Search Results (65)

It is well established that different fasting strategies offer a range of benefits and may even serve as potential therapeutic approaches for metabolic diseases. The biological effects of intermittent fasting (IF) are multidimensional, involving the induction of metabolic switching from glucose to fatty acid and ketone utilization, thereby enhancing fat metabolism and improving glucose tolerance and insulin sensitivity. In addition, IF modulates the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis by lowering IGF-1 levels, a change associated with enhanced cellular protection, reduced tumorigenesis, and delayed aging. Moreover, IF modulates key signaling pathways, including mitogen-activated protein kinases, Notch, and nuclear factor kappa B, which collectively contribute to reduced oxidative stress, attenuated inflammation, and hepatoprotection. Although fasting may present certain challenges, it is essential to be adequately informed about its potential benefits and appropriate preparatory strategies before undertaking various fasting protocols. This review summarizes the current knowledge on various IF protocols and periodic short-term fasting (PSTF) lasting more than 24 h and up to 72 h, highlighting the signaling pathways through which these interventions affect metabolic processes. Additionally, it aims to provide a practical guide for the safe preparation for PSTF lasting more than 24 h and up to 72 h. Full article

This paper presents the results of an archaeometric investigation of the preparatory mortars of the pebble pavements of the Basilica of St. Leucio in Canosa di Puglia (Bari, Southern Italy). The main aim of the presented study is to contribute to the dating of some portions of the pebble pavements by analyzing the preparatory layers and determining whether they pertain to the basilica (6^th century CE) or to the pre-existing temple (2^nd century BCE–4^th century CE). Further purposes are to provide information about the production technologies of the mortars and to identify the nature of the pigments found on some pebbles. In order to contribute to the dating studies of the floors, complicated by previous reuse and restoration, 12 samples of mortars, sometimes including pebbles, were collected in different areas of the site. They were analyzed by polarized light microscopy (PLM), X-ray diffractometry (XRPD), X-ray fluorescence spectroscopy (XRF), and scanning electron microscopy coupled with an energy-dispersive spectrometer (SEM-EDS). The results allowed us to advance chronological data on different pavement areas, to deepen our knowledge on mortar production, in terms of both raw materials and technology, and to identify red ochre as the pigment with which the pavement surface was painted. Full article

In China, fruit tree diseases are a significant threat to the development of the fruit tree industry, and knowledge about fruit tree diseases is the most needed professional knowledge for fruit farmers and other practitioners in the fruit tree industry. Research papers are the primary sources of professional knowledge that represent the cutting-edge progress in fruit disease research. Traditional knowledge engineering methods for knowledge acquisition require extensive and cumbersome preparatory work, and they demand a high level of professional background and information technology skills from the handlers. This paper, from the perspective of fruit tree industry knowledge dissemination, aims at users such as fruit farmers, fruit tree experts, fruit tree knowledge communicators, and information gatherers. It proposes a fast, cost-effective, and low-technical-barrier method for extracting fruit tree disease knowledge from research paper abstracts—K-Extract, based on large language models (LLMs) and prompt engineering. Under zero-shot conditions, K-Extract utilizes conversational LLMs to automate the extraction of fruit tree disease knowledge. The K-Extract method has constructed a comprehensive classification system for fruit tree diseases and, through a series of optimized prompt questions, effectively overcomes the deficiencies of LLM models in providing factual accuracy. This paper tests multiple LLM models available in the Chinese market, and the results show that K-Extract can seamlessly integrate with any conversational LLM model, with the DeepSeek model and the Kimi model performing particularly well. The experimental results indicate that LLM models have a high accuracy rate in handling judgment tasks and simple knowledge Q&A tasks. The K-Extract method is simple, efficient, and accurate, and can serve as a convenient tool for knowledge extraction in the agricultural field. Full article

Time series satellite data, coupled with available ground-based observations, enable geophysicists to survey earthquake precursors in areas of strong geotectonic activity. This paper is focused on pre-seismic atmospheric disturbances resulting from the stress accumulated during the seismogenic process related to the 6 February 2023 Kahramanmaras doublet earthquake sequence in Türkiye. We investigated the pre- and post-seismic anomalies of multiple precursors of different spatiotemporal patterns from MODIS Terra/Aqua and NOAA-AVHRR satellite data (air temperature at 2 m height—AT, air relative humidity—RH, and air pressure—AP, surface outgoing long-wave radiation—OLR, and land surface temperature—LST). Pre-seismic recorded anomalies of AT within seven months and OLR within one month before the main shocks suggested the existence of the preparatory process of the Kahramanmaras doublet earthquake. The 8-Day LST_Day and LST_night data evidenced pre-seismic and post-seismic thermal anomalies for both the Pazarcik and Elbistan earthquakes. The results of this study highlight that the spatiotemporal evolution of earthquake precursors can be important information for updating the seismic hazard in geotectonic active areas. Full article

Background/Objectives: This study investigated the behavior of postural adjustments throughout the entire action: from the preparatory phase (anticipatory postural adjustment, APA), the focal movement phase (online postural adjustments, OPA), to the compensatory phase (compensatory postural adjustment, CPA) while raising the arms in a standing position, both with eyes opened and closed. The goal was to analyze the effects of reduced sensorial information and different heights on postural muscle activity during these three phases. Methods: Eight young women performed rapid shoulder flexion while standing on the ground and on a 1-m elevated platform. The EMG activity of the trunk and lower limb muscles was recorded during all three phases. Results: Although average muscle activity was similar on the ground and the elevated platform, the pattern of postural muscle activation varied across the motor action. During OPA, all postural muscle activity was the highest, while it was the lowest during APA. On the elevated platform postural muscles have increased their activation during APA. In the most stable condition (standing on the ground with eyes opened), muscle activity showed a negative correlation between APA and OPA, but there was no correlation between OPA and CPA. Conclusions: Our results suggest postural control adapts to sensory, motor, and cognitive conditions. Therefore, the increased demand for postural control due to the height of the support base demands greater flexibility in postural synergies and alters muscle activity. Full article

Since the Hellenistic period, preparatory drawings known as sinopiae were employed as guidelines for mosaicists in creating mosaics. The sinopiae served as the basis for style and content, facilitating the placement of colored tesserae in the supporting mortar. The technology of the mosaic and pigments used reflect the capacity of the mosaic workshop and its master. This work explores a polychrome sinopia that was found under a Byzantine mosaic of an Armenian Chapel in Jerusalem, by a multi-analytical characterization of mineralogical and chemical properties. The composition of the pigments in the black and red areas of the sinopia include carbon black and red ochre, respectively, utilized in the fresco technique. Since colored tesserae are placed in wet mortar, it can be deduced that mosaicists worked together with painters during the executionary steps. This has corresponding implications for historical and artistic specializations at mosaic workshops, with deeper understanding of mosaic production processes. This research also highlights the importance of studying sinopiae under floor mosaics, which is a source of information on the pigments, paintings techniques, and the people who executed the work, all embedded in mortar which is well protected below the stone tesserae. Full article

This scoping review was conducted under the Joanna Briggs Institute (JBI) framework. It included primary studies published until 30 April 2023, obtained through a systematic search across PubMed, Web of Science, CINAHL, and MEDLINE databases. The review focused on primary studies that used the Delphi technique in nursing competence research, especially those related to defining core competency frameworks and developing instruments to assess professional competence. The goal was to analyze the different methodological approaches used by authors, synthesize them, and propose recommendations to enhance methodological rigor, reliability, and validity in the application of the Delphi technique. For this purpose, the following review question was established: “What is the available evidence on the use of the Delphi technique in the study of professional competence in nursing?”. The extracted textual elements underwent a content analysis, resulting in dimensions established through an inductive approach. Twenty studies were included, yielding insights into diverse methodological options for conducting Delphi studies, organised around a set of dimensions: (1) preparatory procedures; (2) procedures for accessing and selecting experts; (3) acquisition of expert input; (4) data analysis and consensus; and (5) ethical and legal procedures and guarantees. The study’s limitations include the inability to include certain studies due to a lack of response to requests for clarification from corresponding authors. Additionally, the primary studies’ methodological quality was not assessed, which is another relevant aspect. The study’s results offer valuable insights for researchers intending to utilise the Delphi technique within the context of the research referenced in the included studies. This information encompasses important methodological choices, highlighting their potential benefits and associated risks. The review was prospectively registered on the Open Science Framework (Registration No: osf.io/kp2vw). Full article

Dogs are the most common pet animal species in the UK. Little is known about information and advice gathering within the process of dog acquisition, nor what pre-acquisition research encompasses. This study aimed to better understand the preparatory research undertaken by prospective dog owners in the UK. A 2019 online survey collected quantitative and qualitative data about dog acquisition. Analyses within this study focused on a subset of these current (n = 4381) and potential (n = 2350) owners who had undertaken research, or who reported planning to do so, before acquiring a dog. Additional qualitative data were collected through semi-structured interviews with current (n = 24) and potential (n = 8) dog owners. Among those current owners who had sought information or advice, websites were the most common source of information (76%), followed by family and friends (70%), and online forums (51%). Similar patterns were seen among potential owners. Qualitative data revealed that information was commonly sought on the following: general information about dogs; information about breeds or types of dogs; owner requirements and dog suitability; aspects of dog ownership; and how to source a dog. The majority of prospective owners stated that they had found all the information they wanted (96% of current owners and 90% of potential owners) but some respondents found conflicting advice from different sources and did not know which sources to trust. Our study shows that, for some prospective owners, research into various aspects of dog acquisition and ownership is important. Knowing where to look for correct and unbiased advice, particularly online, is particularly important. Understanding the pre-acquisition research that owners undertake, including the sources they use, information they are interested in finding, and the challenges they face, is of interest to animal welfare and veterinary organisations and those involved in rehoming and selling dogs. This information may help inform interventions aimed at improving the knowledge and decisions made by potential dog owners. Full article

This work explores the generation of James Webb Space Telescope (JWSP) imagery via image-to-image translation from the available Hubble Space Telescope (HST) data. Comparative analysis encompasses the Pix2Pix, CycleGAN, TURBO, and DDPM-based Palette methodologies, assessing the criticality of image registration in astronomy. While the focus of this study is not on the scientific evaluation of model fairness, we note that the techniques employed may bear some limitations and the translated images could include elements that are not present in actual astronomical phenomena. To mitigate this, uncertainty estimation is integrated into our methodology, enhancing the translation’s integrity and assisting astronomers in distinguishing between reliable predictions and those of questionable certainty. The evaluation was performed using metrics including MSE, SSIM, PSNR, LPIPS, and FID. The paper introduces a novel approach to quantifying uncertainty within image translation, leveraging the stochastic nature of DDPMs. This innovation not only bolsters our confidence in the translated images but also provides a valuable tool for future astronomical experiment planning. By offering predictive insights when JWST data are unavailable, our approach allows for informed preparatory strategies for making observations with the upcoming JWST, potentially optimizing its precious observational resources. To the best of our knowledge, this work is the first attempt to apply image-to-image translation for astronomical sensor-to-sensor translation. Full article

The construction industry is among the most prominent contributors to global resource consumption, waste production, and greenhouse gas emissions. A pivotal step toward mitigating these sectoral impacts lies in the adoption of a circular production and consumption system. The use of alternative waste materials can mitigate landfill accumulation and the associated detrimental environmental effects. To highlight unconventional materials, this study began with a bibliometric assessment via a bibliography analyzis software called “Bibliometrix” (version 4.1.3). The outputs from the analyzis can assist in identifying research trends, gaps in literature and benchmark research performance. The search engine used for sourcing publications was Scopus, using the main criteria as “Waste materials used in building and construction”. The time-period analysed was from 2013 to 2023. The results included publications obtained in journal articles, book chapters and conference proceedings. The assessment reviewed 6238 documents from 1482 sources. The results revealed an array of waste materials; however, rubber, textiles, and ceramics had a significant reduction in research attention. Rubber waste presents promising opportunities in civil concrete construction methods. The preparatory steps of textile fibres in composite materials are frequently disregarded, resulting in structural issues for the end-product. Obstacles persist in ceramic technology due to the absence of transparency, primarily because industry entities closely safeguard proprietary information. While sustainability research often emphasizes emissions, practical trials commonly revolve around integrating materials into current systems. A more comprehensive approach, contemplating the complete lifecycle of materials, could provide deeper insights into fostering sustainable construction practices. Researchers can use these findings when determining trends, research gaps, and future research directions. Full article

Paul Delvaux (1897–1994) was a Belgian Surrealist painter known for his dreamlike and enigmatic compositions. His works often featured nude or semi-nude women and deserted urban landscapes, evoking a sense of mystery and intrigue. Delvaux’s meticulous attention to detail and masterful use of light and shadow added depth and realism to his surrealistic style, making him one of the leading figures of the Belgian Surrealist movement. Although writings about Paul Delvaux’s work are not lacking, the literature mainly deals with the stylistic and iconographic aspects of his work. Taking an interest in painting materials and the painter’s technique allows us to understand his personality and to apprehend his work in a different way. In order to collect such information, the early painted production of Delvaux was studied in situ with imaging methods (high-resolution photography, infrared reflectography and X-ray radiography) and non-invasive analytical techniques (MA-XRF and Raman spectroscopy). The results obtained for nine oil paintings produced from 1928 to 1958 are discussed in terms of the support, the preparatory layer, the preparatory drawing, the changes in composition and reuse of paintings, the pictorial layer and the dripping phenomenon. Full article

Agroecological food system transformation remains marginal in South Africa despite numerous policies, plans and programmes favouring sustainable agriculture. Problems of weak budgets, fragmented interventions and lack of coordination reflect the power dynamics in the prevailing food system, dominated by large-scale conventional agriculture and agribusiness. The paper provides an in-depth case study of the importance of promoting agroecological transitions. Following a qualitative research methodology based on a literature review for context, preparatory discussions with local contact points, and semi-structured interviews and focus group discussions with local actors in the field, the paper describes, analyses and characterises the agroecological transitions in the Overberg District in the Western Cape. It considers the broader policy, discursive and organisational landscape of agroecology followed by an in-depth analysis of the site drawing on key informant interviews and focus group discussions. The results demonstrate that local stakeholders are positioned to better connect food and nutrition issues with human health, biodiversity, climate change, natural resource management, and local development. As a result, transformative dynamics could emerge from local projects and programmes. Several lessons and recommendations are drawn to contribute to the policy debate. These highlight the potential of multi-actor coalitions which can develop from specific agroecological initiatives and activate positive dynamics, bringing in multiple interventions of municipalities. Full article

This paper deals with a metrological and qualitative evaluation of the Artec 3D structured-light scanners: Micro and Space Spider. As part of a larger European project called ITSERR, these scanners are tested to reconstruct small archaeological artefacts, in particular cuneiform tablets with different dimensions. For this reason, Micro and Space Spider are compared in terms of the entire workflow, from preparatory work to post-processing. In this context, three cuneiform replica tablets will serve as examples on which the Artec scanners will have to prove their worth. Metric analyses based on distance maps, RMSe calculations and density analyses will be carried out to understand metrological differences between these tools. The creation of 3D models of cuneiform tablets is the first step in developing a virtual environment suitable for sharing the archaeological collection with collaborators and other users. The inclusion of semantic information through specific ontologies will be the next step in this important project. Full article

There are no effective intervention studies for people using substances who are at, or near, the end of their lives. The needs of this group of people have been consistently overlooked even within the literature that identifies marginalised groups of people in need of greater recognition in palliative and end-of-life care. The aims of the project were to: (i) determine what a new, co-produced, model of care should look like for people using substances needing palliative and end-of-life care, and (ii) establish whether the new model had the potential to improve people’s access to, and experience of, end-of-life care. This paper presents the development of the new approach to care. It was developed using participatory action research principles over a course of online workshops during the COVID-19 pandemic lockdown period in the UK. A theory of change that aims to inform future policy and practice development is presented. While the ambition of the research was stunted by the pandemic, the process of its development and dissemination of the model and its resources has continued. Response from participants highlighted the importance of this work, however, in this new field of policy and practice, preparatory work that engages a wide range of stakeholders is crucial to its success. This relationship building and topic engagement are major parts of implementation before more substantial and sustainable development goals can be met. Full article

In 2019 the Far-Infrared Outgoing Radiation Understanding and Monitoring (FORUM) mission was selected to be the 9th Earth Explorer mission of the European Space Agency (ESA). In the preparatory phase of the mission there was the need for accurate and versatile codes to compute the spectrally resolved Earth radiation escaping to space ( outgoing long-wave radiation, OLR), targets for the FORUM measurements.Moreover, for the study of planetary atmospheres, several instruments measuring the planetary radiation escaping to space have been deployed (i.e., the planetary Fourier spectrometer on Mars express or composite infrared spectrometer on Cassini). For both the analysis of the measurements of these instruments and the design of new instruments, reliable radiative transfer codes need to be available. In this paper, we describe two full physics codes, Geofit broadband-Nadir (GBB-Nadir) and Kyoto protocol-informed management of adaptation (KLIMA), both able to compute the OLR spectrum, while GBB-Nadir is only a forward model, and therefore computes the spectra only, KLIMA implements the computation of spectral radiance derivatives with respect to atmospheric parameters and therefore it is suitable to be used in retrieval codes. The GBB-Nadir code can be interfaced with radiative transfer solvers that include representations of multiple scatterings, making it suitable to compute the radiances in all-sky conditions. KLIMA has been extensively validated comparing its radiances to ones generated by the widely used line-by-line radiative transfer model (LBLRTM) code. In this paper, we describe the latest version of both codes and their comparison. We compared the optical depth computed by GBB-Nadir and KLIMA for given values of pressure, temperature and gas columns for most gases active in the far-infrared and thermal-infrared spectral regions. We show that the optical depths computed by the two codes are in very good agreement. We compared the simulated spectra in clear sky conditions for three different atmospheres (equatorial, mid-latitude and polar) at resolutions of the FORUM instrument. The differences found are well below the expected noise of the FORUM instrument. The KLIMA code has already been used to simulate the observations of the Mars atmosphere, while the limb version of the GBB code has been used to simulate the radiances measured in the limb geometry of planetary atmospheres (Titan and Jupiter). Therefore, we may safely affirm that both codes can be used to simulate the nadir measurements of planetary atmospheres. Full article