprecedented rates, with recent projections identifying it as one of the regions most impacted by rising global temperatures. Metrics that characterize phytoplankton abundance, phenology and size structure are widely utilized as ecological indicators that enable a quantitative assessment of the status of marine ecosystems in response to environmental change. Here, using an extensive, updated in situ pigment dataset collated from numerous past research campaigns across the Mediterranean Sea, we re-parameterized an abundance-based phytoplankton size class model that infers Chl-a concentration in three phytoplankton size classes: pico- (<2 μm), nano- (2–20 μm) and micro-phytoplankton (>20 μm). Following recent advancements made within this category of size class models, we also incorporated information of sea surface temperature (SST) into the model parameterization. By tying model parameters to SST, the performance of the re-parameterized model was improved based on comparisons with concurrent, independent in situ measurements. Similarly, the application of the model to remotely sensed ocean color observations revealed strong agreement between satellite-derived estimates of phytoplankton size structure and in situ observations, with a performance comparable to the current regional operational datasets on size structure. The proposed conceptual regional model, parameterized with the most extended in situ pigment dataset available to date for the area, serves as a suitable foundation for long-term (1997–present) analyses on phytoplankton size structure and ecological indicators (i.e., phenology), ultimately linking higher trophic level responses to a changing Mediterranean Sea. Full article

Enhancement and restoration algorithms are widely used in the exploration of coral reefs for improving underwater images. However, by selecting an improvement algorithm based on image quality metrics, image processing key factors such as the execution time are not considered. In response to this issue, herein is presented a novel method built on multicriteria decision analysis that evaluates the processing time and feature point increase with respect to the original image. To set the Decision Matrix (DM), both the processing time and keypoint increase criteria of the evaluated algorithms are normalized. The criteria weights in the DM are set in accordance with the application, and the quantitative metric used to select the best alternative is the highest Weighted Sum Method (WsuM) score. In this work, the DM of six scenarios is shown, since the setting of weights could completely change the decision. For this research’s target application of generating underwater photomosaics, the Dark Channel Prior (DCP) algorithm emerged as the most suitable under a weighting scheme of 75% for processing time and 25% for keypoint increase. This proposal represents a solution for evaluating improvement algorithms in applications where computational efficiency is critical. Full article

Cooperative multi-UAV clusters have been widely applied in complex mission scenarios due to their flexible task allocation and efficient real-time coordination capabilities. The Air Command Aircraft (ACA), as the core node within the UAV cluster, is responsible for coordinating and managing various tasks within the cluster. When the ACA undergoes fault recovery, a handover operation is required, during which the ACA must re-authenticate its identity with the UAV cluster and re-establish secure communication. However, traditional, centralized identity authentication and ACA handover mechanisms face security risks such as single points of failure and man-in-the-middle attacks. In highly dynamic network environments, single-chain blockchain architectures also suffer from throughput bottlenecks, leading to reduced handover efficiency and increased authentication latency. To address these challenges, this paper proposes a mathematically structured dual-chain framework that utilizes a distributed ledger to decouple the management of identity and authentication information. We formalize the ACA handover process using cryptographic primitives and accumulator functions and validate its security through BAN logic. Furthermore, we conduct quantitative analyses of key performance metrics, including time complexity and communication overhead. The experimental results demonstrate that the proposed approach ensures secure handover while significantly reducing computational burden. The framework also exhibits strong scalability, making it well-suited for large-scale UAV cluster networks. Full article

Cracking in semi-rigid cement-stabilized macadam bases constitutes a prevalent distress in asphalt pavements. While extensive research exists on grouting materials for crack rehabilitation, quantitative assessment methodologies for treatment efficacy remain underdeveloped. This study proposes a novel evaluation framework integrating fiber Bragg grating (FBG) technology to monitor pavement mechanical responses under traffic loads. Conducted on the South China Expressway project, the methodology encompassed (1) a method for back-calculating the modulus of the asphalt layer based on Hooke’s Law; (2) a sensor layout plan with FBG sensors buried at the top of the pavement base in seven sections; (3) statistical analysis of the asphalt modulus based on the mechanical response when a large number of vehicles passed; and (4) comparative analysis of modulus variations to establish quantitative performance metrics. The results demonstrate that high-strength geopolymer materials significantly enhanced the elastic modulus of the asphalt concrete layer, achieving 34% improvement without a waterproofing agent versus 19% with a waterproofing agent. Polymer-treated sections exhibited a mean elastic modulus of 676.15 MPa, substantially exceeding untreated pavement performance. Low-strength geopolymers showed marginal improvements. The modulus hierarchy was as follows: high-strength geopolymer (without waterproofing agent) > polymer > high-strength geopolymer (with waterproofing agent) > low-strength geopolymer (without waterproofing agent) > low-strength geopolymer (with waterproofing agent) > intact pavement > untreated pavement. These findings demonstrate that a high-strength geopolymer without a waterproofing agent and high-polymer materials constitute optimal grouting materials for this project. The developed methodology provides critical insights for grout material selection, construction process optimization, and post-treatment maintenance strategies, advancing quality control protocols in pavement rehabilitation engineering. Full article

This study aims to address the critical lack of standardized guidelines for unmanned aerial vehicle (UAV) image acquisition strategies utilizing structure-from-motion (SfM) by focusing on 3D building exterior modeling. A comprehensive experimental analysis was conducted to systematically investigate and quantitatively evaluate the effects of various shooting patterns and parameters on SfM reconstruction quality and processing efficiency. This study implemented a systematic experimental framework to test various UAV flight patterns, including circular, surface, and aerial configurations. Under controlled environmental conditions on representative building structures, key variables were manipulated, and all collected data were processed through a consistent SfM pipeline based on the SIFT algorithm. Quantitative evaluation results using various analytical methodologies (multiple regression analysis, Kruskal–Wallis test, random forest feature importance, principal component analysis including K-means clustering, response surface methodology (RSM), preference ranking technique based on similarity to the ideal solution (TOPSIS), and Pareto optimization) revealed that the basic shooting pattern ‘type’ has a significant and statistically significant influence on all major SfM performance metrics (reprojection error, final point count, computation time, reconstruction completeness; Kruskal–Wallis p < 0.001). Additionally, within the patterns, clear parameter sensitivity and complex nonlinear relationships were identified (e.g., overlapping variables play a decisive role in determining the point count and completeness of surface patterns, with an adjusted R² ≈ 0.70; the results of circular patterns are strongly influenced by the interaction between radius and tilt angle on reprojection error and point count, with an adjusted R² ≈ 0.80). Furthermore, composite pattern analysis using TOPSIS identified excellent combinations that balanced multiple criteria, and Pareto optimization explicitly quantified the inherent trade-offs between conflicting objectives (e.g., time vs. accuracy, number of points vs. completeness). In conclusion, this study clearly demonstrates that hierarchical strategic approaches are essential for optimizing UAV-SfM data collection. Additionally, it provides important empirical data, a validated methodological framework, and specific quantitative guidelines for standardizing UAV data collection workflows, thereby improving existing empirical or case-specific approaches. Full article

The optimal exploitation of genetic variability is essential for the success of breeding programs and for identifying quantitative trait loci (QTLs) in genetic association studies. These benefit from populations with a high number of individuals; however, they are expensive since extensive plant maintenance, characterization, and evaluation are required. Core collections offer a practical solution by reducing the number of individuals while representing the original diversity of the population. This study aimed to construct a core collection for Japanese plum to serve as pre-breeding material and enable genetic association studies for traits that are difficult to evaluate. Starting from a population of 1062 individuals genotyped by sequencing, genetic distance and allele coverage metrics were applied to construct several core collections. Genetic parameters and phenotype distribution comparisons allowed for the selection of a core collection of 108 individuals that maximized genetic variability while representative of the original population, confirmed by linkage disequilibrium and population structure analyses. Its usefulness was validated by successfully mapping flowering and maturity dates through marker–trait association. The core collection constructed here will help in the study of fruit quality traits and biotic and abiotic responses, ultimately generating molecular markers to assist the crop’s molecular breeding. Full article

This study quantitatively evaluates the impact of motion blur—caused by high-speed movement—on image quality in a mobile tunnel scanning system (MTSS). To simulate movement at speeds of up to 70 km/h, a high-speed translational motion panel was developed. Images were captured under conditions compliant with the ISO 12233 international standard, and image quality was assessed using two metrics: blurred edge width (BEW) and the spatial frequency response at 50% contrast (MTF50). Experiments were conducted under varying shutter speeds, lighting conditions (15,000 lx and 40,000 lx), and motion speeds. The results demonstrated that increased motion speed increased BEW and decreased MTF50, indicating greater blur intensity and reduced image sharpness. Two-way analysis of variance and t-tests confirmed that shutter and motion speed significantly affected image quality. Although higher illumination levels partially improved, they also occasionally led to reduced sharpness. Field validation using MTSS in actual tunnel environments demonstrated that BEW and MTF50 effectively captured blur variations by scanning direction. This study proposes BEW and MTF50 as reliable indicators for quantitatively evaluating motion blur in tunnel inspection imagery and suggests their potential to optimize MTSS operation and improve the accuracy of automated defect detection. Full article

Background/Objectives: New-onset refractory status epilepticus (NORSE) is a rare neurologic emergency that often requires immunotherapy despite an unclear etiology and poor response to standard treatments. Tocilizumab, an anti-interleukin-6 monoclonal antibody, has shown promise in case reports; however, objective early biomarkers of treatment response remain lacking. We investigated early electroencephalography (EEG) changes following tocilizumab administration in NORSE patients using both quantitative and qualitative analyses. Methods: We retrospectively analyzed six NORSE patients who received tocilizumab and underwent continuous EEG monitoring during the period of its administration, following the failure of first- and second-line immunotherapies. Clinical characteristics, treatment history, and EEG recordings were collected. EEG features were analyzed from 2 h before to 1 day after tocilizumab treatment. Quantitative EEG metrics included relative band power, spectral ratios, permutation and spectral entropy, and connectivity metrics (coherence, weighted phase lag index [wPLI]). Temporal EEG trajectories were clustered to identify distinct response patterns. Results: Changes in spectral power and band ratios were heterogeneous and not statistically significant. Among entropy metrics, spectral entropy in the theta band showed a significant reduction at 1 day post-treatment. Connectivity metrics, particularly wPLI, demonstrated a consistent decline after treatment. Clustering of subject–channel trajectories revealed distinct patterns including monotonic changes, indicating individual variation in response. Visual EEG review corroborated qualitative improvements in all cases. Conclusions: Tocilizumab was associated with measurable early EEG changes in NORSE, supported by visually noticeable EEG changes. Quantitative EEG may serve as a useful early biomarker for treatment response in NORSE and assist in monitoring the critical phase. Further validation in larger cohorts and standardized protocols is warranted to confirm these findings and refine EEG-based biomarkers. Full article

Snowboard Big Air (SBA), recognized as an Olympic discipline since 2018, emphasizes maneuver difficulty as a key scoring criterion, requiring athletes to integrate technical skill with adaptive responses to dynamic environments in order to perform complex aerial rotations. The takeoff phase is critical, determining both flight trajectory and rotational performance through coordinated lower limb extension and upper body movements. Despite advances in motion analysis technology, quantitative assessment of key takeoff parameters remains limited. This study investigates parameters related to performance, joint kinematics, and rotational kinetics during the SBA takeoff phase to identify key factors for success and provide practical guidance to athletes and coaches. Eleven athletes from the Chinese national snowboard team performed multiple backside tricks (720°, 1080°, 1440°, and 1800°) at an outdoor dry slope with airbag landings. Three-dimensional motion capture with synchronized cameras was used to collect data on performance, joint motion, and rotational kinetics during takeoff. The results showed significant increases in most measured metrics with rising trick difficulty from 720° to 1800°. The findings reveal that elite SBA athletes optimize performance in high-difficulty maneuvers by increasing the moment of inertia, maximizing propulsion, and refining joint kinematics to enhance rotational energy and speed. These results suggest that training should emphasize lower limb power, core and shoulder strength, flexibility, and coordination to maximize performance in advanced maneuvers. Full article

This study addresses the persistent challenge of balancing interpretability and robustness in black-box deep learning models for automatic modulation recognition (AMR), a critical task in wireless communication systems. To bridge this gap, we propose a novel explainable AI (XAI) framework that integrates symbolic feature interaction concepts into communication signal analysis for the first time. The framework combines a modulation primitive decomposition architecture, which unifies Shapley interaction entropy with signal physics principles, and a dual-branch XAI mechanism (feature extraction + interaction analysis) validated on ResNet-based models. This approach explicitly maps signal periodicity to modulation order in high-dimensional feature spaces while mitigating feature coupling artifacts. Quantitative responsibility attribution metrics are introduced to evaluate component contributions through modular adversarial verification, establishing a certified benchmark for AMR systems. The experimental validation of the RML 2016.10a dataset has demonstrated the effectiveness of the framework. Under the dynamic signal-to-noise ratio condition of the benchmark ResNet with an accuracy of 94.88%, its occlusion sensitivity increased by 30% and stability decreased by 22% compared to the SHAP baseline. The work advances AMR research by systematically resolving the transparency–reliability trade-off, offering both theoretical and practical tools for deploying trustworthy AI in real-world wireless scenarios. Full article