Search Results (222)

Triple-negative breast cancer (TNBC) lacks effective molecular targets, leading to poor prognosis. Previous computational methods to identify targets have suffered from low druggability, high complexity, and lack of robust validation. We propose a hybrid methodology combining Boolean network modeling with semidefinite programming (SDP) to analyze a TNBC cell line network. The resulting therapeutic pair underwent a multi-level validation framework, including Boolean simulations, statistical uncertainty quantification (bootstrap), sensitivity analysis, and orthogonal computational support from AlphaGenome, a deep learning model from Google DeepMind. Our analysis identified TK1 and VIM as a computationally robust therapeutic pair. Dual inhibition achieved 99.03% similarity to the apoptotic state with a 95% confidence interval of [98.79%, 99.26%], and was statistically superior to alternative pairs ($p<0.001$). The selection remained optimal across all tested model parameters, demonstrating high robustness. Importantly, the pair has full druggability because both targets have available specific inhibitors. Orthogonal computational evidence from AlphaGenome, stratified by mammary compartment, indicated that both targets exhibit moderate baseline expression in normal mammary epithelium (TK1 = 0.159, VIM = 0.143 in normalized RNA-seq units; n = 13 tracks per gene), with VIM showing a 2.2-fold higher expression in mammary stroma than in epithelium—a gradient consistent with its established role as a mesenchymal marker. Promoter-variant proxy analysis indicated near-zero transcriptomic perturbation upon simulated inhibition of either target in normal mammary epithelium (mean $|{log}_2\mathrm{FC}|<0.001$), supporting a favorable therapeutic window. Our methodology identified TK1–VIM as a computationally robust, druggable therapeutic candidate pair with biologically plausible mechanism of action. Gene-variability analysis identified TK1 and VIM as the highest-scoring candidates, with SDP optimization providing complementary, independent confirmation of this selection. This work provides a computationally grounded candidate strategy and a rigorous methodological benchmark for computational drug target identification; experimental validation remains an essential next step before clinical translation. Full article

This article investigates the discursive construction of populism in the Portuguese digital public sphere, focusing on the communicative strategies of two party media outlets linked to the populist radical right party CHEGA: Folha Nacional and CHEGA TV. Drawing on Entman’s model of framing functions and the literature on populist communication and digital propaganda, the study examines how these outlets articulate simplified, moralized and emotionally charged narratives to mobilize public opinion and legitimize the party’s political agenda. The empirical corpus consists of 4915 video titles and descriptions published between 2024 and 2025 (CHEGA TV, n = 2476; Folha Nacional, n = 2439). Each unit was coded according to five macro-frames characteristic of populist discourse: (1) appeal to the people and antagonism, (2) messianism, (3) moral restitution, (4) anti-system and anti-elite rhetoric, and (5) exclusion of the other. The research combines qualitative frame analysis with quantitative frequency and co-occurrence analysis, enabling the identification of dominant discursive patterns and their temporal evolution. The study contributes by offering a systematic analysis of populist framing in Chega’s party media, an under-explored field, and by proposing a replicable methodological approach to examine the hybridization of propaganda, emotionality and digital political communication in Europe. Full article

This paper is the first attempt to interpret the visual ‘construemes’ by the constructivist poet Alexei N. Chicherin, published in the anthology Mena vsekh which appeared in Moscow in1924. ‘Construemes’ can be considered the most enigmatic artifacts of the Russian avant-garde. Although ‘construemes’ can be easily confused with meaningless visual zaum (‘the transrational’), Chicherin’s actions and the very nature of his personality prevent one from interpreting ‘construemes’ as actionist endeavors to scandalize or a ‘play on nonsense’. Analysis of the poet’s treatise Kan-Fun published in Moscow in 1926 required finding the key to deciphering the ‘construemes’, reveals the positivist nature of Chicherin’s visual–phonological exercises. In the treatise, the poet argues for the primacy of the eye and vision. He illustrates synthetic ‘signs’ or ‘pictograms’ with the quotidian example of propaganda posters, capable of influencing millions more effectively than words alone. The study emphasizes the enigmatic nature of the titles of Chicherin’s books, the Nietzschean subtexts of his self-presentation, encrypted allusions to the esoteric and magical tradition of the Tarot, and religious symbolism. Sixteen illustrations help the understanding of Chicherin’s logic behind the creation of his four ‘construemes’, including the most mysterious composition called ‘Raman’ (‘the shortest Kan-Fun Novel in the world’). The structure of this text synthesizes the verbal, visual–graphic, acoustic (phonological symbols) and musical (notes) levels. The article also examines Chicherin’s proven techniques: the appropriation of the sacred dimension and self-presentation as an actor possessing genuine knowledge and capable of competing alone with the entire literary environment. Full article

Poetry, the bearer of collective memory in the Turkish state tradition, has been used as an art and administrative tool for generations in the Ottoman dynasty. The fact that 27 of the 36 Ottoman sultans wrote poetry and 10 sultans owned a “divan” (poetry book) suggests that this art served a political function for the dynasty. This study aims to investigate whether the sultan poets used poetry as a religiously based political propaganda tool to appear pious and artistic and to reinforce the legitimacy of their reign. Because the poems in these works are noteworthy as texts that promote the image of the sultan as a just, pious, and powerful ruler, legitimise Islamic expansionist policy (jihad), and aim to perpetuate cultural superiority. The study includes an analysis of relevant examples selected from the poems of ten Ottoman sultans (Mehmed II, Bayezid II, Selim I, Suleyman I, Selim II, Murad III, Ahmed I, Osman II, Ahmed III, Selim III). It is argued that these types of poems by Ottoman sultans, besides being the result of a simple literary pursuit; they served as a means of communication that reinforced the religious and political legitimacy of the sultans. Full article

The use of Large Language Models (LLMs) in organizational contexts has grown rapidly, particularly in project management activities. Despite this expansion, a relevant methodological gap can be observed in the literature: the absence of psychometrically validated instruments capable of measuring the acceptability of these technologies prior to their effective adoption, especially in project-oriented governance contexts. Traditional technology adoption models predominantly focus on a posteriori assessment of individual use, providing limited support for prospective analyses that inform strategic decision-making and organizational coordination mechanisms. In response to this gap, this study aims to develop and validate a psychometric scale to indirectly measure the acceptability, through outcome beliefs and with behavioral predispositions serving as structural proxies of the latent construct of LLM use by project management teams, with a focus on a priori judgments that precede the effective adoption of the technology. The initial scale, composed of 17 items, underwent content validation and was administered to a sample of 154 project management professionals. The latent structure was examined through Exploratory and Confirmatory Factor Analyses, resulting in the refinement of the instrument to 13 items distributed across two correlated factors. The results indicate that LLM acceptability is adequately represented by a bidimensional structure comprising the dimensions Intention/Predisposition and Trust/Perceived Benefit, both demonstrating high internal consistency and good statistical fit, and nomological validity evidenced by significant associations with respondents’ self-reported LLM usage frequency. These findings reinforce the conceptualization of acceptability as a prospective and multidimensional construct, relevant for supporting governance decisions and the adoption of artificial intelligence-based technologies in project-oriented organizational systems. The indirect measurement approach adopted here is theoretically grounded in the premise that a priori acceptability is not directly observable but is constituted by cognitive and dispositional beliefs formed prior to use. Full article

The Gonzaga family promoted, in the early seventeenth century, a visual and devotional program aimed at positioning Blessed Luigi Gonzaga as both a spiritual standard-bearer and a political instrument of their dynasty. A comparative analysis of prints, paintings, and liturgical objects from this period has made it possible to reconstruct the iconographic model that shaped subsequent representations of the young religious. The consolidation of the prototype of his likeness was facilitated by his family circle and enabled the dissemination of his charisma and virtues among the nobility and the Society of Jesus across the territories of the Spanish monarchy and the states of the Italian peninsula. This strategy sought to secure the preeminence of the House of Gonzaga through the canonization of a “family saint,” emulating the practices of other Italian dynasties. The article highlights the pressures exerted by the beatus’s relatives on the Jesuits and the papal court in their efforts to accelerate his canonization. The manuscript and printed sources cited underscore that the principal promoters of Luigi’s sanctity were his brother and sister-in-law, Francesco Gonzaga and Bibiana von Pernstein, although their early deaths curtailed broader dissemination initiatives. The couple, together with other members of the Gonzaga–Tana family, relied on narrative, visual propaganda, and political ambition to hasten the canonization of Blessed Luigi—an event that, nonetheless, would be delayed until 1726. In parallel, the circulation of, and devotion to, the earliest images depicting the Jesuit novice’s likeness brings to light the significant role of female agency in the diffusion of his cult. Full article

Disinformation refers to false or misleading information created with the deliberate intention to deceive and cause individual or societal harm. It is typically distinguished from misinformation, which involves falsehoods shared without deceptive intent, and from malinformation, which uses accurate information in misleading or harmful ways. Terms often used interchangeably in public debate—such as fake news, propaganda, and conspiracy theories—describe related but distinct phenomena with differing aims and methods. The term derives from the Soviet concept of dezinformatsiya, originally associated with covert influence operations and strategic deception. Over time, however, its meaning has expanded to encompass a wide range of manipulative practices enacted by both state and non-state actors. Disinformation can take textual, visual, and multimodal forms, including fabricated images and AI-generated content such as deepfakes. Motivations vary and may include political influence, economic gain, ideological mobilisation, or efforts to stigmatise specific groups. Although these practices have long historical precedents, digital and platformised communication environments have amplified their scale, speed, and persuasive potential. This entry provides a narrative overview and conceptual synthesis structured around four dimensions: the history of disinformation, the supply and diffusion mechanisms, the psychological, social, and narrative drivers, and the interventions designed to mitigate its impact. Full article

In the context of early modern Catholic global missions, the Jesuit strategies for proselytizing Protestant heretics within Europe exhibited operational mechanisms distinct from those employed in overseas non-Christian populations. Focusing on the seventeenth-century Jesuit drama Pietas Victrix, this article examines the process by which drama was forged into an ideological weapon serving the project of constructing legitimacy during the Catholic Counter-Reformation. Research demonstrates that Jesuit drama transcended the purely esthetic sphere of literature and art, becoming a propaganda tool that integrated Tridentine dogma, anti-Protestant polemics, and the sacralizing narratives of the Habsburg dynasty. In the play, the Jesuit Nicolaus von Avancini (1611–1686) converts abstract politico-theological ideas into tangible political loyalty through narrative strategies and the coordinated use of multiple art forms, mobilizing sensory spectacle and the affective force of total work of art within the Habsburg court—the empire’s core political arena—to reconfigure confessional identity, contest ideological leadership, and accumulate crucial social legitimacy for both the Habsburgs and the Society of Jesus. This paper contends that Jesuit drama, exemplified by Pietas Victrix, represents a missionary form rooted in Thomistic theology yet highly politicized. By situating the play within the context of the Catholic Counter-Reformation, it demonstrates how drama was forged into a potent ideological weapon for legitimacy contestation. This study provides a case for interpreting how the Jesuits utilized cultural media to participate in power construction and self-representation, thereby refining our understanding of the mechanisms of cultural politics in early modern Europe. Full article

This article examines the eschatological dimension of the sermons of François Le Picart (1504–1556), a prominent Parisian preacher and a precursor who established the codes that enabled the gradual maturation of a theophanic tension of violence in which human beings were destined to become its instruments. Through a close reading of his sermon collections, this study analyzes how Le Picart interwove Pauline soteriology, divine love, repentance, and apocalyptic imagery to construct a moral and affective pedagogy. His eschatological language—linking love with fear and salvation with punishment—transformed anxiety about the end times into a form of spiritual yet emotional collective mobilization. By associating divine justice with anti-heretical rhetoric, Le Picart’s preaching turned theology into an instrument for defending both faith and social order. This article situates his sermons within the broader Catholic renewal of sixteenth-century France, highlighting the imagery and rhetoric of eschatology as key components of early modern anti-Protestant propaganda prior to the religious wars. Full article

The Boxer Rebellion, as a significant historical episode in modern Chinese history, has been primarily studied through official archives and Boxer propaganda Posters. Chinese Christian literature remain underutilized in current scholarship. Quan Huo Ji 拳祸记 (The Record of Boxer Rebellion), is an important ecclesiastical document, compiled by the Catholic priest Li Wenyu. While reflecting an apologetic stance, it nonetheless provides valuable insights from the perspective of common people and narrates the experiences of marginalized individuals, offering a systematic account of the suffering endured by various dioceses. Within this text, three categories of common people emerge. First, the lay faithful, who, under the violent threat of “apostasy or death”, remained steadfast in their faith. Second, anti-Christian civilians, whose motivations—though often framed as expressions of national or social grievance—may in fact reflect a release of personal frustrations and desires. Third, those sympathetic to Christians either maintained a neutral stance or offered assistance within their limited capacity. These individual experiences, often overlooked by mainstream historiography, compensate for the limitations of conventional analytical frameworks. They also vividly illustrate how ordinary people navigated between forced compromise and active resistance. Through a microhistorical lens, these personal trajectories offer a multi-dimensional portrayal of the survival dilemmas. Full article

This paper presents Multi_mil, a multilingual annotated corpus designed for the analysis of information operations in military discourse. The corpus consists of 1000 texts collected from social media and news platforms in Russian, Kazakh, and English, covering military and geopolitical narratives. A multi-level annotation scheme was developed, combining entity categories (e.g., military terms, geographical references, sources) with pragmatic features such as information operation type, emotional tone, author intent, and fake claim indicators. Annotation was performed manually in Label Studio with high inter-annotator agreement ($\mathsf{\kappa }$ = 0.82). To demonstrate practical applicability, baseline models and the proposed Onto-IO-BERT architecture were tested, achieving superior performance (macro-F1 = 0.81). The corpus enables the identification of manipulation strategies, rhetorical patterns, and cognitive influence in multilingual contexts. Multi_mil contributes to advancing NLP methods for detecting disinformation, propaganda, and psychological operations. Full article

‘Deepfakes’ and other forms of digital communications disinformation are now on the virtual frontlines of many armed conflicts. Military commanders can potentially gain significant tactical advantages by misleading enemy forces, opposing governments, and civilian populations into believing X when Y is the true state of affairs. Distinct from military propaganda, deliberate deceptions and subterfuge have long been part of warfare. However, a powerful claim is advanced that deepfakes such as announcing surrender, truce declarations, or similar messages that place soldiers and civilians at greater risk are international humanitarian law (IHL) violations, notably under the 1907 Hague Convention and the 1977 Additional Protocol I to the Geneva Conventions. This four-section critical discussion considers whether, or to what extent, deepfakes are IHL compliant. Selected examples taken from the ongoing Russia–Ukraine war are highlighted to illustrate the potentially grave dangers that deepfakes represent for innocent civilian populations. IHL reform recommendations are made that would reduce deepfake harm—if such reforms are embraced by the international community (an admittedly doubtful prospect). Full article

This article explores the crucial role of media education and media literacy as effective tools in combating disinformation. In the context of the growing influence of digital media and the increasing spread of fake news, propaganda, and manipulative content, the authors examine the level of awareness among young people regarding key media-related concepts such as media literacy, fake news, propaganda, and disinformation. A sociological survey was conducted among students from two Ukrainian higher education institutions—Ivan Franko National University of Lviv and Lviv Polytechnic National University—involving 277 respondents. The research aimed to evaluate the depth of understanding and preparedness of youth to critically assess media content and recognize signs of manipulative information. The findings indicate a clear trend: media awareness and critical thinking skills improve progressively from secondary school students to university students. This article emphasizes the importance of integrating media literacy into formal education systems as a long-term strategy to build a more informed and resilient society. The authors highlight the need for systematic educational initiatives and practical training in media literacy to empower young audiences in navigating the complex media environment and resisting the impact of disinformation. Full article

This article reimagines Hispanidad as a flexible cultural repertoire rather than a fixed ideology, examining how Francoism, after 1945, staged official doctrine as public spectacle that then served as “evidence” of its own legitimacy. Through a combined lens of political theology (Schmitt on decision and secularization) and media theory (Benjamin on the aestheticization of politics; Agamben on glory and acclamation), it analyzes Juan de Orduña’s Alba de América (1951) and its paratexts to show how National-Catholic principles—unity of faith and language, providential destiny, and obedience-based authority—were translated into affect through narrative voice, emblematic staging, liturgical music, and choreographed acclamation. Although the film underperformed commercially, it thrived institutionally, excerpted in newsreels and rebroadcast annually on October 12 as a ritual object of state culture. The article argues that spectacle in Francoist Spain functioned not only as propaganda but also as a mechanism for stabilizing power by shaping collective memory and everyday habits, revealing how aesthetic form can naturalize political authority and offering a model for analyzing the everyday workings of power across media and regimes. Full article