Search Results (2,364)

Effective recovery of materials from construction and demolition waste (CDW) remains a major problem and a real challenge in terms of implementing the circular economy. In many countries, this waste is landfilled due to the lack of modern technological lines for its recovery and recycling, including the sorting of materials suitable for reuse. Understanding the environmental impact of the CDW treatment process is important as it constitutes the final stage of building life cycle assessment and the basis for eco-design of construction processes. In addition, the recovered materials can be used as raw materials for construction, thereby closing the waste loop and aligning with the circular economy concept. The purpose of this study is to compare the environmental impact of three different CDW recovery technologies in order to identify the optimal option. The analysis was performed using the life cycle assessment (LCA) methodology, SimaPro 8.1 software, and the Ecoinvent v3.8 database. 1 Mg of processed CDW was adopted as the functional unit. It was found that the process of recovering materials from CDW allows for sorting over 13% of materials for recycling and approx. 40% of raw materials for reuse (stone aggregates). The conducted analyses showed that all three installations exert a negative impact on the environment. Solution No. 2 had the lowest total environmental impact (15.96 Pt) under the assumptions and datasets used in this study, presenting average electricity and fuel consumption and average weight of sorted materials for recycling. Installation No. 3, which sorts the largest volume of materials for recycling, also used the most electricity; therefore, it could not be considered as the solution with the minimal overall environmental impact. The research revealed that the treatment of CDW in a crusher, applied at all installations, is the process stage resulting in the greatest environmental pressure (16.92 Pt). The high level of sorted recyclable waste enabled a relatively low carbon footprint for processes No. 2 and No. 3, 18.7 and 17.6 kg CO₂ eq, respectively (more than four times lower than for installation No. 1). Future analyses should focus on optimizing the CDW recovery process by avoiding the use of impact crushers, as adding more waste sorting equipment does not significantly enhance environmental benefits. Full article

The current study aims to address the research gap regarding inconsistent findings on the effect of environmental knowledge (EK) in enhancing green purchase intention (GPI) by incorporating pro-environmental behavior (PEB) and environmental concern (EC) as factors to leverage green purchase intention. Five hypotheses were developed and tested using a sample of 300 respondents in Indonesia. Survey data from 300 respondents were analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). The findings demonstrate the pivotal role of pro-environmental behavior in two ways. First, pro-environmental behavior mediates the relationship between environmental knowledge and green purchase intention. Second, while pro-environmental behavior enhances environmental concern, it is insufficient to fully strengthen green purchase intention; additional factors, such as the activation of ethical values of concern, are needed to reinforce this intention further. However, the limitations include reliance on quantitative cross-sectional data and focus on Bali, suggesting a need for longitudinal and cross-cultural studies. Practical recommendations include incorporating local communities in eco-tourism programs to ensure social acceptance and sustainability. In general, the results contribute theoretically by integrating knowledge, concern, and behavior into a cohesive model explaining green consumer intentions in tourism. This comprehensive approach supports efforts to transform individual values and behavior, which are critical alongside systemic or policy changes in advancing sustainable tourism. Full article

Achieving environmentally sustainable growth is a core challenge for developing economies, yet the welfare consequences of green development policies for vulnerable populations remain understudied. This article investigates the distributional impacts of one of the world’s largest development interventions: China’s energy transition. By integrating provincial-level energy metrics with a decade-long household panel survey (CFPS), we employ a fixed-effects model to provide a holistic assessment of the policy’s effects on household well-being. The analysis reveals a stark trade-off: a 10% increase in clean energy adoption generates significant non-monetary well-being gains, equivalent to a 190,000 CNY annual income rise, primarily through improved environmental quality and cleaner cooking fuel access. However, these benefits are partially offset by rising energy costs. Our heterogeneity analysis reveals a clear regressive burden: the transition significantly increases energy expenditures for rural and low-income households, while having a negligible or even cost-reducing effect on their urban and high-income counterparts. Our findings demonstrate that while the energy transition promotes aggregate welfare, its benefits are unevenly distributed, potentially exacerbating energy poverty and inequality. This underscores a critical development challenge: green growth is not automatically inclusive. We argue that for the energy transition to be truly pro-poor, it must be accompanied by robust social protection mechanisms, such as targeted subsidies, to shield the most vulnerable from the adverse economic shocks of the policy. Full article

This study explores how contextual framings influence sustainable decision-making in everyday situations. Building on the literature about the intention–behaviour gap, we examine the combined effect of role activation and environmental risk on pro-environmental preferences. A scenario-based behavioural experiment, conducted via oTree, integrated within-subject role framing (citizen, consumer, neutral) with randomised environmental risk conditions. Participants completed repeated binary choice tasks, where Eco-Preference was defined as the frequency with which they chose the sustainable option. The results indicate that activating a citizen role significantly increased Eco-Preference compared to consumer or neutral framings, while high-risk contexts did not directly boost sustainable behaviour. Instead, risk cues had an indirect effect through motivational states, highlighting the mediating role of Eco-Preference. Theoretically, this study advances Eco-Preference as a latent behavioural construct linking identity-based theories of responsibility with decision-based models of sustainability. Practically, the findings underscore the potential of role-based communication strategies to enhance ecological responsibility, suggesting that both policy and organisational interventions can benefit from fostering civic identities. Ultimately, the framework is applicable across cultures by offering a behavioural measure less prone to survey bias, supporting future comparative research on environmental decision-making. Full article

Acrylamide (ACR), a common dietary pro-oxidant generated in heat-processed foods, disrupts mitochondrial redox homeostasis. While its neurotoxic effects are recognized, the role of ACR in depression remains poorly understood. We hypothesized that dietary ACR exposure promotes depression via SIRT3-dependent mitochondrial oxidative injury. Through an integrative approach combining network toxicology (to prioritize candidate targets), transcriptomics, and Mendelian randomization (MR), we identified SIRT3 as the central mediator. Molecular dynamics simulations demonstrated that ACR’s primary metabolite glycidamide (GA) formed more stable and rigid complexes with key targets (including SIRT3, TP53, CASP3, JUN, PTGS2, and PTK2) than ACR itself, as evidenced by superior structural stability, reduced flexibility, and enhanced hydrogen bonding. Transcriptomic analysis of the human prefrontal cortex (datasets GSE54567 and GSE54568) revealed mitochondrial deacetylase sirtuin 3 (SIRT3) as the most significantly suppressed gene in depression (p < 0.01), suggesting an impairment in Superoxide dismutase 2 (SOD2)-mediated antioxidant defense. MR further established JUN and PTK2 as causal genetic risk factors for depression (JUN: Odds Ratio (OR) = 1.029, 95% CI = 1.002–1.057; PTK2: OR = 1.040, 95% CI = 1.005–1.076; JUN (OR) = 1.048, 95% CI = 1.021–1.076, PTK2: OR = 1.073, 95% CI = 1.039–1.109) of each MR estimates, while other candidates lacked genetic support. Our findings demonstrate that ACR induces depression primarily through SIRT3 suppression, activating JUN/PTK2 pathways, suggesting its potential role in environmental toxicant-induced redox imbalance. Full article

The work is focused on the study of the influence of different types of inorganic fillers, in combination with modifiers, on the rheological, thermal, and mechanical properties of a biodegradable mixture based on PLA/PHB. Ten types of inorganic fillers based on talc, magnesium hydroxide, aluminum hydroxide, calcium carbonate, and silicon dioxide were used in the study, along with three types of modifiers. It was concluded that fillers containing reactive OH groups on their surface act as strong pro-degradants in PLA/PHB blends, and their degrading effect can be suppressed by the addition of reactive modifiers. Each modifier acts specifically with different types of fillers. Therefore, it is necessary to select a suitable filler/modifier combination not only for fillers with different chemical compositions but also for fillers with different morphologies within the same chemical type. Moreover, the preparation of PLA/PHB/magnesium hydroxide blends with suitable processing and application properties opens the possibility of developing environmentally friendly polymeric materials with a reduced flammability. The addition of talc, which has a platelet structure, can increase the barrier properties of the mixture. Full article

Neutrophilic asthma (NA) is an inflammatory phenotype of asthma, characterized by predominantly neutrophilic infiltrations in bronchial mucosa. It is usually diagnosed on the basis of high neutrophil count in induced sputum (from >40% to >76%) with low eosinophils (<2%). The prevalence of NA ranges from 16% to 28% of the adult asthma population depending on the definitions and study methods applied. A clinical picture of NA is characterized by late onset of symptoms, higher exacerbation rate, lower level of symptoms control, and poorer response to steroids compared to eosinophilic phenotype. Comorbidities such as obesity and GERD as well as the influence of environmental factors (air pollution, smoking, bacterial infections) contribute to the development and severe course of the disease. NA is T2-low disease with predominantly Th1/Th17-type inflammation. Neutrophils are key cells responsible for initiating and sustaining inflammation. In addition to their primary functions like phagocytosis, degranulation, and NETosis, neutrophils release several pro-inflammatory cytokines (IL-1α, IL-1β, IL-6, TNF) and chemokines (CXCL-1, -2, -8, -9, -10) responsible for the recruitment of other neutrophils or T cells. Increasing knowledge about the biology of neutrophiles and their role in asthma results in new potential therapies that could improve control of NA, particularly new biologicals targeting Th1/Th17-related cytokines. In this review, we discuss the prevalence, mechanisms, and clinical features of neutrophilic asthma. Furthermore, current therapeutic options and some promising perspectives for the near future are presented. Full article

Maintaining a high-quality urban environment remains a critical yet challenging issue in modern cities, particularly in densely built and historically significant central areas. In response, the European Green Deal initiative aims to promote sustainable urban development. This study presents a multi-criteria assessment methodology for evaluating urban environments, with a focus on prioritizing thermal renovations of buildings to achieve substantial environmental improvements. The research adopts a centrifugal strategy, targeting buildings with the poorest energy performance for phased renovation efforts. Using the model city of Gubin, Poland, as a case study, the assessment proceeds through five stages: evaluating technical wear (Stages I–II), estimating replacement values and renovation costs (Stages III–IV), and finally, quantifying environmental benefits from energy efficiency upgrades (Stage V). Findings reveal that buildings in the lowest energy class (Class G) require investments of 111–193% of their replacement value but can deliver CO₂ emissions reduced to 1/6.2 of the original level (an approximate 84% reduction). The primary contribution of this paper is the development and application of a novel multi-criteria assessment methodology for evaluating urban environments, specifically designed to prioritize thermal renovations in central urban areas to achieve significant environmental and economic benefits. The study provides valuable economic and environmental indicators that can guide the formulation of pro-environmental urban policies and support strategic decision-making in cities with dense populations and aging infrastructure. Full article

In light of escalating global environmental deterioration, studies on pro-environmental intention and behaviour with the ultimate goal of identifying contributing factors to minimise environmental issues are common. Theory of Planned Behaviour (TPB) is widely used to study environmental intentions and behaviours. However, how quality of life (QoL) influences these intentions and interactions among TPB’s own variables within a single research framework has not been thoroughly explored. Therefore, this study extends TPB by incorporating the four dimensions of QoL, as measured by the Control, Autonomy, Self-Realisation, and Pleasure (CASP-19) scale, to understand pro-environmental intentions from Malaysian viewpoints. In this study, quantitative approach was applied, and the data were collected from Malaysians aged 18 and above (N = 182) in Klang Valley, Malaysia. Using Partial Least Squares Structural Equation Modelling (PLS-SEM), a two-step approach was employed to assess the measurement and structural models. The findings confirmed Theory of Planned Behaviour (TPB) is a robust model for environmental studies showing that subjective norm and perceived behavioural control significantly influence attitudes toward pro-environmental behaviour, ultimately leading to pro-environmental intention. Interestingly, this study found no relationship between QoL dimensions and pro-environmental intention. Lastly, both theoretical and managerial implications were discussed, and research limitations and suggestions for future research directions were put forward. Full article

Fluoride is a widespread environmental toxin that disrupts metabolic and endocrine functions, but its impact on pancreatic inflammation and hormone secretion remains unclear. This study examined how chronic fluoride exposure affects pancreatic inflammation and secretory function in rats. Pregnant Wistar rats received sodium fluoride (NaF) at 50 mg/L in drinking water during gestation and lactation. Male offspring continued exposure until 3 months old. Controls received fluoride-free water. Pancreatic tissue and serum were collected. Fluoride levels were measured potentiometrically. Eicosanoids were quantified by SPE and HPLC. Serum insulin, glucagon, and somatostatin were measured by ELISA. Histological and biochemical markers of inflammation and oxidative stress were assessed. Fluoride exposure did not lead to significant accumulation in the pancreas or serum. However, fluoride-exposed rats exhibited a significant decrease in serum insulin and somatostatin concentrations, while glucagon levels remained unchanged. Additionally, the pancreas of fluoride-treated animals showed markedly elevated levels of pro-inflammatory eicosanoids, including prostaglandin E2, leukotrienes A4 and B4, and HETE/HODE derivatives, indicating activation of cyclooxygenase and lipoxygenase pathways. Sustained low-dose fluoride exposure induced pancreatic inflammation and disrupted endocrine homeostasis in rats. These findings suggest that chronic fluoride intake may impair insulin secretion and promote pre-diabetic alterations, warranting further research. Full article

Stem cell (SC)-based therapy exploits the ability of cells to migrate to damaged tissues and repair them. In this context, there is a strong interest in the use of mesenchymal stem cells (MSCs), multipotent SCs that are easy to obtain and are able to differentiate into various cell lineages. However, MSCs undergo cellular senescence during in vitro expansion, and may also become senescent in vivo, influenced by multiple molecular, cellular, and environmental interactions. Therefore, the development of in vitro cell models is crucial to study the mechanisms underlying senescence in MSCs. This study aimed to investigate the effects of tert-butyl hydroperoxide (t-BHP) as a senescence inducer in human dermal MSCs (hDMSCs), a promising tool for tissue repair. t-BHP induced a pro-senescent effect on hDMSCs greater than hydrogen peroxide (H₂O₂), as evidenced by ROS production, DNA damage, cell cycle arrest, inhibition of cell proliferation, changes in cellular and nuclear morphology, and cytoskeletal reorganization, as well as the increase in other senescence markers, including senescence-associated β-galactosidase (SA-β-Gal)-positive cells, and senescence-associated secretory phenotype (SASP). These results indicate that t-BHP could be a promising compound for inducing stress-induced premature senescence (SIPS) in hDMSCs, providing a valuable tool to investigate this process and evaluate the efficacy of senolytic compounds. Full article

Background: Folic acid (FA), also known as vitamin B9, functions as a co-factor in many cellular processes. Ultraviolet radiation (UV) has been shown to cause the formation of free radicals, and chronic exposure of the skin to UV radiation has been demonstrated to result in many adverse effects. Skin protection against harmful environmental factors is one of the aims of cosmetic products. One such substance is folic acid. However, aqueous FA solutions decompose after exposure to UV radiation, and the decomposition products can exhibit variable pro/anti-oxidative roles depending on the cell type and its environment. Objectives: The objective of the present study was to demonstrate the effectiveness of folic acid as a UV-protective agent in vitro cell culture model. Methods: The experimental model comprised an in vitro culture of normal human fibroblasts derived from adult skin (NHDF-Ad). Paramagnetic electron resonance (EPR) was used to assess the interaction of folic acid with free radicals after exposure to UV radiation. RT-qPCR was utilized to evaluate the impact of ultraviolet (UV) radiation on the expression of selected cell cycle regulatory genes (CCND1, P53, BAX, and BCL-2) in vitro cultured fibroblasts that were protected by folic acid. Results: EPR studies revealed the antioxidant properties of folic acid. Free radical forms of folic acid are induced during UV irradiation. The strong effect of UV irradiation on interactions of folic acid with free radicals was observed. The interaction was found to be weaker for the irradiated samples. Molecular studies have demonstrated a decline in the BAX/BCL-2 ratio in cells that have been treated with folic acid and exposed to UV radiation in comparison to the BAX/BCL-2 ratio observed in cells that have been exposed exclusively to UV radiation and not treated with folic acid. Conclusions: Whilst molecular and EPR studies both confirm the effectiveness of folic acid as a UV-protective ingredient in cosmetics and pharmaceutical products, further research in this area is required. Full article

Due to rapid economic development, high energy consumption, and the depletion of natural resources, resulting in climate change, urban planners and architects face the difficult task of creating a new type of sustainable city that takes into account rapid population growth. The aim of this article is to examine the development of contemporary forms of high-rise architecture and the role of the vertical city in responding to shrinking space and developing a realistic strategy for sustainable urban development. Literature analysis, case studies, and multidisciplinary analysis are used. Pro-ecological solutions are identified and analyzed using the most representative buildings in Asia and a theoretical example in Nanjing. The examples are characterized by above-average height, unusual shapes, and the use of advanced pro-ecological strategies. Greenery plays a key role, including regulating the temperature inside the building. Vertical multifunctionality is becoming an increasingly common response to increasing spatial needs. The apparent lack of understanding of the development of high-rise buildings in cities around the world, extending beyond individual skyscrapers, constitutes a research gap. This article discusses Chongqing, an example of a vertical city, which is understood not only in terms of individual high-rise buildings but also as a whole structure. The study addresses the issue of a new type of compact city: the vertical city. The article provides key guidelines and constraints for creating densely populated, yet sustainable and environmentally friendly cities of the future. The practical application of the study can be utilized by urban planners and decision-makers. Full article

Marine mammals are important ecological bio-indicators of marine ecosystems impacted by a plethora of anthropogenic and environmental threats. Genomics detects genetic variation, adaptation to environmental shifts, and susceptibility to diseases in marine mammal species. In this study, eDNA was utilized for the first time in the Pagasitikos Gulf over three consecutive years (2022–2024) in order to detect marine mammal species. Additionally, visual monitoring and eDNA results were compared to reveal the pros and cons of the two methodologies. The gulf was zoned into five different areas with respect to oceanographic features for sampling. DNA extraction was assessed by using a standard protocol of phenol–chloroform followed by PCR amplification using the 16S rRNA gene. A total of 5,209,613 highly filtered sequence reads were attributed to 108 species. Among these, Monachus monachus, Tursiops truncatus, and Ziphius cavirostris species were detected. This novel detection of Z. cavirostris in the relatively shallow waters of the Gulf of Pagasitikos raised the question of whether it was a random event or a new ecological trend. Z. cavirostris and M. monachus appeared to share the same marine areas within the gulf. In the era of the climate crisis, eDNA provides essential information on marine mammals’ ecological status, yields novel detections, and predicts behavioral changes essential to deep-diving species. Full article

Household food waste remains a persistent challenge despite widespread pro-environmental intentions. Drawing on Brehm’s Motivational Intensity Theory, this study examined how perceived difficulty and perceived ability interact with motivation to predict self-reported food waste. We surveyed 939 participants in Flanders and Spain, measuring motivation to avoid waste, self-rated perceived ability to manage food, meal planning perceived difficulty, and food waste. Moderated moderation analyses revealed that motivation and perceived ability each independently predicted lower waste. Crucially, a significant three-way interaction showed that motivation most effectively reduced waste when perceived difficulty was low and perceived ability was high; when perceived difficulty exceeded perceived ability, motivation had no mitigating effect. These findings underscore that effort mobilization influenced by both individual capacity and situational demands is key to closing the intention–behavior gap in food waste. Practically, interventions should go beyond raising awareness to simplify tasks and bolster consumers’ skills, aligning action demands with realistic effort levels. Full article