Search Results (1,363)

Current approaches in neuro-technologies aim to design artificial devices capable of collecting information on in vitro and in vivo brain activities. In this view, a major challenge for new processing technologies is to integrate the peculiar properties of biomaterials and electrical circuits into engineered devices. Herein, the optimization of electroconductive polyvinyl alcohol (PVA) fibers loaded with polyanilines (PANIs) and produced via electrospinning is proposed. Two different polyaniline forms were selected, i.e., doped emeraldine base (dPANI-EB) and doped PANI nanofibers (dPANI-NFs) synthesized by a rapid mixing process. SEM morphological investigation indicated that conductive phases do not remarkably affect fiber morphology, slightly increasing the average diameter. Conversely, PANI fibers remarkably affect the PVA surface’s hydrophilicity, as confirmed by the increase in contact angle. The presence of conductive phases enhances the intrinsic ionic conductivity of PVA fibers, through protonic currents, which also increases the electronic conductivity from 10⁻¹⁰ to 10⁻⁷ S/cm. Preliminary in vitro studies performed on a human neuroblastoma cell line (SH-SY5Y) confirmed the biocompatibility of PVA/PANI nanofibers. These data demonstrate the potential of such nanofibers to be used as biotextiles, and specifically as electroactive interfaces capable of monitoring changes in the levels of biochemical signals (i.e., neurotransmitters) related to the brain’s microenvironment. Full article

A ternary CdS–MoS₂–rGO photocathode was developed to enhance visible light-driven hydrogen evolution through interfacial heterostructure engineering. The composite was fabricated via a solution-based deposition method followed by thermal conversion, resulting in crystalline CdS and MoS₂ phases that were uniformly integrated within a conductive reduced graphene oxide (rGO) framework. Structural and surface analyses (XRD and XPS) confirmed the coexistence of Cd²⁺, Mo⁴⁺, and S²⁻ chemical states without detectable secondary phases. Photoelectrochemical measurements revealed that the ternary architecture significantly improves charge separation efficiency and interfacial charge-transfer kinetics compared to binary and single-component films. The CdS–MoS₂–rGO photocathode exhibited the highest photocurrent density, reduced charge-transfer resistance, and favorable Tafel slope under visible-light irradiation (0.25 sun, neutral electrolyte). Gas chromatography measurements verified that these electrochemical enhancements translate into increased hydrogen production rates, following the trend: CdS–MoS₂–rGO > CdS–rGO > MoS₂–rGO >> rGO. Applied bias photon-to-current efficiency (ABPE) analysis further confirmed improved photon utilization efficiency in the ternary system. The enhanced performance is attributed to synergistic integration of CdS (light harvesting), rGO (rapid electron transport), and MoS₂ (catalytic edge sites), which suppresses recombination and accelerates proton reduction kinetics. These findings demonstrate that rational multi-component heterostructure design is an effective strategy for improving hydrogen evolution rate under mild operating conditions. Full article

Perfluorosulfonic acid (PFSA) membranes, exemplified by Nafion, suffer dehydration-induced degradation at elevated temperatures, although modifications enhance their conductivity and performance. Sulfonated aromatic polymers (SAPs) exhibit weaker phase separation, yielding narrow, tortuous ion channels and lower conductivity than their PFSA membrane counterparts at equivalent ion exchange capacity; however, excessive sulfonation causes swelling and mechanical instability, offset by cost advantages. Phosphoric acid-doped polybenzimidazole (PBI) offers superior thermal stability and high conductivity, with recent advances in polybenzimidazole derivatives and composites driving medium-to-high temperature proton-exchange membrane fuel cell innovation. This review summarizes progress in three major medium-to-high temperature proton-exchange membrane fuel cell categories—perfluorosulfonic acid, sulfonated polymers, and PBI-based membranes—while addressing challenges and future goals for enhanced performance. Full article

Redox-flow batteries are a promising emerging technology for large-scale storage of renewable energy. However, existing ion-exchange membranes used for separating electrolytes are expensive and often ineffective at preventing crossover of redox-active species, leading to a decrease in battery capacity over time. Herein, we introduce a new class of proton-conducting membranes formed by depositing highly alkylated waxy hydrophobic salts on porous polypropylene supports and demonstrate that they form self-assembled nanostructures which exclusively conduct protons via a unique mechanism of action. These new “ionowax” membranes display comparable proton conductivities to existing commercially available functionalized porous polymer membranes but are cheaper and easier to fabricate. We anticipate that these new membranes will facilitate future development of cheaper and/or longer-lasting aqueous redox-flow batteries. Full article

High-temperature proton exchange membrane fuel cells (HT-PEMFCs) coupled with methanol reforming hold promise for distributed energy systems, yet channel hydrodynamics and geometry optimization remain underexplored. This study develops a 3D multiphysics model to investigate coupled behaviors in HT-PEMFCs fueled by methanol reformate. Results reveal bifurcation-induced Dean vortices have dual effects: they cause flow maldistribution (15–18% velocity deviation) and contribute 50% of inlet pressure loss, while generating a lateral pumping effect that enhances local mass transfer. A continuous parametric sweep of channel widths (0.9–1.9 mm) identifies a voltage-dependent performance crossover—narrower channels (1.3 mm) excel at high voltages by improving electronic conduction, whereas wider channels (1.5 mm) perform better at low voltages by mitigating mass transfer limitations. These findings provide quantitative design criteria for optimizing flow field geometry in HT-PEMFC stacks. Full article

The high-temperature proton ceramic membranes with simultaneous separation of hydrogen and oxygen exhibit promising applications in the catalytic conversion field. However, their separation performance often relies on external electrical circuits, which limits practical application. To overcome this limitation, doping strategies have emerged as a viable approach to develop triple-conducting (H⁺/e⁻/O²⁻) membranes for simultaneous hydrogen and oxygen separation in non-electrochemical mode. In this study, honeycomb-structured hollow fiber membranes were fabricated, and the effects of varying Fe³⁺ and Y³⁺ doping concentrations on hydrogen and oxygen permeation fluxes were systematically investigated. At the Fe³⁺ doping level of 0.2 mol, the oxygen permeation flux of 0.692 mL min⁻¹ cm⁻² in BaCe_0.6Zr_0.2Fe_0.2O_3−δ (BCZF) was achieved at 1000 °C, while the hydrogen permeation flux was 0.201 mL min⁻¹ cm⁻². The BaCe_0.55 Fe_0.05Zr_0.2Y_0.2O_3−δ (Fe-BCZY) hollow fiber membrane can enhance the hydrogen permeation flux by 75% at 1000 °C. Furthermore, during the simultaneous permeation of hydrogen and oxygen, a 1.7-fold enhancement in hydrogen permeation performance was achieved for the Fe-BZCY hollow fiber membrane at 1000 °C, and with oxygen permeation flux of 1.76 mL min⁻¹ cm⁻² at the same temperature. More significantly, a hydrogen permeation flux of 0.34 mL min⁻¹ cm⁻² can be achieved at 700 °C under simultaneous hydrogen and oxygen permeation, which is favorable for the application of membrane reactors in catalytic reactions. Full article

Background/Objectives: Several recent human studies have associated the use of certain medicines, such as antibiotics and antacids, with allergic conditions, potentially through microbiome disruption. In contrast, probiotics which may prevent dysbiosis, could have protective effects. Our meta-analysis aimed to evaluate the impact of these drugs (consumed during pregnancy or early life) on the risk of childhood food allergy, based on the available literature. Methods: Literature searches were conducted in the EMBASE, PubMed, Cochrane, and Web of Science databases using predefined PICO criteria. Overall, our meta-analysis included 25 studies involving 1,662,861 mothers and 5,164,280 children. Results: Using the random-effects model, we found that prenatal and early life antibiotic use (up to 2 years of age) was associated with higher odds of food allergy in childhood (OR: 1.34; 95% CI [1.10, 1.63], OR: 1.53; 95% CI [1.18, 1.98], respectively). Proton pump inhibitors were also associated with a risk of food allergies (OR: 2.65; 95% CI [1.22–5.77]), whereas the impact of H2-receptor antagonists was non-significant (OR: 2.07; 95% CI [0.96–4.45]). Probiotic use during the first two years of life was not associated with decreased risk for food allergy in children (OR: 1.25; 95% CI [0.46, 3.38]). Conclusions: These findings suggest an association between microbiome-disrupting medications during pregnancy and early childhood and an increased risk of childhood food allergy, especially those with a family history of food allergy. However, due to the predominantly observational design of the included studies, causality cannot be established. These results highlight the need for cautious and judicious use of such medications in these populations. Full article

Introduction: Non-muscle-invasive bladder cancer (NMIBC) represents approximately 78% of newly diagnosed bladder cancers and is characterized by high recurrence rates and variable progression risk. While transurethral resection of bladder tumor (TURBT) followed by intravesical therapy remains standard management, optimal treatment of high-risk and Bacillus Calmette-Guerin (BCG)-unresponsive disease remains controversial. Radiotherapy (RT), particularly in combination with chemotherapy, has been explored as a bladder-preserving alternative. Material and Methods: We conducted a narrative review of published literature evaluating the role of definitive RT in high-risk NMIBC, with emphasis on T1 disease. Retrospective series, prospective trials, meta-analyses, and contemporary guideline recommendations were examined. For each included study, we extracted data on the extent of TURBT (maximal vs. incomplete/non-specified), use and type of concurrent chemotherapy, radiotherapy technique (3D-conformal, IMRT, or proton), treatment volume (bladder only vs. whole pelvis), and dose/fractionation schedule. Results: Early studies evaluating RT alone demonstrated modest complete response rates. More recent approaches incorporating maximal TURBT followed by concurrent chemoradiotherapy report improved outcomes, with complete response rates of approximately 80–88% and 5-year overall survival comparable to surgical series. The phase II NRG/RTOG 0926 trial in recurrent high-risk T1 disease after intravesical therapy failure demonstrated an 81% complete response rate and favorable bladder preservation outcomes. Meta-analytic data suggest 5-year recurrence-free survival around 54% and overall survival near 70%, although evidence remains limited and largely non-randomized. Advances in image-guided and hypofractionated RT may further improve therapeutic outcomes while limiting toxicity. Conclusions: while definitive chemoradiotherapy is a promising option for selected patients, it remains investigational and should be considered only in those who are unfit for or decline radical cystectomy. Prospective randomized studies are needed to better define its role in contemporary management. Full article

Background: Radiotherapy is essential for skull base tumor management but carries the risk of radiation-induced brain injury (RIBI). This spectrum ranges from transient radiation-induced contrast enhancement (RICE) to irreversible necrosis. Distinguishing these entities from tumor progression is critical, particularly with the increasing adoption of proton therapy. Methods: A comprehensive narrative review of the peer-reviewed literature was conducted up to October 1, 2025. The search strategy focused on adult patients treated for skull base malignancies, synthesizing data on dose–volume metrics, incidence rates, and modality-specific toxicity profiles. Results: RIBI represents a pathophysiological continuum. (a) Descriptive imaging patterns: In prospective proton therapy series, focal RICE occured in 15% of patients, typically at a median of 12 months, and often resolved spontaneously. (b) Modality comparison: Although proton therapy reduces integral brain dose versus photon therapy, elevated linear energy transfer (LET) at the distal Bragg peak may contribute to focal radiation-associated image changes (RAIC), particularly in the temporal lobes. (c) Risk stratification and diagnosis: Risk increased when >1% of the healthy brain received >57.6 Gy (Relative Biological Energy (RBE)) or when V67Gy exceeded 0.17 cc. Advanced MRI and amino acid positron emission tomography (PET) improved differentiation between radiation effects and tumor recurrence. Conclusions: Post-radiation imaging changes are common and often benign. Distinguishing RICE from progression requires multimodal imaging and adherence to specific dose constraints. Management should prioritize surveillance for asymptomatic lesions. Full article

MXene, as a suitable and alternative 2D nanofiller incorporated into a proton exchange membrane (PEM), has recently received considerable attention because of desired mechanical stability, promising conductivity, and active surface functional groups. However, agglomeration or sedimentation in PEMs, as well as the water retention capacity under low humidity of MXene, are limiting factors in the field of PEMs. In this paper, modified MXene and TiO₂ nanoparticles used as functional nanofillers were incorporated into sulfonated poly (ether ether ketone) (SPEEK) to prepare novel SPEEK-based composite PEMs. The effects of the nanofiller contents on self-humidifying and protonic conductivity of the composite PEMs were also investigated under different temperatures. When the contents of functionalized MXene and modified TiO₂ are 5 wt.%, proton conductivity, water uptake and methanol permeability of the composite PEMs can be up to 0.143 S/cm, 60% and 2.27 × 10⁻⁷ cm²/s, respectively, which represent increases of about 192%, about 38% and a decrease of 47%, respectively, compared with that of primary SPEEK PEM. Under the synergistic action of functionalized MXene providing a higher number of exchangeable proton sites, modified TiO₂ with inherent hydrophilicity enhancing water retention and Pt providing catalytic sites for the H₂/O₂ reaction to generate water in situ, the self-humidifying capability and proton conductivity of the composite PEMs were improved significantly. Full article

A low-current compact extraction and matching system has been designed and experimentally tested to evaluate its capability for direct proton injection of 15 keV into a 750 MHz radiofrequency quadrupole for medical applications. The design methodology combined 2D and 3D layouts, supported by detailed electrostatic simulations. First experimental results are reported, including beam current characterization and irradiation measurements under varying operating conditions. These results are benchmarked against simulation data to provide a preliminary evaluation of system performance. Ongoing efforts focus on extending the experimental campaign to consolidate these findings. A comparative study with a gridded-lens-based extraction and transport system is also being conducted to achieve reliable matching of high-quality beams to high-frequency RFQs for clinical implementation. Full article

Proton exchange membrane water electrolyzers (PEMWEs) are an emerging hydrogen production technology with significant advantages. However, their structural design remains incompletely matured. During assembly, the clamping force is transmitted through the endplate to internal components. Improper clamping force causes uneven stress distribution across electrolysis cells, compromising sealing integrity and hydrogen production efficiency. To address uneven force transmission in conventional rectangular endplates, this study proposes a curved stack-facing endplate structure. A multi-objective optimization methodology is employed to identify the optimal curvature radius, which provides pre-deformation compensation during operation. This enables the surface to flatten under clamping force and to ensure tight contact with underlying cells. After optimization, the standard deviation of deformation along each path on the single electrolysis cell decreased by over 10% and the standard deviation of equivalent stress along each path on the endplate dropped by more than 5%. Subsequently, an orthogonal experimental design considering curvature radius and bolt arrangement is conducted to find the optimal combination in stack assembly. The optimal combination is identified and compared with the stack equipped with the original rectangular endplate. The maximum deformation at the four corners of the optimized endplate decreases from 0.28399 mm to 0.27452 mm. Additionally, the stress concentration area in the optimized endplate is reduced by more than half. Results demonstrate significantly reduced stress concentration and substantially more uniform stress distribution in the optimized endplate. Full article

This study elucidates the mechanism enabling the low-voltage electrolysis of black liquor (BL) for integrated resource recovery. The process simultaneously generates protons at the anode via the oxidation of organics (OOR), which occurs at a lower potential than the oxygen evolution reaction (OER), and induces lignin precipitation. Concurrently, hydrogen and hydroxide ions are produced at the cathode through the hydrogen evolution reaction (HER). Driven by the electric field, sodium ions migrate from the anode to the cathode chamber, combining with hydroxide ions to form sodium hydroxide, thereby achieving the synchronous production of acid, alkali, hydrogen, and modified lignin in a single process. Using a platinum electrode, we conducted a mechanistic investigation through linear sweep voltammetry (LSV), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and detailed product analysis. The results show that overall efficiency is controlled by competition at the anode between OOR and OER, which directly determines proton yield. A critical trade-off exists between anodic proton generation and cathodic alkali recovery, driven by the competitive migration of protons and sodium ions across the cation-exchange membrane. The proton yield was highly dependent on the initial BL composition, with a characteristic peak observed under specific conditions. Conversely, the sodium hydroxide recovery rate was maximized when the anolyte pH remained high, minimizing competitive proton migration. This work provides fundamental insights into the interfacial mechanisms of BL electrocatalytic, establishing it as a versatile electrochemical biorefinery platform for simultaneous proton and alkali production from a renewable waste stream, beyond its role as a hydrogen source and lignin recovery. Full article

Background/Objectives: Proton pump inhibitors (PPIs) are known to alter gut microbiota composition; however, their association with disease courses and outcomes in patients with inflammatory bowel disease (IBD) remains uncertain. Our aims were to evaluate the association between PPI use and treatment escalation, Clostridioides difficile infection, and healthcare utilization in IBD. Methods: We conducted a retrospective cohort study on the TriNetX platform. IBD patients with PPIs or histamine-2 receptor antagonists (H2RAs) were matched one-to-one using propensity scores. Outcomes included initiation of corticosteroids, biologic therapy, Clostridioides difficile (C. difficile) infection, and healthcare utilization. Outcomes were assessed during the 0–12-month and 3–12-month follow-up windows. Associations were estimated using odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals. Results: After matching, 12,808 patients were included in each group. During 0–12 months of follow-up, PPI use was associated with higher odds of systemic corticosteroid exposure (OR 1.56, 1.35–1.79), biologic therapy initiation (OR 1.99, 1.72–2.29), C difficile infection (OR 1.42, 1.18–1.70), and healthcare utilization (OR 1.18, 1.03–1.36) compared with H2RA use. Time-to-event analyses showed persistent associations with systemic corticosteroid exposure (HR 1.50, 1.31–1.72) and biologic therapy initiation (HR 1.91, 1.66–2.19), with attenuation of associations for infection and healthcare utilization in 3–12-month lag-time analyses. Similar patterns were observed in ulcerative colitis and Crohn’s disease subgroups. Conclusions: PPI was associated with higher risks of treatment escalation and C. difficile compared with H2RA in IBD. These findings highlight the importance of individualized selection and periodic reassessment of acid suppression therapy as part of personalized management strategies in IBD. Full article

The sole use of carbon nanotubes (CNTs) as single-electrode carriers in direct methanol fuel cells (DMFCs) creates structural disparities that increase resistance, impair catalyst utilization, and limit discharge duration. This study presents a novel dual-electrode CNT-based carrier structure designed to enhance mass transport and electron conduction, thereby improving DMFC power output and durability. The CNTs were grown in situ via nitrogen sintering onto the microporous layer, with parameters optimized to enhance surface morphology and conductivity. The impact of this dual-electrode CNT carrier was evaluated through microstructural characterization, cyclic voltammetry, electrochemical performance testing, and service life assessment. Results demonstrate that the structure improves catalyst dispersion, electrochemical active surface area (ECSA), and charge transfer efficiency, while reducing ohmic resistance and charge transfer impedance. Compared to traditional carbon black (CB) carriers, peak power increased by 51.06%. Under China Light Vehicle Test Cycle (CLTC) conditions, discharge duration increased by a factor of 1.7, indicating higher energy efficiency. These improvements are attributed to the dual-electrode architecture’s synergistic enhancement of proton transport, balanced electrochemical kinetics, and reduced interfacial resistance. Full article