Search Results (560)

Highly pathogenic avian influenza (HPAI) remains a persistent threat to global poultry production and public health. Current vaccine platforms show limited cross-clade efficacy and often fail to induce mucosal immunity. Recent advances in microbiome research reveal critical roles for gut commensals in modulating vaccine-induced immunity, including enhancement of mucosal IgA production, CD8⁺ T-cell activation, and modulation of systemic immune responses. Engineered commensal bacteria such as Lactococcus lactis, Bacteroides ovatus, Bacillus subtilis, and Staphylococcus epidermidis have emerged as promising live vectors for antigen delivery. Postbiotic and synbiotic strategies further enhance protective efficacy through targeted modulation of the gut microbiota. Additionally, artificial intelligence (AI)-driven tools enable predictive modeling of host–microbiome interactions, antigen design optimization, and early detection of viral antigenic drift. These integrative technologies offer a new framework for mucosal, broadly protective, and field-deployable vaccines for HPAI control. However, species-specific microbiome variation, ecological safety concerns, and scalable manufacturing remain critical challenges. This review synthesizes emerging evidence on microbiome–immune crosstalk, commensal vector platforms, and AI-enhanced vaccine development, emphasizing the urgent need for One Health integration to mitigate zoonotic adaptation and pandemic emergence. Full article

Animal protein production represents a complex system of lives transformed into nutrition, with profound ethical and environmental implications. This study provides a quantitative analysis of animal lives required to produce human-consumable protein across major food production systems. Categorizing animal lives based on cognitive complexity and accounting for all lives involved in production, including direct harvests, reproductive animals, and feed species, reveals dramatic variations in protein efficiency. The analysis considers two categories of animal life: complex-cognitive lives (e.g., mammals, birds, cephalopods) and pain-capable lives (e.g., fish, crustaceans). Calculating protein yield per life demonstrates efficiency differences spanning more than five orders of magnitude, from 2 g per complex-cognitive life for baby octopus to 390,000 g per life for bovine dairy systems. Key findings expose disparities between terrestrial and marine protein production. Terrestrial systems involving mammals and birds show higher protein yields and exclusively involve complex-cognitive lives, while marine systems rely predominantly on pain-capable lives across complex food chains. Dairy production emerges as the most efficient system. Aquaculture systems reveal complex dynamics, with farmed carnivorous fish requiring hundreds of feed fish lives to produce protein, compared to omnivorous species that demonstrate improved efficiency. Beyond quantitative analysis, this research provides a framework for understanding the ethical and ecological dimensions of protein production, offering insights for potential systemic innovations. Full article

True slime molds (Eumycetozoa) remain under-explored globally, particularly in water-logged forest habitats. Despite evidence suggesting a high biodiversity potential in the Knyszyn Forest of north-eastern Poland, no systematic effort had previously been undertaken there. In the present survey, plant substrates from eight swampy sub-compartments were incubated for over four months, resulting in the detection of fifteen slime mold species. Four of these taxa are newly reported for northern and north-eastern Poland, while several have been recorded only a handful of times in the global literature. These findings underscore how damp, nutrient-rich conditions foster Eumycetozoa and demonstrate the effectiveness of moist-chamber culturing in revealing rare or overlooked taxa. Current evidence shows that, although slime molds may occasionally colonize living plant or fungal tissues, their influence on crop productivity and tree vitality is negligible; they are therefore better regarded as biodiversity indicators than as pathogens or pests. By establishing a replicable framework for studying water-logged environments worldwide, this work highlights the ecological importance of swamp forests in sustaining microbial and slime mold diversity. Full article

The use of the Soil and Water Assessment Tool (SWAT) model driven by China Meteorological Assimilation Driving Datasets (CMADS) for runoff simulation research is of great significance for regional flood prevention and control. Therefore, from the perspective of production-living-ecological space, this article combined multi-source data such as DEM, soil texture and land use type, in order to construct scenarios of territorial spatial change (TSC) across distinct periods. Based on the CMADS-L40 data and the SWAT model, it simulated the runoff dynamics in the Xitiaoxi River Basin, and analyzed the hydrological response characteristics under different TSCs. The results showed that The SWAT model, driven by CMADS-L40 data, demonstrated robust performance in monthly runoff simulation. The coefficient of determination (R²), Nash–Sutcliffe efficiency coefficient (NSE), and the absolute value of percentage bias (|PBIAS|) during the calibration and validation period all met the accuracy requirements of the model, which validated the applicability of CMADS-L40 data and the SWAT model for runoff simulation at the watershed scale. Changes in territorial spatial patterns are closely correlated with runoff variation. Changes in agricultural production space and forest ecological space show statistically significant negative correlation with runoff change, while industrial production space change exhibits a significant positive correlation with runoff change. The expansion of production space, particularly industrial production space, leads to increased runoff, whereas the enlargement of agricultural production space and forest ecological space can reduce runoff. This article contributes to highlighting the role of land use policy in hydrological regulation, providing a scientific basis for optimizing territorial spatial planning to mitigate flood risks and protect water resources. Full article

Land consolidation (LC) is a sustainability-oriented policy tool designed to address land fragmentation, inefficient spatial organization, and ecological degradation in rural areas. This research proposes a Production–Living–Ecological (PLE) spatial utilization efficiency evaluation system, based on an integrated methodological framework combining Principal Component Analysis (PCA), Entropy Weight Method (EWM), Attribute-Weighting Method (AWM), Linear Weighted Sum Method (LWSM), Threshold-Verification Coefficient Method (TVCM), Jenks Natural Breaks (JNB) classification, and the Obstacle Degree Model (ODM). The framework is applied to Qian County, located in the Guanzhong Plain in Shaanxi Province. The results reveal three key findings: (1) PLE efficiency exhibits significant spatial heterogeneity. Production efficiency shows a spatial pattern characterized by high values in the central region that gradually decrease toward the surrounding areas. In contrast, the living efficiency demonstrates higher values in the eastern and western regions, while remaining relatively low in the central area. Moreover, ecological efficiency shows a marked advantage in the northern region, indicating a distinct south–north gradient. (2) Integrated efficiency consolidation potential zones present distinct spatial distributions. Preliminary consolidation zones are primarily located in the western region; priority zones are concentrated in the south; and intensive consolidation zones are clustered in the central and southeastern areas, with sporadic distributions in the west and north. (3) Five primary obstacle factors hinder land use efficiency: intensive utilization of production land (PC1), agricultural land reutilization intensity (PC2), livability of living spaces (PC4), ecological space security (PC7), and ecological space fragmentation (PC8). These findings provide theoretical insights and practical guidance for formulating tar-gated LC strategies, optimizing rural spatial structures, and advancing sustainable development in similar regions. Full article

Rural revitalization, as a crucial strategic goal for rural development in contemporary China, encompasses multidimensional connotations and requirements. Following the establishment of the ‘three rights separation’ system in 2014, land transfer has increasingly assumed a vital role, demonstrating a close and complex intrinsic logical relationship with rural revitalization. To comprehensively analyze the diverse impacts of land transfer on rural revitalization as discussed in the literature, we employ a ‘goal–strategy–indicator–outcome’ analytical framework to conduct a meta-analysis and visual assessment of 131 cases drawn from 52 articles published over the past decade. We systematically explore the pathways by which land transfer impacts rural revitalization and validate the results using typical cases reported by the Ministry of Agriculture and Rural Affairs through Python 3.9 analysis. The findings reveal the following: (1) Land transfer generally exerts a positive impact on rural revitalization (81.7% of 107 cases). (2) It significantly boosts living standards (84% positive cases) and industrial prosperity (88.4% positive cases); rural cultural civilization shows 100% positive cases yet with statistically insignificant coefficients, while its impacts on ecological livability (60%) and effective governance (70.6%) are insignificant. (3) Among 12 indicators, those related to agricultural production and farmers’ livelihoods are positive, whereas those concerning rural ecology and governance are negative. This study indicates that land transfer plays a key role in the rural revitalization strategy, but the ecological impacts and governance challenges that it presents require ongoing attention and optimization at the policy level. Full article

In the stage of high-quality development, the functional coordination between transportation systems and territorial space is a key issue for improving urban spatial efficiency. This paper breaks through the traditional volume-to-capacity ratio analysis paradigm and innovatively integrates the “production-living-ecological space” theory. By introducing an improved accessibility evaluation model and developing a coordination measurement algorithm, a three-dimensional evaluation mechanism covering development potential assessment, service efficiency diagnosis, and resource allocation optimization is established. Empirical research indicates that the improved accessibility indicators can precisely identify the transportation location value of regional functional cores, while the composite coordination indicators can deconstruct the spatiotemporal matching characteristics of “transportation facilities—spatial functions,” providing a dual decision-making basis for the redevelopment of existing space. This measurement system innovatively realizes the integration of planning transmission mechanisms with multi-scale application scenarios, guiding both overall spatial planning and urban renewal area re-optimization. The methodology, applied to the urban villages of Guangzhou, can significantly increase land utilization intensity and value. The research results offer a technical tool for cross-scale collaboration in land space planning reforms and provide theoretical innovations and practical guidance for the value reconstruction of existing spaces under the context of new urbanization. Full article

Extremophiles are microorganisms capable of living on Earth in ecological niches characterized by peculiar conditions, including extreme temperatures and/or pH, high salt concentrations, and the presence of heavy metals. The development of unique structural and functional adaptation strategies has stimulated an increasing scientific interest since their discovery. The importance of extremophiles lies in their exploitability in significant bioprocesses with several biotechnological applications and their role as a fundamental source of numerous high-value-added biomolecules. This review aims to examine the diversity and specificities of extremophilic archaea and bacteria, with particular emphasis on their potential applications and development in biotechnology and biomedicine. The use of extremophiles and their extremozymes has allowed applications in several fields, such as bioremediation, sustainable agriculture, the recovery of bioactive molecules for use in bioenergy, biomedicine, and nanoparticle production. The comprehension and exploitation of the complex molecular mechanisms that enable life in extreme environments represent a challenge to mitigate current climate change problems and to invest in sustainable development towards a green transition. Full article

Italy supplies about one-seventh of the European Union’s total glass production, and the sector’s sizeable resource demands make it a linchpin of national industrial strategy. With growing environmental regulations and the push for resource efficiency, Material Flow Accounting has become essential for companies to stay compliant and advance sustainability. The investigation concentrates on Italy’s glass industry to clarify its material requirements, ecological footprint, and overall sustainability performance. STAN software v2, combined with an Economy-Wide Material Flow Accounting (EW-MFA) framework, models the national economy as a single integrated input–output system. By tracking each material stream from initial extraction to end-of-life, the analysis delivers a cradle-to-grave picture of the sector’s environmental impacts. During the 2021 production year, Italy’s glass makers drew on a total of 10.5 million tonnes (Mt) of material inputs, supplied 76% (7.9 Mt) from domestic quarries, and 24% (2.6 Mt) via imports. Outbound trade in finished glass removed 1.0 Mt, leaving 9.5 Mt recorded as Domestic Material Consumption (DMC). Within that balance, 6.6 Mt (63%) was locked into long-lived stock, whereas 2.9 Mt (28%) left the system as waste streams and airborne releases, including roughly 2.1 Mt of CO₂. At present, the post-consumer cult substitutes only one-third of the furnace batch, signalling considerable scope for improved circularity. When benchmarked against EU-27 aggregates for 2021, Italy registers a NAS/DMI ratio of 0.63 (EU median 0.55) and a DPO/DMI ratio of 0.28 (EU 0.31), indicating a higher share of material retained in stock and slightly lower waste generated per ton of input. A detailed analysis of glass production identifies critical stages, environmental challenges, and areas for improvement. Quantitative data on material use, waste generation, and recycling rates reveal the industry’s environmental footprint. The findings emphasise Economy-Wide Material Flow Accounting’s value in evaluating and improving sustainability efforts, offering insights for policymakers and industry leaders to drive resource efficiency and sustainable resource management. Results help scholars and policymakers in the analysis of the Italian glass industry context, supporting in the data gathering, while also in the use of this methodology for other sectors. Full article

The escalating global contamination of aquatic ecosystems by pharmaceuticals and endocrine-disrupting chemicals (EDCs) stemming from diverse anthropogenic sources represents a critical and pervasive threat to planetary Earth. These contaminants exhibit bioaccumulative properties in long-lived organisms and undergo trophic biomagnification, leading to elevated concentrations in apex predators. This review synthesizes current knowledge regarding the far-reaching impacts of pharmaceutical and EDC pollution on the reproductive biology of aquatic fauna, focusing on the heightened vulnerability of the endangered African penguin. A rigorous literature review across key scientific databases—PubMed, Scopus, Web of Science, and Google Scholar—using targeted search terms (e.g., penguins, contaminants of emerging concern, penguin species, seabird species, Antarctica, pharmaceuticals, personal care products, EDCs) underpins this analysis. This review explores the anthropogenic sources of pharmaceuticals and EDCs in aquatic ecosystems. It discusses the mechanisms by which these chemicals disrupt the reproductive physiology of aquatic fauna. Recent studies on the ecological and population-level consequences of these contaminants are also reviewed. Furthermore, the review elaborates on the urgent need for comprehensive mitigating strategies to address their effects on vulnerable penguin populations. These approaches hold the potential to unlock innovative pathways for conservation initiatives and the formulation of robust environmental management policies aimed at safeguarding aquatic ecosystems and the diverse life they support. Full article

Fermented foods represent an intricate ecosystem that delivers live microbes and numerous metabolites, influencing gut health. In this review, we explore how complex microbial communities and metabolites generated during food fermentation modulate the gut microbiome and affect human health. We discuss fermentation-induced biochemical transformations, including enhanced fiber fermentability; nutrient availability; and the synthesis of bioactive metabolites such as short-chain fatty acids, exopolysaccharides, bacteriocins, and modified polyphenols. We describe the dynamic microbial ecology of fermented foods, influenced by ingredient variations, highlighting its effect on health-related metabolic outcomes. Fermented products when consumed transiently introduce beneficial microbes and bioactive compounds into the gut, thereby boosting microbial diversity, resilience, and barrier function. We review clinical and preclinical studies to substantiate the roles of fermented foods in immune regulation, metabolic homeostasis, cognitive function, and inflammation mitigation. Individual variability in response to fermented foods has been emphasized, underscoring the potential for personalized nutrition strategies informed by advanced omics technologies. By integrating microbial ecology, metabolomics, and clinical evidence, this review positions fermented food intake as a strategic dietary intervention for microbiome modulation and health promotion. Full article

Intensified human activities and changes in land-use patterns have led to numerous eco-environmental challenges. A comprehensive understanding of the eco-environmental effects of land-use transitions and their driving mechanisms is essential for developing scientifically sound and sustainable environmental management strategies. However, existing studies often lack a comprehensive analysis of these mechanisms due to methodological limitations. This study investigates the eco-environmental effects of land-use transitions in the Poyang Lake Region over the past 30 years from the perspective of the production-living-ecological space (PLES) framework. Additionally, a geographically explainable artificial intelligence (GeoXAI) framework is introduced to further explore the mechanisms underlying these eco-environmental effects. The GeoXAI framework effectively addresses the challenges of integrating nonlinear relationships and spatial effects, which are often not adequately captured by traditional models. The results indicate that (1) the conversion of agricultural space to forest and lake spaces is the primary factor contributing to eco-environmental improvement. Conversely, the occupation of forest and lake spaces by agricultural and residential uses constitutes the main driver of eco-environmental degradation. (2) The GeoXAI demonstrated excellent performance by incorporating geographic variables to address the absence of spatial causality in traditional machine learning. (3) High-altitude and protected water areas are more sensitive to human activities. In contrast, geographic factors have a greater impact on densely populated urban areas. The results and methodology presented here can serve as a reference for eco-environmental assessment and decision-making in other areas facing similar land-use transformation challenges. Full article

Soundscape is the sonic environment that a living being, like a human or animal, experiences in a certain setting. It affects how a space functions and how the being perceives its quality. Consequently, the soundscape is crucial in ecosystems globally. In recent decades, researchers have explored soundscapes using various methodologies across different disciplines. This study aims to provide a brief overview of the soundscape research history, pinpoint key authors, institutions, and collaboration networks, and identify trends and main themes through a bibliometric analysis. A search in the Scopus database on 26 February 2025 found 5825 articles, reviews, and conference papers on soundscape published from 1985 to 2024. The analysis indicated a significant increase in soundscape publications, rising from 1 in 1985 to 19 in 2002, and reaching 586 in 2024. J. Kang was the most prolific author with 265 publications, while University College London emerged as the most productive institution. Co-citation analysis revealed three research groups: one focused on urban soundscapes, another on aquatic soundscapes, and a third on soundscapes in landscape ecology. The keyword co-occurrence analysis identified three themes: “soundscape(s), acoustic environment, and urban planning”, “noise, animal(s), bioacoustics, biodiversity, passive acoustic monitoring, fish, and bird(s)”, and “human(s), sound, perception, and physiology”. Full article

The final recipient of nanoparticles, including various types of copper-based nanoparticles (Cu-based NPs), is the aquatic environment. Their increased production, especially as a component of antimicrobial agents, raises concerns about uncontrolled environmental release and subsequent ecological risks. The high reactivity of Cu-based NPs enables interactions with biotic and abiotic environmental components, leading to bioaccumulation and disorders in living organisms, such as fish in various life stages, especially in embryos or hatchlings. Increasing concentration of Cu-based NPs causes various toxic effects, mainly through the induction of oxidative stress. These effects include impairment of antioxidant mechanisms, as well as damage to genetic material, cells and tissues, growth retardation, metabolic disorders, increased mortality, or hatching inhibition. The aim of this review is to describe the release routes of Cu-based NPs and their adverse effects on fish, while emphasizing the need for further research on their toxicity and measures to control their release to the environment. Given the limited data on the toxicity of Cu-based NPs, especially concerning sensitive fish developmental stages, further studies are required. Full article

The subtropics are affected by severe climate change, which may induce heat stress in animals. Moreover, the region is significantly seasonal; hence, mitigating climate risks and implementing climate adaptation measures are necessary. Sustainable Development Goals 1, 2, and 13 call for no poverty, zero hunger, and climate action. These are the most severe problems affecting food security in the modern world. Food security refers to a situation in which all people have physical, social, and economic access to sufficient, proper, and healthy food that satisfies their dietary requirements. Nevertheless, the projected increase in the human population implies a greater demand for employment opportunities; hence, developing countries are building more industrial areas. The burning of fossil fuels in various industries potentiates climate change and environmental pollution. It is predicted that the ecological temperature will increase by almost 2.3–4.8 °C by 2100 due to climate change. Agriculture and animal products remain vital in Africa as drivers of the economy and transformation for sustainable livelihood and development. Sheep production has long been used as a source of income and livelihood and provides jobs for people who live in rural areas. It is also sometimes used for ritual ceremonies and to pay penalties to local authorities. Nevertheless, sheep have been identified to be sensitive to heat stress, characterized by low reproductive performance, low microbiota quantities, and poor general health. There are different strategies for mitigating heat stress; however, many smallholder farmers have limited access to education and lack the financial support required to incorporate artificial shade and plant trees for shade to limit heat stress. In this review, we aim to understand the effects of environmental heat stress on sheep production and reproductive performance. Based on this review, it can be concluded that heat stress can threaten food security if not addressed, especially for farmers who depend on sheep rearing. As a result, future studies are recommended to understand different adaptation methods that can be used to mitigate the heat stress effect on sheep productivity, reproductivity, and general health. Full article